An assessment of the average glandular dose of breast cone-beam CT in China based on clinical patients.

Objectives: To quantify the non-compressed breast characteristics of females and the typical scanning parameters of breast cone-beam computed tomography (CBCT), and to provide a preliminary assessment of the average glandular dose (AGD) of breast CBCT in China.

Methods: This study retrospectively analysed three-dimensional breast imaging data from 1,590 Chinese women who underwent non-enhanced breast CBCT scans in different regions between October 2020 and November 2023. Initially, a semi-automatic measurement tool integrated into the breast CBCT system was used to quantify the breast characteristics for each patient, including effective diameter at the chest-wall (Deff), chest-wall to nipple length (CNL), breast volume (BV), glandular volume (GV), and volumetric breast density (VBD).

5.0T MRA techniques for evaluating Moyamoya disease: 4D-ASL-MRA vs. 3D-TOF-MRA.

Purpose: Three-dimensional time-of-flight MR-angiography (3D-TOF-MRA) at 5.0T showed comparable capacity to 7.0T for visualizing small vessels, but has not yet been compared with arterial spin labeling (ASL)-based four-dimensional MR-angiography (4D-ASL-MRA) at 5.

Disorders of Gut Microbiota and Plasma Metabolic Profiles May Be Associated with Lymph Node Tuberculosis.

The association of gut microbiota with lymph node tuberculosis (LNTB) remains unexplored. This study employed metagenomic sequencing and plasma metabolomics analyses to investigate the role of gut microbiota in LNTB patients. Significant alterations in gut microbial diversity were observed in LNTB patients, characterized by a notable reduction in bacterial taxa involved in short-chain fatty acid (SCFA) synthesis, including , , , and , compared to healthy individuals.

Exploring the Influence of Human-Computer Interaction Experience on Tourist Loyalty in the Context of Smart Tourism: A Case Study of Suzhou Museum.

As digital technology evolves rapidly, smart tourism has become a significant trend in the modernization of the industry, relying on advanced tools like big data and cloud computing to improve travelers' experiences. Despite the growing use of human-computer interaction in museums, there remains a lack of in-depth academic investigation into its impact on visitors' behavioral intentions regarding museum engagement. This paper employs Cognitive Appraisal Theory, considers human-computer interaction experience as the independent variable, and introduces destination image and satisfaction as mediators to examine their impact on destination loyalty.

Glymphatic dysfunction in HIV: a resting-state fMRI biomarker linking cognitive impairment and immune suppression.

Objective: To investigate glymphatic dysfunction in people living with HIV (PLWH) and its associations with immunological status and cognitive function, utilizing the coupling strength of global blood-oxygen-level-dependent and cerebrospinal fluid (gBOLD-CSF).

Design: Retrospective study of 75 PLWH and 52 non-HIV controls undergoing neuropsychological tests and resting-state functional magnetic resonance imaging (rs-fMRI).

Methods: GBOLD-CSF coupling, Montreal Cognitive Assessment (MoCA) and seven cognitive domain scores were calculated.

The Role of Mitochondrial Energy Metabolism in the Mechanism of Exercise Improving Depression.

Depression is the most disabling neuropsychiatric disorder, but its exact mechanisms remain unclear. Mitochondrial energy metabolism may play a key role in the onset and development of depression. Cytokines such as PGC-1α, NLRP3, and BDNF can influence mitochondrial energy metabolism by regulating mitochondrial biogenesis, immune inflammation, and neuroplasticity, thereby mediating the occurrence and progression of depression.

Comparative evaluation of 5.0 T and 3.0 T time-of-flight magnetic resonance angiography in assessing collateral circulation in moyamoya angiopathy.

Background: Time-of-flight magnetic resonance angiography (TOF MRA) is a widely recognized noninvasive diagnostic tool of moyamoya angiopathy (MMA). 3.0 T TOF MRA may lack the precision needed to evaluate collaterals in MMA, whereas 5.

Liver sinusoidal endothelial cells secret C-X-C motif chemokine ligand 10 to promote the recruitment of invariant NKT cells in acetaminophen-induced liver injury.

Drug-induced liver injury (DILI) has become a significant public health concern. Liver sinusoidal endothelial cells (LSECs), serving as the primary defense barrier in the liver, play a crucial role in maintaining the sinusoidal microenvironment. However, the adaptive changes occurring in LSECs and the mechanisms that regulate the immune microenvironment during the initial stages of acetaminophen (APAP)-induced liver injury (AILI) remain unclear.

Efficacy and Safety of Cold Atmospheric Plasma-Assisted Therapy for Herpes Zoster: A Randomized, Parallel, Positive-Controlled, Non-inferiority Multicenter Clinical Trial.

Introduction: There is growing evidence that cold atmospheric plasma (CAP) can boost skin wound healing and inhibit various viruses. Here, we evaluated the effectiveness and safety of CAP as an adjunct treatment for herpes zoster (HZ). We hypothesized that CAP was similar to or better than the helium-neon (He-Ne) laser in promoting HZ wound and pain recovery.

Cerium-Based Nanozyme Functionalized by Conducting Polymers with Dual Enzyme Activities for Intelligent Colorimetric Sensing of Hexavalent Chromium.

Conducting polymers (CPs) have emerged as a class of promising organic conducting materials and attracted extensive attention due to their intrinsic electrical conductivity and easy synthesis process. New design strategies to enhance the catalytic activity of nanozymes by CP functionalization would be highly desirable. Herein, we report the fabrication of CPs-functionalized cerium-based nanozymes and study their application in the intelligent colorimetric sensing of Cr (VI).

Single cell analysis of pan-cancer tumor microenvironment in immunotherapy.

The high heterogeneity of tumor microenvironment (TME) is a key factor affecting immunotherapy. We integrated immunotherapy related scRNA-seq and bulk datasets to analyze the TME, mine key factors and dissect the mechanism in immunotherapy. Analyzing the cell composition of TME in cancer immunotherapy, we revealed key TME cell types, including B cells, CD8+ T cells and fibroblasts.

p67phox/NOX2 inhibits psoriasis by regulating the HIF-1α-glycolysis axis via p53-AMPK in keratinocytes.

Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, oxidative stress, and metabolic reprogramming. While reactive oxygen species (ROS) are implicated in skin inflammation, their cellular sources and regulatory mechanisms in psoriatic pathophysiology remain poorly defined. Here, we identify p67phox/NOX2, a critical ROS-generating enzyme, as a key regulator of glucose metabolism in psoriatic keratinocytes.

Battery-inspired electrochemically charged polyimide coating for ion-electric synergistic rapid bacteria-killing.

Broad-spectrum bacteria-killing strategies based on inorganic metal ions or electrical stimulation have good application prospects in conferring implant-associated infections. However, balancing biocompatibility and antibacterial properties remains challenging. Inspired by aqueous zinc-ion batteries (AZIBs), this work proposed an innovative electrochemically charged hydrated-derived polyimide (HPI) coating on titanium implants to achieve safe and rapid sterilization by ion-electric synergistic effect.

Insufficient S-sulfhydration of cAMP-response element binding protein 1 participates in hyperhomocysteinemia or cisplatin induced kidney fibrosis via promoting epithelial-mesenchymal transition.

Hydrogen sulfide (HS) has been reported to alleviate kidney injury in chronic kidney disease (CKD). Epithelial-mesenchymal transition (EMT) is the essential mechanism of kidney fibrosis. However, the underlying mechanism needs to be further explored.

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus.

Dermoscopy is an important non-invasive form of examination that plays a critical role in the diagnosis of rheumatic diseases accompanied by skin lesions. This technique is performed in real-time and can thus assist in determining the skin biopsy site. Skin lesions are common and important manifestations of most rheumatic diseases, including lupus erythematosus.

Preparation and Electrochemical Characteristics of the Co-Doped LiLaZrO Solid Electrolyte with Fe and Bi.

Solid-state electrolytes (SSEs) have emerged as the most promising alternative to liquid electrolytes in batteries due to their enhanced stability and safety. Among these, the garnet-type LiLaZrO (LLZO) solid electrolyte has attracted significant research interest due to its wide electrochemical stability window and good air stability. However, the ionic conductivity of LLZO is lower due to its high sintering temperature and unstable phase structure.

Predicting the incidence of hematologic toxicity in concurrent chemoradiotherapy for cervical cancer using pelvic MRI imaging.

Background And Objectives: Cervical cancer is one of the most common malignancies in women. Concurrent chemoradiotherapy (CRT) is the standard treatment approach for this disease; however, it can result in severe hematologic toxicity (HT), affecting the treatment outcomes and prognosis. This study aimed to use pelvic magnetic resonance imaging (MRI) to delineate the red bone marrow and analyze its relationship with HT.

Myocardial native T1 and extracellular volume measurements at 5T: Feasibility study and initial experience.

Background: T1 mapping is a robust and highly reproducible technique for quantitative assessment of cardiomyopathy. The aim of this study is to investigate the feasibility of 5T myocardial T1 mapping and to establish preliminary reference values for myocardial T1 at 5T.

Methods: Twenty-eight healthy volunteers (median age, 42 [interquartile range (IQR): 29-54] years; 14 male) and 11 patients (median age, 44 [IQR: 34-51] years; 7 male) underwent cardiovascular magnetic resonance at 5T.

Tonsillar microbiota alterations contribute to immune responses in psoriasis by skewing aged neutrophils.

Background: The interplay between microbiota and the onset of immune-mediated diseases is increasingly coming to light. However, the role of tonsillar microbiota in cutaneous inflammation remains largely unknown.

Objectives: To determine how the tonsillar microbiota influences skin inflammation in psoriasis and to uncover the underlying molecular mechanisms.

A "three-in-one" thermosensitive gel system that enhances mucus and biofilm penetration for the treatment of vulvovaginal candidiasis.

The special physiological barriers of women, such as vaginal mucus and self-cleaning behavior, pose great challenges for the treatment of vulvovaginal candidiasis (VVC), and the drug resistance caused by fungal biofilms limits the application of existing antifungal drugs. Based on this, we designed a "three-in-one" thermosensitive gel system (AF/BP Gel) loaded with antibiofilm nanoparticles (AF NPs) and mucus penetration-assisting nanoparticles (BP NPs) to achieve vaginal adhesion while enhancing mucus and biofilm penetration. AF NPs were loaded with farnesol (FAR) and amphotericin B (AMB), and FAR is one of quorum sensing molecules which can interfere with biofilm-related genes such as ALS3, HWP1, RAS1, CPH1, EFG1, NRG1, TUP1, UME6, and disperse mature biofilm, thus playing a synergic antibiofilm role with AMB.

Trajectories and Influencing Factors of Self-Management Behaviour in Patients With Knee Osteoarthritis: A Longitudinal Study.

Aim: To explore the trajectory of self-management behaviour and its influencing factors in patients with knee osteoarthritis.

Design: This is a prospective, longitudinal observational study.

Methods: From January 2024 to April 2024, 126 patients with knee osteoarthritis who were hospitalized in two tertiary-level hospitals in Hunan Province were selected to be surveyed on the day of discharge, 1 month after discharge and 3 months after discharge using the Chinese version of the Chronic Disease Self-Management Research Measurement Scale.

Successful pregnancy in a complex chromosomal rearrangement carrier using preimplantation genetic testing for structural rearrangements: A case report.

Rationale: Complex chromosomal rearrangements (CCRs) frequently lead to unfavorable reproductive consequences, such as recurrent miscarriage. Preimplantation genetic testing for structural rearrangements (PGT-SR) has become a successful method for embryo diagnosis in CCR families.

Patient Concerns: A woman of childbearing age experienced repeated miscarriages during her attempts to conceive.

NLRX1 deficiency exacerbates skin inflammation in atopic dermatitis by disrupting mitophagy.

NLRX1 is an important regulator of inflammatory signaling in innate immune cells. Recent studies indicate NLRX1 activation may be a novel mechanism for inflammatory diseases, however, it has not been explored in atopic dermatitis (AD). Our study aims to investigate the potential role of NLRX1 in the pathogenesis of AD.

Tetrapyrrole organics-modified cerium nanozyme with enhanced oxidase-like activity for integration of detection and degradation of antibiotic.

The massive accumulation of antibiotics accelerates the emergence of antibiotic resistance causing inevitable risks to human and ecosystem. To realize the integration of detection and degradation of antibiotics, it is urgent for exploring novel nanozyme materials with the excellent catalytic activity. Integrating nanozyme with tetrapyrrole-based organics is an effective strategy to enhance the catalytic activity.