Oxytocin enhances oligodendrocyte development and improves social deficits in autistic rats.

Purpose: Autism spectrum disorder (ASD) is a neurodevelopmental condition with complex etiological factors, including genetic predisposition and environmental influences. In particular, exposure to environmental stressors in utero has increasingly been implicated in disrupting fetal neurodevelopment and potentially contributing to the pathogenesis of ASD in offspring. The aim of this study was to investigate the therapeutic potential of oxytocin and to elucidate its underlying molecular mechanisms in a valproic acid (VPA) exposure-induced rat model of ASD.

Synergistic Photothermal Ice Inhibition Strategy for Scalable Cryopreservation of Macroscopic Spheroids and Immune Cells in Advanced Immunotherapy.

Scalable and effective cryopreservation of human immune cells and biological samples is challenging for advanced cellular therapeutics. However, current cryoprotectants are limited due to trade-offs between robust ice inhibition and uniform thermal management to mitigate Ostwald ripening. Herein, we develop a nonpermeable nanocryoprotectant (PVA@PPy) by combining antifreezing poly(vinyl alcohol) (PVA) with photothermal polypyrrole (PPy).

Nonvolatile PCM-driven photonic computing using programmable sub-wavelength digital metasurfaces.

We present a programmable nonvolatile convolutional core based on sub-wavelength phase-change digital meta-surfaces, designed to enable energy-efficient and scalable optical computing. Utilizing sub-wavelength SbSe cylindrical arrays, the kernel achieves enhanced weight distinguishability, reduced insertion loss, and fine-tuned multi-level reconfigurability, addressing the requirements of optical neural networks (ONNs). Experimental results further demonstrate a weight range from 0.

Anode-Protective Covalent Organic Framework Layer with Synergistic Cation-Anion Regulation for Dendrite-Free Lithium Metal Batteries.

Lithium (Li) dendrite formation in Li metal batteries intrinsically challenges Coulombic efficiency (CE) and safety. While constructing an anode protective layer offers a potential solution for dendrite suppression, existing approaches are limited by insufficient molecular-level control over both Li and anion dynamics simultaneously. Herein, we construct a binary cooperative magnesium porphyrin-based covalent organic framework (Mg-Por-COF) protective layer designed for synergetic cation-anion regulation at the anode-electrolyte interface.

Regulatory effects of ginseng polysaccharide on growth restriction and intestinal dysfunction caused by a high cottonseed meal diet in Ctenopharyngodon idella.

This study aimed to investigate the regulatory effects of ginseng polysaccharides (GP) on growth impairment and intestinal injury induced by high-cottonseed meal (CM) diets in grass carp. Juvenile fish (50.01 ± 0.

Bioinspired Co-Assembled Hydrogels Constructed from Marine Self-Assembling Peptides and Polyphenol Network: Antioxidant and Infected Wound Healing.

Infectious wounds pose formidable clinical challenges due to hypoxia, exacerbated inflammation, and persistent microbial colonization. To address this, we developed a bioinspired multifunctional hydrogel (PTDPs) through the in situ freeze-thaw co-assembly of polyvinyl alcohol (PVA), tea polyphenols (TP), polydopamine (PDA), and marine-derived self-assembling peptides (AAPs). The resultant PTDP hydrogel formed an intricate hydrogen-bonded network that enhanced mechanical robustness and substrate adhesion.

Application of monoclonal antibodies in diabetes: A bibliometric analysis from 2004-2024.

Monoclonal antibodies (mAbs) have shown significant promise in diabetes treatment through immunobiological mechanisms. To comprehensively understand the current development status and future trends of this research field, this study used bibliometric methods to retrieve literature data from the Web of Science Core Collection database from 2004 to 2024 and conducted a comprehensive analysis using R software and VOSviewer. A total of 900 papers were published by 4,678 authors from 56 countries, with global publication volume and average citation frequency peaking in 2019, after which the field entered a stable development phase.

LINC00599 Promotes Pulmonary Hypertension via Liquid-Liquid Phase Separation With G3BP1 and MYH9.

Background: Pulmonary hypertension (PH) represents a significant cardiovascular disorder marked by both functional and structural alterations within the pulmonary vasculature. Long noncoding RNAs have been closely associated with PH pathogenesis and progression, particularly in vascular remodeling and cell proliferation. Nonetheless, how long noncoding RNAs interact with downstream targets to modulate PH remains unclear.

Baseline 25-hydroxyvitamin D levels predict the effects of vitamin D supplementation on joint symptoms and cartilage loss in patients with knee osteoarthritis.

Objectives: To examine whether the baseline vitamin D level modifies the effects of vitamin D supplementation on knee symptoms and cartilage loss in patients with symptomatic knee OA.

Methods: This was a post hoc analysis for the VIDEO study, which was a large ( = 413), randomized, double-blind, placebo-controlled clinical trial in knee OA patients with 25-hydroxyvitamin D [25(OH)D levels ranging from 12.5 to 60 nmol/l].

Enabling an ultraefficient lithium-selective construction through electric field-assisted ion control.

Membranes with precise ion transport behaviors are regarded as an alternative for lithium (Li) extraction from water streams. Current membranes demonstrate limited viability due to the lack of efficient Li-selective architectures. We propose an electric field-assisted ion control hypothesis in reinforcing ultraefficient Li-selective membranes, in which an ionized zeolitic imidazolate framework layer (Q-PEI@ZIF) is constructed via polyethylenimine (PEI) in situ confinement conversion and subsequent quaternization of 2,3-epoxypropyl trimethyl ammonium chloride.

Chain mediating roles of rumination and emotion regulation self-efficacy in the relationship between social support and depression among college students.

This study explores the relationship between social support(SS) and depression in college students, focusing on the mediating roles of rumination and emotion regulation self-efficacy (ERSE). A survey was conducted with 1,433 Chinese university students (53.3% male, M = 20.

Liquid Bridges Mediate Crack Initiation, Propagation, and Coalescence to Suppress Film Failure within Flexible Electronics.

Recent flexible electronics with conformal interfaces between devices and human bodies are prone to receive circuit failure caused by uncontrollable cracking during physiological movements. A structural engineering strategy is reported that utilizes capillary-stabilized liquid bridges to spontaneously mediate crack initiation, propagation, and coalescence for film reinforcement. Specifically, rigid nanowire array are decorated onto flexible polydimethylsiloxane substrates and the nanoscale gaps between the nanowires are filled with non-volatile ionic liquids to form well-regulated meniscus.

A Mindfulness Breast Care App to reduce body image distress and stigma for breast cancer survivors: Development and preliminary quality assessment.

Objectives: This study aimed to develop and preliminarily assess the quality of a Mindfulness Breast Care (MBC) App to reduce body image distress and stigma among breast cancer survivors (BCSs).

Methods: The development process of the MBC App involved: 1) establishing a research group; 2) determining of the content of the MBC App based on Mindfulness-Based Cognitive Therapy and 3) technical exploitation and maintenance. A mixed-methods study was conducted.

Pose detection and localization of pineapple fruit picking based on improved litehrnet.

To achieve accurate detection of the pineapple fruit picking area and pose under complex backgrounds and varying lighting conditions, this study proposes a pineapple keypoint detection model (LTHRNet) based on an improved LiteHRNet. Image data of pineapple fruits under different lighting conditions were collected, and six keypoints were defined to characterize the morphological features of the fruit. In the model design, LTHRNet incorporates the LKA_Stem module to enhance initial feature extraction, the D-Mixer module to capture both global and local feature relationships, and the MS-FFN module to achieve multi-scale feature fusion.

Enhanced removal of organic micropollutants using 2D metal-organic framework interlayered nanofiltration membrane.

Organic micropollutants (OMPs) present considerable threats to both human health and the environment. Traditional thin film composite (TFC) nanofiltration (NF) polyamide membranes, despite their high water permeance and salt rejection capabilities, often fail to effectively remove OMPs. This study addresses this limitation by incorporating two-dimensional (2D) zinc(II) tetrakis(4-carboxy-phenyl)porphyrin (Zn-TCPP) metal-organic framework (MOF) nanosheets as interlayers in TFC membranes (TFNi), using a polyethylene glycol (PEG) assisted exfoliation technique to mitigate issues of nanosheet restacking and aggregation.

Effects of tele-rehabilitation after deep brain stimulation on cardiopulmonary fitness and gait in patients with Parkinson's disease.

Introduction: The postoperative motor function of patients with Parkinson's disease (PD) treated with deep brain stimulation (DBS) is significantly improved, but the level of physical activity is still low. Tele-rehabilitation provides a convenient and flexible rehabilitation method. The aim of this study was to explore the effects of tele-rehabilitation after DBS on cardiopulmonary fitness and gait in PD patients.

Investigating Overlapping Immune-related Genetic Markers in Cholangiocarcinoma and Inflammatory Bowel Disease for Predictive Prognosis.

This study aims to explore the common immune-related gene characteristics of cholangiocarcinoma (CHOL) and inflammatory bowel disease (IBD) to predict disease prognosis. By analyzing the gene expression data from the TCGA, GEO, and NGDC databases, differentially expressed immune-related genes (DE-IRGs) were screened, and a prognostic model was constructed. The results showed that CCR7, OSM, S100P, ACVR1C, OSMR, SPP1, and PIK3R3 were key immune-related genes, and their expressions were closely related to the occurrence and development of CHOL and IBD.

The Value of Quantitative Ultrasound Elastography in the Assessment of Non-Alcoholic Fatty Liver Disease in Children.

Objective: This preliminary investigation aimed to assess the value of two elastography techniques, sound touch elastography (STE) and sound touch quantification (STQ), in measuring liver stiffness in children with non-fatty versus fatty livers.

Methods: This study used a case-control design. The STE and STQ were used to measure and compare liver stiffness in 121 children with fatty livers and 251 children with non-fatty livers, respectively.

[Clinical characteristics and genotypes of patients with Congenital fibrinogen disorders].

Objective: To explore the clinical features and genetic mutation sites of 28 patients with Congenital fibrinogen disorders (CFDs).

Methods: A total of 28 unrelated CFDs patients admitted to Wenzhou People's Hospital from June 2018 to April 2023 were enrolled into this research. A total of 2.

Green Synthesis and Particle Size Control of High-Purity Alumina Based on Hydrolysis of Alkyl Aluminum.

This study introduces a green synthesis strategy for producing high-purity alumina (≥99.99%) through the controlled hydrolysis of aluminum isopropoxide, coupled with a novel impurity removal protocol to address persistent challenges in conventional methods, such as residual silicon/iron impurities and particle agglomeration. The experimental results indicate that LaO, 1-(2-pyridylazo)-2-naphthol (PAN), and phenolphthalein exhibit effective removal capabilities for silicon/iron impurities.

Asymmetric Manganese Sites in Covalent Organic Frameworks for Efficient Nitrate-to-Ammonia Electrocatalysis.

The electrocatalytic nitrate reduction reaction (NO RR) holds tremendous potential for remediating NO pollution while enabling clean ammonia (NH) production. However, most catalysts achieve high conversion efficiency relying on high NO concentrations. How to catalyze the NO RR with a low concentration of NO is still a challenge due to the competing hydrogen evolution reaction (HER).

Ginseng and Platycodon grandiflorum ameliorated pulmonary fibrosis and inflammation targeting TLR4-P2X7r/NLRP3 signaling pathway.

Ethnopharmacological Relevance: Ginseng and Platycodon grandiflorum (Jacq.) A. DC.

Quantitative Skeletal-Charge Engineering of Anion-Selective COF Membrane for Ultrahigh Osmotic Power Output.

Osmotic energy contained in water bodies can generate abundant renewable electricity through reverse electrodialysis (RED) that relies on ion permselective membranes. Anion-permselective membrane RED offers a stable and sustainable energy output potential by maintaining a consistent driving force across the membrane, providing advantages in sustainability and versatility over cation-selective membranes. But significant challenges persist in developing anion-selective membranes that feature high selectivity and low impedance.