Visible-Light-Driven TiO/Pt Nanozyme-Embedded Dressings: Integrating PDT, Oxygenation, and Biomechanical Support for Pressure Ulcer Repair.

Pressure ulcer (PU) cause metabolic disorders and ischemia via prolonged pressure, leading to secondary infection, inflammation, and vascular neuropathy. However, existing therapies rely on microenvironment, HO, low repair efficiency, and lack efficient collaborative therapy. Herein, a confined multifunctional TiO/Pt nanozyme is developed via atomic layer deposition for PUs repair.

Incidence and Risk Factors for Progression of Acute Kidney Injury to Chronic Kidney Disease After Liver Transplantation: A Retrospective Cohort Study.

Acute kidney injury (AKI) following liver transplantation has the potential to progress to chronic kidney disease (CKD), which can result in extended hospital stays, elevated healthcare costs, and increased mortality rates. This retrospective cohort study seeks to examine the prognosis of AKI progression to CKD post-liver transplantation and to identify its independent risk factors. A cohort of 443 patients who developed AKI post-liver transplantation was analyzed, with participants categorized into a CKD group and a non-CKD group.

Outbreak dates of virus could be predicted by their protein sequence.

Introduction: Since 1970, monkey-pox, the last outbreak of smallpox, coronavirus was outbreak in the world for more than 50 years. To find if the outbreak dates could be predicted by their one-dimension protein sequence, the mathematical model was needed to establish between them.

Methods: (A) collecting the outbreak dates of monkey-pox, smallpox, and coronavirus, determine the outbreak time interval between the pathogen strain and the reference strain SARS-CoV-2 D614, z.

Consumption of fermented Cd and Pb contaminated wheat flour increases potential health risk.

Fermentation can increase the availability of heavy metals in wheat flour, however, its effect on the health risk of heavy metal contaminated wheat flour has not been fully investigated. A contaminated wheat flour (Pb = 0.26, Cd = 0.

Maternal and neonatal outcomes following cesarean delivery on maternal request at different parities in China: A prospective cohort study.

Background: Cesarean delivery on maternal request (CDMR) has been associated with an elevated a higher incidence of postpartum maternal and neonatal complications when compared to vaginal delivery. However, there is a notable lack of research investigating the influence of parity on the maternal and neonatal complications linked to CDMR, particularly within the Chinese population. This prospective cohort study, conducted in China, aims to investigate the short-term maternal and neonatal complications associated with CDMR among low-risk nulliparous and parous populations.

Overcoming the Activity-Stability Trade-Off in Electrocatalysts via Unconventional Two-Step Structural Reconstructions of Amorphous Oxides.

The activation of lattice oxygen in oxide catalysts via structural reconstruction is critical for optimizing the catalytic performance in oxidation-reduction systems. However, in electrochemical O evolution, the structural transformations preceding electrochemical reconstruction and their impact on the resulting structural inhomogeneity have long remained insufficiently understood. Here, we activate the lattice oxygen of the W-doped Co-Fe amorphous oxide through spontaneous and electrochemical bulk reconstructions.

Urban ground dust pollution in a Pb smelting area: quantifying nonferrous metal smelting and construction contributions to heavy metal accumulation and associated health risks.

Heavy metals in construction site dusts from long-term nonferrous metal smelting areas may be affected by both smelting and construction activities, and when disturbed, lead to human health risks. However, this has not been extensively studied. In this work, 67 dust samples from various surfaces were collected from three apartment building construction sites in a long-term nonferrous metal smelting affected city in China; Cd, Cr, Cu, Mn, Ni, Pb and Zn concentrations were determined.

Expression of concern: The effect of metal ions on endogenous melanin nanoparticles used as magnetic resonance imaging contrast agents.

Expression of Concern for 'The effect of metal ions on endogenous melanin nanoparticles used as magnetic resonance imaging contrast agents' by Anqi Chen , , 2020, , 379-390, https://doi.org/10.1039/C9BM01580A.

Long-term nonferrous metal smelting affects metal accumulation/transfer in a soil-plant-woodlouse system.

Nonferrous metal smelting is one of the main sources of heavy metal pollution in the environment, yet its effect on heavy metal transfer in soil-plant-animal systems is not well investigated. In this work, soil, plant (Humulus scandens [HS], Digitaria sanguinalis [DS], and Setaria viridis [SV]), and woodlouse (Armadillidium vulgare) samples were collected in a long-term nonferrous metal smelting area from 26 sites over approximately 7 km and analyzed for Cd, Cu, Mn, Ni, Pb, and Zn concentrations. Cadmium and Pb were the most accumulated soil metals, with mean concentrations of 4.

Physiological, transcriptomic, and metabolomic integrated analyses reveal key factors involved in manganese sulfate mitigating cadmium toxicity in wheat.

Manganese (Mn) has been reported to play a beneficial role in alleviating heavy metal toxicity in plants. However, the molecular mechanisms through which manganese sulfate (MnSO) mitigates cadmium (Cd) toxicity in wheat remain poorly understood. Herein, we conducted a hydroponic experiment to explore the Cd and Mn accumulation, cell wall components, antioxidative system, transcriptomic and metabolomic responses of wheat seedlings after MnSO application under Cd stress.

Assessment of coffee endophytic yeasts for efficient mucilage removal and consistent quality improvement in coffee production.

Endophytic yeasts are commonly isolated from coffee plants, yet their capacity for mucilage removal remains underexplored. In this study, 42 pectinolytic yeast strains were isolated from coffee cherries and classified into five species. Among them, Pichia kluyveri YE7 showed superior mucilage removal and cold tolerance, achieving complete mucilage degradation within 4-12 h at 5-30 °C.

Effectiveness of Photodynamic Therapy, 2% Salicylic Acid, and Their Combination for Moderate Acne.

Objective: This study aimed to investigate the effectiveness of photodynamic therapy combined with 2% salicylic acid for treating moderate acne.

Methods: This retrospective study included outpatients with moderate acne who consulted the Department of Dermatology at Suining First People's Hospital in Sichuan Province between April 2019 and December 2019. The patients were grouped into the photodynamic group, the salicylic acid group, and the combination therapy group, according to whether they received aminolevulinic acid photodynamic therapy, a 2% supramolecular salicylic acid topical masque applied once daily for 10 minutes and then washed off for four consecutive weeks, 2% salicylic acid therapy, or both treatments combined.

Health risk and disease burden of daily hospitalizations for vaginitis due to air pollution: evidence from a heavily-polluted-city in China.

Background: The impact of ambient air pollutants on gynecological infections, particularly vaginitis, has been minimally explored.

Method: Data were collected from a heavily polluted city in Central China from 2015 to 2017. We employed a Poisson generalized additive model (GAM) to evaluate the impacts of air pollutants on vaginitis hospitalizations.

Relationship between self-management behavior and family care among Chinese older adults hospitalized for stroke: the mediating role of chronic disease resource utilization.

Background: The importance of self-management behavior has been widely acknowledged in global studies, demonstrating its effectiveness in improving patients' emotional well-being, enhancing quality of life, preventing stroke recurrence, and reducing mortality and readmission rates. However, existing research indicates that self-management behavior among older adults hospitalized for stroke remains underdeveloped. Furthermore, limited studies have examined the correlations between self-management behavior, family care, and chronic disease resource utilization in this population.

Atomic Metal‒Nonmetal Catalytic Pair Cooperatively Drives Efficient Enzyme-Mimetic Catalysis.

Single-atom catalysts with maximum atom utilization and well-defined coordination environments are promising alternatives to natural enzymes. However, their catalytic performance in enzymatic reactions is intrinsically restricted by the scaling relations, which impose an inherent trade-off between substrate adsorption/activation and product desorption. Here we report atomically dispersed manganese‒sulfur (Mn─S) catalytic pairs with strong electronic coupling that integratively drive enzymatic catalysis, in which the S atom not only modulates the electronic structure of the adjacent Mn site to promote substrate adsorption and activation, but also functions as the secondary catalytic site for stabilizing oxygenated intermediates and facilitating product desorption.

Automatic identification and characteristics analysis of crack tips in rocks with prefabricated defects based on deep learning methods.

In complex geological environments, the morphology, orientation and distribution characteristics of cracks in the rock directly affect the stability assessment for rock masses and engineering safety decisions. However, the traditional manual interpretation method is inefficient and influenced by subjective factors, which makes it tough to fulfill the requirements for high-precision and automated detection. Especially in the rock specimen analysis of prefabricated multi-angle cracks, image quality and algorithm adaptability have emerged as the critical bottlenecks restricting the identification accuracy.

Roles and Molecular Mechanisms of Serum Exosomal miRNA-223 and miRNA-132 in Juvenile Idiopathic Arthritis.

Introduction: The pathogenesis of juvenile idiopathic arthritis (JIA) has not yet been clarified and is closely related to persistent overactivation of the JAK/STAT signaling pathway. MicroRNA (miRNA)-223 (miR-223) and miRNA-132 (miR-132) might be involved in the development of JIA. However, the mechanism underlying the pathogenesis of JIA is unclear.

Metabolomic Profiling Reveals Social Hierarchy-Specific Metabolite Differences in Male .

The giant freshwater prawn (, GFP) is a highly valuable crustacean species in global aquaculture. However, a social hierarchy exists among the distinct male morphotypes, specifically blue-clawed males (BC), orange-clawed males (OC), and small males (SMs). In this study, to identify the specific metabolites among BC, OC, and SM, hemolymph samples were collected for the untargeted liquid chromatography-mass spectrometry metabolomics (LC-MS).

Nuclear p62/SQSTM1 facilitates ubiquitin-independent proteasomal degradation of BMAL1.

Brain and muscle arnt-like protein 1(BMAL1) is a critical regulator of circadian rhythm. Although transcriptional regulation of BMAL1 has been extensively studied, the mechanisms governing the stability of BMAL1 at the protein level remain unclear. p62/SQSTM1 is a crucial factor in proteostasis regulation and is involved in both autophagy and the ubiquitin-proteasome system.

Risk factors analysis of airway mucus plugs in community-acquired refractory mycoplasma pneumoniae pneumonia: a case-control study.

Background: To analyze the clinical characteristics and explore the risk factors for airway mucus plugs in children with community-acquired refractory Mycoplasma pneumoniae pneumonia (ca-RMPP).

Methods: A retrospective study was conducted on hospitalized children diagnosed with ca-RMPP from October 2023 to October 2024. The patients were divided into airway mucus plugs group and non-airway mucus plugs group based on the imaging findings under fiberoptic bronchoscopy.

Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1.

A promising therapeutic approach in oncology involves immune checkpoint blockade (ICB), which stimulates anti-tumor immune responses. Nevertheless, the effectiveness of this treatment in clinical settings remains limited, underscoring the need for complementary strategies. Recent studies highlight the potential of type I interferon (IFN-I) inducers to reprogram the tumor microenvironment and enhance ICB outcomes.

Machine Learning and DIA Proteomics Reveal New Insights into Carbapenem Resistance Mechanisms in .

The emergence of Carbapenem-resistant (CRKP) represents a major public health concern, primarily driven by its ability to evade a wide range of antibiotics. Despite extensive genomic studies, proteomic insights into antibiotic resistance mechanisms remain scarce. Here, we employed a Data-Independent Acquisition (DIA)-based quantitative proteomics approach to investigate proteomic differences between 78 CRKP and 18 Carbapenem-sensitive (CSKP) clinical isolates.

Employing machine learning for early detection of poly-victimization in rural children: a survey study in China's Chaoshan region.

Background: Poly-victimization (PV), encompassing multiple forms of victimization including physical abuse, emotional maltreatment, neglect, and peer violence, poses a significant public health challenge among children, particularly in rural areas with high rates of children whose parents have migrated to cities for work, leaving them in rural areas (left-behind children). This study investigates PV among rural children in the Chaoshan region of China, an area with distinct economic and cultural characteristics.

Methods: A thematic survey on PV occurrence was conducted among rural children in Shantou and Jieyang areas using a unified strategy.

Transposon insertion sequencing reveals novel hypermutator genes in .

Mutation rates in bacteria are an important determinant of adaptation to new environments and success in different niches. In some bacterial pathogens, "hypermutator" variants-most often associated with mutations in components of the DNA mismatch repair system-are associated with increased antibiotic resistance and poorer patient outcomes. We report the serendipitous finding of novel hypermutator genes in through genome-scale mutant fitness screening.

Online tool for cross-sectional and longitudinal comparison of socio-economic status indices based on postcodes in Australia.

Background: Socio-economic status (SES) is strongly associated with health outcomes, yet it remains relatively difficult to measure, particularly for longitudinal comparisons.

Aim: We have developed an interactive online tool (available at bit.ly/SEIFA-POA) that facilitates SES assessment based on postcodes (POA).