Resveratrol Improves Idiopathic Pulmonary Fibrosis by Targeting IKZF3.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited treatment options. This study investigates the therapeutic potential of resveratrol, a natural compound, in treating IPF by targeting IKZF3, a transcription factor upregulated in IPF patients. Using bioinformatics analysis of the GSE110147 dataset, we identified IKZF3 as a key molecule in IPF progression.

Stereo-Talker: Audio-driven 3D Human Synthesis with Prior-Guided Mixture-of-Experts.

This paper introduces Stereo-Talker, a novel one-shot audio-driven human video synthesis system that generates 3D talking videos with precise lip synchronization, expressive body gestures, temporally consistent photo-realistic quality, and continuous viewpoint control. The process follows a two-stage approach. In the first stage, the system maps audio input to high-fidelity motion sequences, encompassing upper-body gestures and facial expressions.

Nuclear Transport Receptor Importin-β Inhibition Enhances Cell Cycle Arrest Induced by CKS2 Knockdown to Suppress Neuroblastoma Progression.

Cyclin-dependent kinases regulatory subunit 2 (CKS2) is a key regulator of the cell cycle, but its role in neuroblastoma remains poorly understood. This study investigates the function and mechanisms of CKS2 in neuroblastoma through bioinformatics analyses, as well as in vitro and in vivo experiments. Data from the GEO and TCGA databases indicate that elevated CKS2 expression is associated with poor prognosis in neuroblastoma.

Fostering academic engagement through soft skills and positive emotions: a sustainable development perspective on university education.

Introduction: Soft skills, including curiosity, initiative, perseverance, social awareness, adaptability, and leadership, are increasingly recognized as essential for fostering positive emotions and academic engagement in higher education. However, the pathways linking these skills to academic engagement remain underexplored, especially within the Chinese university context.

Methods: This study investigated the relationships among soft skills, positive emotions, and academic engagement among 335 undergraduate students (197 females, 58.

Bimodal Electrochemiluminescence of Ru-MOFs in the Presence of Double Coreactants for CEA Detection.

A dual-potential electrochemiluminescence (ECL) immunosensor, featuring simultaneous cathodic and anodic emission from ruthenium-based metal-organic frameworks (Ru-MOFs) as the sole luminophore and iron-monatomic catalysts (FeNC-SN SACs) with tunable sulfur functional groups and abundant Fe-N sites as a highly efficient coreactivity accelerant, is presented for the first time. Cathodic ECL emission originates from the Ru-MOFs/KSO system, whereas anodic ECL emission is achieved via the Ru-MOFs/polyethylene imine (PEI) system. The experimental results revealed a linear relationship between the variation in the ECL signal variation of the immunosensor and the concentration of CEA, which ranged from 0.

Ti-Based Metallic Biomaterials for Antitumor Applications.

Titanium (Ti)-based metallic biomaterials (MBs) are traditionally employed as mechanical supports and constraints in clinical practice, owing to their superb comprehensive mechanical properties, great corrosion resistance, and good biocompatibility. Recently, Ti-based MBs have emerged as promising candidates for antitumor applications. These developments focus on the functionalization of Ti-based MBs to inhibit tumor propagation and recurrence.

Muscular Cystic Lesions: A Highly Misdiagnosed Extraosseous Ewing Sarcoma: Two Case Reports and Literature Review.

Background: A retrospective analysis was carried out on two cases of extraosseous Ewing sarcoma (ES) that were initially misdiagnosed as lymphatic malformations, with a focus on clinical manifestations, imaging characteristics, and other relevant case data. A comprehensive review of the literature was performed to enhance the understanding of cystic extraosseous ES.

Case Presentation: Both cases in this study originated from cystic lesions in the muscular interstitial space.

β-Elemene inhibits adipogenesis in 3T3-L1 cells by regulating AMPK pathway.

The prevalence of childhood obesity in global is quickly augmented, resulting into grievous public health problems and influencing adolescent development. β-Elemene is a sesquiterpene, and can extracted from traditional Chinese medicine- L. β-Elemene has been discovered to display regulatory functions in multiple diseases, but it's roles in obesity need further investigations.

Tubulin Regulates the Stability and Localization of STMN2 by Binding Preferentially to Its Soluble Form.

Loss of the tubulin-binding protein STMN2 is implicated in amyotrophic lateral sclerosis (ALS) but how it protects neurons is not known. STMN2 is known to turn over rapidly and accumulate at axotomy sites. We confirmed fast turnover of STMN2 in U2OS cells and iPSC-derived neurons and showed that degradation occurs mainly by the ubiquitin-proteasome system.

Sensitive and selective chemosensor for Fe detection using carbon dots synthesized by microwave method.

The excessive accumulation of heavy metal ions can pose significant hazards to human health and the environment, hence the detection and removal of heavy metal ions from water bodies are essential. Generally, carbon dots (CDs) are used as a good fluorescence sensor to sense heavy metal ions. In this study, using one-step microwave method, CDs were synthesized with the traditional Chinese medicine Radix Vladimiriae as a carbon source for the first time.

Exploring Potential Associations between Benzo[]pyrene, Nicotine Exposure, and Lung Cancer: Molecular Insights, Prognostic Biomarkers, and Immune Cell Infiltration.

Benzo[]pyrene (BaP) and nicotine exposure have been implicated in lung cancer development. This study aims to elucidate the molecular mechanisms and potential biomarkers associated with this exposure in lung cancer patients. We integrated gene expression data from The Cancer Genome Atlas lung cancer cohort and the Comparative Toxicogenomics Database to identify differentially expressed genes (DEGs) associated with BaP and nicotine exposure.

Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study.

Objectives: This cross-sectional study aims to evaluate the association between calcium and vitamin D supplementation for osteoporosis treatment and the development of kidney stones while investigating the impact of urinary calcium excretion on kidney stone risk among patients receiving this supplementation treatment.

Design: The study involved collecting data from 204 Chinese Han patients aged 50-89 with osteoporosis in the southwest region of China. These patients had been on daily doses of 600 mg of calcium carbonate and 0.

A single-center study examining the safety and effectiveness of ERCP with pancreatoscopy and endoluminal radiofrequency ablation for main-duct IPMN treatment.

To assess the safety and efficacy of treatment for intraductal papillary mucinous neoplasm (IPMN) involving the main pancreatic duct (MPD) using endoscopic retrograde cholangiopancreatography (ERCP) combined with digital single-operator pancreatoscopy and radiofrequency ablation (RFA). A retrospective analysis was performed. Patients with episodes of acute pancreatitis at the First Affiliated Hospital of Chongqing Medical University were screened.

[Preparation and intestinal absorption mechanism of herpetrione and Herpetospermum caudigerum polysaccharides based self-assembled nanoparticles].

In this experiment, self-assembled nanoparticles(SANs) were prepared by the pH-driven method, and Her-HCP SAN was constructed by using herpetrione(Her) and Herpetospermum caudigerum polysaccharides(HCPs). The average particle size and polydispersity index(PDI) were used as evaluation indexes for process optimization, and the quality of the final formulation was evaluated in terms of particle size, PDI, Zeta potential, and microstructure. The proposed Her-HCP SAN showed a spheroid structure and uniform morphology, with an average particle size of(244.

Long-Range ZZ Interaction via Resonator-Induced Phase in Superconducting Qubits.

Superconducting quantum computing emerges as one of the leading candidates for achieving quantum advantage. However, a prevailing challenge is the coding overhead due to limited quantum connectivity, constrained by nearest-neighbor coupling among superconducting qubits. Here, we propose a novel multimode coupling scheme using three resonators driven by two microwaves, based on the resonator-induced phase gate, to extend the ZZ interaction distance between qubits.

Differences in the permeation of Licoricchalcone A-polysaccharide self-assembled nanoparticles on healthy and DNCB-induced atopic dermatitis in Balb/c mice.

Nanoformulation have been widely used in skin and transdermal drug delivery. However, the differences in integral nanoparticles absorption in healthy and diseased skin have not yet fully analyzed. The present study attempted to explore the percutaneous absorption of drugs via lesional skin by using atopic dermatitis (AD) as a model, dinitrochlorobenzene (DNCB) induced AD-like skin.

Selinexor targeting XPO1 promotes PEG3 nuclear accumulation and suppresses cholangiocarcinoma progression.

Background: The role of selinexor, a targeted inhibitor of exportin 1 (XPO1), in the treatment of cholangiocarcinoma is not yet fully understood. This study conducted comprehensive in vitro and in vivo investigations to elucidate the effects of selinexor on cholangiocarcinoma, with a focus on its mechanistic relationship with the cellular localization of Paternally Expressed Gene 3 (PEG3).

Methods: A patient-derived xenograft (PDX) model was established using samples from a cholangiocarcinoma patient in immunodeficient mice to assess the in vivo effects of selinexor.

Resveratrol reversed rosiglitazone administration induced bone loss in rats with type 2 diabetes mellitus.

Rosiglitazone (RSG), as an insulin-sensitizing drug to treat type 2 diabetes mellitus (T2DM) is reported to decrease bone quality and increase bone fracture risk. The multiple off-target effects of Resveratrol (RSV), a natural specific agonist of Sirtuin1 (Sirt1) with pro-osteoblastogenesis and anti-adipogenesis effects, on bone loss in T2DM are still under discussion. In this study, successfully ovariectomized rats were fed with high-fat diet and STZ (HFD/STZ) to induced T2DM mice.

[Preparation and intestinal absorption mechanism of self-assembled nanoparticles of Herpetospermum caudigerum].

In this experiment, the micro-precipitation method was used to prepare self-assembled nanoparticles of Herpetospermum caudigerum Wall.(MP-SAN). The process was optimized using average particle size and polydispersity index(PDI)as evaluation indexes.

L-VSM: Label-Driven View-Specific Fusion for Multiview Multilabel Classification.

In the task of multiview multilabel (MVML) classification, each instance is represented by several heterogeneous features and associated with multiple semantic labels. Existing MVML methods mainly focus on leveraging the shared subspace to comprehensively explore multiview consensus information across different views, while it is still an open problem whether such shared subspace representation is effective to characterize all relevant labels when formulating a desired MVML model. In this article, we propose a novel label-driven view-specific fusion MVML method named L-VSM, which bypasses seeking for a shared subspace representation and instead directly encodes the feature representation of each individual view to contribute to the final multilabel classifier induction.

STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases.

Stathmins are small, unstructured proteins that bind tubulin dimers and are implicated in several human diseases, but whose function remains unknown. We characterized a new stathmin, STMND1 (Stathmin Domain Containing 1) as the human representative of an ancient subfamily. STMND1 features a N-terminal myristoylated and palmitoylated motif which directs it to membranes and a tubulin-binding stathmin-like domain (SLD) that contains an internal nuclear localization signal.

Fabrication and in vitro/vivo evaluation of quercetin nanocrystals stabilized by glycyrrhizic acid for liver targeted drug delivery.

The purpose of this study was to design novel drug nanocrystals (NCs) stabilized by glycyrrhizic acid (GL) for achieving liver targeted drug delivery due to the presence of GL receptor in the hepatocytes. Quercetin (QT) exhibits good pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty hepatitis, liver fibrosis, and liver cancer. It was selected as a model drug owing to its poor water solubility.

Determination of diethylstilbestrol in environmental water based on electrochemical senser modified with vanadium based metal organic framework material composite.

In this research, the MIL-47/ACET/Nafion/GCE electrochemical senser for the determination of diethylstilbestrol (DES) was prepared with vanadyl sulfate (VOSO·HO) and terephthalic acid (HBDC) as the main raw materials, compounded with acetylene black (ACET) and perfluorosulfonic acid polymer (Nafion). The compound DES belongs to the category of estrogens, and prolonged exposure to the environment can have detrimental effects on the physiological functioning of both humans and animals. Due to the strong DES enrichment performance of MIL-47(V-MOFs) with large specific surface area, in addition to the excellent conductivity and electrocatalysis of composite materials, this modified senser had good electrochemical response to DES.

Everolimus inhibits hepatoblastoma by inducing autophagy-dependent ferroptosis.

Everolimus, a known inhibitor of the mammalian target of rapamycin (mTOR), has shown uncertain efficacy in treating hepatoblastoma. This study delves into the potential anti-hepatoblastoma properties of everolimus and its intricate relationship with autophagy and ferroptosis, both in vitro and in vivo. In vivo, tumor tissue from hepatoblastoma patient and human hepatoblastoma cell line HuH-6 were xenografted into nude mice to establish xenograft models for observing the effect of everolimus on tumor growth.