Associations of PFOA and PFOS Exposure with Liver Injury: Evidence from the Dongfeng-Tongji Cohort, NHANES 2003-2018, and Integrative Adverse Outcome Pathway Analysis.

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are representatives of perfluoroalkyl substances (PFAS) that could persist in the environment and concentrated in animal livers. However, epidemiological studies on the associations of PFOA/PFOS exposure with liver injury in women are limited, with mechanisms not fully understood. This study aimed to clarify these associations and explore possible mechanisms.

Engineering silica-stabilized Pickering emulsions as versatile protein carriers.

Oil-in-water (o/w) Pickering emulsions (PEs), featuring multi-leveled structures and particle-assembled interfaces, have emerged as promising platforms for biomedical applications, due to their superior stability and biocompatibility compared to conventional surfactant-stabilized emulsions. In this study, silica nanoparticles (SNPs) with tunable sizes, surface charges, and morphologies were synthesized and utilized as stabilizers for o/w PEs. Bovine serum albumin and varicella-zoster virus glycoprotein E were selected as model proteins to evaluate the feasibility of SNP-stabilized PEs as protein carriers.

Root-Zone Temperature Drives Coordinated Photosynthesis, Root Architecture, and Metabolism Responses in (Trucz.) Baill.

Soil warming due to climate change has a significant potential impact on crop yield and quality. (Trucz.) Baill, a multipurpose plant disseminated in the highly climate-sensitive region of Northeast Asia, is affected by soil warming, which limits the supply and quality of raw materials.

Understanding face processing in autism spectrum disorder: insights from cognitive neuroscience.

Faces convey critical information for social communication, such as identity, expression, and eye gaze. Unfortunately, individuals with autism spectrum disorder (ASD) often experience difficulties in processing this information, and these deficits lead to their suffering from social interactions. Importantly, since face processing is a social skill developed during early childhood, its deficits may be an early symptom of ASD.

hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.

Background: Sarcopenia, a multifactorial syndrome characterized by progressive loss of skeletal muscle mass and strength, combined with impaired physical function, is associated primarily with aging but also driven by chronic inflammation, immobility, and endocrine dysregulation. It leads to increased risks of frailty, falls, and loss of independence, posing a major public health challenge for aging populations. Although human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and their derived exosomes (MSC-Exos) have demonstrated remarkable potential in regenerative medicine, their safety and efficacy in treating sarcopenia remain unclear.

Neutrophil extracellular traps and neuropsychiatric lupus: Signaling pathways involved in NET formation and mechanisms affecting the central nervous system.

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus (SLE) that affects the central or peripheral nervous system. The clinical management of NPSLE faces significant challenges due to the absence of specific diagnostic biomarkers and the lack of standardized, evidence-based diagnostic and therapeutic protocols. Therefore, a comprehensive understanding of the pathogenesis of NPSLE and the exploration of novel therapeutic targets have become urgent priorities in current research.

Cost-effectiveness analysis of first-line treatment for advanced soft tissue sarcomas in China.

Objectives: To evaluate the cost-effectiveness of four first-line treatment strategies-anlotinib, pazopanib, regorafenib, and conventional chemotherapy-for patients with advanced soft tissue sarcomas (STSs) in China.

Methods: A partitioned survival model was developed to simulate costs and quality-adjusted life years (QALYs) over a lifetime horizon from the Chinese healthcare system perspective. Relative treatment efficacies were derived from a network meta-analysis (NMA).

Itraconazole inhibits the Wnt/β-catenin signaling pathway to induce tumor-associated macrophages polarization to enhance the efficacy of immunotherapy in endometrial cancer.

Background: Endometrial cancer (EC) is a common gynecologic malignancy with limited treatment options. This study aimed to evaluate the potential of itraconazole (ITZ), a widely used antifungal drug, as an anti-tumor agent and an adjuvant to immunotherapy for EC.

Methods: The effects of ITZ on Ishikawa cells were assessed using proliferation assays, apoptosis assays, and invasion assays.

Correction: Physical and mental health management for the older adult using XGBoost algorithm supported by new media technology: developing personalized health intervention plans using healthcare data from the CLHLS database.

[This corrects the article DOI: 10.3389/fpubh.2025.

Apple Juice Fermented with Improves Its Flavor Profile and Probiotic Potential.

Fermented apple juice (FAJ), a nutrient-dense beverage rich in vitamins, offers multiple health benefits, including improved digestion, enhanced fat metabolism, and sustained energy provision with reduced caloric intake. To advance the development of probiotic-enriched flavored and functional juices, this study establishes () as a safe and effective starter culture for apple juice fermentation. The selected strain exhibited minimal biogenic amine synthesis, producing only 30.

Leucine-Rich Repeat Containing 15 Promotes the Inflammatory Response in Rheumatoid Arthritis by Regulating NF-κB Pathway.

Purpose: To explore the influence and molecular mechanism of leucine-rich repeat containing 15 (LRRC15) in rheumatoid arthritis (RA) model induced by collagen-induced arthritis (CIA) in rats and interleukin-1 beta (IL-1β) treated fibroblast-like synoviocytes (FLSs).

Methods: LRRC15 expression was analyzed using reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blot analysis, and immunohistochemistry. Hematoxylin-eosin (H&E) and safranin-O-green staining were performed to assess the pathological changes in the joint tissues of rats.

A GSH-consuming polymeric nanoparticles drives ferroptosis amplification and combines chemotherapy to amplify breast cancer treatment.

Currently, given variations in the abnormal tumor microenvironment (TME), significant progress has been made in the treatment of breast cancer (BC) based on TME-responsive nanosystems-mediated ferroptosis. Due to inherent deficiencies such as the limited efficacy of Fe-induced catalysis, the lack of endogenous hydrogen peroxide (HO), and the overexpression of glutathione (GSH) in tumor cells, the treatment of ferroptosis is restricted. Here, this document highlighted polymeric nanoparticles with GSH resection (ssP-tHB@Fe/DOX), demonstrating significant improvements in TME responses, biocompatibility, and anti-tumor effects.

Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration.

Mitochondrial defects are early pathological changes in neurodegenerative disease (ND). Homocysteine (Hcy) is an independent risk factor for ND. However, whether and how Hcy induces mitochondrial defects during the process of neurodegeneration is unclear.

IL-36-related genes predict prognosis of gastric cancer.

Introduction: Gastric cancer (GC) is one of the most frequently encountered malignant tumors in the clinic. Because effective early screening techniques are lacking, most patients have advanced disease at first diagnosis. The interleukin (IL)-36 family plays a vital role in regulating the immune system, inflammatory responses, and the occurrence and development of cancer.

Serum polychlorinated biphenyl levels and risk of incident chronic kidney disease: A prospective study in the Dongfeng-Tongji cohort.

Emerging evidence suggests environmental polychlorinated biphenyls (PCBs) exposure may impair function, but prospective evidence linking PCB exposure to chronic kidney disease (CKD) incidence remains scarce. In the Dongfeng-Tongji cohort, we enrolled 1,902 CKD-free participants at baseline and measured seven serum PCB congeners (PCB-28, PCB-52, PCB-101, PCB-118, PCB-138, PCB-153, and PCB-180) using gas chromatography-tandem mass spectrometry (GC-MS/MS). Incident CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.

Halogen-Tuned BiOX (X = Cl, Br, I) Layered Crystals with Superior Broadband Nonlinear Saturable Absorption for Pulsed Laser Modulation.

Nonlinear optical (NLO) materials play indispensable roles in various fields, such as information, energy, and biology. However, the ideal NLO materials necessitate a balance between the band gap and the nonlinear coefficient, which severely restricts the further development of nonlinear optics. BiOX (X═Cl, Br, and I) crystals, with their layered structure, combine the advantages of nontoxicity, a tunable band gap, and remarkable optoelectronic properties, rendering them highly promising NLO materials.

Integrating multi-omics data to optimize immunotherapy in endometrial cancer: a comprehensive study.

Immunotherapy represents a pivotal therapeutic modality in endometrial cancer (EC). Nevertheless, the efficacy of this treatment is limited to a subset of patients. The present investigation endeavors to amalgamate multi-omics data in order to elucidate the determinants impacting individual immune responsiveness and enhance the optimization of immunotherapy for EC.

An innovative treatment for hypoxic-ischemic encephalopathy: Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement.

Stem cell therapy shows promise for treating brain injuries; neural stem cells in particular are capable of repairing damage by forming new nerve cells and supporting recovery. However, optimizing the implantation and functionality of these cells in damaged brain regions remains challenging. Silk fibroin, a natural protein derived from silkworm silk, is a biocompatible material with exceptional properties that are useful for tissue engineering.

Development Of the VAMPCT Score for Predicting Mortality in CKD Patients with COVID-19.

Chronic kidney disease (CKD) patients with coronavirus disease 2019 (COVID-19) are at significant risk of death. However, clinical identification of high-risk individuals remains suboptimal despite the recognition of many pathophysiological and comorbidity-related risk factors. We aim to develop a clinically simple machine learning (ML)-based score to predict acute COVID-19 mortality among CKD patients.

Physical and mental health management for the older adult using XGBoost algorithm supported by new media technology: developing personalized health intervention plans using healthcare data from the CLHLS database.

Introduction: With the increasing aging population, there is a growing need for precise and intelligent health management solutions tailored to older adult individuals. This study proposes a comprehensive digital health management platform that integrates new media technologies to support physical and mental well-being among the older adult.

Methods: A personalized health management system was designed by integrating multi-source health data and employing artificial intelligence and blockchain technologies to ensure personalized and secure services.

PINK1 Deficiency Facilitates Palmitic Acid-Induced Inflammation by Disrupting Mitochondrial Function to Activate mtDNA-cGAS-STING Signaling.

Metabolic cells exhibit low-grade chronic inflsammation characterized by excessive production and secretion of proinflammatory cytokines and chemokines in response to overnutrition and energy excess. Mitochondrial dysfunction is closely associated with metabolic inflammation. PINK1 (phosphatase and tensin homology-induced putative kinase 1) is a crucial pathway controlling mitochondrial autophagy, essential for maintaining mitochondrial quality control and metabolic homeostasis.

A pay-it-forward approach to improve feedback rate of HPV-based self-sampling in cervical cancer screening among women in ethnic minority regions of China: a randomized controlled trial protocol.

Background: Human papillomavirus (HPV) infection is the primary cause of cervical cancer, and HPV self-sampling has emerged as a novel screening method with the potential to increase screening coverage and early detection of cervical cancer. However, the implementation of HPV self-sampling in China faces several challenges, including sociocultural factors, economic burdens, and low feedback rates. This study will aim to improve the feedback rate of HPV self-sampling results through a Pay-It-Forward approach and explore its impact on HPV positivity rates and subsequent treatment compliance.

Association between organochlorine pesticides and metabolic dysfunction-associated steatotic liver disease: Findings from the Dongfeng-Tongji cohort.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally. However, its environmental chemical contributors remain unclear.

Objective: To estimate the association between organochlorine pesticides (OCPs) and incident MASLD among Chinese population.

Associations of depressive symptoms and lifestyles with cognitive function: results from two cross-sectional studies among middle-age and older Chinese populations.

Background: Depression and cognitive decline are both major health problems worldwide. This study aims to investigate the effects of depressive symptoms and its joint function with lifestyles on cognitive function among the Chinese populations.

Methods: This research included two cross-sectional studies from Hubei (n = 7756) and Shanghai (n = 4751), China.