Ultralong-Lived Excitons in Metallo-Quinoline-Incorporated Covalent Organic Frameworks Promote Photoreductive Cross-Coupling.

Designing long-lived excitons in photocatalysts is crucial for efficient charge separation. However, most of the current organic photocatalysts are characterized by a relatively short exciton lifetime within the range of picoseconds due to localized excitons with large binding energies. Herein, we report the design of ultralong-lived excitons with a lifetime exceeding 8000 ps by constructing metallo-quinoline-incorporated covalent organic frameworks (COFs).

Genome-Wide Identification of Gene Family in Ten Cotton Species and Function Analysis of Involved in Cold Stress Response.

Basic Pentacysteine (BPC) represents a class of plant-exclusive transcription factors, serving pivotal roles in orchestrating developmental processes and mediating responses to both biotic and abiotic stressors. However, the genome-wide characteristics and low-temperature response mechanism of the gene family in cotton remain unclear. Employing a genome-wide screening approach, this study characterized 60 distinct BPC transcription factor genes across ten species.

Comprehensive Analysis of Corydalis decumbens From Different Regions Using UHPLC-HRMS and Chemometrics.

The therapeutic efficacy of traditional Chinese medicines (TCMs) is intrinsically linked to their quality. Differentiating Dao-di medicinal materials from non-Dao-di ones is essential for ensuring the authenticity, superior quality, and therapeutic efficacy of TCMs. Corydalis decumbens (Thunb.

Impact of growth parameters on refraction and ocular biometry in Chinese preschool children (3-6 years): the Beijing children eye study.

Background: This study aims to investigate the relationship between growth and ocular biometry/refraction in preschool children aged 3-6 years.

Methods: This study performed a retrospective evaluation utilizing anonymized data from a pre-existing cohort of children aged 3-6 years, who were recruited from 11 kindergartens in the Shunyi District of Beijing. Out of the 1,144 children assessed, a total of 1,021 (89.

Discovery of Osivelotor (GBT021601): A Potent, Next-Generation Sickle Hemoglobin Polymerization Inhibitor.

This report details the discovery path of GBT021601 (osivelotor) (), a novel, small molecule, sickle hemoglobin (HbS) polymerization inhibitor. Following a streamlined testing funnel with cassette dosing in rat pharmacokinetic (PK) studies, we identified this next-generation HbS polymerization inhibitor, which had improved PK properties compared with the first-in-class drug, voxelotor (). GBT021601 has ∼4.

Beyond slowness: Exploring destination stimuli and tourists' emotional connections in slow tourism.

The present study investigated how tourists engage with destination stimuli to construct emotional connections with a place. Guided by Lazarus' cognitive appraisal theory (CAT), this interpretive qualitative study adopted a constructivist paradigm and hybrid thematic analysis to explore emotional experiences in a Chinese slow tourism (ST) context. The present study identified five types of stimuli, namely, the built environment, the natural environment, the social environment, events and products, and the brand-related effect, underpinning three emotional connections, namely, temporal-spatial reconstruction, healing, and anti-consumerism.

Anode-Protective Covalent Organic Framework Layer with Synergistic Cation-Anion Regulation for Dendrite-Free Lithium Metal Batteries.

Lithium (Li) dendrite formation in Li metal batteries intrinsically challenges Coulombic efficiency (CE) and safety. While constructing an anode protective layer offers a potential solution for dendrite suppression, existing approaches are limited by insufficient molecular-level control over both Li and anion dynamics simultaneously. Herein, we construct a binary cooperative magnesium porphyrin-based covalent organic framework (Mg-Por-COF) protective layer designed for synergetic cation-anion regulation at the anode-electrolyte interface.

Chiral resolution of (R, S)-1-chloro-1-phenylethane by haloalkane dehalogenase DbjA in micro-aqueous phase.

Optically pure (S)-1-phenylethanol, a crucial synthetic intermediate widely applied in the pharmaceutical and food industries, is currently produced via well-established biological methods primarily relying on ketoreductase-mediated asymmetric synthesis and lipase-catalyzed kinetic resolution. This study presents a biocatalytic approach utilizing haloalkane dehalogenase DbjA for the kinetic resolution of racemic 1-chloro-1-phenylethane in organic solvents to synthesize (S)-1-phenylethanol. Following systematic optimization of reaction conditions, the system achieved an enantiomeric excess (ee) of 97 % for (S)-1-chloro-1-phenylethane and an (S)-1-phenylethanol yield of 46 % (ee > 99 %), demonstrating exceptional enantioselectivity (E = 536).

Glucose-containing vs. glucose-free dialysate for patients with maintenance hemodialysis: Study protocol for a multicenter randomized controlled study-GLUMO study.

Purpose: To mitigate the risk of infection and disordered blood lipid metabolism, glucose-free dialysate is widely utilized in China and European countries. While glucose-free dialysis does not necessarily lead to hypoglycemia, several other metabolic adjustments must occur to maintain normal blood glucose levels. Additionally, glucose-free dialysis may also increase the loss of amino acids and the susceptibility to hypotension and cardiovascular events.

NaOH-Mediated Intermolecular Cascade Cyclization Reaction of Conjugated Dieneimines with α-Halomalonates to Access Functionalized Cyclopentene Cores.

An efficient intermolecular cascade cyclization of conjugated dieneimines with α-halomalonates in the presence of a NaOH base was developed. This method facilitates the synthesis of a diverse range of functionalized cyclopentenes featuring two adjacent stereocenters, including a quaternary carbon center, in high yields with excellent diastereoselectivities and perfect regioselectivities. The reaction proceeds through a sequence of Michael addition, cyclopropanation, isomerization, ring opening of the cyclopropane intermediate, isomerization, and intramolecular cyclization.

Application of histogram analysis based on DCE-MRI in predicting metachronous liver metastasis and metastasis-free survival in rectal cancer.

Background: This study aimed to construct histogram analysis (HA) based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) from primary tumor and mesorectum for early post-treatment risk stratification of metachronous liver metastasis (MLM) and prediction of metastasis-free survival (MFS) in rectal cancer.

Methods: This retrospective study included preoperative images and clinical data of 251 patients between March 2019 and August 2023. Image segmentation was performed by manually delineating the primary tumor and mesorectum.

Modulating the direction of catalytic glyoximate sites of covalent organic frameworks towards electrocatalytic nitrate reduction.

Two-dimensional (2D) covalent organic frameworks (COFs) with metal centers are ideal templates to construct electrocatalysts due to their high degree of structural controllability. However, the metal centers are stacked in columns with limited space, which impedes the mass delivered to catalytic sites across the pore channels. Herein, we demonstrate a topologic synthesis strategy for constructing catalytic sites in three-dimensional (3D) space.

Social support and depressive symptoms: the role of childhood maltreatment and brain activity in a moderated mediation model.

Low social support, characterised by insufficient emotional, instrumental, or informational aid, increases the risk of major depressive disorder (MDD), yet its impact on brain function remains unclear. To examine this, we recruited 32 participants with MDD and low social support, 52 with high social support, and 54 healthy controls. We collected data including functional magnetic resonance imaging measures, sociodemographic information, social support dimensions, depressive symptom severity, and childhood maltreatment to investigate how social support relates to neural activity and depression severity, with childhood maltreatment as a potential moderating factor.

Discovery of anthraquinone-triazene derivatives as novel antitumor agents causing DNA damage.

In this study, 40 anthraquinone-triazene derivatives were designed, and AT-9 and AT-10 were screened out as potential antitumor candidates based on their strong binding affinities to DNA and topoisomerase II using molecular docking and molecular dynamics simulations. Antiproliferative assays revealed that AT-9 and AT-10 exhibited significantly stronger inhibitory effects on A549 and HeLa cell lines compared to the reference mitoxantrone. The binding modes of AT-9 and AT-10 with DNA were confirmed by spectra and gel electrophoresis.

Significant prognostic value of cell-cycle proteins in early-stage small cell carcinoma of cervix.

Small cell carcinoma of cervix (SCCC) was a highly aggressive tumor with dismal prognosis. Current treatment strategies manifested poor survival outcomes and novel treatment options were needed exploration. We aimed to investigate several prognostic biomarkers for SCCC and conducted a novel risk-score system to predict cancer specific survival (CSS) in early-stage SCCC.

Identification of a stable genetic locus and candidate genes for Fusarium head blight resistance on wheat chromosome 3BL.

Fusarium head blight (FHB) is a devastating wheat disease worldwide. Identifying novel quantitative trait loci (QTLs) and resistance-associated genes is critical for breeding resistant cultivars. In this study, we conducted a comprehensive genetic analysis of FHB resistance in a diverse panel of 240 wheat accessions phenotyped over three years.

Automated microvascular invasion prediction of hepatocellular carcinoma via deep relation reasoning from dynamic contrast-enhanced ultrasound.

Hepatocellular carcinoma (HCC) is a major global health concern, with microvascular invasion (MVI) being a critical prognostic factor linked to early recurrence and poor survival. Preoperative MVI prediction remains challenging, but recent advancements in dynamic contrast-enhanced ultrasound (CEUS) imaging combined with artificial intelligence show promise in improving prediction accuracy. CEUS offers real-time visualization of tumor vascularity, providing unique insights into MVI characteristics.

Recent advances on iron bound phosphorus in wetland sediments: characteristics, influencing factors, interactions with organic matter and emerging contaminants.

Phosphorus (P), as a key limiting element in wetland ecosystems, its occurrence forms, migration and transformation directly affect biological productivity and environmental safety. Among them, iron-bound phosphorus (Fe-P), as the most abundant reactive P form in sediments, dominates the bioavailability of P through the redox-driven dissolution-precipitation process. This work summarizes the data on P components in multiple wetlands around the world to illustrate the significant contribution of Fe-P to the endogenous P in sediments, it critically reviews the extraction, detection and quantification methods of sedimentary Fe-P, as well as their advantages and disadvantages.

Integrated transcriptome and metabolome analysis reveals the therapeutic mechanism of Huang-Qi-Si-Wu-Tang in experimental pulmonary arterial hypertension.

Background: Pulmonary arterial hypertension is a complex vascular disease involving pathological remodeling of vascular cells, inflammatory cells, and the extracellular matrix. Current PAH therapies, which are primarily vasodilators, cannot reverse the disease pathogenesis or cure PAH. Novel therapeutic agents targeting the core process of vascular remodeling are desperately needed, and their mechanisms warrant systematic investigation.

Sex disparity in hepatocellular carcinoma recurrence after curative liver resection: a multicenter comprehensive analysis.

Background And Aims: The impact of sex disparity on the patterns of recurrence after curative resection of hepatocellular carcinoma (HCC) remains controversial. The aim of this study was to comprehensively investigate the influence of sex differences in HCC recurrence following curative hepatectomy.

Methods: Patients who underwent curative-intent resection for HCC between July 2015 and June 2020 were identified from a multicenter database and analyzed retrospectively.

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases.

Aortic aneurysms and dissections rupture are life-threatening cardiovascular emergencies. Early prevention and control of disease progression are essential for improving patient outcomes. Vascular stem cells play a crucial role in the repair of vascular injuries across various vascular diseases.

K-means clustering analysis of C/C, O/O and H/H isotope ratios for identification of alcohol origin.

Using a single qualitative and quantitative test for ethanol consumption sometimes fails to reflect the objective facts at the beginning of the incident for a variety of reasons, such as metabolism, diffusion, collection contamination, storage losses, and decomposition. Stable isotope signatures, because they are natural properties of the substance itself, have the ability to describe the origin of the substance and therefore have the potential to directly trace ethanol. Previous studies have shown that discrimination of ethanol origins can be achieved to a certain extent by combining the measurement of δC values with the calculation of likelihood ratios.

Killing two birds with one stone: a simple and integrated platform based on an Fe-MOF for dual-mode detection and photocatalytic elimination of tetracycline.

The persistence of tetracycline (TC) antibiotic residues in foodstuffs and aquatic systems poses critical threats to human health and the ecological environment, driving an imperative demand for developing multifunctional platforms capable of simultaneous visual monitoring and high-efficiency elimination of these contaminants. Herein, a simple yet novel colorimetric sensor that integrates detection and degradation of TCs has been constructed based on the excellent peroxidase-like activity of the metal-organic frameworks (MOFs) MIL-101(Fe). Colorless 3,3',5,5'-tetramethylbenzidine (TMB) can be effectively oxidized to generate blue oxidized TMB (ox-TMB) by MIL-101(Fe), which exhibits a characteristic peak at 652 nm.

Frailty: An Important Determinant Influencing Glycaemic Control in Elderly Chinese Patients Diagnosed With Type 2 Diabetes.

Few studies have investigated blood glucose levels and complication management in elderly patients with type 2 diabetes (T2D) at community hospitals in China. The objective of this study was to investigate the factors influencing blood glucose control in elderly patients with T2D. One thousand one hundred and fifty elderly patients (age ≥ 65 years) with T2D were involved in the study to assess blood glucose control, health status (including comorbidities and cognitive status), complication management, and adherence to medication according to the guidelines of the American Diabetes Association.