"Fight Fire with Fire": Trace-Water-Induced Controllable Synthesis of Hydrophobic Armors to Stabilize Metal-Organic Cage-Based Crystalline Frameworks.

Metal-organic cage-based crystalline frameworks (MCFs) are distinguished for high porosity and diverse functionality, while their applications are constrained by degradation in wet environments. Inspired by the "fight fire with fire" method in traditional Chinese medicine, trace-water-induced synthesis of armors is proposed to stabilize MCFs. Water at ppm concentration is enriched on the hydrophilic surface of MCFs, and then polymerizes with diisocyanate under the catalysis of MCFs to form hydrophobic shells.

Assessment of Rivaroxaban Plasma Concentration Using Chromogenic Anti-Xa Assays and UHPLC-MS/MS in Chinese Patients With Atrial Fibrillation.

Accurate quantification of rivaroxaban concentration is essential in some specific clinical situations. A prospective study was conducted to compare the rivaroxaban concentration measured by Zhenyuan anti-Xa assay with that by reference methods (ultrahigh performance liquid chromatography with tandem mass spectrometry [UHPLC-MS/MS] and Biophen DiXal) in 243 plasma samples from 182 patients with non-valvular atrial fibrillation. Zhenyuan anti-Xa assays demonstrated less bias versus reference methods in samples with concentrations exceeding 50 μg/L compared to those in the < 50 μg/L group.

Vonoprazan Improves Efficacy of Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Multicenter Randomized Controlled Trial.

Background: Rescue treatment for non-naive patients with persistent Helicobacter pylori (H. pylori) infection is lacking, especially in areas where tetracycline is unavailable. This trial aimed to evaluate the efficacy and safety of replacing proton pump inhibitor (PPI) with potassium-competitive acid blocker (P-CAB) in bismuth quadruple therapy (BQT) containing amoxicillin and furazolidone as rescue therapy.

Prevalence of psychological problems among individuals and couples during assisted reproductive technology(ART) treatment: a systematic review and meta-analysis.

Background: The psychological problems of infertile couples deserve more attention given the impact on pregnancy outcomes.

Aims: This systematic review and meta-analysis was designed to assess the prevalence of anxiety, depression, and stress in couples during assisted reproductive treatment.

Materials And Methods: We conducted searches on PubMed, Embase, and Web of Science from the outset until September 2024.

Successful experience of transcatheter residual right-to-left shunting closure after patent foramen ovale occlusion.

Background: Residual shunt after patent foramen ovale (PFO) occlusion is associated with recurrent stroke, and limited literature address the specific management of such cases. Herein we report our experience with secondary interventional treatment.

Methods: From July 2020 to January 2023, patients who underwent PFO occlusion for more than one year with residual right-to-left shunting (rRLS) screened by contrast transthoracic echocardiography (cTTE) constituted the study population.

Once- Versus Twice-Daily Tacrolimus Therapy: Does Improved Adherence Lead to Better Efficacy?-A Pharmacokinetic Perspective.

Tacrolimus, a critical immunosuppressant in organ transplantation, is available in immediate-release (IR-T) and extended-release (ER-T) formulations. While ER-T improves patient adherence, clinical studies have not demonstrated superior outcomes compared to IR-T. However, the underlying reasons for this discrepancy remain unclear.

A real-world based study for immunogenicity and safety for three immunization schedules of polio vaccine.

To evaluate the immunogencity and safety for three immunization schedules of inactivated poliovirus vaccine (IPV) and bivalent oral poliovirus vaccine (bOPV) for providing a basis for further optimization of the polio sequential immunization schedule. To obtain immunogenicity data and to active surveillance the occurrence of adverse events following immunization (AEFI), healthy infants ≥ 2 months of age were randomly chosen in Hebei Province, and were divided into three groups to be vaccinated with IPV-bOPV-bOPV(Group a), IPV-IPV-bOPV(Group b) and IPV-IPV-IPV(Group c) at 2, 3 and 4 months of age respectively. AEFI cases related to poliomyelitis vaccines in Hebei province by passive surveillance from January 1, 2018 to December 31, 2022 were obtained from national adverse event following immunization surveillance system (NAEFISS).

Positively Photo-Responsive Adsorption Over Binary Copper Porphyrin Framework and Graphene Film Sorbents.

Photo-responsive adsorption has emerged as a vibrant area because it provides a promising route to reduce the energy consumption of the traditional adsorption separation. However, the current methodology to fabricate photo-responsive sorbents is still subject to the photo-deforming molecular units. In this study, a new initiative of photo-dissociated electron-hole pairs is proposed to generate amazing adsorption activity, and prove its feasibility.

Analysis of the implication of steroid 5 alpha-reductase 3 on prognosis and immune microenvironment in Liver Hepatocellular Carcinoma.

Introduction: This study combined the bioinformatics and experiment-related technologies to analyze the impact of steroid 5 alpha-reductase 3 (SRD5A3) on the prognosis and immune microenvironment of Liver Hepatocellular Carcinoma (LIHC).

Method: Gene expression and clinical data were obtained from public databases. The prognosis was evaluated using survival, multifactor Cox, enrichment, and mutation analyses.

Handling delayed or missed direct oral anticoagulant doses: model-informed individual remedial dosing.

Nonadherence to direct oral anticoagulant (DOAC) pharmacotherapy may increase the risk of thromboembolism or bleeding, and delayed or missed doses are the most common types of nonadherence. Current recommendations from regulatory agencies or guidelines regarding this issue lack evidence and fail to consider individual differences. This study aimed to develop individual remedial dosing strategies when the dose was delayed or missed for DOACs, including rivaroxaban, apixaban, edoxaban, and dabigatran etexilate.

Neurosyphilis Presenting as Psychiatric Symptoms at Younger Age: A Case Report.

Neurosyphilis is a central nervous system infection caused by that imitates various neurological and mental disorders. Therefore, patients with this disease are prone to misdiagnoses. Here, we report a case of neurosyphilis with a psychotic disorder as the main manifestation.

Nanosecond-pulsed plasma protects against bacterial fruit blotch and promotes melon seedling growth.

Background: Bacterial fruit blotch (BFB), known as the 'cancer' of cucurbits, is a seed-borne disease of melons caused by Acidovorax citrulli. Traditional chemical treatments for BFB are ineffective and adversely affect the environment. Using dielectric barrier discharge (DBD) nanosecond-pulsed plasma technology, melon seeds were treated to promote germination and growth and to control BFB.

Excitation generated preferential binding sites for ethane on porous carbon-copper porphyrin sorbents: ethane/ethylene adsorptive separation improved by light.

Energy-efficient separation of CH/CH is a great challenge, for which adsorptive separation is very promising. CH-selective adsorption has big implications, while the design of CH-sorbents with ideal adsorption capability, particularly with the CH/CH-selectivity exceeded 2.0, is still challenging.

Profiles of HBcrAg and pgRNA in Pregnant Women With Chronic HBV Under Different Disease Phases and Antiviral Prophylaxis.

Background: Pregnant women with chronic hepatitis B (CHB) exhibit unique clinical features in terms of postpartum immune system reconstitution and recovery from pregnancy-related changes. However, current studies focus primarily on the outcomes of maternal-infant transmission and postpartum hepatitis flares. We aimed to evaluate the profiles of hepatitis B core-related antigen (HBcrAg) and pregenomic RNA (pgRNA) in pregnant women with CHB.

The Experience of Cervical Cancer Patients Undergoing Hysterectomy: A Qualitative Study.

Introduction: Due to different social and cultural backgrounds, cervical cancer patients' experience of the treatment process and quality of life after treatment will be different. This study sought to gain in-depth understanding of the experiences of Chinese cervical cancer patients as regards their quality of life and physical symptoms.

Methodology: Semi-structured interviews were used to collect data.

Stable Mg Single-Atom Solid Base Catalysts Anchored on Metal-Organic Framework-Derived Nitrogen-Doped Carbon.

Solid base catalysts are widely used in the chemical industry owing to their advantages of environmental friendliness and easy separation. However, their application is limited by basic site aggregation and poor stability. In this study, we report the preparation of magnesium (Mg) single-atom catalysts with high activity and stability by a sublimation-trapping strategy.

Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review.

Introduction: Quetiapine exhibits notable pharmacokinetic and pharmacodynamic (PK/PD) variability, the origins of which are poorly understood. This systematic review summarizes published population PK/PD studies and identifies significant covariates accounting for this variability to inform precision dosing.

Methods: We systematically searched the PubMed, Web of Science, and Embase databases and compared study characteristics, model parameters, and covariate effects.

Prevalence of psychological problems among caregivers of children and adolescents with neurodevelopmental disorders during the COVID-19 pandemic: A meta-analysis and systematic review.

Background: The COVID-19 pandemic impacted children and adolescents with neurodevelopmental disorders, which caused difficulties and increased caregivers' burden.

Aim: The objective of this study was to assess the prevalence of psychological problems among caregivers of children and adolescents with neurodevelopmental disorders. Methods and procedures We searched the PubMed, Embase and Web of Science databases for relevant studies published from December 2019 to March 2023.

Photo-Responsive Carbon Capture over Metalloporphyrin-C Metal-Organic Frameworks via Charge-Transfer.

Great efforts have been devoted to the study of photo-responsive adsorption, but its current methodology largely depends on the well-defined photochromic units and their photo-driven molecular deformation. Here, a methodology to fabricate nondeforming photo-responsive sorbents is successfully exploited. With C-fullerene doping in metalloporphyrin metal-organic frameworks (PCN-M, M = Fe, Co, or Ni) and intensively interacting with the metalloporphyrin sites, effective charge-transfer can be achieved over the metalloporphyrin-C architectures once excited by the light at 350 to 780 nm.

Coumarin-functionalized metal-organic frameworks: adsorbents with photo-responsive active sites for adsorptive desulfurization.

Photo-responsive metal-organic frameworks (PMOFs) have great potential in on-demand controllable adsorption processes under distinct light conditions, which is challenging to realize by conventional adsorbents with static frameworks and properties. Here, we report a new type of adsorbent with photo-responsive active sites for adsorptive desulfurization. Coumarin monomers were incorporated in MIL-101(Cr) to construct the photo-responsive adsorbents by coordinating with unsaturated chromium sites.

Transformation of Type III to Type II Porous Liquids by Tuning Surface Rigidity of Rhodium(II)-Based Metal-Organic Polyhedra for CO Cycloaddition.

Porous liquids (PLs), a summation of porous hosts and bulky solvents bestowing permanent cavities, are the prominent emerging materials. Despite great efforts, exploration of porous hosts and bulky solvents is still needed to develop new PL systems. Metal-organic polyhedra (MOPs) with discrete molecular architectures can be considered as porous hosts; however, many of them are insoluble entities.

Photo-Induced Construction and Recovery of Cu Sites in Metal-Organic Frameworks.

The adjustment of the valence state of metal ions is crucial for various applications because peculiar activity originates from metal ions with specific valence. Cu can interact with molecules possessing unsaturated bonds like CO via π-complexation, while Cu doesn't have such ability. Meanwhile, Cu sites are easily oxidized to Cu , leading to the loss of activity.