Acupuncture for Rapid Pain Relief and Restoration of Motor Function in Acute Lateral Ankle Sprains: A Randomized Controlled Trial Protocol Based on Infrared Thermography.

Purpose: Acute lateral ankle sprain (ALAS) is a prevalent clinical sports injury disease, rapid relief of symptoms and return to normal functional activity are urgent needs of ALAS patients. The aim of this study is to observe the immediate therapeutic effect of acupuncture on ALAS patients in the short term and to evaluate the efficacy at different time points through a multidimensional assessment system, which is expected to provide a simple, rapid, safe and effective therapeutic option for ALAS patients.

Patients And Methods: This is a single-center, prospective, randomized clinical trial.

Streptococcus salivarius CCFM1416 Modulates Oral Immunity via IL-17/IKBζ and Combats Candida albicans Infection.

Oropharyngeal candidiasis (OPC) commonly occurs in immunocompromised individuals, and enhancing endogenous antimicrobial defenses with probiotics has emerged as an effective prevention strategy. Given the critical role of human β-defensin-2 (HBD-2) in combating Candida albicans infection in the oral cavity, this study aimed to identify oral commensal bacteria promoting HBD-2 production in the host. Thirty-five Streptococcus salivarius strains were screened using the HOK-16B cell line, and two were identified as significantly promoting HBD-2 secretion.

Functional Analysis of BmHemolin in the Immune Defense of Silkworms.

has been identified as a crucial immune gene in insect immune defense. The silkworm is susceptible to infections by pathogenic microorganisms when reared on artificial diets. In this study, through comparative analysis of the expression patterns of BmHemolin in silkworms fed on mulberry leaves and artificial diets, we found that the expression of BmHemolin was significantly upregulated in silkworms reared on artificial diets, and this upregulation was highly likely induced by pathogenic microorganisms.

Surgical treatment of proximal femur unicameral bone cysts in children: a retrospective single-center study.

Objective: The aim of this study was to present clinical and radiological outcomes of surgical treatment for proximal femur unicameral bone cysts (UBCs) in children.

Methods: Pediatric patients recruited from our institution between 2015 and 2024 with proximal femur UBC were analyzed retrospectively. Patients were divided into two groups according to whether internal fixation was used.

Oral Supplementation of Medium-Molecular-Weight Hyaluronic Acid (200-600 kDa) As a Functional Food Ingredient Alleviates D-Galactose-Induced Skin Aging.

Hyaluronic acid (HA), a functional food ingredient with multitarget biological activities, shows potential in combating age-related disorders. HA levels in skin cells may serve as potential biomarkers for aging and decrease with age. This study first investigated the antiaging efficacy of oral supplementation with HA with different molecular weights (MWs) (2, 30-50, 80-100, 200-600, and 1000 kDa) in a D-galactose-induced aging mouse model.

Infrared visualized snakes-inspired artificial vision systems with CMOS sensors-integrated upconverters.

Biological visions have inspired the development of artificial vision systems with diverse visual functional traits, however, the detected wavelength is only in visible light between 0.4 and 0.78 μm, restricting their applications.

PRMT5 promotes cellulase production by regulating the expression of cellulase gene eg2 through histone methylation in Ganoderma lucidum.

Background: Cellulase can degrade cellulose into reducing sugar, participating in the natural carbon cycle. Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating significant potential in environmental protection and bioenergy development. Ganoderma lucidum, as a white rot fungus, secret a large amount of cellulase during growth.

Constructing porous aluminum borate/polymeric carbon nitride for efficient carbon dioxide capture and photocatalytic conversion.

Photocatalytic CO reduction technology is a current research hotspot in negative carbon technologies, yet it faces bottlenecks such as insufficient CO capture capacity of catalysts and low separation efficiency of photogenerated carriers. This study aims to construct a photocatalyst integrating efficient CO capture and photocatalytic conversion by leveraging the adsorption capacity of porous aluminum borate and the superior photocatalytic capability of carbon nitride. Porous aluminoborate frameworks (PKU) was synthesized via a solid-state reaction and interfacially coupled with polymeric carbon nitride (PCN) prepared through ammonium formate-urea calcination to fabricate the adsorption-catalysis bifunctional composite catalyst PKU/PCN.

FPR3 orchestrates macrophage polarization in breast cancer: multi-omics dissection of prognostic relevance and therapeutic targeting.

Background: The N-formyl peptide receptor family (FPRs) is implicated in the progression of diverse cancer types, yet studies specifically exploring their roles in breast cancer remain scarce.

Methods: A comprehensive analysis integrating bulk RNA-seq transcriptomics, methylomics, single-cell transcriptomics, and spatial single-cell transcriptomics data was conducted to elucidate the distinctive characteristics of FPRs in breast cancer. This study particularly focused on delineating the e xpression profiles of FPR3 across distinct breast cancer subtypes, while systematically investigating its prognostic implications and association with macrophage polarization patterns in breast cancer patients.

Development of an XGBoost-based prediction model for wound recurrence risk in diabetic foot ulcer patients treated with antibiotic-loaded bone cement.

Background: This study aims to improve the surgical cure rate, develop interventions to reduce the incidence of postoperative nonunion or recurrence of diabetic foot wounds, and formulate an optimal prediction model to quantify the predictive risk value of antibiotic bone-cement failure in the treatment of diabetic foot.

Methods: The training and test sets were created once the cases were collected. Based on feature correlation, feature importance, and feature weight, LASSO analysis, random forest, and the Pearson correlation coefficient approach were used to identify the features.

Generation of wideband chaos with time-delay signature suppression by asymmetric dual-path optical injection.

Chaotic lasers exhibit wideband spectrum and noise-like time series properties, which is widely used in the fields of secure communication, chaotic lidar, optical sensing and so on. We propose and demonstrate a method for generating wideband low time-delay chaotic laser based on asymmetric dual-path optical injection and filter feedback experimentally. A chaotic signal with a standard bandwidth of 36.

Radiometric calibration and reflectivity inversion of spaceborne LiDAR.

Light detection and ranging (LiDAR) onboard satellites are used not only for global height measurement but also to actively obtain global surface reflectance, which helps in separating surface targets on the basis of their reflectivity properties. In this paper, methods for obtaining surface reflectance with the LiDAR onboard the Terrestrial Ecosystem Carbon Inventory Satellite, which is nicknamed Goumang, are studied. The radiation model for LiDAR to obtain surface reflectance is constructed on the basis of the transmission path of the laser.

Super-resolution reconstruction of off-axis digital holography based on Real-ESRGAN.

Off-axis digital holography plays a crucial role in high-precision three-dimensional imaging. However, high-resolution phase images are often affected by the limited pixel size of the sensor. To address this issue, this study proposes, for the first time, to the best of our knowledge, the application of Real-ESRGAN for the super-resolution reconstruction of off-axis digital holography images.

Immediate Analgesic Efficacy of Acupuncture in Acute Postoperative Pain Following Internal Fixation of Intertrochanteric Femoral Fractures: Protocol for a Randomized Controlled Trial.

Purpose: Intertrochanteric femur fractures (IFF) undergoing internal fixation often present with persistent, intolerable hip pain after surgery. Therefore, the immediate alleviation of pain constitutes a critical clinical necessity for participants. This study aims to evaluate the immediate analgesic efficacy of acupuncture within 10 minutes of treatment in participants experiencing acute postoperative pain following internal fixation of IFF.

The Advanced Lung Cancer Inflammation Index and Mortality in Patients with Cardiovascular-Kidney Metabolic Syndrome: Insights from NHANES.

Background: The advanced lung cancer inflammation index (ALI) is a marker of inflammation, yet its prognostic value in cardiovascular-kidney-metabolic (CKM) syndrome has not been explored. This study examines the relationship between ALI and mortality risk in patients with CKM.

Methods: We analyzed data from 14,301 CKM patients in the National Health and Nutrition Examination Survey (1999–2018).

Reduced hysteresis in LaCeFeSi hydrides by grain size reduction.

Magnetic cooling technology, based on the magnetocaloric effect (MCE), offers an energy-efficient and eco-friendly alternative to conventional gas compression, but is often hindered by large magnetic hysteresis, which limits cyclic performance. In this study, we show that the hysteresis of LaCe(Fe,Si)₁₃ hydrides - a promising material for room-temperature refrigeration - can be significantly reduced by refining the microstructure of the precursor alloy. Substituting Ce for La in (LaCe)(Fe,Si)H increases hysteresis losses from 12.

A novel adjuvant system BK-02 with CpG2006 and MF59 enhances the immunogenicity of a herpes zoster subunit vaccine.

Introduction: Reactivation of the varicella-zoster virus (VZV) results in herpes zoster (HZ), which can lead to complications such as postherpetic neuralgia. The commercially available HZ subunit adjuvanted vaccine, Shingrix®, offers significant protection against HZ in older adults. However, the adjuvant system of this vaccine has limitations that necessitate the development of alternative adjuvant systems.

Impact of Live CCFM1332 and Its Postbiotics on Colonization, Alveolar Bone Resorption and Inflammation in a Rat Model of Periodontitis.

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria such as (), which leads to alveolar bone destruction and systemic inflammation. Emerging evidence suggests that probiotics may mitigate periodontal pathology. To systematically evaluate the alleviative effects and mechanisms of different forms of probiotics, including live bacteria and postbiotics, on periodontitis, we first screened and identified CCFM1332 ( CCFM1332) through in vitro antibacterial and anti-biofilm activity assays.

The Rheb-mTORC1 Coordinates Cell Cycle Progression and Endoreplication in .

The mechanistic target of the Rapamycin complex 1 (mTORC1) signaling pathway plays a pivotal role in regulating crucial life processes, including cell growth and proliferation, by sensing and integrating various signals, such as growth factors, energy status, and amino acids. Our previous studies showed that activation of the mTORC1 signaling pathway enhances silk protein synthesis and silk gland size. Here, the potential of the molecular mechanism mTORC1 to regulate the growth and development of silk gland cells was investigated.

Lumefantrine ameliorates DSS-induced colitis by targeting FLI-1 to suppress NF-κB signaling.

Background: Current therapeutic options for inflammatory bowel disease (IBD) remain suboptimal due to limited efficacy, significant side effects, and high relapse rates, necessitating novel treatment strategies. Lumefantrine, a clinically established antimalarial drug, emerges as a compelling repurposing candidate based on its putative anti-inflammatory activity, though its efficacy and mechanism in IBD remain unexplored.

Methods: A murine IBD model was induced by 3% dextran sulfate sodium (DSS).

Electron-deficient B-site engineering in CeNiO for efficient PMS activation and tetracycline degradation.

The efficiency of peroxymonosulfate (PMS) activation in advanced oxidation processes is often hindered by weak electronic interactions between the active sites and PMS molecules. To address this challenge, this study presents the synthesis of Fe-doped CeNiO (Fe-CNO) using a combined approach of Fe doping and a metal-organic framework (MOF)-derived strategy. The core innovation involves the introduction of Fe to induce electron-deficient B-site engineering, which strategically reconstructs the electronic structure of the original Ni sites, converting them into highly active, electron-deficient centers.

Pressure-enhanced and quantum-dot-activated photoluminescence in zero-dimensional organic metal halide hybrids family: Dual-channel modulation.

Lead-free zero-dimensional (0D) organic metal halide hybrids (OMHHs) offer exceptional structural and property flexibility for applications in electronics and optoelectronics. Here, a comprehensive investigation into the modulation effects of pressure and laser on a 0D OMHHs family was conducted. For TPP2MnCl4 ([(C6H5)4P]2MnCl4), high-pressure studies up to 10 GPa reveal competition between lp-π interactions and π-π stacking, accompanied by an 18-fold photoluminescence (PL) enhancement.

Retinal Vascular Fingerprints as Novel Biomarkers for Primary Angle Closure Disease Progression.

Purpose: To evaluate retinal vascular parameters across primary angle-closure disease (PACD) stages and explore their association with glaucomatous optic neuropathy (GON).

Design: A cross-sectional, hospital-based study.

Participants: We enrolled 638 eyes from 425 participants aged ≥40 years with PACD and further classified them into primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG) groups.