Infrared visualized snakes-inspired artificial vision systems with CMOS sensors-integrated upconverters.

Biological visions have inspired the development of artificial vision systems with diverse visual functional traits, however, the detected wavelength is only in visible light between 0.4 and 0.78 μm, restricting their applications.

CMOS-integrated organic neuromorphic imagers for high-resolution dual-modal imaging.

Simultaneously capturing static images and processing dynamic visual information within a single sensor enables a more comprehensive and efficient acquisition of scene information, thereby enhancing the understanding and processing of complex scenes. However, current artificial visual systems present significant challenges in device integration and multimodal operation. Here, we developed a 640×512-pixel CMOS-integrated organic neuromorphic imager featuring dual modes: standard (frame-based imaging) and synaptic (neuromorphic imaging).

Colloidal Quantum-Dot Heterojunction Imagers for Room-Temperature Thermal Imaging.

Room-temperature operation or high-operation temperature (HOT) is essential for mid-wave infrared (MWIR) optoelectronics devices providing low-cost and compact systems for numerous applications. Colloidal quantum dots (CQDs) have emerged as a rising candidate to enable photodetectors to operate at HOT or room temperature and develop the next-generation infrared focal plane array (FPA) imagers. Here, band-engineered heterojunctions are demonstrated to suppress dark current with well-passivated mercury telluride (HgTe) CQDs enabling room-temperature MWIR imaging by single-pixel scanning and 640 × 512 FPA sensitive thermal imaging above 250 K.

An isolate of human blood-associated partitivirus naturally infects the phytopathogenic fungus Bipolaris maydis.

Human blood-associated partitivirus (HuBPV) was first identified through metagenomic analysis of serum samples from two Peruvians, but its natural host remains unknown. Here, we report the detection of an HuBPV strain (HuBPV-Bm) in the phytopathogenic fungus Bipolaris maydis strain HN11 in Hubei Province, China. The dsRNA1 and dsRNA2 of HuBPV-Bm show more than 97.

Association of ambient ozone exposure with early cardiovascular damage among general urban adults: A repeated-measures cohort study in China.

Longitudinal evidence of long-term ozone exposure on heart rate variability (HRV, an early indicator of cardiovascular damage) is lacking and the potential mechanism remains largely unclear. Our objectives were to evaluate the cross-sectional and longitudinal associations of ozone exposure with HRV alteration, and the potential roles of protein carbonyl (PC, biomarker of oxidative protein damage) and transforming growth factor (TGF)-β1 in this association. This repeated-measures prospective study included 4138 participants with 6617 observations from the Wuhan-Zhuhai cohort.

Longitudinal joint effects of polycyclic aromatic hydrocarbons exposure and genetic susceptibility on fasting plasma glucose: A prospective cohort study of general Chinese urban adults.

The effects of environmental polycyclic aromatic hydrocarbons (PAHs) exposure on glycemic regulation and the underlying genetic mechanism were still unclear. This study aimed to analyze the longitudinal joint effects of PAHs exposure and genetic susceptibility on fasting plasma glucose (FPG) through a longitudinal study. We included 4104 observations (2383 baseline participants and 1721 6-year follow-up participants) from Wuhan-Zhuhai cohort.

PbS-based SWIR micro-spectrometer with on-chip Fabry-Perot filter array.

Miniaturized and portable on-chip spectrometers have been widely explored to facilitate many applications including chemical analysis, environmental monitoring, medical diagnostics, and astronomical observations. However, the optical spectra of micro-spectrometers are mostly within the visible range. Here, we develop high-performance short-wave infrared (SWIR) micro-spectrometers through the integration of wafer-scale uniform lead sulfide (PbS) thin films with an on-chip Fabry-Perot filter array.

Associations of short-term ambient temperature exposure with lung function in middle-aged and elderly people: A longitudinal study in China.

The short-term associations of ambient temperature exposure with lung function in middle-aged and elderly Chinese remain obscure. The study included 19,128 participants from the Dongfeng-Tongji cohort's first (2013) and second (2018) follow-ups. The lung function for each subject was determined between April and December 2013 and re-assessed in 2018, with three parameters (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV], and peak expiratory flow [PEF]) selected.

The role of IBV PL1pro in virus replication and suppression of host innate immune responses.

Background: Coronavirus papain-like proteases (PLpros) play a crucial role in virus replication and the evasion of the host immune response. Infectious bronchitis virus (IBV) encodes a proteolytically defective remnant of PL1pro and an active PL2pro. However, the function of PL1pro in IBV remains largely unknown.

Synthesis and Characterization of Bipyridyl-(Imidazole) Mn(II) Compounds and Their Evaluation as Potential Precatalysts for Water Oxidation.

Metalloenzymes make extensive use of manganese centers for oxidative catalysis, including water oxidation; the need to develop improved synthetic catalysts for these processes has long motivated the development of bioinspired manganese complexes. Herein, we report a series of bpy-(imidazole) (n = 1 or 2) (bpy = 2,2'-bipyridyl) ligands and their Mn complexes. Four Mn complexes are structurally characterized using single-crystal X-ray diffraction, revealing different tridentate and tetradentate ligand coordination modes.

Longitudinal association of polycyclic aromatic hydrocarbons and genetic risk with lung function.

To quantify the association of polycyclic aromatic hydrocarbons (PAHs) and the polygenic risk score (PRS) with lung function decline, we developed a repeated-measures study with 4681 observations from baseline and 6-year follow-up of the Wuhan-Zhuhai cohort. Lung function and urinary monohydroxylated PAH metabolites (OH-PAHs) were measured for each observation. The PRS was derived from 246 lung function-associated genetic variants weighted by the effect size of the decreasing ratio of forced expiratory volume in 1 s by forced vital capacity (FEV1/FVC).

Mercury telluride colloidal quantum-dot focal plane array with planar p-n junctions enabled by in situ electric field-activated doping.

Colloidal quantum dot (CQD)-based photodetectors are promising alternatives to bulk semiconductor-based detectors to be monolithically integrated with complementary metal-oxide semiconductor readout integrated circuits avoiding high-cost epitaxial growth methods and complicated flip-bonding processes. To date, photovoltaic (PV) single-pixel detectors have led to the best performance with background-limit infrared photodetection performance. However, the nonuniform and uncontrollable doping methods and complex device configuration restrict the focal plane array (FPA) imagers to operate in PV mode.

Intraocular pressure effect of intravitreal conbercept injection for retinopathy of prematurity.

Intravitreal injection of conbercept (IVC) is a novel anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP). This study aimed to assess the intraocular pressure (IOP) effect of IVC. All IVC surgeries were performed in the Department of Ophthalmology, Guangdong Women and Children Hospital, from January 2021 to May 2021.

Cross-sectional and longitudinal relationships between ozone exposure and glucose homeostasis: Exploring the role of systemic inflammation and oxidative stress in a general Chinese urban population.

The adverse health effects of ozone pollution have been a globally concerned public health issue. Herein we aim to investigate the association between ozone exposure and glucose homeostasis, and to explore the potential role of systemic inflammation and oxidative stress in this association. A total of 6578 observations from the Wuhan-Zhuhai cohort (baseline and two follow-ups) were included in this study.

Steric Effects on the Chelation of Mn and Zn by Hexadentate Polyimidazole Ligands: Modeling Metal Binding by Calprotectin Site 2.

Recently, there has been increasing interest in the design of ligands that bind Mn with high affinity and selectivity, but this remains a difficult challenge. It has been proposed that the cavity size of the binding pocket is a critical factor in most synthetic and biological examples of selective Mn binding. Here, we use a bioinspired approach adapted from the hexahistidine binding site of the manganese-sequestering protein calprotectin to systematically study the effect of cavity size on Mn and Zn binding.

Associations of selenium exposure with blood lipids: Exploring mediating DNA methylation sites in general Chinese urban non-smokers.

Selenium (Se) is widely distributed in the total environment and people are commonly exposed to Se, while the potential effects and mechanisms of Se exposure on blood lipids have not been well established. This study aimed to assess the associations of urinary Se (SeU) with blood lipids and explore the potential mediating DNA methylation sites. We included 2844 non-smoke participants from the second follow-up (2017-2018) of the Wuhan-Zhuhai cohort (WHZH) in this study.

PM-related DNA methylation and the association with lung function in non-smokers.

PM exposure leads to lung function alteration. The potential pathway underlying above association, especially the role of DNA methylation is unclear. The objectives of this study are to evaluate the associations of personal PM concentrations with DNA methylation at the epigenome-wide level, and investigate how PM-related DNA methylation affects lung function.

Short-term impacts of air pollution on the platelet-lymphocyte ratio and neutrophil-lymphocyte ratio among urban adults in China.

The short-term impacts of urban air pollution on the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) remain obscure. In this study, we included 3487 urban adults from the Wuhan-Zhuhai cohort. Individual inhalation exposure to air pollutants was estimated by combining participants' daily breath volume and ambient concentrations of six air pollutants (including fine particulate matter (PM), inhalable particulate matter (PM), nitrogen dioxide (NO), sulfur dioxide (SO), carbon monoxide (CO) and ozone (O)).

Ultrasensitive Colloidal Quantum-Dot Upconverters for Extended Short-Wave Infrared.

Infrared-to-visible upconverters converting low-energy infrared to higher-energy visible light without bringing in complicated readout integrated circuits have triggered enormous excitement. However, existing upconverters suffer from limited sensing wavelengths, low photon-to-photon (p-p) efficiency, and high minimum detectable infrared power. Here, we reported the colloidal quantum-dot (CQD) upconverters with unprecedented performance.

Cross-sectional and longitudinal relationships between urinary 1-bromopropane metabolite and pulmonary function and underlying role of oxidative damage among urban adults in the Wuhan-Zhuhai cohort in China.

1-bromopropane is a US Environmental Protection Agency-identified significant hazardous air pollutant with concerned adverse respiratory effect. We aimed to investigate the relationship between 1-bromopropane exposure and pulmonary function and the underlying role of oxidative damage, which all remain unknown. Pulmonary function and urinary biomarkers of 1-bromopropane exposure (N-Acetyl-S-(n-propyl)-L-cysteine, BPMA) and oxidative damage to DNA (8-hydroxy-deoxyguanosine, 8-OHdG) and lipid (8-iso-prostaglandin-F2α, 8-iso-PGF2α) were measured for 3259 Chinese urban adults from the Wuhan-Zhuhai cohort.

AMER3 variants modify the U-shaped association of urinary total hydroxyphenanthrene with fasting plasma glucose: A newfound gene-environment interaction.

As a polycyclic aromatic hydrocarbon, environmental exposure to phenanthrene is widespread worldwide. The potential effects and mechanism of phenanthrene exposure on fasting plasma glucose (FPG) have not been well determined. In this study, we aim to explore the effects of phenanthrene exposure and AMER3 variants on fasting plasma glucose (FPG) through a longitudinal epidemiological study.

Long-term personal PM exposure and lung function alternation: A longitudinal study in Wuhan urban adults.

Background: The effect of long-term PM exposure on lung function has not been well established.

Objectives: To investigate the effects of long-term personal PM exposure on lung function decline, obstructive, and restrictive ventilatory disorders.

Method: Personal PM concentrations were evaluated using an estimation model.

The methylation of the AMER3 gene mediates the negative association between urinary polycyclic aromatic hydrocarbon metabolites and fasting plasma glucose in non-smokers: A new clue for the development of hypoglycemic agents.

Polycyclic aromatic hydrocarbons (PAHs) have been reported to cause various health damages. However, some PAH derivatives are still used as agents, and some of them have hypoglycemic effects. Till now, few studies explored the relationship between urinary PAH metabolites and fasting plasma glucose (FPG).

Systemic inflammation mediates the association of heavy metal exposures with liver injury: A study in general Chinese urban adults.

Heavy metal exposures have been reported to be associated with increased risk for liver injury. However, the potential mechanisms of the association remain unclear. A repeated-measure study of 9367 observations was conducted to quantify the associations of urinary heavy metals with serum alanine aminotransferase (ALT), a biomarker for liver injury, and assess the mediating role of systemic inflammation in such associations among general Chinese adults.

Short-term effects of real-time individual fine particulate matter exposure on lung function: a panel study in Zhuhai, China.

Fine particulate matter (PM) is still the primary air pollutant in most Chinese cities and its adverse effects on lung function have been widely reported. However, short-term effects of individual exposure to PM on pulmonary expiration flow indices remain largely unknown. In this study, we examined the short-term effects of real-time individual exposure to PM on lung function in a panel of 115 healthy adults.