"Fight Fire with Fire": Trace-Water-Induced Controllable Synthesis of Hydrophobic Armors to Stabilize Metal-Organic Cage-Based Crystalline Frameworks.

Metal-organic cage-based crystalline frameworks (MCFs) are distinguished for high porosity and diverse functionality, while their applications are constrained by degradation in wet environments. Inspired by the "fight fire with fire" method in traditional Chinese medicine, trace-water-induced synthesis of armors is proposed to stabilize MCFs. Water at ppm concentration is enriched on the hydrophilic surface of MCFs, and then polymerizes with diisocyanate under the catalysis of MCFs to form hydrophobic shells.

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid-Liquid Phase Separation.

RNA-binding proteins (RBPs) play a pivotal role in post-transcriptional regulation of gene expression, critically influencing skeletal myogenesis, muscle growth, and regeneration. Despite the recent identification of RBP Rps27l (ribosomal protein S27-like) as a regulator affecting myogenic proliferation and differentiation, its functions and regulatory mechanisms in skeletal muscle development remain largely unknown. In this study, it is observed that muscle-specific Rps27l knock-in (M─KI) mice exhibit significantly increased muscle mass, enlarged myofiber size, a higher proportion of fast-twitch myofibers, and enhanced muscle regeneration capabilities compared to wild-type controls.

Mycn Is Essential for Pubertal Mammary Gland Development and Promotes the Activation of Bcl11b-Maintained Quiescent Stem Cells.

This investigation examines the function of the mouse gene in regulating and activating quiescent mammary stem cells, which are vital for mammary gland development. The mammary gland, consisting of luminal and basal cells, progresses through complex developmental stages from embryonic development through puberty, adulthood, pregnancy, lactation, and involution. Quiescent stem cells, existing in a reversible non-proliferative state, are essential for gland maintenance, yet their activation mechanisms remain poorly understood.

Unlocking the Synthetic Potential of Yarrowia lipolytica: Innovating Gene Expression Tools.

Yarrowia lipolytica, with its robust lipid metabolism capabilities, efficient secretion system and generally recognised as safe (GRAS) status, has become a highly promising microbial chassis in synthetic biology. However, compared with model microorganisms such as Saccharomyces cerevisiae, the underdevelopment of gene expression tools in Y. lipolytica has become a critical bottleneck, limiting its industrial application.

Curcumin and its novel formulations for diabetes mellitus and its complications: a review.

Diabetes mellitus (DM), a growing global health crisis, drives demand for safe, effective therapies. Curcumin (CUR), a turmeric-derived polyphenol, shows promise in combating DM and its complications (such as diabetic wound healing (DWH), diabetic atherosclerosis (DA), and diabetic encephalopathy (DE)) multi-target mechanisms. Despite its efficacy and low toxicity, CUR's clinical application is hindered by poor solubility and bioavailability.

 (Balsaminaceae), a new species from Sichuan, China.

K.Huang & Z.X.

hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.

Background: Sarcopenia, a multifactorial syndrome characterized by progressive loss of skeletal muscle mass and strength, combined with impaired physical function, is associated primarily with aging but also driven by chronic inflammation, immobility, and endocrine dysregulation. It leads to increased risks of frailty, falls, and loss of independence, posing a major public health challenge for aging populations. Although human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and their derived exosomes (MSC-Exos) have demonstrated remarkable potential in regenerative medicine, their safety and efficacy in treating sarcopenia remain unclear.

Assessment of Rivaroxaban Plasma Concentration Using Chromogenic Anti-Xa Assays and UHPLC-MS/MS in Chinese Patients With Atrial Fibrillation.

Accurate quantification of rivaroxaban concentration is essential in some specific clinical situations. A prospective study was conducted to compare the rivaroxaban concentration measured by Zhenyuan anti-Xa assay with that by reference methods (ultrahigh performance liquid chromatography with tandem mass spectrometry [UHPLC-MS/MS] and Biophen DiXal) in 243 plasma samples from 182 patients with non-valvular atrial fibrillation. Zhenyuan anti-Xa assays demonstrated less bias versus reference methods in samples with concentrations exceeding 50 μg/L compared to those in the < 50 μg/L group.

MiR-145-5p Regulates Inflammatory Response via Targeting CD40 in Chronic Rhinosinusitis With Nasal Polyposis.

Chronic rhinosinusitis with nasal polyps (CRSwNP) lacks effective therapies, highlighting miRNAs as potential therapeutic targets owing to their biological functions and analytical accessibility. This study aimed to investigate the role of miR-145-5p in CRSwNP. Serum samples and inferior turbinate mucosa tissues were collected from 175 CRSwNP patients and 90 nasal septum deviation (NSD) subjects.

Identification and experimental validation of BMX as a crucial PANoptosis‑related gene for immune response in Spinal Cord Injury.

Spinal cord injury (SCI) is a debilitating neurological condition that severely impacts motor, sensory, and autonomic functions, leading to significant challenges in patient quality of life and imposing substantial economic burdens on society. PANoptosis is an emerging concept in programmed cell death that combines three key processes: pyroptosis, apoptosis, and necroptosis. Research has demonstrated the significant roles of apoptosis, necroptosis, and pyroptosis in the progression of SCI.

Vonoprazan Improves Efficacy of Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Multicenter Randomized Controlled Trial.

Background: Rescue treatment for non-naive patients with persistent Helicobacter pylori (H. pylori) infection is lacking, especially in areas where tetracycline is unavailable. This trial aimed to evaluate the efficacy and safety of replacing proton pump inhibitor (PPI) with potassium-competitive acid blocker (P-CAB) in bismuth quadruple therapy (BQT) containing amoxicillin and furazolidone as rescue therapy.

Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators.

Tumor necrosis factor α (TNFα) plays a critical role in inflammatory and autoimmune diseases. While biologic drugs have improved patient outcomes in conditions like rheumatoid arthritis by disrupting TNFα signaling, small molecule targeting has been challenging due to the strong TNF-receptor binding and difficulty in disrupting the TNF trimer. This research presents small molecule TNFα inhibitors with a novel bridged-piperazine core, developed through molecular dynamics simulation and scaffold hopping.

Advances and Perspectives on the Anti-Fibrotic Mechanisms of the Quercetin.

Fibrosis is a pathological process that affects multiple tissues and organs and a significant contributor to mortality, particularly in developed countries. Dietary flavonoids, especially quercetin (QUR), have emerged as key bioactive compounds with protective effects on vital organs such as the liver, heart, lungs, and kidneys. As a prominent focus in natural product research, QUR exhibits diverse anti-fibrotic mechanisms across various fibrotic conditions, including modulation of the TGF-[Formula: see text], NF-[Formula: see text]B, Nrf2, and AREG/EGFR signaling pathways.

Roles of MARCKSL1, MCM6, RFC4, and PLAU genes in esophageal cancer and their association with radiotherapy response.

Esophageal cancer is a highly lethal malignancy with high incidence and mortality rates, which continue to pose a significant threat to public health worldwide. Despite the adoption of multidisciplinary treatments, improving long-term survival rates remains a major challenge. Therefore, conducting in-depth research into the molecular mechanisms of esophageal cancer, identifying predictive biomarkers, and developing personalized treatment and monitoring strategies are crucial to enhancing clinical outcomes and patient prognosis.

Machine learning for prediction of infection based on basic health examination data in adults: a retrospective study.

Objective: This study aimed to investigate the feasibility of developing machine learning models for non-invasive prediction of () infection using routinely collected adult health screening data, including demographic characteristics and clinical biomarkers, to establish a potential decision-support tool for clinical practice.

Methods: The data was sourced from the adult health examination records within the health management centers of the hospital. The Least Absolute Shrinkage and Selection Operator (LASSO) regression was employed for feature selection.

The regulatory role of Sigmar1 in CVB3-induced myocarditis.

Sigma-1 receptor (Sigmar1) is associated with endoplasmic reticulum (ER) stress. This study investigated whether Sigmar1 affect myocarditis progression via Coxsackievirus B3 (CVB3)-caused ER stress. Neonatal mouse cardiomyocytes (NMCs) were transfected with Sigmar1 and/or stress-induced phosphoprotein 1 homology and U-box containing protein 1 (STUB1) overexpression plasmids and exposed to CVB3 for 2 h.

Initiating antidepressant treatment in pregnancy: Timing, intensity, and influential maternal and familial factors.

Objective: To describe the timing and intensity of antidepressant initiation in pregnancy using longitudinal trajectories of antidepressant prescription fills to identify associated sociodemographic, lifestyle, somatic, mental health, pregnancy, and paternal factors.

Methods: This population-based cohort within the Norwegian Mother, Father and Child Cohort study linked to MoBa Genetics and the Prescribed Drug Registry included 1879 women with a new episode of self-reported depression/anxiety during pregnancy. Antidepressants were measured by week and average daily dose.

Prediction and Screening of Lead-Free Double Perovskite Photovoltaic Materials Based on Machine Learning.

The search for stable, lead-free perovskite materials is critical for developing efficient and environmentally friendly energy solutions. In this study, machine learning methods were applied to predict the bandgap and formation energy of double perovskites, aiming to identify promising photovoltaic candidates. A dataset of 1053 double perovskites was extracted from the Materials Project database, with 50 feature descriptors generated.

Anti-atherosclerotic effects and molecular targets of salvianolic acids from Bunge.

Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma] is a traditional Chinese medication used extensively as a therapeutic agent against atherosclerosis (AS) because of its substantial cardiovascular protective properties as well as ability to regulate the signaling cascades and molecular targets involved in AS. Preclinical research has shown that the hydrophilic metabolites of Bunge represented by danshensu (DSS), salvianolic acid A (SAA), and salvianolic acid B (SAB) can reduce endothelial dysfunction, inhibit smooth muscle cell migration and proliferation, block platelet aggregation, have antithrombotic properties, and modulate vascular tone. Furthermore, studies have shown that salvianolic acid is clinically beneficial, while some evidence also supports its safety and effectiveness in diseases linked to AS.

Prevalence and risk factors for residual back pain after percutaneous vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis.

Objective: The purpose of this study was to evaluate the occurrence and potential causes of residual back pain following percutaneous vertebral augmentation (percutaneous vertebroplasty/percutaneous kyphoplasty) in patients with osteoporotic vertebral compression fracture.

Methods: To investigate the occurrence and risk factors of residual back pain, a comprehensive search was conducted in several databases including PubMed, Web of Science, Embase, Cochrane Library, China Knowledge Resource Integrated Database (CNKI), Chinese Biomedical Database (CBM), Wanfang Database, and Weipu Database (VIP) from the inception until October 10, 2023. After applying inclusion and exclusion criteria, the articles were filtered.

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway.

Ethnopharmacological Relevance: According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

Prevalence of psychological problems among individuals and couples during assisted reproductive technology(ART) treatment: a systematic review and meta-analysis.

Background: The psychological problems of infertile couples deserve more attention given the impact on pregnancy outcomes.

Aims: This systematic review and meta-analysis was designed to assess the prevalence of anxiety, depression, and stress in couples during assisted reproductive treatment.

Materials And Methods: We conducted searches on PubMed, Embase, and Web of Science from the outset until September 2024.

Successful experience of transcatheter residual right-to-left shunting closure after patent foramen ovale occlusion.

Background: Residual shunt after patent foramen ovale (PFO) occlusion is associated with recurrent stroke, and limited literature address the specific management of such cases. Herein we report our experience with secondary interventional treatment.

Methods: From July 2020 to January 2023, patients who underwent PFO occlusion for more than one year with residual right-to-left shunting (rRLS) screened by contrast transthoracic echocardiography (cTTE) constituted the study population.