An analysis of the mediating effect of presenteeism between job crafting and organizational silencing in junior nurses: a cross sectional study.

Background: Organizational silence is prevalent in the healthcare industry, especially among junior nurses likelier to remain silent on work issues due to their lack of experience and weak voice. This negative behavior not only affects the efficiency of team communication but may also reduce the quality of care. At the same time, presenteeism (working with illness or inefficiency) is becoming increasingly prominent in the nurse population, further exacerbating burnout and organizational silence.

Proton beam therapy for chondrosarcoma: A systematic narrative review and meta-analysis.

Background: This study systematically evaluated the efficacy and safety of proton beam therapy in patients with chondrosarcoma by integrating relevant studies.

Methods: We searched for the relevant studies on the PubMed, Cochrane Library, and Embase databases on 18 June 2025 using screening criteria established. Statistical analyses were performed using STATA (version 14.

Alkaloid derivatives in Qing-Luo-Yin alleviated experimental arthritis in rodents by activating PPARγ.

The herbal formula Qing-Luo-Yin (QLY) shows potential in activating PPARγ. This study investigated how this property contributed to its anti-rheumatic effects. Some mice with antigen-induced arthritis (AA) were orally treated with QLY and/or PPARγ antagonist/agonist (T0070907/rosiglitazone).

A Yolk-Shell FeO/Pd@ZrO Catalyst with Space-Confined Effect for Enhancing 4-Nitrophenol Reduction.

Submicron catalysts with tailored 3D architectures offer unique opportunities to manipulate nanoscale mass transport and active site distribution, thereby enhancing catalytic performance. Herein, we constructed a yolk-shell FeO@H-ZrO carrier to provide a semi-open interstitial cavity. Subsequently, Pd nanoparticles were introduced into this cavity by a vacuum-assisted strategy, which resulted in precise confinement and uniform dispersion of Pd nanoparticles.

Understanding face processing in autism spectrum disorder: insights from cognitive neuroscience.

Faces convey critical information for social communication, such as identity, expression, and eye gaze. Unfortunately, individuals with autism spectrum disorder (ASD) often experience difficulties in processing this information, and these deficits lead to their suffering from social interactions. Importantly, since face processing is a social skill developed during early childhood, its deficits may be an early symptom of ASD.

A Dual-Functional Prodrug for Imaging and Eradication of Drug-Resistant Gram-Negative Bacteria.

Gram-negative bacteria are increasingly resistant to antibiotics, making the development of effective antimicrobial agents crucial in combating global health threats. In this context, IspH, a key enzyme in the methylerythritol phosphate (MEP) pathway essential for isoprenoid biosynthesis, represents a promising target to develop antibacterial agents for ablating Gram-negative bacteria. However, the anionic groups commonly present in IspH inhibitors hinder their ability to penetrate bacterial cells, preventing them from exhibiting biological activity.

Zn-ZIF-confined polythiophene-derived uniform dual-doped porous carbon, for boosting oxygen reduction in Zn-air batteries.

Zn-ZIF-confined polythiophene was synthesized solvent-free mechanochemical polymerization of thiophene within Zn-ZIF, followed by controlled carbonization to yield uniform N,S-co-doped porous carbons (N,S-PCs). The resulting N,S-PCs exhibit Pt/C-comparable oxygen reduction activity with superior durability, demonstrating excellent performance as efficient and stable air cathodes in Zn-air batteries.

Potential role of SLC6A3 in neurodevelopmental impairments associated with corpus callosum abnormalities: insights from CNV analysis and clinical phenotyping.

Objective: This study aimed to investigate the role of pathogenic copy number variations (CNVs) in neurodevelopmental impairments among children with corpus callosum abnormalities (CCAs). We focused primarily on SLC6A3 associated mechanisms and aimed to delineate genotype-phenotype correlations in our cases.

Methods: From January 2021 to July 2023, 13 children with MRI-confirmed CCAs underwent chromosomal microarray analysis (CMA) for CNV detection.

Fucoxanthin protects retinal ganglion cells and regulates Parkin-mediated mitophagy in experimental glaucoma.

Objective: Glaucoma is a common neurodegenerative disease resulting in irreversible blindness. This study investigates whether fucoxanthin can safeguard retinal ganglion cells (RGCs) by modulating Parkin-mediated mitophagy in experimental glaucoma.

Methods: An experimental glaucomatous model was induced in Sprague-Dawley rats via translimbal laser photocoagulation.

CDK11 Mediates Autophagy to Promote Breast Cancer Cell Proliferation and Migration by Regulating BCL-2.

Cyclin-dependent kinase 11 (CDK11), involved in various cellular processes including cell cycle regulation, apoptosis, and autophagy, is overexpressed in breast cancer and correlates with poor clinical outcomes. However, its exact mechanisms remain largely elusive. In the present study, we demonstrated that inhibiting CDK11 suppresses cell proliferation and migration and induces autophagy in breast cancer cells.

Mechanistic Insight into the Cleavage Site Specificity of Collagenase VhaC to the Y-G Bonds in Collagen.

M9 collagenases have various biotechnological and medical applications due to their high activity and specificity to collagen. Although the collagenolytic mechanism of M9 collagenases has been studied, the molecular basis for their cleavage site specificity remains unknown. Here, the mechanism of the Y-G bond cleavage site specificity of M9 collagenase VhaC was studied.

Medical Science Data Value Evaluation Model: Mixed Methods Study.

Background: Medical science data hold significant value, and open platforms play a crucial role in unlocking this potential. While relevant platforms are being developed, the overall usage of these data values remains limited.

Objective: This study aims to propose a set of practical and effective data value evaluation processes and methods for medical science data open platforms, enabling them to manage and unlock the value of these data.

Hexafluoropropylene oxide dimer acid (GenX) induces apoptosis in primary cortical neurons via stimulating ROS production and NF-κB activation.

Hexafluoropropylene oxide dimer acid (HFPO-DA), commonly known as GenX, is a replacement for perfluorooctanoic acid (PFOA) which readily accumulates in the brain and exhibits neurotoxic effects. However, the adverse impacts of GenX on neurons and its underlying mechanisms remain poorly understood. In this study, primary cortical neurons isolated from neonatal mice were exposed to varying concentrations of GenX to assess cell viability, intracellular reactive oxygen species (ROS) levels, and morphological alterations.

Adenine/adenine contacts defined in the G-quadruplex for highly selective Tb binding.

The folding of nucleic acids is strongly dependent on metal ions. For example, G-quadruplex (G4) structures are usually determined by the specific K/Na coordination. However, G4 constructs highly selective to high-valent metal ions (for instance, trivalent metal ions) have not been found due to their strong and nonspecific phosphate backbone interactions.

Fabrication of flexibility-rigidity alternately assembled solid-state luminescence covalent organic frameworks: application to rifampicin antibiotics detection and latent fingerprint recognition.

To enhance the fluorescence properties of covalent organic frameworks (COFs) for broader applications, we introduce flexibility-rigidity alternately assembled red fluorescent COFs, named COF-MA. Its uniquely wide layer spacing (7.054 Å) significantly reduces π-π stacking interactions, suppressing fluorescence self-quenching and boosting solid-state emission.

Gut microbiota links to cognitive impairment in bipolar disorder via modulating synaptic plasticity.

Background: Cognitive impairment is an intractable clinical manifestation of bipolar disorder (BD), but its underlying mechanisms remain largely unexplored. Preliminary evidence suggests that gut microbiota can potentially influence cognitive function by modulating synaptic plasticity. Herein, we characterized the gut microbial structure in BD patients with and without cognitive impairment and explored its influence on neuroplasticity in mice.

Genome-wide analyses reveal intricate genetic mechanisms underlying egg production efficiency in chickens.

Background: Compared to many other vertebrates, chickens have a high reproductive efficiency in terms of egg production. The classic traits for evaluating egg-laying performance include age at first egg, egg number, clutch size, laying rate, etc. These egg-laying traits were not specifically designed to characterize egg production efficiency and stability.

Molecular docking and SARs guiding the gradual development of thiazole-2-yl amide derivatives containing biphenyl groups as promising antifungal scaffolds.

Background: The antifungal activities ofthe initially synthesized thiazol-2-ylbenzamide derivatives were relatively limited, suggesting potential for structural optimization. Inspired by the promising bioactivities of biphenyl scaffolds, and guided by molecular docking and structure-activity relationships (SARs), 42 thiazol-2-ylamide derivatives containing a biphenyl scaffold were synthesized through gradual structural modification, and their antifungal and anti-oomycete activities were assessed. Furthermore, the most potent compound G41 was selected for preliminary mechanistic studies.

[Analysis of a neonate with Hypoparathyroidism-sensorineural deafness-renal dysplasia syndrome and a literature review].

Objective: To analyze the phenotype and genotype of a neonate with Hypoparathyroidism-sensorineural deafness-renal dysplasia syndrome (HDR).

Methods: A female neonate with HDR syndrome and thyroid deficiency detected at the First Affiliated Hospital of Zhengzhou University on December 6,2023 was selected as the study subject, Low-coverage whole-genome sequencing (Lc WGS) and whole exome sequencing (WES) were carried out. Using "hypoparathyroidism""sensorineural deafness""renal dysplasia""HDR""Barakat" and"GATA3" as keywords, the CNKI, Wanfang Data Knowledge Service Platform and PubMed database were searched, and the retrieval time was set from the establishment to March 2025.

Ginkgo ketone ester tablets for the treatment of cognitive impairment associated with chemotherapy for breast cancer - a prospective cohort study.

Background: Chemotherapy-related cognitive impairment (CRCI) affects up to 75% of breast cancer patients during treatment, with 35% experiencing persistent post-treatment deficits. Current interventions show limited efficacy, creating urgent need for targeted therapies. Ginkgo Ketone Ester (GBE), containing neuroprotective flavonoids and terpene lactones, represents a potential therapeutic strategy.

An open dataset and machine learning algorithms for Niacin Skin-Flushing Response based screening of psychiatric disorders.

Background: Niacin Skin-Flushing Response (NSR) has emerged as a promising objective biomarker for the precise diagnosis of mental disorders. However, its diagnostic potential has been constrained by the limitations of traditional statistical approaches. The advent of Artificial Intelligence (AI) offers a transformative opportunity to overcome these challenges.

Single-cell RNA sequencing uncovers intestinal immune alterations and cellular diversity from chronic fluoride exposure in mice.

Chronic exposure to high-fluoride drinking water impairs intestinal structure and function, potentially damaging extraluminal tissues via the gut-organ axis. However, how lifelong exposure to naturally occurring moderate-to-high-fluoride water affects intestinal cells and their underlying mechanisms remain unclear. Single-cell RNA sequencing identified cellular heterogeneity and candidate risk genes in the mouse ileum after 56 weeks of 50-ppm fluoride exposure.

The bibliometric and visualization analysis of alcohol-induced osteonecrosis of the femoral head: research trends and future directions (1998-2024).

Background: Osteonecrosis of the femoral head (ONFH) is a progressive, debilitating orthopedic condition that primarily results from compromised vascular supply. Chronic alcohol intake is a well-established non-traumatic etiological factor in ONFH. Despite the increasing global research on ONFH, a bibliometric analysis using explicit literature searches in Web of Science reveals that no studies have specifically focused on alcohol-induced osteonecrosis of the femoral head (AONFH).

Identification of novel disease-causing variants and their influence on clinical presentation in dihydrofolate reductase deficiency.

Dihydrofolate reductase (DHFR) deficiency is a rare autosomal recessive disorder of folate metabolism, which is crucial for DNA/RNA synthesis and normal growth. Only seven molecularly confirmed cases, all presenting with megaloblastic anemia and neurological symptoms, have been reported. We report two cases from a non-consanguineous Chinese family.

Treatment effectiveness of hydroxychloroquine in patients with primary Sjögren's syndrome: a real-world Study.

Objective: This study aimed to evaluate the effectiveness of hydroxychloroquine (HCQ) in reducing disease activity and explore its optimal dosing and combination therapies in patients with primary Sjögren's syndrome (pSS).

Methods: We conducted a retrospective study of 1089 hospitalized pSS patients. Multivariable logistic regression was used to estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs).