A novel three-dimensional evaluation protocol to assess the consistency of critical screw angles between preoperative planning and 3d-printed patient-specific acetabular revision prostheses.

Background: Screw fixation is pivotal for prosthetic stability. For 3D-printed customized acetabular revision prostheses designed for complex, large-scale bone defects, precise adherence to preoperative screw trajectory planning is critical. However, there remains a lack of standardized three-dimensional (3D) evaluation protocols to quantify intraoperative screw angular alignment fidelity relative to preoperative digital plans, hindering universal validation criteria.

Physiological and Performance Adaptations to Running-Based Interval Interventions in Soccer Players: Comparative Analysis of Sprint Interval Training, Small-Sided Games, and Repeated-Sprint Training.

Purpose: The objective of this study was to investigate the impact of a 6-week program involving various forms of running-based interval interventions on the physiological and performance adaptations of male soccer players during preseason.

Methods: A total of 40 young trained collegiate soccer players (21 [1.3] y) were randomly assigned to 4 groups: traditional sprint interval training (SIT, 20-s trials), small-sided games, repeated-sprint training (RST, 5-s trials), and an active control group, each of 10 members.

Noncontrast CT-based deep learning for predicting intracerebral hemorrhage expansion incorporating growth of intraventricular hemorrhage.

Intracerebral hemorrhage (ICH) is a severe form of stroke with high mortality and disability, where early hematoma expansion (HE) critically influences prognosis. Previous studies suggest that revised hematoma expansion (rHE), defined to include intraventricular hemorrhage (IVH) growth, provides improved prognostic accuracy. Therefore, this study aimed to develop a deep learning model based on noncontrast CT (NCCT) to predict high-risk rHE in ICH patients, enabling timely intervention.

Integrative single-cell and bulk transcriptomic analysis reveals the landscape of T cell mitotic catastrophe associated genes in esophageal squamous cell carcinoma.

Background: Mitotic catastrophe (MC) is a well-recognized endogenous mechanism of tumor cell death, characterized as a delayed cell death process associated with aberrant mitosis. However, its prognostic significance in the context of intratumoral heterogeneity in esophageal squamous cell carcinoma (ESCC) remains largely unexplored.

Methods: We performed an in-depth analysis of single-cell RNA sequencing (scRNA-seq) data from ESCC obtained from the Gene Expression Omnibus (GEO) database.

A prognostic model integrating radiomics and deep learning based on CT for survival prediction in laryngeal squamous cell carcinoma.

Accurate prognostic prediction is crucial for patients with laryngeal squamous cell carcinoma (LSCC) to guide personalized treatment strategies. This study aimed to develop a comprehensive prognostic model leveraging clinical factors alongside radiomics and deep learning (DL) based on CT imaging to predict recurrence-free survival (RFS) in LSCC patients. We retrospectively enrolled 349 patients with LSCC from Center 1 (training set: n = 189; internal testing set: n = 82) and Center 2 (external testing set: n = 78).

Regulatory effects of ginseng polysaccharide on growth restriction and intestinal dysfunction caused by a high cottonseed meal diet in Ctenopharyngodon idella.

This study aimed to investigate the regulatory effects of ginseng polysaccharides (GP) on growth impairment and intestinal injury induced by high-cottonseed meal (CM) diets in grass carp. Juvenile fish (50.01 ± 0.

MYC-Mediated Osseous Regeneration via BMSCs/PRP/β-TCP/PCL Bioprinted Constructs: Rapid Defect Rehabilitation and Preliminary Clinical Efficacy Evaluation.

Bone defects present significant clinical challenges due to their morphological heterogeneity and structural complexity, necessitating regenerative strategies that integrate structural adaptability, biomechanical stability, and osteogenic potential. In this study, a bioengineered construct composed of bone marrow mesenchymal stem cells (BMSCs), platelet-rich plasma (PRP), polycaprolactone (PCL), and β-tricalcium phosphate (β-TCP) was fabricated using 3D bioprinting. In vitro assays assessed osteoprogenitor cell proliferation (CCK-8), migration (Transwell), differentiation (ALP staining), and endothelial tubulogenesis (Matrigel assay).

Vascularized and Perfusable Human Heart-on-a-Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. However, the pathophysiological mechanisms of CVDs are not yet fully understood, and animal models do not accurately replicate human heart function. Heart-on-a-chip technologies with increasing complexity are being developed to mimic aspects of native human cardiac physiology for mechanistic studies and as screening platforms for drugs and nanomedicines.

Effects of Cholesterol Supplementation in High Soybean Meal Diet on Growth, Lipid Metabolism, and Intestinal Health of Juvenile Rice Field Eel .

The rising cost of fish meal (FM) in aquaculture feed has prompted the search for alternative protein sources like soybean meal (SBM). However, SBM-based diets can negatively affect fish growth, lipid metabolism, and intestinal health. One possible solution is to add cholesterol to SBM-based feeds to mitigate these adverse effects, but the optimal levels and the resulting benefits remain unclear.

Analysis of electromagnetic coupling between two compartments of an aircraft cabin through an aperture.

Wireless communication technology has emerged as a significant development direction in the aerospace domain. Different compartments in an aircraft are typically physically separated by metal partitions, which makes electromagnetic (EM) coupling unattainable. In this study, we propose using a small aperture on the partition to establish an EM connection instead of cables.

- Signaling Drives Fibrocyte-Mediated Pulmonary Fibrosis: Mechanistic Insights and Therapeutic Potential.

Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by chronic inflammation and excessive extracellular matrix deposition, with fibrocytes playing a pivotal role in fibrotic remodeling. This study aimed to identify upstream molecular mechanisms regulating fibrocyte recruitment and activation, focusing on the pathway as a potential therapeutic target. We utilized Mendelian Randomization and phenome-wide association analyses on genes involved in sphingolipid metabolism to identify potential regulators of idiopathic pulmonary fibrosis (IPF).

Injectable functionalised Lycium barbarum polysaccharide/alginate hydrogel particles for the treatment of bone defects.

The treatment of bone defects presents a number of significant clinical challenges. In recent years, plant-derived hydrogels have demonstrated considerable potential as a means of intervening in bone defects. In this study, a alginate hydrogel (Alg) system containing the Chinese medicinal plant Lycium barbarum was prepared with the objective of promoting the repair of bone defects.

Decursin Suppresses Esophageal Squamous Cell Carcinoma Progression via Orchestrated Cell Cycle Deceleration, Apoptotic Activation, and Oncoprotein Degradation.

Esophageal squamous cell carcinoma (ESCC) remains a lethal malignancy with limited therapeutic options. This study investigated the antitumor efficacy and mechanisms of decursin, a natural pyranocoumarin derivative, against ESCC. In vitro analyses demonstrated that decursin selectively inhibited ESCC cell viability (IC50: 14.

Fermented black soldier fly larvae as a sustainable replacement for marine fish in Asian swamp eel diets.

Background And Aim: Fermented black soldier fly larvae (BSFL) have emerged as a sustainable and economically viable protein source in aquaculture. However, their potential as a replacement for marine fish in the diets of Asian swamp eels (, ASEs) remains underexplored. This study assessed the effects of partially substituting marine fish with fermented BSFL on ASE growth performance, intestinal development, and hepatic health.

Interaction of xanthatin as a bioactive sesquiterpene lactone with cyclin-dependent kinase-6 enzyme to regulate prostate cancer cell proliferation.

Targeting cyclin-dependent kinase 6 (CDK6) in cancer treatment is a promising strategy due to the central role of this enzyme in regulating cell proliferation. As research continues, more selective CDK6 inhibitors may emerge, potentially offering even greater specificity and fewer side effects. Xanthatin as a bioactive sesquiterpene lactone extracted from Xanthium strumarium L.

Prognostic significance of calcium-related genes in lung adenocarcinoma and the role of in macrophage polarization and erlotinib resistance.

Background: Calcium signaling is critical in tumorigenesis. This study analyzed the characteristics of a calcium-related prognostic genes (CRPGs) signature in lung adenocarcinoma (LUAD) for prognostic value and explored as a potential therapeutic target for erlotinib resistance.

Methods: Clinical and RNA sequencing data from LUAD patients were obtained from the TCGA and GEO databases.

Correction: Xie et al. Exploring the Mechanisms and Preventive Strategies for the Progression from Idiopathic Pulmonary Fibrosis to Lung Cancer: Insights from Transcriptomics and Genetic Factors. 2024, , 2382.

In the original publication, there was a mistake in Figure 11 as published [...

Numerical simulation study on the mining pressure law and collaborative failure of soft-hard interlayer working face.

Aiming at the problem that the roof of the soft-hard interbedded coal seam is prone to delamination and caving without warning during coal mining, taking the No. 2201 working face of a certain mine as the engineering background, a numerical simulation was carried out to study the mine pressure laws and fracture characteristics of the working face with soft-hard interbedded roof. The results show that: when the working face advances 32 m, the roof undergoes the first caving.

Surgical Intervention Combined With Photodynamic Therapy for Treatment of Perifolliculitis Capitis Abscedens et Suffodiens.

Perifolliculitis capitis abscedens et suffodiens (PCAS) is a chronic recurrent disease. Single treatment modalities are commonly ineffective. A surgical intervention combined with photodynamic therapy (PDT) may be an effective treatment strategy.

Multiparameter MRI-based model integrating radiomics and deep learning for preoperative staging of laryngeal squamous cell carcinoma.

The accurate preoperative staging of laryngeal squamous cell carcinoma (LSCC) provides valuable guidance for clinical decision-making. The objective of this study was to establish a multiparametric MRI model using radiomics and deep learning (DL) to preoperatively distinguish between Stages I-II and III-IV of LSCC. Data from 401 histologically confirmed LSCC patients were collected from two centers (training set: 213; internal test set: 91; external test set: 97).

Impact of Intertarget Distances on Single-Isocenter Radiotherapy Plans with jaw-Tracking and jaw-Fixed Techniques for Vertebral Metastases.

IntroductionMultiple targets with varying distances are common in radiotherapy. Reducing treatment time in the plan design helps minimize patient movement and discomfort during the treatment process. This retrospective study aimed to investigate the impact of varying intertarget distances (ITDs) on the dosimetric differences and delivery efficiency of two single-isocenter techniques.

An Evaluation of Soybean Protein Concentrate as a Replacement for Fish Meal with Methionine Supplementation in Diets for Hybrid Sturgeon ( ♀ × ♂).

Soy protein concentrate (SPC) is a cost-effective alternative to fish meal (FM) in aquaculture, but its deficiency in essential amino acids, particularly methionine, limits its application. This study evaluated the effects of methionine supplementation on growth, liver and intestinal health, and muscle quality in hybrid sturgeon ( ♀ × ♂) fed SPC-based diets. Four diets were formulated: an FM control diet, and SPC diets supplemented with 0% (M0), 0.

Development of a multi-module data-driven integrated framework for identifying drivers of atmospheric particulate nitrate and reduction emissions: An application in an industrial city, China.

Atmospheric particulate nitrate (pNO), a crucial component of fine particulate matter, significantly contributes to haze pollution. The formation of pNO is driven by multiple factors including meteorology, emissions, and atmospheric chemistry. Understanding the key drivers of pNO formation and developing an accurate and physically meaningful method for the timely assessment of the direct causes of pNO pollution are essential.

In Situ Partial-Cyclized Polymerized Acrylonitrile-Coated NCM811 Cathode for High-Temperature ≥ 100 °C Stable Solid-State Lithium Metal Batteries.

High-nickel ternary cathodes hold a great application prospect in solid-state lithium metal batteries to achieve high-energy density, but they still suffer from structural instability and detrimental side reactions with the solid-state electrolytes. To circumvent these issues, a continuous uniform layer polyacrylonitrile (PAN) was introduced on the surface of LiNiMnCoO via in situ polymerization of acrylonitrile (AN). Furthermore, the partial-cyclized treatment of PAN (cPAN) coating layer presents high ionic and electron conductivity, which can accelerate interfacial Li and electron diffusion simultaneously.