Multi-scale design of the structure and mechanical performance of the deep-sea hydrothermal mussel (Bathymodiolus aduloides) shell.

Deep-sea hydrothermal vents are renowned for being among the most extreme environments on Earth. However, the mussel shells found in these vent sites demonstrate remarkable productivity, despite being subjected to high pressure as well as unusual levels of heavy metals, pH, temperature, CO, and sulphides. To comprehend how these mussels endure such extreme conditions, a systematic comparative study was conducted, focusing on the unique chemical composition, structural designs, and mechanical properties of hydrothermal vent mussels (Bathymodiolus aduloides) in comparison to shallow-water mussels (Mytilus edulis).

Functional differentiation of industrial hemp rhizosphere microbiome along environmental gradients.

The southwestern, central, and northeastern regions of China are the primary cultivation areas for industrial hemp. Microorganisms within the soil-root continuum play a crucial role in plant health. However, the mechanisms by which these microbial communities respond to environmental gradients remain unclear.

Lithium fine-tunes biodegradation of Zn-based implant to promote osseointegration through immunomodulation.

The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process, posing challenges in achieving stable osseointegration. It is thus critical to tailor the biodegradation profiles of these implants to establish a conductive tissue microenvironment for bone tissue regeneration. In this study, we demonstrate that Zn-Li alloy forms a layer of Li-containing degradation products at the bone-implant interface to accommodate the bone regeneration process.

Noninvasive assessment of pulmonary vascular resistance: a synergistic approach using computed tomography pulmonary angiography and echocardiography in pulmonary hypertension.

Background: Pulmonary vascular resistance (PVR) is essential in managing pulmonary hypertension (PH) and has prompted the search for noninvasive assessment techniques. This study investigates the integration of morphological parameters from computed tomography pulmonary angiography (CTPA) and functional parameters from transthoracic echocardiography (TTE) to develop a noninvasive method for evaluating PVR in patients with PH.

Methods: Data from PH patients who underwent CTPA, TTE, and right heart catheterization (RHC) were analyzed retrospectively.

The post-synthetic modification of a Cd-MOF and its fluorescence sensing properties.

In this work, a three-dimensional metal-organic framework, [CdL(HO)] (Cd-MOF) was synthesized by using 2-(6-carboxypyridin-2-yl)terephthalic acid ligand (HL); and its post-synthetic modification composite, Eu@Cd-MOF was obtained by one-pot reaction of Euions with Cd-MOF. The FT-IR, PXRD, XPS, EDS, and fluorescence spectra were employed to verify the successful encapsulation of Euions into Cd-MOF. The luminescence measurements showed that Eu@Cd-MOF had a fluorescence quenching response with minocycline (MC), a widely used drug of broad-spectrum tetracycline antibiotics; and its limit of detection (LOD) for MC was 6.

Whole-genome resequencing revealed genetic structure and specific breed identification loci of Ningxia Jingyuan chicken breed (Gallus gallus).

Background: Jingyuan (JY) chicken breed is one of the Chinese regional livestock and poultry genetic resources protection breeds raised in Ningxia, China. The phenotypic characteristics of JY chickens, such as feather color, skin color, and meat quality, exhibit distinct local traits, but the genetic foundation remains unclear.

Results: This study utilized whole-genome resequencing to analyze the genetic structure, genome diversity, selection signals, and genes associated with meat quality, growth and development of the Ningxia JY chicken breed.

Enhancing Antithermal Quenching in YTaNbO:Tb Phosphor Based on Excitation Driving and Energy Transfer.

Tb-doped phosphors, serving as critical green-emitting materials for solid-state lighting, face severe reliability limitations in high-power devices due to their high-temperature thermal quenching effects. This study proposes a synergistic strategy combining excitation-driven modulation with host-activator energy transfer optimization through Ta/Nb cosubstitution in novel YTaNbO:3%Tb phosphors, achieving integrated innovation in thermal quenching suppression and dual-mode thermal response functionality. Photoluminescence measurements and density functional theory (DFT) calculations demonstrate energy transfer from [Ta/NbO] to Tb in the phosphors, while minor Nb substitution ( = 0.

Heteroatom-Modulated Asymmetric Cobalt Single-Atom Catalysts on MOF-Derived Carbon Enabling Durable Zinc-Iodine Batteries.

The rational design of catalytic host materials with optimized electronic structures and confined architectures is crucial for addressing the shuttle effect and sluggish kinetics in aqueous zinc-iodine batteries. In this study, an asymmetric cobalt single-atom catalyst is developed by anchoring Co-NP sites on a nitrogen-phosphorus co-doped carbon matrix (Co-N-PC) derived from metal-organic frameworks (MOFs). The coordination engineering of Co centers via phosphorus incorporation disrupts the symmetry of conventional Co-N configurations, enhancing charge redistribution and reducing the energy barrier for iodine dissociation as confirmed by density functional theory calculations.

Paired associative electroacupuncture and transcranial magnetic stimulation induced plasticity in human primary motor cortex.

Objective: Paired-associative stimulation (PAS) integrates transcranial magnetic stimulation (TMS) with peripheral nerve stimulation to modulate the primary motor cortex (M1) in a non-invasive manner. Numerous studies highlight its impact on M1 excitability; however, the interplay between electroacupuncture (EA) and TMS on M1 excitability remains largely unexplored. So, we designed a new PAS protocol (namely EA-PAS, an integration of EA and TMS at M1) to investigate whether the EA-PAS has the same effects as the original PAS.

High Performance Aluminum Ion Batteries Enabled by the Coordination Between Vanadium-Based PBAs Cathode and Aqueous Eutectic Electrolyte.

The practical application of aqueous aluminumion batteries (AAlBs) faced with critical challenges, such as low rate performance and poor cycling stability due to the absence of ideal cathode materials. To address the bottlenecks of low electrochemical activity, structural instability, and narrow voltage window in Prussian blue analogues (PBAs) for AAIBs, this study develops a universal synthesis strategy integrating acid-assisted method with ligand modulation to prepare high-performance vanadium-based PBAs (V-PBAs) cathodes. Through precise coordination environment control, V and Fe/Co/Ni synergistically enhance multi-electron redox activity.

Lotus carbon dots doped sodium alginate hydrogel beads for effective adsorptive removal of Cd and potential application in Pb removal from wastewater.

A cost-effective and environmentally friendly composite hydrogel for the adsorption of Cd was fabricated by combining sodium alginate with lotus carbon dots (SA@lotus CDs). The impact of many factors, including doping amount, dose, pH, initial solution concentration, adsorption period, and temperature, on the process of Cd adsorption was studied. The adsorption isotherm was fitted well to the Langmuir isotherm model with high accuracy (R = 0.

Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI.

Mitochondria coordinate with lysosomes to maintain cellular homeomstasis. However, in mitochondrial defect condition, how they communicate is less clear. Here, utilizing dMterf4 RNAi fly model, we find that expression of lysosomal alpha-mannosidase VI (LManVI) is significantly downregulated.

IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation.

Nonalcoholic fatty liver disease (NAFLD) has posed a huge threat to public health globally, but there are currently no approved drugs available. Growing evidence has proved the close association between increased Th17 cells and NAFLD progression. Interleukin-4 induced protein 1 (IL4I1), an amino acid oxidase secreted by immune cells, was reported to regulate the Th17 cells, but its exact role in NAFLD progression has not been fully explained yet.

Investigation of in vitro delivery conditions for self-amplifying mRNA.

Self-amplifying mRNA (SAM) shows promise for vaccines and gene therapy because of its self-replicating ability. However, current studies lack sufficient information for systematic parameter optimization and differentiation from conventional non-replicating mRNA (NRM). Therefore, the transfection efficiency of NRM and SAM platforms was evaluated by comparing delivery vectors and optimizing parameters for the SAM protocol.

APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells.

Background: CD157 marks a population of tissue-resident vascular endothelial stem cells (VESCs) in mice known for their critical role in homeostatic endothelial cell (EC) turnover and the rapid response to vascular damage in the liver by regeneration. Nevertheless, the mechanism underlying the maintenance and differentiation of postnatal VESCs under both physiological and pathological conditions remains unclear.

Methods: APJ knockout (KO) mice were utilized to explore the role of apelin/APJ signaling in VESC functionality.

Near-Infrared Light-Driven Efficient Tumor Elimination via Strong Oxidative Photogenerated Holes in Donor-Acceptor Supramolecular Porphyrin.

Efficient photocatalytic tumor therapy relies on deep tissue penetration via near-infrared (NIR) light absorption and potent oxidative stress induced by efficient photogenerated hole (h) migration. Herein, we report a supramolecular donor-acceptor (D-A) structure fabricated by integrating self-assembled tetra-(4-carboxyphenyl) porphyrin (SA-TCPP) with amino-functionalized graphene quantum dots (GQDs-NH). The D-A configuration significantly narrowed the band gap for extended NIR absorption and amplified the interfacial electric field 6.

Gut microbiota contribute to high-altitude adaptation in tree sparrows.

Unlabelled: The intricate relationship between gut microbiota and various physiological functions in animals has emerged as a focal point in understanding host adaptability. Unlike the native birds of the Qinghai-Tibet Plateau (QTP), the tree sparrow () is believed to have colonized the plateau within the last few thousand years. Given the vast expanse and harsh conditions of the plateau, the role of gut microbiota in facilitating the tree sparrow's adaptation to this high-altitude habitat remains largely unexplored and holds significant scientific interest.

Current Sensor with Optimized Linearity for Lightning Impulse Current Measurement.

Impulse current measurement technology is widely used in various applications, including lightning protection monitoring in power systems, welding current measurement in aircraft and shipbuilding industries, as well as high-current measurement in pulsed power systems. With the advancement of industrial technology, the measurement range of impulse currents has continuously expanded, reaching levels as high as mega-amperes (MA). The calibration of the scale factor for impulse current measurement devices is determined through comparison with standard measurement devices.

Visual analysis of ovarian cancer immunotherapy: a bibliometric analysis from 2010 to 2025.

Research on immunotherapy for ovarian cancer is rapidly advancing, and harnessing the immune system to fight tumors is at the forefront of cancer treatment. This article aims to discuss the prospect and development trend of immunotherapy for ovarian cancer from the perspective of bibliometrics. Articles about tumor burden and immunotherapy were collected from the Web of Science Core Collection (WoSCC) (retrieved on 1 May 2025).

Balance Control of Capacity and Stability of the Bimetallic Prussian Blue Cathode for High-Performance Sodium-Ion Batteries.

Prussian blue analogs (PBAs) are one of the most promising cathode materials for sodium-ion batteries (SIBs) due to their open three-dimensional backbone structure and well-developed sodium-ion diffusion channels. However, the practical application of PBAs still faces great challenges, such as a high content of anionic vacancies and poor structural stability. In this work, we synthesized nickel-manganese bimetallic PBAs by a simple coprecipitation method, and adjusting the ratio of nickel (electrochemically inert element) and manganese (electrochemically active element) can effectively control the charging and discharging depth of the battery.

Efficient surface reaction pathways in metal-free organic semiconductors for practical photocatalytic hydrogen peroxide production.

Hydrogen peroxide (HO) is a versatile oxidant widely used in pharmaceuticals, environmental protection, and chemical manufacturing. However, conventional HO production relies on energy-intensive processes and costly metal-based catalysts, raising economic and environmental concerns. As a sustainable alternative, photocatalytic HO synthesis harnesses solar energy, water, and oxygen under mild conditions.

Stereocomplexation-Promoted Alternating Supramolecular Copolymerization of Peptide-(Lactic Acid) Conjugates.

Spontaneous association of multiple components into coassemblies significantly amplifies the complexity of supramolecular systems. Owing to varied noncovalent interactions, the precise regulation of the copolymerization pathway, molecular arrangement, and assembled morphology remains a huge challenge. Here, we report an intriguing system as the first example of using complementary stereocomplexation between enantiomeric (lactic acid)s (LAs) to govern the supramolecular copolymerization behavior of a series of amphiphilic peptide conjugates.

Roles and Molecular Mechanisms of Serum Exosomal miRNA-223 and miRNA-132 in Juvenile Idiopathic Arthritis.

Introduction: The pathogenesis of juvenile idiopathic arthritis (JIA) has not yet been clarified and is closely related to persistent overactivation of the JAK/STAT signaling pathway. MicroRNA (miRNA)-223 (miR-223) and miRNA-132 (miR-132) might be involved in the development of JIA. However, the mechanism underlying the pathogenesis of JIA is unclear.

LincRNA-MSTRG.673.2 Promotes Chicken Intramuscular Adipocyte Differentiation by Sponging miR-128-3p.

Intramuscular fat content is positively correlated with meat flavor and juiciness. Increasing the intramuscular fat (IMF) content of chickens while increasing their growth rate has become a hot topic in molecular breeding. The group's previous studies showed that miR-128-3p inhibited chicken intramuscular adipocyte differentiation and lipogenesis.

Age-related differences in sleep quality among community-dwelling elderly: Evidence from a Shanghai cross-sectional study.

This cross-sectional study investigated sleep quality differences between young-old (65-79 years) and old-old (80+ years) elderly individuals in Shanghai. Among 832 participants, 30.2 % exhibited sleep disorders (PSQI > 5), with the old-old group showing significantly poorer sleep quality (higher PSQI scores and incidence of sleep disorders, both P < 0.