[Effect of 3D laparoscopic radical prostatectomy on urinary control and sexual function of patients with prostate cancer].

Objective： To investigate the effects of 3D laparoscopic radical resection prostatectomy(LRP) on urinary control and sexual function of patients with prostatic cancer. Methods： A total of 268 patients who were treated with LRP in the Fifth People's Hospital of Huai'an City from January 2019 to May 2022 were selected and divided into 2 groups according to surgical methods, with 134 cases in each group. The patients in the control group were treated with traditional LRP, and the 3D LRP was used in the observation group.

Global, regional, and national burden and trends of eating disorders among women of childbearing age from 1990 to 2021: Insights from the global burden of disease study 2021.

Objective: Eating disorders (ED) pose a significant global health challenge for women of childbearing age (WCBA). This study aims to systematically evaluate the global disease burden and temporal trends of eating disorders in this vulnerable population.

Methods: This study utilized Global Burden of Diseases (GBD) data to assess the burden and trends in prevalence, incidence, and Disability-Adjusted Life Years (DALYs) rates of eating disorders, estimating percentage changes and annual percentage changes (EAPC).

Changes in heart rate variability parameters following pulsed-field ablation in patients with atrial fibrillation: A systematic review and meta-analysis HRV changes after pulsed-field ablation in AF.

Introduction: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia. Pulmonary vein isolation (PVI) is a cornerstone for catheter ablation for AF. Most recently, pulsed-field ablation (PFA) has emerged as a novel technique that minimizes tissue damage due to its tissue selectivity with promising clinical success.

Profiles of oral microbiota and metabolites in periodontitis and benign prostatic hyperplasia patients: a pilot study.

Emerging evidence suggests a potential link between periodontitis and benign prostatic hyperplasia (BPH). We have demonstrated that experimental periodontitis and the periodontal pathogen exacerbate the progression of BPH. In this study, we focused on the characteristics and alterations of the oral microbiome and metabolites in patients with BPH and those with both BPH and periodontitis.

Causal associations between fibroblast growth factors and breast cancer: Evidence from 2-sample Mendelian randomization analysis.

Previous studies have suggested a potential association between fibroblast growth factors (FGFs) and breast cancer (BC), but the evidence for the relationship between specific FGFs with BC is limited and controversial. To explore the interactions between 13 FGFs and 3 fibroblast growth factor receptors (FGFRs) with BC and its subtypes (ER+ and ER-), we conducted a Mendelian randomization (MR) analysis based on genome-wide association study summary statistics of European ancestry. Several techniques were used to ensure the stability of the causal effect, such as inverse-variance weighting, weighted median, MR-Egger regression, and Mendelian Randomization Pleiotropy Residual Sum and Outlier.

ABC Transporter Protein-mediated Multidrug Resistance in Breast Cancer and Development of Targeting Strategies.

Drug resistance (MDR) poses a significant challenge in breast cancer (BrCa) treatment, resulting in reduced efficacy and increased tumor recurrence. Resolving MDR in BrCa is necessary for improving the clinical efficacy of antitumor therapy. However, the molecular mechanisms underlying MDR are complex and involve various biological processes, including ABC drug transporter-mediated drug efflux, abnormal drug metabolism, and the development of the tumor microenvironment.

Superionic Surface Li-Ion Transport in Carbonaceous Materials.

Unlike Li-ion transport in the bulk of carbonaceous materials, little is known about Li-ion diffusion on their surface. In this study, we have discovered an ultrafast Li-ion transport phenomenon on the surface of carbonaceous materials with limited reversible Li insertion capacity and high surface area. An ionic conductivity of 18.

DNA methylation variations of DNA damage response in glioblastoma: NSUN5 modulates tumor-intrinsic cytosolic DNA-sensing and microglial behavior.

Background: Variations in DNA methylation within the DNA damage response (DDR) mechanism could have significant implications for glioma prognosis and immune responses. This study aimed to explore the global DNA methylation landscape of DDR genes in gliomas and identify key epigenetically regulated genes influencing glioma biology and immunity.

Methods: This study incorporated a range of public and local glioma datasets.

Lipoprotein(a) elevation independently associates with incident atrial fibrillation irrespective of inflammatory status.

Background: Atrial fibrillation (AF) significantly increases stroke, heart failure, and mortality risk. Elevated lipoprotein(a) (Lp[a]) is implicated in AF pathogenesis, but its relationship with systemic inflammation (assessed by high-sensitivity C-reactive protein [hs-CRP]) remains unclear.

Objective: We investigated whether the Lp(a)-AF association is independent of baseline inflammatory status.

Sinomenine hydrochloride alleviates autoimmune myocarditis via suppressing Th1 cell induced-M1 macrophage pyroptosis.

Background: CD4 T cells are crucial to the cardiac autoimmunity of myocarditis, with the underlying pathogenesis remaining unclear. Sinomenine hydrochloride, a natural compound from Sinomenium acutum, is reported to protect against some autoimmune diseases. This study aimed to elucidate the role of CD4 T-helper 1 (Th1) cells in regulating inflammatory cell death and investigate the effect of sinomenine hydrochloride on Th1 cells and myocarditis.

A Cardiac Magnetic Resonance-Based Risk Stratification for Life-Threatening Ventricular Tachyarrhythmias in Heart Failure: The SNE Score.

Risk stratification for sudden cardiac death (SCD) mainly relies on severely reduced left ventricular ejection fraction (LVEF), but its poor predictive efficacy fails to meet clinical needs. Myocardial scarring identified using cardiac magnetic resonance (CMR) imaging has emerged as a potent risk indicator for SCD and life-threatening ventricular tachyarrhythmias (LTVTA). This study aimed to develop a risk prediction score for SCD and ventricular tachyarrhythmias in symptomatic heart failure.

Percutaneous endocardial septal radiofrequency ablation in patients with hypertrophic obstructive cardiomyopathy.

Objective: Percutaneous endocardial septal radiofrequency ablation (PESA) shows promise as a treatment for hypertrophic obstructive cardiomyopathy (HOCM). We aimed to explore the efficacy and safety of PESA require further study during a long-term follow-up.

Methods: We enrolled 25 patients HOCM who underwent PESA.

MiR-4429 Serves as a Protective Regulator by Targeting GNAI2 in Coronary Artery Disease.

Increasingly evidence suggests that microRNA (miRNA) plays a pivotal role in coronary artery disease (CAD). This study investigated the abundance of miR-4429 in the serum of CAD patients and explored the function of miR-4429 and its target GNAI2.A total of 164 participants were enrolled.

Efficacy and safety of low-dose rivaroxaban in elderly patients with atrial fibrillation for oral anticoagulation therapy: Rationale, design, and study protocol for a multicenter randomized controlled trial (SAFE-AF).

Background: Non-vitamin K antagonist anticoagulant (NOAC) is considered the first-line treatment for atrial fibrillation (AF) patients to reduce the risk of stroke, especially in the elderly. However, robust clinical evidence is lacking regarding the appropriateness of low-dose NOAC.

Design: The SAFE-AF trial is an investigator-initiated, multicenter, open-label, randomized controlled, blind endpoint evaluation, non-inferiority designed trial comparing the efficacy and safety of low-dose rivaroxaban with standard-dose rivaroxaban in patients aged ≥70 years with AF.

PARK7 is a Key Regulator of Oxidative Stress - Related Breast Cancer Risk: A Multi-Omics Study.

Oxidative stress (OS) is closely associated with the occurrence and progression of breast cancer (BC). However, its role as a potential etiological factor or trigger remains unclear. This study aims to systematically investigate the potential causal effects and mechanisms of OS-related genes in BC by integrating multi-omics data.

A homotopy estimation based temporal-spatial spectrum prediction for UAV communications with arbitrary flight paths.

Due to the rapid growth of unmanned aerial vehicles (UAVs), their spectrum resources become scarce, leading to UAVs requiring spectrum prediction to share the spectrum with other users. However, contemporary prediction methods may have difficulty in predicting the spectrum states at the next location, because the UAVs cannot obtain the historical data in advance to train prediction models. This paper introduces a temporal-spatial spectrum prediction approach for arbitrary flight within a specific region.

Liver sinusoidal endothelial cells secret C-X-C motif chemokine ligand 10 to promote the recruitment of invariant NKT cells in acetaminophen-induced liver injury.

Drug-induced liver injury (DILI) has become a significant public health concern. Liver sinusoidal endothelial cells (LSECs), serving as the primary defense barrier in the liver, play a crucial role in maintaining the sinusoidal microenvironment. However, the adaptive changes occurring in LSECs and the mechanisms that regulate the immune microenvironment during the initial stages of acetaminophen (APAP)-induced liver injury (AILI) remain unclear.

Antigen-presenting CAFs orchestrate immunosuppressive niches via CXCL13-mediated immune cell infiltration dysregulation and prognostic stratification in triple-negative breast cancer.

Antigen-presenting cancer-associated fibroblasts (apCAFs) are a recently identified stromal cell subset in the tumor microenvironment, playing a significant role in tumor immune regulation through their unique antigen-presenting function. This study aimed to elucidate the biological significance of apCAFs in triple-negative breast cancer (TNBC) by analyzing single-cell transcriptomic data from nine TNBC patients in public databases and integrating TCGA data. Three major CAF subpopulations were identified, with apCAFs primarily establishing functional connections with various cell types, including T cells, via the MIF signaling pathway.

Plasma Lipidomic Profiles Investigating the Effects of Combined Therapy With Quetiapine and Magnesium Valproate in Emerging Adults With Bipolar II Disorder During Depressive Episodes: A Follow-Up Study.

Bipolar disorder (BD) is associated with alterations in plasma lipid profiles, which may contribute to its pathogenesis. However, the detailed plasma lipidomic composition of bipolar II disorder during depressive episodes (BPD-II) remains underexplored. This study investigates the temporal changes in plasma lipidomics in BPD-II patients at emerging adulthood undergoing treatment with quetiapine combined with magnesium valproate.

Association between oxidative stress and metabolic-associated fatty liver disease in the US population.

Limited research have been conducted on the interrelationship and role of oxidative stress and Metabolic Associated Fatty Liver Disease (MAFLD) within the population. The Oxidative Balance Score (OBS) serves as a metric for evaluating an individual's overall oxidative stress status. This study seeks to investigate the impact of OBS on the population and elucidate its potential mechanisms.

Sex differences in systolic blood pressure response to exercise testing: a real-world clinical analysis.

The American Heart Association recommends sex-specific thresholds for defining exaggerated systolic blood pressure response to exercise (ESBPR), primarily based on data from young healthy populations. However, their applicability and the sex differences in systolic blood pressure (SBP) response to exercise in real-world clinical settings remain unclear. We conducted a cross-sectional study of 44 418 adults (40.

Exosomes in hypoxia: generation, secretion, and physiological roles in cancer progression.

The hypoxic microenvironment represents a universal hallmark feature of most solid tumors, profoundly shaping cancer progression through multifaceted mechanisms. Acting as nanoscale molecular envoys, exosomes transport oncogenic cargoes (including non-coding RNAs, mutated proteins, and metabolites) to reprogram stromal cells, prime pre-metastatic niches, and establish tumor-host metabolic symbiosis. Their lipid bilayer architecture ensures the protection of labile hypoxia-responsive factors, positioning them as critical amplifiers of intercellular crosstalk within the tumor microenvironment.

Corrigendum: FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.

[This corrects the article DOI: 10.3389/fphar.2024.

Free-space creation of multipole high-order non-integer Bessel beams.

Bessel beams with integer vortex phases and vector vortex polarization have attracted attention for their stable, nondiffracting propagation. Research has focused on integer-order beams, while non-integer beams face challenges due to phase-polarization coupling, limiting their stable propagation in free space. We generate stable multipole high-order non-integer Bessel beams (NBBs) through phase-polarization control.