An analysis of the mediating effect of presenteeism between job crafting and organizational silencing in junior nurses: a cross sectional study.

Background: Organizational silence is prevalent in the healthcare industry, especially among junior nurses likelier to remain silent on work issues due to their lack of experience and weak voice. This negative behavior not only affects the efficiency of team communication but may also reduce the quality of care. At the same time, presenteeism (working with illness or inefficiency) is becoming increasingly prominent in the nurse population, further exacerbating burnout and organizational silence.

Development of autoimmune antibodies against human phospholipase A2 receptor and the application as diagnostic criteria for primary membranous nephropathy.

Introduction: Membranous nephropathy (MN) is a severe chronic kidney disease (CKD) with ~ 30% of patients progressing to end-stage renal disease within 10 years. Phospholipase A2 receptor (PLA2R) is one of the major target antigens of MN. Despite the importance of PLA2R antibodies in the pathogenesis, diagnosis, and prognosis of MN, anti-human PLA2R monoclonal antibodies have not been obtained.

Carbide nano-islands with confined Mo-Ru sites enable sequential HO adsorption and dissociation for accelerated hydrogen evolution.

Ru single atoms anchored on highly dispersed MoC nano-islands were embedded within nitrogen-doped carbon nanosheets, in which Mo-Ru tandem sites synergistically delivered a low overpotential of 78 mV at 10 mA cm and mass activity 15× higher than that of commercial Pt/C for the alkaline electrocatalytic hydrogen evolution reaction.

Role of TGF-β3 in Regulating Neural Crest Cell Fate and Craniofacial Development: Insights From Zebrafish Models.

Background: Craniofacial malformations, caused by dysregulated neural crest cell (NCC) differentiation, affect approximately one-third of newborns worldwide. Although TGFB3 mutations were recently associated with human coronoid process hypertrophy (CPH) and other craniofacial disorders, the mechanisms by which TGF-β3 regulates NCC fate determination through cell-cell communication remains unknown.

Methods: A zebrafish model was used to investigate the impact of tgfb3 on craniofacial cartilage and bone development.

CO Capture Performance and Preliminary Mechanistic Analysis of a Phase Change Absorbent.

Phase change absorbents are deemed a promising alternative for CO capture due to their excellent CO absorption performance, good stability, and low renewable energy consumption. To address the issues of insufficient loading capacity, low regeneration efficiency, and high energy consumption during regeneration in current chemical absorbents, a novel phase change absorbent was developed. As an amino acid ionic liquid phase change absorbent with tetraethylenepentamine as the cation, imidazole as the anion, and n-propanol as the phase separation agent, this absorbent offers a potential solution.

Genome Sequencing and Comparative Genomic Analysis of Multidrug-Resistant in a Neurological Intensive Care Unit.

Background: is an important cause of nosocomial infections and community-acquired pneumonia. However, the evolutionary convergence of multidrug resistance (MDR) and virulence factors undoubtedly increases the risk of infection and lethality of , especially in intensive care units. How to effectively prevent and correctly treat infections has become a significant challenge for healthcare professionals.

Effects of oat flour on rice flour and fermented rice cake: Processing properties, quality attributes, and starch digestive characteristics.

The rising incidence of diet-related chronic and celiac diseases underlines the demand for high-quality, functional gluten-free products that improve health. This study systematically evaluated the impact of oat flour (OF) substitution at different levels on the mixed flour and the final FGCs (OF 0%, OF 10%, OF 20%, OF 30%, OF 40%), along with underlying mechanisms. OF substitution enhanced the system's water-binding capacity, the integrity of starch granules, and viscoelasticity, while inhibiting gelatinization and promoting short-term retrogradation, as evidenced by reduced pasting enthalpy and increased pasting temperature and setback value.

The westerlies-monsoon interaction shaped asymmetric lake expansions over the Tibetan Plateau in warming periods.

Modelling studies and recent observations suggest that the westerlies-monsoon interactions (WMI) have led to a spatial imbalance in lake expansions across the Tibetan Plateau (TP) during the past decades under anthropogenic warming. However, whether such imbalance reflects a short-term phenomenon or a long-term climatic trend remains unclear. Here, we present a 240,000-year lake level reconstruction from the inner TP to examine the extent to which WMI also operated for previous interglacials, natural warm regimes with large-scale climatic boundary changes.

Ring-core fiber-based coupling and amplification of OAM modes: realizing efficient second-to-first and second-to-second order mode conversion.

Two fully fiber-coupled orbital angular momentum (OAM) mode amplifiers are designed using side-polishing and bonding techniques with dual ring-core erbium-doped fibers (RC-EDFs). Mode matching conditions at 1550 nm are selected to facilitate power coupling between the two RC-EDFs, enabling the coupling, transmission, and amplification of both second-to-first order OAM modes and second-to-second order OAM modes. By designing the structural parameters and ring spacing of the two RC-EDFs, two types of all-fiber in-line OAM amplifiers are developed, each achieving a gain exceeding 30 dB.

Safety evaluation of tucatinib: Adverse event signal mining and analysis based on the FAERS database.

The purpose of this study was to evaluate the adverse events (AEs) associated with tucatinib by mining data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) and explore potential drug-related AEs, thereby guiding safe clinical use.

Optical measurement and manufacture at the Shanghai Synchrotron Radiation Facility.

The Optics Group at the Shanghai Synchrotron Radiation Facility (SSRF) specializes in optical component metrology and fabrication. Established alongside the SSRF phase I beamline construction, the optical metrology laboratory is equipped with a 1D-scanning Long Trace Profiler (LTP), laser interferometers, white light interferometers, and atomic force microscopes. This instrumentation enables characterization of surface errors across high, medium, and low spatial frequency domains.

[Construction and application of a standard operating procedure for urinary incontinence management in patients undergoing radical prostatectomy].

Objective: To explore the effect of evidence-based standardized procedures (SOP) on urinary incontinence management in patients with radical prostatectomy.

Methods: Sixty-three patients who underwent radical prostatectomy from October 2022 to September 2023 were included in the control group. And 63 patients who underwent radical prostatectomy from October 2023 to September 2024 were included in the observation group.

Spatiotemporal dependence of heavy precipitation on soil moisture anomalies in the Yangtze River Basin, China.

Against the background of global warming, the drivers of heavy precipitation (HP) and flooding have become markedly more complex. Soil moisture (SM) not only contributes to flood generation but also influences the occurrence of HP through land-atmosphere feedback, underscoring its central role in predicting extreme events. In this study, precipitation intensity and frequency conditioned on antecedent SM states were quantitatively assessed utilizing a novel SM memory-based statistical framework.

Causal relationship between gut microbiome, immune cell, and systemic lupus erythematosus: A Mendelian randomization analysis.

Systemic lupus erythematosus (SLE) is a highly heterogeneous, multifactorial complex disease. Its pathogenic mechanisms are extremely intricate, primarily characterized by immune dysregulation caused by the combined influence of genetic, environmental, and biological factors. In recent years, increasing evidence has shown that gut microbiome play a crucial role in the onset and progression of SLE.

Studies on the Design, Synthesis, and Insecticidal Activity Evaluation of New Caffeine-Acrylate Derivatives as Potential Ryanodine Receptor Activators.

On the basis of insecticidal leading structures of methylxanthine-acrylates and , a series of new caffeine-acrylate derivatives were designed and synthesized via various structural optimization strategies. The structures of new compounds were confirmed through H NMR, F NMR, C NMR, and high-resolution mass spectrometry (HRMS). The bioassays showed that some of the new ester compounds possessed high insecticidal potentials against L.

Assessment of coffee endophytic yeasts for efficient mucilage removal and consistent quality improvement in coffee production.

Endophytic yeasts are commonly isolated from coffee plants, yet their capacity for mucilage removal remains underexplored. In this study, 42 pectinolytic yeast strains were isolated from coffee cherries and classified into five species. Among them, Pichia kluyveri YE7 showed superior mucilage removal and cold tolerance, achieving complete mucilage degradation within 4-12 h at 5-30 °C.

Zeaxanthin improves myopia by regulating the HIF-1α-glycolysis signaling pathway.

Myopia, a highly prevalent refractive error worldwide, occurs when parallel light rays are refracted by the optical system of the eye and converge in front of the retina, leading to blurred vision, with limited effective intervention options available currently. As a natural small-molecule carotenoid, zeaxanthin (Zea) demonstrates antioxidant and anti-inflammatory properties; however, its involvement in myopia is not yet well understood. Accordingly, this research was designed to examine the effects of Zea in treating myopia and the underlying mechanisms involved.

Association between cardiovascular-kidney-metabolic health metrics and long-term cardiovascular risk: Findings from the Chinese Multi-provincial Cohort Study.

Background: The American Heart Association (AHA) introduced the concept of cardiovascular-kidney-metabolic (CKM) health and stage, reflecting the interaction among metabolism, chronic kidney disease (CKD), and the cardiovascular system. However, the association between CKM stage and the long-term risk of cardiovascular disease (CVD) has not been validated. This study aimed to evaluate the long-term CVD risk associated with CKM health metrics and CKM stage using data from a population-based cohort study.

Machine learning to predict postdialysis fatigue in patients undergoing hemodialysis.

Background: Machine learning (ML) has been widely used to predict complications and prognosis in patients undergoing hemodialysis (HD). However, accurate and efficient models for predicting postdialysis fatigue (PDF) in this population are still needed because PDF is surprisingly prevalent.

Aims: This study aimed to explore the potential of ML models for predicting PDF in patients undergoing HD.

Impact of Circadian Rhythm and Sleep Architecture Changes on Prognosis in Patients with Acute Hemorrhagic Stroke.

Objective: Research is limited on whether circadian rhythm and sleep architecture alterations during acute intracerebral hemorrhage (ICH) influence patient outcomes. This study aims to characterize these changes and explore their association with clinical prognosis, offering new insights for diagnosis and treatment.

Methods: We enrolled 100 acute hemorrhagic stroke patients who underwent continuous, contactless sleep monitoring via a smart mattress for 3-5 consecutive days.

In Situ Polymerization Controlled Growth of Perovskite via Benzoic Acid Crosslinking Agent for Highly Efficient and Mechanically Robust Flexible Perovskite Solar Cell.

The controlled growth of perovskite on flexible substrates is essential for achieving highly efficient and stable flexible perovskite solar cells (FPSCs). Herein, a novel strategy of 4-hydroxybenzoic acid (4-HBA) is developed to regulate the crystallization dynamics of perovskite. In situ cross-linking network of 4-HBA provided an excellent formwork for high-quality perovskite growth by controlling excessive nucleation and prolonging crystallization.

The mechanism of action in Mussaenda pubescens (Yuye Jinhua) against influenza A virus: Evidence from in vitro and in vivo studies.

Background: Influenza A virus (IAV) is recognized as a predominant etiological agent responsible for severe contagious diseases in both humans and animals, characterized by elevated pathogenicity and mortality rates. Mussaenda pubescens (Yuye Jinhua, YYJH), a traditional medicinal herb known for its anti-inflammatory and detoxifying properties, has been predominantly utilized in conjunction with other therapeutic modalities to manage influenza virus infections. However, the standalone therapeutic efficacy and underlying mechanisms of YYJH against IAV infection remain insufficiently clarified.

Inactivation of Geobacillus stearothermophilus spores by induced electric field in different food mediums.

The spores of Geobacillus stearothermophilus exhibit exceptionally strong heat resistance, posing a significant concern for food safety. This study investigated the influence of induced electric field (IEF) on the inactivation of G. stearothermophilus spores across different mediums.

Myeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II-Induced Cardiac Hypertrophy.

Hypertension is the leading cause of cardiac remodelling and heart failure. Recent evidence has highlighted the role of the non-hemodynamic function of angiotensin II in hypertension. MyD88 is the canonical adaptor of TLRs and IL-1Rs, which serves as the central node in regulating inflammatory responses.

Overexpression of housekeeping gene enhances anthocyanin and terpenoid accumulation in strawberry fruits with minimal impact on plant growth and development.

Anthocyanins and terpenoids are secondary metabolites with well-documented health benefits. Isopentenyl transferases (IPTs) are key enzymes in cytokinin (CK) biosynthesis. While ADP/ATP-type IPTs and their associated -zeatin (Z)-CKs and iP-CKs are considered to play regulatory roles in growth and development, as well as stress acclimation in plants, tRNA-type IPTs and -zeatin CKs (Z-CKs), which may serve housekeeping functions, remain less studied.