A Novel Arene Trifluoromethyl-Based F-Labeling Strategy for Enhanced Biomolecular Tracer Development in PET Imaging.

Biologically active molecules, such as carbohydrates, peptides, and proteins, are attractive candidates for positron emission tomography (PET) imaging because of their strong target affinity and biocompatibility. Among available radionuclides, fluorine-18 (F) is widely used in clinical practice because of its moderate half-life and high-quality imaging properties. However, traditional F-labeling methods often require a laborious procedure and harsh conditions, which may compromise the structural integrity and biological functions.

Assessing the impact of liver fat fraction on portal hemodynamics in nonalcoholic fatty liver disease using MRI proton density fat fraction and MRI 4D Flow.

Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition with significant implications for liver and cardiovascular health. Alterations in portal hemodynamics due to hepatic steatosis remain poorly understood.

Aim: This study aims to explore the correlation between liver fat fraction (FF) and portal hemodynamics in NAFLD patients.

Predicting the Uniaxial Compressive Strength of Cement Paste: A Theoretical and Experimental Study.

This study presents a progressive strength prediction model for cement paste based on the hypothesis that compressive strength is governed by the microstructural compactness of hydration products. A three-stage modeling framework was developed: (1) a semi-empirical model for pure cement paste incorporating water-to-cement ratio and paste density; (2) a density-corrected effective water-cement ratio w/ceff that accounts for the physical effects of mineral additives including fly ash, slag, and limestone powder; and (3) a hydration-informed strength model incorporating curing age and temperature through an equivalent hydration degree αte. Experimental validation using over 60 cement paste mixes demonstrated high predictive accuracy, with coefficients of determination up to 0.

Exploring F/F Isotopic Exchange for the Synthesis of [F]Trifluoromethylated Arenes.

The presence of the trifluoromethyl aromatic (Ar-CF) moiety can enhance the interactions with targets, membrane permeability, metabolic stability, and drug efficacy. It also prioritizes positron emission tomography (PET) imaging without altering original drug structures. Although the simplicity of F/F isotope exchange has flourished in boron-, silicon-, phosphorus- and sulfur-based F-radiochemistry, its application to CF(sp)-F bond formation remains challenging.

Stereo-Talker: Audio-driven 3D Human Synthesis with Prior-Guided Mixture-of-Experts.

This paper introduces Stereo-Talker, a novel one-shot audio-driven human video synthesis system that generates 3D talking videos with precise lip synchronization, expressive body gestures, temporally consistent photo-realistic quality, and continuous viewpoint control. The process follows a two-stage approach. In the first stage, the system maps audio input to high-fidelity motion sequences, encompassing upper-body gestures and facial expressions.

Case Report: Early detection of neonatal volvulus by ultrasound in a 2-day-old neonate: timely intervention prevents complications.

Intestinal malrotation is a congenital anomaly arising from improper rotation or fixation of the embryonic gut, potentially leading to life-threatening complications such as volvulus. It typically presents within the first month of life with symptoms including bilious vomiting and scaphoid abdomen. In this report, we describe a case involving a 2-day-old term neonate who exhibited two episodes of hematochezia and one episode of hematemesis, without accompanying scaphoid abdomen or bilious vomiting.

Polysaccharide isolated from Dahlia root tubers affects the proliferation of HUVECs and promotes angiogenesis in zebrafish.

Dahlia root tubers are rich in polysaccharides with various biological activities. However, reports on isolation and structural characterization of these polysaccharides remain limited. In this study, a neutral polysaccharide (DLH-W) was isolated from Dahlia root tubers.

Development and evaluation of a Tc-labeled olaparib analog for PARP imaging.

Background: Poly(ADP-ribose) polymerase (PARP) is an important therapeutic target in cancer treatment, and dynamic assessment of its expression level is essential for achieving precision therapy. Although F-labeled PARP-targeted radiotracers have demonstrated remarkable tumor-imaging capabilities in preclinical studies, their high lipophilicity leads to increased non-specific uptake in abdominal organs, which has severely hindered their clinical translation. Furthermore, while PET imaging provides superior resolution and sensitivity, its infrastructure and operational demands may limit widespread accessibility in certain regions.

Cyclin D2 - a potential biomarker in uterine corpus endometrial carcinoma through methylation chip and bioinformatic analysis.

Background: The incidence and mortality of uterine corpus endometrial carcinoma (UCEC) is increasing. Despite advances in diagnosis and treatment, the fundamental molecular mechanisms remain unclear to some extent. In this study, the role and clinical significance of Cyclin D2 (CCND2) in UCEC is discussed and explored.

Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein -GlcNAcylation.

Introduction: Curcumin has garnered increasing attention in male reproductive research due to its potential anti-infertility properties. This study aimed to explore the protective effects of curcumin on spermatogenesis impairment in mice with cryptorchidism and to elucidate the underlying mechanisms.

Methods: A total of 56 male Kunming mice aged 10 to 15 days were randomly assigned to different groups, including a control group (BO) and a cryptorchid group with five curcumin treatment groups (CC25, CC50, CC100, CC200, and CC300) receiving varying doses of curcumin (25, 50, 100, 200, and 300 mg/kg, respectively).

Association between daily sitting time and breast cancer among obese women: a nationwide population-based study.

Background: We aimed to explore the association between daily sitting time and breast cancer in obese women, and further examine the mitigating role of physical activity in this relationship.

Materials And Methods: A secondary analysis of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 1999-2020 were used. Subjects were divided into four groups based on the duration of daily sitting time (< 4, 4 to 6, 6 to 8, and > 8 h).

Self-cross-linked carboxymethyl chitosan/polyethylene glycol hydrogel containing bioactive peptide accelerates bacterial-infected wound healing.

Bacterial infection significantly delays wound healing and leads to chronic or non-healing wounds. Development of wound dressings against bacterial-infected wounds is urgently needed. Herein, a self-cross-linked carboxymethyl chitosan/polyethylene glycol hydrogel (CMCS-PEG-P) containing bioactive peptide YIAEDAER (Tyr-Ile-Ala-Glu-Asp-Ala-Glu-Arg) was prepared.

Neuromorphic chips for biomedical engineering.

The modern medical field faces two critical challenges: the dramatic increase in data complexity and the explosive growth in data size. Especially in current research, medical diagnostic, and data processing devices relying on traditional computer architecture are increasingly showing limitations when faced with dynamic temporal and spatial processing requirements, as well as high-dimensional data processing tasks. Neuromorphic devices provide a new way for biomedical data processing due to their low energy consumption and high dynamic information processing capabilities.

Functional brain response pattern under rubber hand illusion based on fNIRS.

The rubber hand illusion (RHI), where people experience a sense of ownership over a rubber hand, has been researched by various neuroimaging methods. Here we used functional near-infrared spectroscopy (fNIRS) to analyze the activation and functional connectivity of related brain regions under RHI. Meanwhile, three brain functional network parameters were calculated and analyzed: degree, clustering coefficient, and characteristic path length.

The impact of teachers' motivating style and student-teacher relationships on adolescents' class participation: The indirect role of learning motivation.

In today's competitive society, education's importance is widely recognized. Adolescence is a crucial stage during which individuals experience significant physical and mental growth and form positive learning attitudes. As society's future drivers, adolescents' learning and class participation are vital for personal growth and social progress.

Structural optimization of biodegradable tracheal stent based on mechanical properties of trachea.

Tracheal stent implantation serves as a critical intervention for tracheal stenosis, where biodegradable magnesium (Mg) alloy stents have emerged as promising alternatives due to their ability to eliminate long-term complications associated with permanent stents. However, the uneven stress distribution on the stent often leads to premature failure through localized rapid degradation and structural collapse. This study systematically investigated the biomechanical interactions between biodegradable stents and tracheal tissues to guide optimized stent design.

Effectiveness of Transtheoretical Model-Based Motivational Interviewing on Glycemic Control Among Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Control Trials.

Background: Optimal glycemic control is known to be challenging for people with type 2 diabetes (T2D) due to the maintenance of long-term self-management behavior. Incorporating the transtheoretical model (TTM) components into motivational interviewing (MI) has been applied to promote self-management behaviors such as physical activity in T2D patients. However, the effectiveness of the TTM-based MI intervention in improving glycemic control, self-management, and self-efficacy in adults with T2D remains unclear.

MXene-TiCT-Based Neuromorphic Computing: Physical Mechanisms, Performance Enhancement, and Cutting-Edge Computing.

Neuromorphic devices have shown great potential in simulating the function of biological neurons due to their efficient parallel information processing and low energy consumption. MXene-TiCT, an emerging two-dimensional material, stands out as an ideal candidate for fabricating neuromorphic devices. Its exceptional electrical performance and robust mechanical properties make it an ideal choice for this purpose.

[Effects of drought stress training on polysaccharide accumulation and drought resistance of Codonopsis pilosula].

In order to clarify the effects of drought stress training on the quality and drought resistance of Codonopsis pilosula, this study used PEG to simulate drought stress and employed potting with water control for the drought stress training of C. pilosula plants. The polysaccharide content, secondary metabolites, antioxidant system, and photosynthetic pigment system of C.

Genetic Evolutionary Analysis of Lumpy Skin Disease Virus Strain Under Immune Pressure Exerted by Heterologous Goat Poxvirus Vaccines.

Lumpy skin disease (LSD) is an important infectious disease that threatens the global cattle industry. Recently, LSD has occurred frequently in Asia. The attenuated goat poxvirus (GTPV) vaccine is widely used to prevent LSD in cattle in China; however, sporadic cases of LSD still occur in immunized cattle.

LNP-encapsulated miRNA29b for corneal repair: A novel approach to combat fibrosis.

Severe corneal injuries often result in corneal scarring, leading to visual impairment and corneal blindness. Currently, there is a lack of effective anti-corneal fibrosis drugs in clinical practice. MicroRNA-based therapies hold significant potential in combating fibrosis.

Mechanical and biological characteristics of 3D-printed auxetic structure in bone tissue engineering.

The auxetic structures are highly effective in bone implants due to their unique deformation characteristics. However, ideal tissue engineering scaffolds must possess suitable mechanical properties and biocompatibility. The biological effects of auxetic structures require further study.

Tumor-specific liquid metal nitric oxide nanogenerator for enhanced breast cancer therapy.

Nitric oxide (NO) modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment and integrated platforms for combination or synergistic therapies. Although a nanoengineering strategy has been proposed to overcome deficiencies of NO gas or small NO donor molecules, such as short half-life, lipophilicity, non-selectivity, and poor stability, it remains challenging to prepare NO nanomedicines with simple composition, multiple functions and enhanced therapeutic efficacy. Herein, we build a liquid metal nanodroplet (LMND)-based NO nanogenerator (LMND@HSG) that is stabilized by a bioreducible guanylated hyperbranched poly(amido amine) (HSG) ligand.

Purification-Free Bortezomib-Drug Conjugates Optimize Drug Economy and Cancer Therapeutic Synergy.

As a promising candidate in overcoming resistance, providing synergy, and developing treatments, conjugated combination drugs mostly prevail over drug cocktails in establishing prodrugs and precisely codelivering multiple drugs for combination chemotherapies. However, current drug-drug conjugation methods (e.g.

Diphthamide formation in Arabidopsis requires DPH1-interacting DPH2 for light and oxidative stress resistance.

Diphthamide is a posttranslationally modified histidine residue of eukaryotic TRANSLATION ELONGATION FACTOR 2 (eEF2) and the target of diphtheria toxin in human cells. In yeast and mammals, the 4Fe-4S cluster-containing proteins Dph1 and Dph2 catalyze the first biosynthetic step of diphthamide formation. Here, we identify Arabidopsis (Arabidopsis thaliana) DPH2 and show that it is required for diphthamide biosynthesis, localizes to the cytosol, and interacts physically with AtDPH1.