A longitudinal observational study of demoralization within 6 months following cancer diagnosis: a cross-lagged panel network analysis.

Purpose: To identify the dynamic change and explore the longitudinal correlates of demoralization in patients after cancer diagnosis, provide comprehensive references for interventions targeting demoralization at different time points.

Methods: This study included 127 cancer patients from a tertiary hospital in Guangzhou, China. Demoralization was assessed at three time points: 1 (T1), 3 (T2), and 6 (T3) months after cancer diagnosis.

Durable complete response to sintilimab plus chemotherapy in gallbladder cancer with extensive metastasis: A case report.

Background: Gallbladder cancer is a highly malignant and aggressive tumor, often diagnosed at an advanced stage. The prognosis for advanced gallbladder cancer remains poor, with limited options for effective treatment.

Case Summary: A 65-year-old male patient presented with a soft tissue mass in the gallbladder.

Comprehensive evaluation of regional variations in phytochemical composition and bioactive properties of Artemisia argyi.

Ethnopharmacological Relevance: Artemisia argyi (A. argyi) from distinct cultivation ecoregions exhibit significant phytochemical and bioactivity variations. However, no systematic study has yet elucidated their intrinsic correlations, hindering reproducible quality marker development.

Malignant Peripheral Nerve Sheath Tumor (MPNST) of the Uterine Cervix - A Systematic Literature Review and New Case Report with Possible New Therapeutic Approaches.

Malignant schwannomas of the visceral organs are extremely rare. To date, 19 cases of cervical schwannoma have been reported in the literature worldwide. A single case prompted a review of the literature.

Deciphering the genetic basis of sex differentiation in silver-lipped pearl oyster ( ) based on integrative transcriptomic analysis.

The silver-lipped pearl oyster ( ) is the largest and most commercially valuable pearl-producing oyster, renowned for its ability to generate large, lustrous pearls. This species is a sequential hermaphrodite, with pearl production displaying notable sexual dimorphism. Consequently, understanding the molecular mechanisms governing sex determination and differentiation is crucial for advancing breeding strategies in the pearl oyster industry.

[Preparation and intestinal absorption mechanism of herpetrione and Herpetospermum caudigerum polysaccharides based self-assembled nanoparticles].

In this experiment, self-assembled nanoparticles(SANs) were prepared by the pH-driven method, and Her-HCP SAN was constructed by using herpetrione(Her) and Herpetospermum caudigerum polysaccharides(HCPs). The average particle size and polydispersity index(PDI) were used as evaluation indexes for process optimization, and the quality of the final formulation was evaluated in terms of particle size, PDI, Zeta potential, and microstructure. The proposed Her-HCP SAN showed a spheroid structure and uniform morphology, with an average particle size of(244.

Impact of miRNAs involved in the STAT3 signaling pathway on esophageal cancer (Review).

Esophageal cancer (ESCA) is a common tumor noted in the digestive tract, which is highly malignant due to unclear early symptoms and poor last‑stage treatment effects; its mortality rate is relatively high. MicroRNA (miR) and signal transducer and activator of transcription 3 (STAT3) are key components of cellular signaling pathways; their interaction forms a complex and intricate information network that controls several types of biological behaviors in the cells. In the tumor cell, these signal transduction pathways are abnormally active, indicating that the STAT3 signaling pathway mediated by miRs is involved in the progression of various cancer types.

NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.

GWASs have linked the 3p21.1 locus, which is associated with the expression levels of NEK4, to bipolar disorder. Here, we use integrative analyses of GWAS statistics and eQTL annotations to establish that elevated NEK4 expression in the hippocampus is associated with an increased risk of bipolar disorder.

Establishment and verification of novel TNM staging system for lung mucinous adenocarcinoma.

Background: Lung adenocarcinoma is a high-mortality rate cancer. Within this category, Lung mucinous adenocarcinoma (LMAC) is a rare and distinct subtype of lung adenocarcinoma necessitating further investigation. The study was launched to compare the difference of survival features between LMAC and lung non-mucinous adenocarcinoma (LNMAC) and to investigate the significance and demand for developing a new staging system tailored to LMAC.

eIF6 Promotes Gastric Cancer Proliferation and Invasion by Regulating Cell Cycle.

Objective: To investigate the role and function of eIF6 in gastric cancer (GC).

Methods: The expression level of eIF6 in GC tissues and normal tissues was detected in different high-throughput sequencing cohorts. Survival analysis, gene differential analysis, and enrichment analysis were performed in the TCGA cohort.

Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach.

Background And Hypothesis: Investigating the shared brain protein and genetic components of schizophrenia (SCZ) and bipolar I disorder (BD-I) presents a unique opportunity to understand the underlying pathophysiological processes and pinpoint potential drug targets.

Study Design: To identify overlapping susceptibility brain proteins in SCZ and BD-I, we carried out proteome-wide association studies (PWAS) and Mendelian Randomization (MR) by integrating human brain protein quantitative trait loci with large-scale genome-wide association studies for both disorders. We utilized transcriptome-wide association studies (TWAS) to determine the consistency of mRNA-protein dysregulation in both disorders.

Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters.

As SARS-CoV-2 continues to evolve and COVID-19 cases rapidly increase among children and adults, there is an urgent need for a safe and effective vaccine that can elicit systemic and mucosal humoral immunity to limit the emergence of new variants. Using the Chinese Hu191 measles virus (MeV-hu191) vaccine strain as a backbone, we developed MeV chimeras stably expressing the prefusion forms of either membrane-anchored, full-length spike (rMeV-preFS), or its soluble secreted spike trimers with the help of the SP-D trimerization tag (rMeV-S+SPD) of SARS-CoV-2 Omicron BA.2.

Identification of Critical Amino Acids of Coxsackievirus A10 Associated with Cell Tropism and Viral RNA Release during Uncoating.

Coxsackievirus A10 (CV-A10) is a prevailing causative agent of hand-foot-mouth disease, necessitating the isolation and adaptation of appropriate strains in cells allowed for human vaccine development. In this study, amino acid sequences of CV-A10 strains with different cell tropism on RD and Vero cells were compared. Various amino acids on the structural and non-structural proteins related to cell tropism were identified.

Photo-Responsive Carbon Capture over Metalloporphyrin-C Metal-Organic Frameworks via Charge-Transfer.

Great efforts have been devoted to the study of photo-responsive adsorption, but its current methodology largely depends on the well-defined photochromic units and their photo-driven molecular deformation. Here, a methodology to fabricate nondeforming photo-responsive sorbents is successfully exploited. With C-fullerene doping in metalloporphyrin metal-organic frameworks (PCN-M, M = Fe, Co, or Ni) and intensively interacting with the metalloporphyrin sites, effective charge-transfer can be achieved over the metalloporphyrin-C architectures once excited by the light at 350 to 780 nm.

Stroke-induced damage on the blood-brain barrier.

The blood-brain barrier (BBB) is a functional phenotype exhibited by the neurovascular unit (NVU). It is maintained and regulated by the interaction between cellular and non-cellular matrix components of the NVU. The BBB plays a vital role in maintaining the dynamic stability of the intracerebral microenvironment as a barrier layer at the critical interface between the blood and neural tissues.

Multispectral transparent electromagnetic-wave-absorbing optical window technology based on a random grid.

A multimode detection system has stringent requirements in terms of electromagnetic characteristic control and electromagnetic compatibility. To meet these requirements, we designed and manufactured a type of transparent electromagnetic-wave-absorbing optical window based on a random grid (EAOWRG) in this study. Owing to the design and regulation of the materials of the random grid and the structures of the metasurface, the optical window has excellent multispectral transparency, electromagnetic wave absorption, and electromagnetic shielding performance.

[Research progress of the regulation of orphan nuclear receptors on chronic liver diseases].

The development of chronic liver disease can be promoted by excessive fat accumulation, dysbiosis, viral infections and persistent inflammatory responses, which can lead to liver inflammation, fibrosis and carcinogenesis. An in-depth understanding of the etiology leading to chronic liver disease and the underlying mechanisms influencing its development can help identify potential therapeutic targets for targeted treatment. Orphan nuclear receptors (ONRs) are receptors that have no corresponding endogenous ligands to bind to them.

Crop rotations increased soil ecosystem multifunctionality by improving keystone taxa and soil properties in potatoes.

Continuous cropping of the same crop leads to soil degradation and a decline in crop production, and these impacts could be mitigated through rotation cropping. Although crop rotation enhances soil fertility, microbial community diversity, and potato yield, its effects on the soil ecosystem multifunctionality (EMF) remain unclear. In the present research, we comparatively examined the effects of potato continuous cropping (PP) and rotation cropping [potato-oat rotation (PO) and potato-forage maize rotation (PFM)] on the soil EMF as well as the roles of keystone taxa, microbes abundance, and chemical properties in EMF improvement.

Analysis of Cytological Misdiagnosis and Oversight of Adenoid Cystic Carcinoma of Salivary Gland.

Objective: In this article on adenoid cystic carcinoma (ACC) of salivary gland, we intend to summarize the causes of misdiagnosis and oversight of ACC hoping to improve cytological diagnostic accuracy, clinical management and patient treatment.

Methods: The study retrospectively reviewed 32 patients with ACC of salivary gland, registered at the Affiliated Hospital of Southwest Medical University from July 2014 to June 2021. These cases were diagnosed by FNA and surgical excision biopsy.

Giant cell tumor of tendon sheath: A report of 216 cases.

Background: In this article on giant cell tumor of tendon sheath (GCTTS), we intend to summarize and analyze the clinical and pathological features of GCTTS hoping to improve clinical management and patient treatment.

Methods: The study retrospectively reviewed 216 patients of GCTTS, registered at the Affiliated Hospital of Southwest Medical University from January 2010 to December 2020. These cases were diagnosed by surgical excision.

Efficacy of Coxsackievirus A2 vaccine candidates correlating to humoral immunity in mice challenged with a mouse-adapted strain.

Background: In recent years, Coxsackievirus A2 (CV-A2) has become one of the main serotypes of enterovirus species A associated with hand, foot and mouth disease (HFMD) in China. It has also caused HFMD epidemics in many countries all over the world. Currently, there are no effective, preventive vaccines against it.

[Icariin improves erectile function in spontaneously hypertensive rats by up-regulating Nrf2].

Objective: To investigate whether icariin improves erectile function in spontaneously hypertensive rats (SHR) by regulating the NRF2 pathway.

Methods: We equally randomized 24 ten-week-old healthy male Wistar-Kyoto rats (WKR) and healthy male SHR rats into four groups: WKR control, WKR + icariin, SHR control and SHR + icariin, the controls treated intragastrically with normal saline, and the animals in the WKR + icariin and SHR + icariin groups with icariin, all at 10 mg/kg/d for 4 weeks. Then we obtained the body weight and serum T level of the rats and measured the maximum intracorporeal pressure / mean arterial pressure (ICPmax/MAP) and the contents of nuclear factor-erythroid 2-related factor-2 (Nrf2), memeoxygenase-1 (HO-1), endothellial nitric oxide synthase (eNOS), peroxisome proliferator activated receptor gamma (PPAR-γ) , dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide (NO), cyclic guanosine monophosphate (cGMP) and asymmetric dimethylarginine (ADMA) in the corpora cavernosa tissue.