Efficacy of voice training on benign vocal cord lesions after surgery: A systematic review, meta-analysis, and trial sequential analysis of randomized clinical trials.

Background: Voice training (VT) aids patients in achieving or restoring physiological harmony among the vocal organs and in correcting the faulty conditioned reflexes induced by benign vocal cord lesions (BVLs). Herein, we designed a systematic review and meta-analysis for the first time to evaluate the effect of VT on BVLs after surgery based on several outcomes.

Methods: Four electronic databases (PubMed, Web of Science, Scopus, and Cochrane Library) and 3 Chinese databases (CNKI, VIP, and Wanfang) were searched through September 26, 2024, without any restrictions.

Farnesylation-Dependent Kinetochore Targeting of CENP-F Is Essential for Oocyte Meiotic Progression and Female Fertility.

Background: During mammalian oocyte meiosis, accurate chromosome segregation critically depends on precise regulation of kinetochore-microtubule (K-MT) attachments, a process monitored by the spindle assembly checkpoint (SAC). While CENP-F has been well characterized as a kinetochore-associated protein that stabilizes K-MT connections during mitosis, its functional mechanisms during meiosis remain poorly understood. In particular, there is still controversy over whether farnesylation modification governs localization and functionality of CENP-F.

Pruritic Plaque on the Right Lower Limb: A Rare Case of Kimura Disease and Literature Review.

Kimura disease, though rare in adolescents, should be considered in cases of persistent itchy nodules. Histopathology confirms diagnosis. Surgical excision is effective for localized lesions, with favorable outcomes.

Tegoprazan-based versus esomeprazole-based triple therapy plus bismuth for first-line Helicobacter pylori eradication: A nationwide, multicenter, double-blind, double-dummy, randomized controlled trial.

Background: Although triple therapy plus bismuth (TTPB), comprising a proton pump inhibitor (PPI), two antibiotics, and bismuth, is widely used to eradicate Helicobacter pylori (H. pylori), eradication rates have been suboptimal. Potassium-competitive acid blockers (P-CABs) offer stronger and more stable gastric acid inhibition compared to PPIs.

Analysis of fecal microbiome in Chinese patients with non-severe aplastic anemia.

By analyzing the fecal microbiome data of patients with non-severe aplastic anemia (NSAA), this study aims to explore the potential role of dysbiosis in the immune-mediated pathogenesis of NSAA. This study included 21 newly diagnosed NSAA patients from the Affiliated Hospital of Nanjing University of Chinese Medicine between July 2018 and June 2021, along with 24 healthy controls who underwent routine health checkups. Fecal samples were collected for DNA extraction.

Effectiveness of Physical Exercise on Hematopoietic Stem Cell Transplantation: An Umbrella Review.

Objectives: To systematically evaluate and synthesize the available evidence regarding whether physical exercise is effective on improving outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT).

Study Design: There were altogether 10 databases adopted for retrieving systematic reviews till March 2024. The Measurement Tool to Assess Systematic Reviews II (AMSTAR-II) statement and the Grading of Recommendations Assessment, Development and Evaluation system were employed for assessing, summarizing, and grading the evidence.

Relationship between eosinophil counts and carbohydrate intake in US children with asthma.

Purpose: To study the relationship between eosinophil levels and carbohydrate intake in children with asthma.

Methods: This cross-sectional study, which was nationally representative, used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2020 cycle on children with asthma. The study investigated the relationship between eosinophil levels and carbohydrate intake using multiple linear regression models, restricted cubic spline, stratified analysis and sensitivity analysis.

Digital health interventions for cancer-related cognitive impairment in breast cancer patients: A scoping review.

Background: Breast cancer is a common malignancy among women worldwide, frequently associated with cancer-related cognitive impairment, which significantly affects quality of life. Non-pharmacological therapies, especially digital health interventions (DHIs), show potential in mitigating cognitive impairment related to cancer through tailored and interactive cognitive training. Nonetheless, current research fails to systematically integrate intervention strategies, behavioral change techniques (BCTs), and their effectiveness.

Risk factors for refractory in Chinese children: a meta-analysis.

Background: With the increase of the incidence rate of in children and the widespread use of azithromycin, the number of cases of refractory increased accordingly. infection was generally considered a self-limiting disease. However, under certain special circumstances, it was highly likely to develop into a refractory disease.

The combination of nitrogen fertilizers and EDDS enhances remediation efficiency of Bidens pilosa L. in Cd-contaminated soils.

Biodegradable chelating agents and nitrogen (N) fertilizers are widely used for the remediation of heavy metal-contaminated soils due to their ability to promote plant growth, enhance metal mobility and facilitate plant uptake. In this study, a pot experiment was conducted to investigate the effects of nitrate nitrogen (N-NO), ammonium nitrogen (N-NH) and amide nitrogen (N-amide) with different concentrations of 25, 50 and 75 mg N·kg combined with (S,S)-ethylenediaminedisuccinic acid (EDDS) (1 mmol·L) on growth, biomass and phytoextraction efficiency of Bidens. pilosa L.

Fabrication of macrophage-membrane coated functionalized ROS-responsive thiolated chitosan-based nanoparticles to attenuate atherosclerosis: Investigation on diabetic hyperlipidaemia-induced mice model.

Background: Diabetic hyperlipidemia, which is characterized by oxidative stress and chronic inflammation, plays a significant role in atherosclerosis (AC), a key cause of cardiovascular disease. To reduce the progression of AC, effective treatment options that target the underlying causes of diabetic hyperlipidemia are required.

Methodology: This study used macrophage-membrane-loaded β-CD functionalized thiolated ROS-responsive NPs (MM@R-β-tCh NPs) as a targeted therapy for diabetic hyperlipidemia-induced AC.

Thermosensitive polygalacturonic acid glycoprotein hydrogel encapsulating bionic shikonin nanoparticles for the treatment of psoriasis.

Psoriasis is histopathologically characterized by hyperproliferation of keratinocytes, loss of the granular layer, and elongation and thickening of the rete ridges in the epidermis. The thickening of the stratum corneum in psoriatic skin poses a significant barrier to effective drug delivery, as many therapeutic agents with poor solubility, limited release, and side effects struggle to penetrate the skin and achieve prolonged retention, thereby limiting their therapeutic efficacy. To address these challenges, we developed a non-invasive transdermal delivery system.

Effectiveness of probiotic therapy as an adjunct in the management of periodontal disease in type 2 diabetics: A systematic review and meta-analysis.

Background: Periodontal disease and diabetes mellitus are chronic diseases with a high global prevalence and are closely associated. Adjunctive probiotic therapy has garnered increasing attention in the management of type 2 diabetes mellitus (T2DM) with periodontal disease.

Objective: This review elucidates the effect of probiotic therapy on inflammatory markers, periodontal parameters, and glycated hemoglobin (HbA1c) in people with both T2DM and periodontal disease.

Developmental pathways in plants: Lessons from Arabidopsis for crop innovation.

The emergence of molecular biology, along with the use of Arabidopsis thaliana as a model organism, has significantly enhanced our understanding of plant development. Research on Arabidopsis has led to the identification of key regulatory genes involved in various developmental processes. In the past decade, advances in genome sequencing and the decoding of numerous plant genomes have enabled the application of these findings from Arabidopsis to crop species.

Efficacy and Safety of Plecanatide in Chinese Patients with Functional Constipation: A Phase III Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

Background: Plecanatide is a novel guanylate cyclase-C agonist for the treatment of functional constipation (FC). Its efficacy may vary across different racial populations.

Objective: This study aimed to comprehensively evaluate the efficacy, safety, and pharmacokinetics of plecanatide in Chinese patients with FC.

The CsphyB-CsPIF4-CsBRC1 module regulates ABA biosynthesis and axillary bud outgrowth in cucumber.

Shoot branching is an important crop agronomic trait that directly affects plant architecture and crop productivity. Although phytochrome B (phyB), BRANCHED1 (BRC1), and abscisic acid (ABA) mediate axillary bud outgrowth, it is unknown if there is any integrating factor among them in the Plantae. We report that mutation of CsphyB or inactivation of CsphyB by shade inhibits lateral bud outgrowth in cucumber.

Rhein-induced apoptosis in colorectal cancer cell lines: A mechanistic study of the myeloid differentiation primary response gene 88/toll-like receptor 4/nuclear factor kappa-B signaling pathway.

Objective: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, and targeted therapies for CRC are urgently needed. This study aimed to investigate the mechanisms through which rhein induces apoptosis in CRC cells, focusing on its influence on the myeloid differentiation primary response gene 88 (MYD88)/toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway.

Material And Methods: Cell Counting Kit-8 assay was conducted, with three non-cytotoxic concentrations of rhein selected for further analysis.

PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation manner.

Background: Drug resistance and relapse are still major challenges in acute myeloid leukemia (AML) because of the inability to effectively eradicate leukemia stem cells (LSCs). Senescence induction combined with immune killing may offer promising strategies for LSC eradication. However, whether and how drug-resistant LSCs retain stemness via senescence and immune regulation remains unknown.

The association between alpha-1-acid glycoprotein and asthma in United States: a cross-sectional study from NHANES.

Background: Alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM), is an acute-phase protein associated with asthma. However, research on the relationship between AGP and asthma risk is limited. This study aims to investigate the association between AGP and asthma in the United States.

Association of the 2020 Healthy Eating Index with asthma in children and adolescents in the United States: a cross-sectional study of NHANES.

Objective: Our goal was to investigate the connection between asthma and HEI-2020.

Data Sources: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020.

Study Selections: Diet quality was measured as HEI-2020 scores using 24-h and 2-day dietary recall data.

Deciphering the Transcriptomic Complexity of Yak Skin Across Different Ages and Body Sites.

Differences in skin and hair phenotypes between the scapular and ventral regions of yaks (Bos grunniens) are obvious and become more prominent with age. However, the genetic mechanism that causes differences in yak skin at different ages has not been reported. In this study, we investigated the transcriptomic profile of yak skin across different ages (0.

Characteristics of Neonicotinoids in Colostrum from Shanghai, China (2007-2019): Concentration Levels, Temporal Trends, and Potential Health Risk.

Neonicotinoids (NEOs) are widely used neuroactive insecticides with several adverse effects on human health. This study examined 186 colostrum samples collected at three time points between 2007 and 2019 from Shanghai, China to investigate the distribution and temporal variations of NEOs. The median total concentration (ΣNEOs) was 136 ng/L, with the imidacloprid equivalent concentration (IMIeq) of 249 ng/L.

Effects of two typical organophosphate flame retardants on DNA damage of GT1-7 cells and relevant molecular mechanism.

The tris (2-chloroethyl) phosphate (TCEP) and tri-n-butyl phosphate (TNBP) are two typical organophosphate esters (OPEs), which have estrogenic activity. However, fewer studies have been conducted on their genotoxicity and mechanisms. In this study, we evaluated the effects of TCEP and TNBP on cellular DNA damage in GT1-7 cells and examined the role of estrogen signaling in regulating DNA damage.

Cloning and Transcriptional Activity Analysis of the Bovine Gene Promoter: Transcription Factors Sp1 and GR Regulate Bovine Expression.

Growth rate of bovine skeletal muscle has a major impact on beef yield. Cadherin-11 () was found to be a potential candidate gene for growth and development in beef cattle. This study confirmed the high expression of in bovine using a tissue expression analysis.

Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation.

Background: Whereas intestinal epithelial barrier dysfunction is implicated in inflammatory bowel disease (IBD), the underlying mechanisms remain elusive. Tumor necrosis factor α stimulated gene 6 (TSG-6) is a secretory protein with anti-inflammatory properties. Our previous research demonstrated TSG-6 can relieve intestinal inflammation and mucosal damage.