Noncontrast CT-based deep learning for predicting intracerebral hemorrhage expansion incorporating growth of intraventricular hemorrhage.

Intracerebral hemorrhage (ICH) is a severe form of stroke with high mortality and disability, where early hematoma expansion (HE) critically influences prognosis. Previous studies suggest that revised hematoma expansion (rHE), defined to include intraventricular hemorrhage (IVH) growth, provides improved prognostic accuracy. Therefore, this study aimed to develop a deep learning model based on noncontrast CT (NCCT) to predict high-risk rHE in ICH patients, enabling timely intervention.

Exploring the aerobic stability, antioxidant and microbial community of Broussonetia papyrifera ensiled with ferulic acid esterase-producing Lactiplantibacillus plantarum in combination with cellulase and/or xylanase.

Background: Ferulic acid possesses certain antioxidant and antibacterial properties. Additionally, ferulic acid esterase (FAE) and cellulolytic enzymes have been associated with synergistic degradation of ferulic acid ester bonds, thereby facilitating greater release of ferulic acid from lignocellulose, which could have important effects on silage quality and aerobic stability.

Methods: This study examined the effects of ensiling Broussonetia papyrifera with FAE-producing Lactiplantibacillus plantarum (LP), cellulase (CE) and xylanase (XY) under aerobic exposure conditions.

Liver regeneration-associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition.

The literature suggests that hepatocellular Yes-associated protein 1 (YAP1) signaling is activated following hepatectomy and that such activation can suppress the growth of metastatic liver tumors. The prognosis of a real-world cohort of 240 patients with colorectal cancer liver metastasis (CRLM) undergoing major and minor hepatectomy was compared after adjusting for confounding factors. To model CRLM, we induced liver metastasis in mice by transsplenically injecting MC38 cells.

A prognostic model integrating radiomics and deep learning based on CT for survival prediction in laryngeal squamous cell carcinoma.

Accurate prognostic prediction is crucial for patients with laryngeal squamous cell carcinoma (LSCC) to guide personalized treatment strategies. This study aimed to develop a comprehensive prognostic model leveraging clinical factors alongside radiomics and deep learning (DL) based on CT imaging to predict recurrence-free survival (RFS) in LSCC patients. We retrospectively enrolled 349 patients with LSCC from Center 1 (training set: n = 189; internal testing set: n = 82) and Center 2 (external testing set: n = 78).

Morphological structure, chemical composition and formation mechanism in the haze of blueberry wine.

In this study, the morphological and structural characteristics of three types of blueberry wine haze (BWH) were observed by scanning electron microscopy, atomic force microscopy and X-ray diffraction techniques. Results revealed that BWH exhibited a monolayer stacking structure with individual layer thicknesses of 1.1-1.

A sprayable TQ/Ce6@SAB/F-gel for accelerating wound healing via hypoxia-tolerant photodynamic therapy and immune-metabolic pathway.

Chronic diabetic wounds are characterized by hypoxia, persistent microbial infection, and impaired healing, posing significant challenges to conventional therapies. Herein, we present a novel sprayable double-network hydrogel platform designed to achieve efficient antimicrobial activity and accelerated wound repair under hypoxic conditions by leveraging a type I photodynamic therapy (PDT) and immune-metabolic regulatory strategy. Specifically, we employ salvianolic acid B (SAB) to form a self-assembled hydrogel (SAB-gel) and incorporate fibrin to construct a robust and acidic double-network SAB/F-gel with enhanced mechanical strength and acidic environment.

Polysaccharides Target Gut Microbiota to Suppress NOD2-Driven Inflammation and Modulate Bile Acid Metabolism in Colitis.

, a traditional medicinally edible herb, exhibits potent anti-inflammatory activity. Its primary active components are fermentable polysaccharides, which enhance the proliferation of beneficial gut microbiota. However, the role of the gut microbiota in the anti-inflammatory effects of polysaccharides (PCPs) has not been adequately explored, and the mechanisms involved remain largely unelucidated.

Adsorbent of bacteria and inflammatory Factors: Injectable dual-network hydrogel for osteomyelitis treatment.

Current treatments for osteomyelitis are often hampered by biofilm formation, the emergence of multidrug-resistant (MDR) bacteria, and limited antibiotic penetration into infected bone tissue, all of which impede bone regeneration and prolong the disease progression. Herein, based on the chlorogenic acid (CA)-Mg coordination and covalent crosslinking of genipin (GP) with proteins, we proposed an injectable dual-network natural hydrogel named as CA-Mg/BSA-GP (CMBG) hydrogel. GP functions as a biological crosslinker, facilitating the adsorption and crosslinking exogenous bovine serum albumin (BSA) and polypeptide antibiotics, as well as endogenous inflammatory factors and bacterial surface proteins within the infection microenvironment.

Prevalence and associated factors of chronic pain among nurses: a national cross-sectional study.

Background: Musculoskeletal pain is common among nurses and can lead to absenteeism, reduced productivity and impaired physical and mental health. Long-term pain may develop into chronic pain, which is a more serious and longer-lasting condition that will cause further harm to nurses' health. Therefore, this study aims to investigate the prevalence and characteristics of chronic pain and its associated factors among nurses in tertiary hospitals in China.

MRI assisted ultrasonic thermometry: a new strategy for non-invasive temperature monitoring in HIFU therapy.

High-Intensity Focused Ultrasound (HIFU) is a well-established non-invasive tumor ablation technique. However, accurately and real-time monitoring the temperature distribution within the HIFU focal region remains a significant challenge. Although Magnetic Resonance Imaging (MRI) temperature measurement is considered the gold standard for controlling focal temperatures during HIFU treatment, it suffers from limitations in spatiotemporal resolution.

Anthocyanin-sulfated polysaccharide-ovalbumin nanocomplex: Intestinal absorption mechanism and intracellular antioxidant activity in Caco-2 cells.

This study investigated intestinal absorption and cellular antioxidant efficacy of anthocyanin (ACN)-loaded ovalbumin (OVA)-carrageenans (ι-, λC)/dextran sulfate (DS) nanocomplexes. Utilizing Caco-2 cells, we assessed endocytic pathways, intracellular trafficking, and delivery efficacy of ternary nanocomplexes. ACN-loaded nanocomplexes could be internalized by cells in a time-, dose-, energy-dependent manner, with macropinocytosis, lipid raft/caveolae, and actin co-mediated endocytosis routes playing pivotal roles.

Role of laccase and xylanase, with or without ferulic acid esterase-producing Lactiplantibacillus plantarum, on the aerobic stability, microbial composition and in vitro degradability of mulberry silage.

Laccase (L), xylanase (X), and ferulic acid esterase (FAE) act on lignin - carbohydrate complexes. Whether these enzymes, alone or combined, can improve mulberry ensiling and aerobic stability is unclear. This study assessed the effects of L, X, and FAE - producing L.

Extreme Wetness Reduces Soil Microbial Residue Carbon More Substantially Than Extreme Drought Across Grassland Ecosystems.

Soil microbial residue carbon (MRC) represents a significant component of soil carbon pools and regulates the response of soil carbon sequestration to precipitation changes. However, the response of soil MRC to extreme drought and wetness and the underlying mechanisms in regional grassland ecosystems remain unclear. Here, we quantified the responses of soil MRC content to extreme drought and wetness and identified the key drivers using a coordinated precipitation change experiment across nine alpine and temperate grassland ecosystems in China.

Extreme Dry-Heat Climate Impacts on Greenhouse Gas Emission Intensity in Wheat Production: Insights and Mitigation Strategies.

Extreme dry-heat (EDH) climate poses significant challenges to global food production and exacerbates greenhouse gas (GHG) emissions, impeding efforts to mitigate agricultural climate impacts. However, the concurrent effects of long-term EDH climate and mitigation strategies on cropland productivity and GHG emissions remain poorly understood. Here, we integrated field observations, agroecosystem model outputs, and nursery data to examine how environmental factors and management practices influence wheat GHG emission intensity across the U.

Practice revolution in local interventional therapy for liver metastases.

The treatment of liver metastases is undergoing a transformation from single-modality therapy to multimodal combination therapy, with local interventional treatments playing an increasingly important role. This review explores the synergistic effects between local interventional therapy and systemic treatment, the reconstruction of interventional therapy indications driven by advances in systemic treatment, and the impact of local interventional therapy on systemic treatment "switching" strategies. Through multidisciplinary collaboration and innovative interventional materials and techniques, local interventional therapy has evolved from a traditional palliative approach to become an essential component in the comprehensive treatment system for liver metastases.

Combining aggregated attention and transformer architecture for accurate and efficient performance of Spiking Neural Networks.

Spiking Neural Networks (SNNs), which simulate the spiking behavior of biological neurons, have attracted significant attention in recent years due to their distinctive low-power characteristics. Meanwhile, Transformer models, known for their powerful self-attention mechanisms and parallel processing capabilities, have demonstrated exceptional performance across various domains, including natural language processing and computer vision. Despite the significant advantages of both SNNs and Transformers, directly combining the low-power benefits of SNNs with the high performance of Transformers remains challenging.

Association between chronic pain and mental health among nurses in China: a national cross-sectional study.

Background: Due to high intensity, workloads and shift work, nurses have become a high prevalence group of pain. If not promptly intervened, pain may become chronic pain through the mechanisms of peripheral sensitization and central sensitization, which in turn induces psychological symptoms such as anxiety and depression, forming a vicious circle of "pain-mental health comorbidity". In addition, long-term pain may accelerate the transition from acute pain to chronic pain, which will cause more serious damage to nurses' health.

Distinct white matter alteration patterns in post-infectious and gradual onset chronic fatigue syndrome revealed by diffusion MRI.

While post-infectious (PI-ME/CFS) and gradual onset (GO-ME/CFS) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) manifest similar symptoms, it has long been suspected that different disease processes underlie them. However, the lack of biological evidence has left this question unanswered. In this study, how white matter microstructural changes in PI-ME/CFS and GO-ME/CFS patients were investigated.

A physically consistent dataset of water-energy-carbon fluxes across the Soil-Plant-Atmosphere Continuum.

Hight-quality and Long-term measurements of land-atmosphere fluxes are vital for climate monitoring and Land Surface models (LSMs) benchmarking. Eddy covariance provides key in-situ data for theory and LSMs evaluation, but most flux towers lack continuous soil-plant-atmosphere measurements. Here, we present a long-term global dataset of water, energy and carbon fluxes, along with the corresponding above and below-ground hydrological, photosynthetic, and radiative data derived from the STEMMUS-SCOPE model simulations at 170 sites.

Predicting oxidative stability of Camellia oil based on multimodal data fusion strategy integrating NIR and Raman spectroscopies with chemometrics.

Oxidative stability, a critical determinant of nutritional value and shelf life in Camellia oil, is conventionally assessed via destructive chemical analyses that incur time delays and sample loss. To address these limitations, this study developed a rapid, non-destructive chemometric framework by integrating near-infrared (NIR) and Raman spectroscopy through a three-tiered data fusion strategy (low-, mid-, and high-level). Notably, high-level fusion synergistically leveraged spectral features from both techniques, achieving superior prediction accuracy for oxidative stability (R = 0.

Extreme Drought Decreases the Stability of Above- but Not Below-Ground Productivity Across Eurasian Steppes.

Ecological stability plays a crucial role in determining the sustainability of ecosystem functioning and nature's contribution to people. Although the disruptive effects of extreme drought on ecosystem structure and functions are widely recognized, their effect on the stability of above- and belowground productivity remains understudied. We assessed the effects of drought on ecosystem stability using a 3-year drought experiment established in six Eurasian steppe grasslands.

SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1 myeloid cells in hepatocellular carcinoma.

Tumor-infiltrating myeloid cells (TIMs) are pivotal cell populations involved in the immunosuppressive tumor immune microenvironment (TIME). However, there has been little success in large-scale clinical trials of myeloid cell modulators. We aim to investigate potential molecular targets for TIMs and disclose the underlying mechanism.

Cellular Senescence in Human Chondrocytes in Relation to Osteoarthritis.

IntroductionCellular senescence, i.e., a state of permanent cessation of cell division, is a hallmark of aging and has been associated with age-related diseases, most notably osteoarthritis (OA).

Investigation of the astringency-masking effect of ι-carrageenan on natural polyphenols and its differential mechanism at various concentrations.

The astringency of natural polyphenols affects consumers' acceptance for food, and it is urgent to find safe and effective astringency-masking substances. This study introduced ι-carrageenan (CA) as a novel astringency-masking agent and investigated its interaction mechanism using epigallocatechin gallate (EGCG) and β-casein (βCN) as model compounds. Sensory evaluation demonstrated that 0.

Association of the 2020 Healthy Eating Index with asthma in children and adolescents in the United States: a cross-sectional study of NHANES.

Objective: Our goal was to investigate the connection between asthma and HEI-2020.

Data Sources: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020.

Study Selections: Diet quality was measured as HEI-2020 scores using 24-h and 2-day dietary recall data.