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Research on immunotherapy for ovarian cancer is rapidly advancing, and harnessing the immune system to fight tumors is at the forefront of cancer treatment. This article aims to discuss the prospect and development trend of immunotherapy for ovarian cancer from the perspective of bibliometrics. Articles about tumor burden and immunotherapy were collected from the Web of Science Core Collection (WoSCC) (retrieved on 1 May 2025). R package "Bibliometrics" analyzes key bibliometric characteristics and creates a three-filed map to show the relationships between institutions, countries, and keywords. VOSviewer is used for co-author analysis, co-occurrence analysis, and visualization. CiteSpace calculates citation burst citations and keywords. A total of 1,449 publications were retrieved from 15 years of scientific research. The China and United States (US) published the most articles. The most productive journals were Cancer Immunology Immunotherapy and Journal for Immunotherapy of Cancer. The top institution with the highest output was HARVARD UNIVERSITY. In recent years, the hot keywords of strong citation burst strength were "dendritic cells," "monoclonal antibody," and "adoptive immunotherapy." This bibliometric analysis mapped a basic knowledge structure. The tumor burden and immunotherapy field is entering a rapidly growing stage and keeping its value for future research.
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http://dx.doi.org/10.3389/fmed.2025.1573512 | DOI Listing |
Pediatr Blood Cancer
September 2025
Nuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
Background: Local control strategies in pediatric oncology are guided by disease-specific considerations. Effective communication of the goals of surgical procedure and associated intraoperative events plays a crucial role in shaping subsequent treatment decisions. However, accurately and comprehensively documenting these findings remains challenging, with considerable variability across different tumor types.
View Article and Find Full Text PDFEur J Pharmacol
September 2025
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, PR China. Electronic address:
We previously screened a peptide PDBAG1 that remarkably inhibited triple-negative breast cancer, and found that its target was C1QBP. Recently, C1QBP has been reported as a potential tumor marker in ovarian cancer, which of the mortality rate ranks first among malignant tumors of the female reproductive tract. However, it is unclear whether and how PDBAG1 plays a regulatory role in ovarian cancer.
View Article and Find Full Text PDFEur J Pharm Sci
September 2025
Department of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary. Electronic address:
Platinum-group metal half-sandwich complexes are considered to be potential replacements of the clinically widely used platins which have several side effects and tend to cause resistance to develop. In our previous works, we used a range of 2-pyridyl-substituted N- and C-glycosyl heterocycles as N,N-chelating ligands to prepare ruthenium(II), osmium(II), iridium(III) and rhodium(III) polyhapto arene/arenyl half-sandwich complexes. Some of these complexes, particularly with the C-glucopyranosyl isoxazole derived ligand in its O-perbenzoylated form, exhibited greater anticancer efficiency than cisplatin and had minimal or negligible effects on non-transformed fibroblasts.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Res
September 2025
Department of Clinical Laboratory, North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Care Hospital-Tangshan, China; Key Laboratory of Molecular Medicine for Abnormal Development and Related Diseases in Tangshan City-Tangshan, China. Electronic address: wu
Cisplatin resistance continues to be a major obstacle in the treatment of ovarian cancer (OC). Gap junction protein β-2 (GJB2), a key member of the connexin family, is well-known for its association with hereditary deafness. However, its role in ovarian cancer chemotherapy resistance remains unexplored.
View Article and Find Full Text PDFJ Inorg Biochem
September 2025
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin 541004, PR China. Electronic address:
This study reports the synthesis and antitumor evaluation of six novel dinuclear calcium(II) complexes with the general formula [Ca(μ-O)(QM)(QH)], designated as CaQ1 through CaQ6. These complexes incorporate various deprotonated 8-hydroxyquinoline ligands (H-QM-H-QM) and 1,10-phenanthroline derivatives (QH), synthesized using Ca(NO)·4HO. The specific compositions are as follows: CaQ1: H-QM = 5,7-dibromo-8-hydroxyquinoline (x = 1), QH = bathophenanthroline; CaQ2: H-QM = 5,7-dichloro-8-quinolinol (x = 2), QH = bathophenanthroline; CaQ3: H-QM = 5,7-diiodo-8-hydroxyquinoline (x = 3), QH = 1,10-phenanthroline; CaQ4: H-QM = 5,7-dichloro-8-quinolinol (x = 2), QH = 1,10-phenanthroline; CaQ5: H-QM = clioquinol (x = 4), QH = 1,10-phenanthroline; CaQ6: H-QM = 5,7-dibromo-8-hydroxyquinoline (x = 1), QH = 1,10-phenanthroline.
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