Wearable Point-of-Care Biosensor for Biomolecular Assay in Health Monitoring.

Wearable biosensors represent a significant advancement in preventive health monitoring by enabling early disease detection through real-time bioanalysis. This review examines the evolution of point-of-care testing (POCT), with a focus on materials, fabrication techniques, and real-world applications. These biosensors utilize advanced materials, such as supramolecular hydrogels, and innovative manufacturing methods, providing high sensitivity, specificity, and portability.

SLC38A1 protects against aging-related oxidative stress and lipid peroxidation in C2C12 myoblasts: Implication of a ferroptosis-related regulator for skeletal muscle aging.

Ferroptosis has been implicated in skeletal muscle aging. Nevertheless, specific ferroptosis-related genes (FRGs) governing skeletal muscle aging remain unclear. The aim of this study was to identify ferroptosis-related marker genes associated with skeletal muscle aging, uncovering potential therapeutic targets for skeletal muscle aging.

Study on the alteration of gut microbiota in ovariectomized rats and the impact of estrogen intervention over a 3-month period.

Postmenopausal osteoporosis (PMOP) is a common primary osteoporosis. With the aging of the population, it is becoming a major disease that endangers health and quality of life. The purpose of this study was to explore the effect of gut microbiota on PMOP by observing the changes in the levels of estradiol, bone density, and gut microbiota diversity in rats after 3 months of OVX surgery.

Elevated THOC5 expression in liver cancer and its implications for tumor progression and therapeutic response.

Purpose: Cancer remains a major global cause of death, with rising incidence influenced by environmental factors. The THOC5 gene, part of the THO complex, has emerged as a potential regulator in cancer biology. This study investigates THOC5 expression across various cancers, its role in prognosis, and its potential therapeutic implications, particularly in liver hepatocellular carcinoma (LIHC).

Controllable Synthesis of an Upconversion Metal-Organic Framework Core-Shell Hybrid for Highly Sensitive Fluorescence Detection of Dufulin in Crops and Fruits.

Developing a sensitive analysis of dufulin with high anti-interference performance remains challenging. Herein, a metal-organic framework (MOF)-encapsulated upconversion nanoparticle (UC) core-shell hybrid sensor (UC@CuMOF) was designed for the sensitive detection of dufulin. With the encapsulation of the CuMOF shell, the luminescence of UC under a 980 nm laser was strongly quenched by the shell through the photoinduced electron transfer effect.

Strategies for enhancing yield and quality of forage-grain dual-purpose ratoon rice: role of first-season density and nitrogen management.

The "forage-grain dual-purpose" model helps ease land-use competition and supports high-yield, high-quality rice production. However, integrated strategies to simultaneously improve silage rice and ratoon rice yield and quality across both seasons require further systematic study. A two-year field study (2022-2023) was conducted using two widely cultivated indica hybrid rice cultivars, F You 498 (FY498) and Chuankangyou Simiao (CKYSM), in Southwest China.

Multi-tracer PET and MR imaging visualize distinct metabolic and inflammatory profiles in the white matter of NMOSD and MOGAD.

This study investigates distinct neuroinflammatory patterns in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using multi-tracer PET and MR imaging. Eight NMOSD (5F/3M; median age 36.5) and six MOGAD patients (2F/4M; median age 34.

To patent or not to patent: challenges and solutions to the patent ban on new genomic techniques plant in EU.

The Proposal for a new Regulation on plants produced by certain new genomic techniques (NGTs) embraces the deregulation of NGT plants but introduces a patent ban on them. This move has generated significant legal uncertainties and has become the focal point of a broader debate over the patentability of NGT plants. In reviewing the rationale and challenges underlying the patent ban, this article argues that the abandonment of patents diverges from established expectations.

Nature-Inspired MXene Electrode with the Highly Interconnected Gradient Nanoconfined Architecture.

Achieving efficient ion transport in thick electrodes remains a fundamental challenge in electrochemical systems with high energy density, primarily due to prolonged diffusion pathways and poorly integrated architectures. Leveraging the nanoconfinement effect, (sub)nanoscale channels can significantly accelerate ion transport kinetics to maximize electrochemical performance. Inspired by the hierarchical network structure of bamboo membrane, a gradient nanoconfined MXene electrode (GNC-MX) is designed, where multiscale interlayer spacing is coupled with in-plane mesopores that bridge adjacent nanoconfined channels, enabling synergistic vertical and horizontal ion migration.

Biofilms: Characteristics and Control Strategies.

The are a family of bacteria that typically cause respiratory, arthritic, and genitourinary disease in humans. spp. of animal origin are also the causative agents of porcine wheezing disease, chronic respiratory disease and arthritis in chickens and other conditions.

Laser-Ultrasound Responsive Nanoreactor to Remodel the Microenvironment of Antibiotic-Resistant Bacterial Infection for Diabetic Wound Healing.

Diabetic wounds with drug-resistant bacterial infections pose a formidable clinical challenge, which is attributed to adverse microenvironments, including hypoxia, biofilm formation, and insufficient reactive oxygen/nitrogen species (ROS/RNS). To overcome these issues, a laser-ultrasound responsive nanoreactor that comprises NO-intercalated and defect-rich CoMn-layered double hydroxide (LDH) on black phosphorus (BP) nanosheets (D-CoMn LDH-NO@BP) is fabricated. It exhibits catalase-like activity for O generation, facilitates NO release under acidic conditions, and promotes ROS/RNS generation upon laser-ultrasound activation, resulting in ferroptosis, biofilm degradation, and hypoxia alleviation for accelerated wound healing.

Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice.

Male infertility, as a globally significant reproductive health issue, remains idiopathic in over 40% of cases. Reproductive disorders in males induced by environmental pollutants, such as di(2-ethylhexyl) phthalate (DEHP), have garnered considerable attention in recent years. DEHP induces testicular oxidative stress and ferroptosis via its active metabolite MEHP, thereby leading to spermatogenic dysfunction.

Accurate and Scalable Quantum Hydrodynamic Simulations of Plasmonic Nanostructures Within OFDFT.

Quantum hydrodynamic theory (QHT) provides a computationally efficient alternative to time-dependent density functional theory for simulating plasmonic nanostructures, but its predictive power depends critically on the choice of ground-state electron density and energy functional. To construct ground-state densities, we adopt orbital-free density functional theory and numerically evaluate the effect of different exchange-correlation functionals and kinetic energy functionals. A suitable energy functional to reproduce both the DFT-calculated work function and charge density is identified.

Synergistic chemotherapy and phototherapy co-delivery nanoparticle preparation and anti-triple negative breast cancer study.

In this study, the amphiphilic polymer HA-ANI, formed by grafting hyaluronic acid (HA) and 6-(2-nitroimidazolyl)hexylamine (ANI), was self-assembled in water to form nanoparticles (NPs), which were modified to obtain dual drug-loaded nanoparticles (P/I NPs) by dialysis loading of paclitaxel (PTX) and IR780. Electron microscopy and dynamic light scattering (DLS) results showed that the P/I NPs presented a near-spherical shape with a size of 221.10 ± 2.

Biocompatible Mesoporous Materials for Bone Therapy.

As global population aging intensifies, bone-related diseases have become a significant public health challenge, necessitating the development of efficient and precise bone repair strategies. Biocompatible mesoporous materials (BMMs), characterized by their high specific surface area, tunable pore size, multidimensional functionalization potential, and excellent biocompatibility, have demonstrated revolutionary application prospects in treating bone-related diseases. This review systematically summarizes the latest research progress and application mechanisms of BMMs (e.

Adaptive changes in the intestinal microbiota of giant pandas following reintroduction.

The biggest challenge during the reintroduction of captive giant pandas into the wild is their ability to adapt to the natural environment, and the role of gut microbiota in this process remains unknown. Here, the gut microbiota was analyzed and categorized into training, exploration (1-3 months post-release) and stable period (4-6 months post-release) by activity intensity of released pandas. We found that the gut microbiota diversity of pandas was significantly higher during the stable period compared to the training period.

Role of lncRNA MGP202 in Modulating B Cell Dynamics and Its Implications in Ulcerative Colitis.

Background: The upregulation of long noncoding RNA (lncRNA) MGP202 in ulcerative colitis (UC) patients suggests its potential significance in the disease. Understanding its role in UC pathogenesis and its impact on B cell dynamics is crucial for diagnostic and therapeutic advancements.

Methods: We investigated the expression and function of MGP202 in UC patients by examining its localization in colon specimens, performing knockdown and overexpression experiments in Raji B cells, and evaluating its interaction with hsa-miR-5590-3p.

Development and reliability testing of an orthopaedic nurses' knowledge, attitudes, and practices (KAP) questionnaire on perioperative nutrition management for older adults with hip fractures.

Background: In China, orthopaedic nurses serve as the primary providers of perioperative nutritional management for older adults with hip fractures. Their knowledge, attitudes, and practices regarding nutritional management directly impact protocol implementation, therapeutic efficacy, and patient rehabilitation outcomes. Although enhancing these competencies is crucial, no validated assessment tool currently exists for this specific context.

Synergistic antibacterial, anti-adhesion, and lubricating hydrogel coating with carbon quantum dots for urinary catheters: A multifaceted strategy against catheter-associated infections.

Urinary catheters (UCs) encounter persistent challenges, including catheter-associated urinary tract infections (CAUTIs) and friction-induced tissue damage. Here, we developed multifunctional carbon quantum dots (CQDs) - polyacrylic acid (PAA) - polyethylene glycol (PEG) - poly-N-isopropyl acrylamide (PNIPAM) (CAPPN) hydrogel coatings for polyvinyl chloride (PVC) UCs, which integrated CQDs with interfacial engineering to achieve synergistic antibacterial, anti-adhesion, and lubrication properties. The hydrothermally synthesized CQDs (3.

Associations of addiction-like eating with personal relative deprivation, compensatory health beliefs, and body mass index from the life history perspective.

Background: The rising global overweight/obesity rate has led to an increase of research attention in one of its antecedents: addiction-like eating (AE). Under the framework of life history (LH) theory, the present study aimed at examining not only the association between AE and body mass index (BMI) but also the effects of LH strategy on AE, via two cognitive mediators (i.e.

Construction of a predictive model for concurrent infection in liver failure patients based on prognostic nutritional index and inflammatory cytokine analysis.

Objective: This study aimed to explore the relationship between the Prognostic Nutritional Index (PNI, a composite indicator of albumin and lymphocyte count reflecting nutritional and immune status) and inflammatory cytokines in predicting infections among liver failure patients, and to construct a predictive model based on these indicators.

Methods: A retrospective analysis was conducted on 163 patients with liver failure admitted to our hospital between January 2020 and December 2023. Patients were categorized into an Infection group and a Non-infection group based on the presence of concurrent infections.

Association of possible sarcopenia and its components with all-cause mortality in a middle-aged and older population: a 9-year cohort study.

The association of possible sarcopenia and its components with all-cause mortality needs further study. This study analyzed the association of possible sarcopenia, handgrip strength and 5-time chair stand test with all-cause mortality in a Chinese middle-aged and older community population. This cohort study included a total of 11,233 participants aged ≥ 45 years from the 2011-2020 China Health and Retirement Longitudinal Study.

Predictive value and ranking of writhing and fidgety movements for cerebral palsy: A meta-analysis based on the Superiority Index.

Background: This meta-analysis assessed the diagnostic value of writhing and fidgety general movements (GMs) for predicting cerebral palsy.

Methods: We searched PubMed, EMBASE, Cochrane Library, CINAHL, and Web of Science for cohort or case-control studies evaluating GMs. We calculated the superiority index (S), sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR), and area under the curve (AUC) using STATA.

Clinical characteristics and risk factors of ocular hypertension: a case-control study.

Purpose: This study investigates the clinical characteristics of ocular hypertension (OHT) by analyzing factors such as Schlemm's canal morphology, intraocular pressure (IOP), iris traits, angle configuration, lens thickness (LT), and retinal nerve fiber layer (RNFL) thickness.

Methods: A total of 60 OHT patients (120 eyes) and 60 healthy controls (120 eyes) underwent cross-sectional and case-control analyses using measurements like IOP, visual acuity, and anterior segment OCT imaging. Statistical analyses involved independent t-tests, Mann-Whitney U tests, correlation analysis, and multivariate logistic regression, with continuous adjustment for spherical equivalent (SE) and central corneal thickness (CCT).