Senkyunolide I alleviates allergic rhinitis by inhibiting JAK1/3-STAT3/6 and JNK signalings.

Background: Allergic rhinitis (AR) is a common allergic disease with a high incidence rate. Senkyunolide I (SEI), a bioactive ingredient isolated from Ligusticum sinense 'Chuanxiong', exhibits known analgesic and anti-inflammatory effects, yet its anti-AR potential remains unexplored. Here, we aim to investigate the therapeutic efficacy and molecular mechanisms of SEI against AR.

Late retroperitoneal recurrence of adult-type ovarian granulosa cell tumors: Two case reports and literature review.

Adult-type ovarian granulosa cell tumors are rare low-grade malignancies characterized by late recurrence and atypical clinical manifestations. This study reports two cases of recurrent adult-type ovarian granulosa cell tumor with distinct timelines and anatomical sites, including one case with two postoperative recurrences. We analyze their imaging features, surgical management, histopathology, postoperative follow-up, and review relevant literature.

Comparative Subchronic Oral Toxicity of Gardeniae Fructus and Shuizhizi Water Extracts in Sprague-Dawley Rats Over 90 Days.

To compare the safety profiles of Gardeniae Fructus (Zhizi) and its counterfeit, Shuizhizi, Sprague-Dawley rats were orally administered aqueous extracts of Zhizi and Shuizhizi at 1.8 and 5.4 g/kg/day for 28 and 90 days, followed by a 28-day recovery period.

A hydrogel-based nanoparticles sustained-release system selectively targeting pro-inflammatory microglia for spinal cord injury repair.

Spinal cord injury (SCI) often results in irreversible neurological deficits, primarily due to chronic neuroinflammation driven by activated proinflammatory microglia. Effective therapeutic interventions require both precise targeting of pathological immune cells and sustained modulation of the inflammatory microenvironment. Here, we present a cell specific, hydrogel-based nanoparticle system (MG1-MM@Candesartan-Gel) designed for the selective and prolonged delivery of the angiotensin II type 1 receptor (AT1R) antagonist Candesartan to proinflammatory microglia.

Efficacy and safety of Shen-Qi Paste, a Traditional Chinese Medicine, in dialysis patients with sarcopenia: A randomized, double-blind, placebo-controlled trial.

Background: The lack of effective treatments for sarcopenia remains a major unmet medical need. Shen-Qi Paste (SQP), a Traditional Chinese Medicine (TCM) dietary formulation developed on the basis of the theory of "same origin of medicine and food," offers a novel therapeutic strategy. Unlike conventional approaches that are focused solely on nutrition and exercise, SQP targets the underlying TCM-defined etiologies (e.

Comparative efficacy of non-steroidal anti-inflammatory drugs in preventing postoperative macular edema following cataract surgery: a systematic review and Network Meta-analysis.

Aim: To assess and rank the efficacy of various non-steroidal anti-inflammatory drugs (NSAIDs) in preventing postoperative macular edema (PME) after cataract surgery.

Methods: A comprehensive search was conducted across PubMed, Embase, Cochrane Library, and Web of Science databases. Randomized controlled trials (RCTs) comparing different NSAIDs and control treatments for the prevention of PME were included.

CD4 T Cell Subsets and as Novel Biomarkers of Immune Dysregulation in Dilated Cardiomyopathy.

Recent multiomics advancements have improved our understanding of immune dysregulation in dilated cardiomyopathy (DCM). However, specific immune cell subsets and their regulatory genes are still ambiguous. This study aimed to explore immune cell imbalances and regulatory genes in DCM, discover diagnostic biomarkers, and identify potential therapeutic targets.

Single-Cell Transcriptomics Reveals Effects of Long-Term Contact Lens Wearing on the Human Corneal Epithelium.

Purpose: Corneal contact lenses (CLs) are increasingly used as a treatment for myopia correction. This study aimed to elucidate the molecular mechanisms underlying corneal epithelial pathological changes induced by long-term CL wear, thereby providing potential targets for the prevention and management of CL-related corneal complications.

Methods: We initially conducted single-cell RNA sequencing on intact corneal epithelium samples obtained from myopic patients with prolonged CL wear and nonwearing controls.

LYnet: Computational identification of tumor T cell antigens using convolutional and recurrent neural networks.

Background: Immunotherapy represents a paradigm shift in oncology, offering advantages in efficacy and specificity over traditional therapies. Key to its success is the identification of T-cell antigens, which are essential for triggering an effective antitumor immune response. Current methodologies for antigen prediction, however, lack the precision required for optimal vaccine development.

Efficient luminescent stable Chichibabin diradicaloid for near-infrared imaging and photothermal therapy.

Diradicaloids have garnered significant attention due to their unique electronic, photophysical properties and potential applications in functional materials. Characterized by a narrow band gap and near-infrared (NIR) absorption, diradicaloids are promising candidates for NIR-guided photothermal therapy. However, they are often unstable and exhibit non-emissive properties due to high chemical reactivity and very efficient internal conversion.

Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression.

Heart failure (HF) is a complex condition. Among altered signal transduction pathways associated with HF pathogenesis, the stress-activated p38 mitogen-activated protein kinase (Mapk) pathway has attracted attention for its role in HF progression and cardiac hypertrophy. However, the mechanisms by which p38-Mapk influences HF remain unclear.

Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells.

Background: Myocardial infarction (MI) is a high-prevalence disease that threatens human survival and quality of life worldwide. Considerable evidence has suggested that periodontitis (PD) is detrimental to MI. However, the direct impact of PD on MI is unclear; which oral pathobionts contribute to and how microbial signals regulate the pathogenesis of MI remain obscure.

Knowledge, attitudes, and practices regarding home-based cardiac rehabilitation in patients with chronic heart failure.

Chronic heart failure (CHF) represents an escalating public health issue characterized by high rates of morbidity, mortality, and increasing healthcare expenditures. Although home-based cardiac rehabilitation (HBCR) has been proven effective in managing CHF, patient engagement remains suboptimal. This study aimed to examine the knowledge, attitudes, and practices (KAP) associated with HBCR in patients with CHF.

Selective Plasticity of Hippocampal Sub-Regions in the Amnestic Mild Cognitive Impairment After Acupuncture.

Background: Acupuncture has been demonstrated to be effective in reducing cognitive decline in patients with amnestic mild cognitive impairment (aMCI). Hippocampal atrophy has been typically reported as a core neuromechanism in the aMCI. However, whether and how hippocampal subregions plasticity exists in aMCI after acupuncture remains largely unknown.

Single Atom-Substituted Chalcogenides with Anion Vacancy Bonded on Graphene Nanotubes for Achieving "1+1+1>3" Synergistic Enhanced Sodium Storage.

Developing distinctive composite anodes with multiple active components is critical for enhancing the charge storage capability of sodium-ion hybrid capacitors (SIHCs). Herein, In single atom-substituted SnS with moderate sulfur vacancies in situ bonded on N-doped graphene nanotubes (In─SnS@NG) is ingeniously engineered as a superior anode. Theoretical calculations and in situ/ex situ characterizations illustrate that the introduced Sn(In)─N interfacial bonds immensely strengthen composites integration and boost charge transfer, then In single atom substitution effectively elevates d band center and enhances Na adsorption.

Effects of dietary supplementation with periplaneta americana-derived antimicrobial peptides on (PA-AMPs) growth performance, immune function, and gut health in yellow-feathered broilers.

This study aimed to comprehensively investigate the effects of American cockroach antimicrobial peptide (PA-AMPs) on yellow-feathered broilers. Three hundred one-day-old yellow-feathered broilers were randomly divided into five groups: the control group (CON) fed a basal diet, three PA-AMPs treatment groups with 100 mg/kg, 200 mg/kg, and 300 mg/kg PA-AMPs added to the basal diet respectively, and the ARY group with 20 mg/kg chlortetracycline in the basal diet. Each group had six replicates of 10 chickens each, and the experiment lasted for 70 days.

GPR55 activation alleviates cognitive dysfunction caused by neuropathic pain through modulation of microglia polarization and synaptic plasticity via the CaMKKβ/AMPK/SOCS3 signaling pathway.

Cognitive impairment induced by neuropathic pain substantially diminishes quality of life, with hippocampal neuroinflammation identified as a critical pathogenic factor. Although G protein-coupled receptor 55 (GPR55) demonstrates anti-inflammatory, analgesic, and neuroprotective properties, its therapeutic potential and molecular mechanisms in neuropathic pain-induced cognitive deficits remain uncharacterized. Using a spared nerve injury (SNI) mouse model, we systematically investigated GPR55's neuroprotective mechanisms.

Correction: Effects of different dietary supplements combined with conditioning training on muscle strength, jump performance, sprint speed, and muscle mass in athletes: a systematic review and network meta-analysis.

[This corrects the article DOI: 10.3389/fnut.2025.

alleviated colitis by downregulating the TNF signaling pathway mediated by cIAP1/2 in mice.

The gut microbiota and its associated micro-ecosystem are closely related to the onset and development of ulcerative colitis (UC). It is known that () helps rebuild gut eubiosis from diabetes dysbiosis; however, its effects on UC remain unknown. This study aims to investigate the therapeutic effects and mechanisms of on UC.

Unraveling the Spatiotemporal Heterogeneity in the Oxidation Potential of Fine Particulate Matter in China.

The oxidative potential (OP) of fine particulate matter (PM) is a more robust health impact indicator than mass concentration alone. While China's stringent air pollution controls have significantly reduced PM levels, the temporal evolution of OP and its relationship with PM remain unclear. This study establishes a national PM OP database (2000-2020) using a source-oriented CMAQ model.

Order-Disorder Phase Stabilization by Pressure-Induced Charge Transfer Enhances the Ferroelectric Photovoltaic Effect in Multiferroic BaFeO.

Multiferroic ferroelectric photovoltaic (FPV) materials, combining magnetic and ferroelectric properties, are of paramount importance for optoelectronic and photovoltaic applications. However, optimizing both the remanent polarization and the optical bandgap-key factors for enhanced FPV performance-presents a significant challenge due to their trade-off. This work shows that pressure-induced charge transfer between different metal sites can break this trade-off.

Monocarboxylate Transporter 4 Inhibition Reduces Synovial Hyperproliferation and Metabolic Reprogramming Under Hypoxia in Rheumatoid Arthritis.

Objectives: In hypoxic conditions, the acidic environment characteristic of rheumatoid arthritis (RA) induces metabolic changes in fibroblast-like synoviocytes (FLS), markedly promoting the synovial proliferation. Monocarboxylate transporter 4 (MCT4) plays a crucial role in cellular pH regulation and synovial fibroblast activation by regulating lactate export. This study investigates the impact of MCT4 inhibition on RA and elucidates its underlying mechanisms.

Clinical characteristics and risk factors of ocular hypertension: a case-control study.

Purpose: This study investigates the clinical characteristics of ocular hypertension (OHT) by analyzing factors such as Schlemm's canal morphology, intraocular pressure (IOP), iris traits, angle configuration, lens thickness (LT), and retinal nerve fiber layer (RNFL) thickness.

Methods: A total of 60 OHT patients (120 eyes) and 60 healthy controls (120 eyes) underwent cross-sectional and case-control analyses using measurements like IOP, visual acuity, and anterior segment OCT imaging. Statistical analyses involved independent t-tests, Mann-Whitney U tests, correlation analysis, and multivariate logistic regression, with continuous adjustment for spherical equivalent (SE) and central corneal thickness (CCT).

Evaluation of FFR and CPET in patients with coronary chronic total occlusion treated with DCB vs. DES.

Background: Drug-coated balloon (DCB) is a novel therapeutic strategy for coronary chronic total occlusion (CTO). However, fractional flow reserve (FFR), a key indicator of evaluating coronary function, and cardiopulmonary exercise testing (CPET), an important indicator of cardiopulmonary function, are rarely reported for evaluating the effectiveness of DCB in CTO lesions.

Methods And Results: In this retrospective study, 100 patients were enrolled and classified into the DCB group ( = 48) and the drug-eluting stent (DES) group ( = 52).

C-14 oxygenated quassinoids with control effect against larvae of Diaphorina citri Kuwayama from fruits of Picrasma quassioides.

Background: Diaphorina citri is one of the most severe pests affecting citrus production worldwide. Our previous research identified a series of quassinoids that exhibit insecticidal activity against D. citri adults.