Screening for endocrine hypertension in China: protocol for a multicentre prospective cohort study.

Introduction: Secondary hypertension accounts for 5%-10% of all hypertensive patients. Among these conditions, endocrine hypertension, such as primary aldosteronism (PA), Cushing's syndrome (CS) and pheochromocytoma and paraganglioma (PPGL), is a common and significantly harmful cause. With advancements in diagnostic techniques, the prevalence of endocrine hypertension is much higher than previously reported, but large-scale epidemiological survey data in this field are still lacking in China.

NHC-Catalyzed Enantioselective Access to Pyrazoles with a Nitrile-Containing All-Carbon Quaternary Center.

Chiral nitriles are valuable structural motifs found in numerous pharmaceuticals and natural products. This study presents an efficient method for synthesizing chiral nitriles via a cycloaddition reaction between -cyano-substituted ,-unsaturated aldehydes and 3-methyl-1-phenyl-1-pyrazole-5-amine. The transformation is catalyzed by -heterocyclic carbene (NHC) at low loadings, affording the corresponding chiral nitriles in good to excellent yields with excellent enantioselectivities.

Decoupling adsorption affinity and regeneration barrier via dynamic electron redistribution in Fe-Zr metal-organic framework gels.

Amid global efforts toward low-energy gas purification, we present a bimetallic metal-organic framework gel (FeU-1) that overcomes the trade-off between adsorption capacity and regeneration energy. FeU-1 achieves a high toluene uptake of 975 mg/g (P/P = 0.97), while reducing the desorption activation energy from 169.

Impact of thyroid nodule location on the risk of papillary thyroid carcinoma.

Background: Thyroid nodules are a widespread disease in endocrine system. While ultrasound is the preferred non-invasive examination, it still has some limitations. The study aims to evaluate the correlation between the location of thyroid nodules and pathological diagnosis of thyroid cancer (TC).

An Ultra-Low Discharge and High Energy Efficiency Li-CO Battery Enabled by Plasmon-Enhanced AuRu-TiO Bifunctional Cathode.

The extremely sluggish kinetics of CO evolution reaction of the lithium-carbon dioxide (Li-CO) batteries lead to a high charging potentials (over 4.0 V) and large over-potentials (over 1.0 V), thus limiting its development.

Microsporidian infection disrupts gut microbiome and drives metabolic dysregulation in Macrobrachium nipponense.

The gut microbiome plays a crucial role in maintaining host health, yet its functions in aquatic animals remain incompletely understood. Given its economic significance in Asian aquaculture, the oriental river prawn (Macrobrachium nipponense) was chosen to assess microbiome dynamics during infection with Potaspora macrobrachium, an emerging microsporidian pathogen. Histopathological analysis confirmed severe microsporidian infections in diseased prawns.

A Long-Lasting Rechargeable Seawater Zn-Air Battery Enabled by Vacancy-Driven CoO-MoS Bifunctional Cathodes.

The global energy crisis and unsustainable reliance on fossil fuels make it particularly urgent to develop efficient renewable energy storage solutions. Aqueous zinc-air batteries (ZABs) have become extremely promising candidates due to their low cost, abundant surface resources, inherent safety, and high theoretical energy density. This study explores the feasibility of using seawater as an electrolyte for ZABs, with the aim to reduce costs and alleviate competition for limited freshwater resources.

Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury.

In adult mammals, programmed cell death (PCD) facilitates tissue remodeling and regeneration in spinal cord injury (SCI), but excessive activation impedes SCI repair. However, no comprehensive pan-PCD atlas exists that encompasses diverse cell death patterns to fully elucidate PCD in adult SCI and develop strategies for modulating the excessive PCD response. Here, we identified neonatal mice with balanced PCD post-SCI as an ideal model for adult SCI.

Analysis of the Accuracy of Unattended Automated Blood Pressure Measurements and Control of Blood Pressure Thresholds: A Multicenter Cross-Sectional Study.

Accurate blood pressure measurement is fundamental for the diagnosis and management of hypertension. The emergence of u-AOBP has been proposed as a potential alternative or complementary approach for assessing patients' blood pressure status within clinical settings. However, robust evidence is lacking to determine its application in diagnosing hypertension within the clinical practice in China.

From data to Diagnosis: How artificial intelligence is revolutionizing preoperative assessment of thyroid nodules and cancer.

Background: Thyroid nodules are frequently detected in the general population, raising concerns about the challenges of overdiagnosis and overtreatment. Artificial intelligence (AI) offers novel solutions for the preoperative evaluation of thyroid nodules. However, there has not yet been a comprehensive literature review on current applications.

Epidemiologic trends for pediatric Hodgkin and non-Hodgkin lymphomas: a U.S. population-based study.

Pediatric Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are distinct from adult forms and occur less frequently. We identified 7,871 children and 226,211 adults with lymphoma from the Surveillance, Epidemiology, and End Results database from 1975 to 2018. The age-adjusted incidence rate for pediatric lymphoma was 24.

Mesenchymal Stromal Cells and Graft-versus-Host Disease: Preclinical and Clinical Studies.

Graft-versus-host disease (GVHD) remains one of the most severe complications following allogeneic hematopoietic stem cell transplantation (HSCT), significantly contributing to transplant-related morbidity and mortality. While systemic corticosteroids are the standard first-line therapy, a substantial proportion of patients develop steroid-refractory GVHD, which is associated with poor clinical outcomes. Mesenchymal stromal cells (MSCs), a heterogeneous population of multipotent stromal cells derived from diverse tissue sources, have garnered increasing attention due to their immunomodulatory capacity and ability to promote tissue repair.

Lipid Droplet-Organized MDM2-Mediated P53 Degradation: A Metabolic Switch Governing Diet-Driven Tumor Progression.

TP53 inactivation in human cancers often results from MDM2/MDMX overexpression, yet therapeutic targeting remains challenging owing to incomplete mechanistic understanding. Lipid droplet (LD) enrichment is identified as a key trigger for MDM2-mediated p53 degradation. High-fat diet (HFD)-induced LD accumulation in tumor cells elevates LD-surface MDM2 through Cyb5r3-Myh9 interactions, which recruit cytoplasmic p53/Myh9 complexes to LDs.

Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation.

Background: Acute graft-versus-host disease (aGVHD) remains a major life-threatening complication of allogeneic haematopoietic cell transplantation (allo-HSCT), often limiting the therapeutic efficacy of allo-HSCT. Recent studies have suggested that mesenchymal stem cells (MSCs) may be beneficial for the treatment of aGVHD. However, the therapeutic potential of MSCs is often negatively impacted by their heterogeneity.

Data-Knowledge-Dual-Driven Electrolyte Design for Fast-Charging Lithium Ion Batteries.

Electric vehicles (EVs) starve for minutes-level fast-charging lithium-ion batteries (LIBs), while the heat gathering at high-rate charging and torridity conditions has detrimental effects on electrolytes, triggering rapid battery degradation and even safety hazards. However, the current research on high-temperature fast-charging (HTFC) electrolytes is very lacking. We revolutionized the conventional paradigm of developing HTFC electrolytes integrating with high-throughput calculation, machine-learning techniques, and experimental verifications to establish a data-knowledge-dual-driven approach.

FSDM: An efficient video super-resolution method based on Frames-Shift Diffusion Model.

Video super-resolution is a fundamental task aimed at enhancing video quality through intricate modeling techniques. Recent advancements in diffusion models have significantly enhanced image super-resolution processing capabilities. However, their integration into video super-resolution workflows remains constrained due to the computational complexity of temporal fusion modules, demanding more computational resources compared to their image counterparts.

Chromosome-scale assembly of the Xenocypris davidi using PacBio HiFi reads and Hi-C technologies.

Xenocypris davidi is a benthic fish species widely distributed in the water systems south of the Yellow River in China, playing a significant role in aquatic ecosystems. Despite its ecological and economic importance, genomic resources for X. davidi are limited, hindering a comprehensive understanding of its evolutionary adaptations and genetic improvements.

Past, present and future epidemiology of echinococcosis in China based on nationwide surveillance data 2004-2022.

Objectives: We evaluated the epidemiological characteristics of echinococcosis, a global public health threat, in China to inform global control efforts.

Methods: Descriptive, statistical, cluster, spatial, and trend analyses were used to evaluate the epidemiology at national, provincial, and county levels based on 2004-2022 nationwide surveillance data from China.

Results: Between 2004 and 2022, China recorded 72,676 cystic echinococcosis (CE) cases, 11,465 alveolar echinococcosis (AE) cases, and 5703 others, with an average annual cases per million (ANpM) of 3.

Ultrafast Li-Rich Transport in Composite Solid-State Electrolytes.

Solid-state lithium (Li) metal batteries (SSLMBs) have garnered considerable attention due to their potential for high energy density and intrinsic safety. However, their widespread development has been hindered by the low ionic conductivity of solid-state electrolytes. In this contribution, a novel Li-rich transport mechanism is proposed to achieve ultrafast Li-ion conduction in composite solid-state electrolytes.

Cas12a is competitive for gene editing in the malaria parasites.

Malaria, caused by the Plasmodium parasites, has always been one of the worst infectious diseases that threaten human health, making it necessary for us to study the genetic function and physiological mechanisms of Plasmodium parasites from the molecular level to find more effective ways of addressing the increasingly pressing threat. The CRISPR (Clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated protein) is an RNA-guided adaptive immune system, which has been extensively developed and used as a genome editing tool in many organisms, including Plasmodium parasites. However, due to the physiological characteristics and special genomic characteristics of Plasmodium parasites, most of the tools currently used for genome editing of Plasmodium parasites have not met expectations.

Melamine-Copolymerization Strategy Engineered Fluorinated Polyimides for Membrane-Based Sour Natural Gas Separation.

Membrane-based gas separation provides an energy-efficient approach for the simultaneous CO and HS removal from sour natural gas. The fluorinated polyimide (PI) membranes exhibited a promising balance between permeability and permselectivity for sour natural gas separation. To further improve the separation efficiency of fluorinated PI membranes, a melamine-copolymerization synthetic approach is devised that aims to incorporate melamine motifs with high sour gas affinity into the structure of the PI membranes.

Metabolic Reprogramming of Neural Stem Cells by Chiral Nanofiber for Spinal Cord Injury.

Exogenous neural stem cells (NSCs) have great potential to reconstitute damage spinal neural circuitry. However, regulating the metabolic reprogramming of NSCs for reliable nerve regeneration has been challenging. This report discusses the biomimetic dextral hydrogel (DH) with right-handed nanofibers that specifically reprograms the lipid metabolism of NSCs, promoting their neural differentiation and rapid regeneration of damaged axons.

Engineered Extracellular Vesicles from Antler Blastema Progenitor Cells: A Therapeutic Choice for Spinal Cord Injury.

Deer antler blastema progenitor cells (ABPCs) are promising for regenerative medicine due to their role in annual antler regeneration, the only case of complete organ regeneration in mammals. ABPC-derived signals show great potential for promoting regeneration in tissues with limited natural regenerative ability. Our findings demonstrate the capability of extracellular vesicles from ABPCs (EVs) to repair spinal cord injury (SCI), a condition with low regenerative capacity.