Synergistic antibacterial, anti-adhesion, and lubricating hydrogel coating with carbon quantum dots for urinary catheters: A multifaceted strategy against catheter-associated infections.

Urinary catheters (UCs) encounter persistent challenges, including catheter-associated urinary tract infections (CAUTIs) and friction-induced tissue damage. Here, we developed multifunctional carbon quantum dots (CQDs) - polyacrylic acid (PAA) - polyethylene glycol (PEG) - poly-N-isopropyl acrylamide (PNIPAM) (CAPPN) hydrogel coatings for polyvinyl chloride (PVC) UCs, which integrated CQDs with interfacial engineering to achieve synergistic antibacterial, anti-adhesion, and lubrication properties. The hydrothermally synthesized CQDs (3.

Enhanced antibacterial and corrosion resistance performance of fluorine-doped diamond-like carbon coatings on 316 L stainless steel.

Biomedical materials must meet increasingly stringent standards for antibacterial efficacy and corrosion resistance. This study investigates the enhancement of these properties in 316 L stainless steel through the application of fluorine-doped diamond-like carbon (F-DLC) coatings. A series of F-DLC coatings with varying fluorine (F) concentrations were fabricated using plasma-enhanced chemical vapour deposition (PECVD).

Ag quantum dots-doped poly (vinyl alcohol)/chitosan hydrogel coatings to prevent catheter-associated urinary tract infections.

The prevention of catheter-associated urinary tract infections (CAUTIs) significantly impacts the reduction of morbidity and mortality associated with the use of indwelling urinary catheters. This study focused on developing an antibacterial double network hydrogel coating for latex urinary catheters, which incorporated Ag quantum dots (Ag QDs) in a polyvinyl alcohol (PVA)-chitosan (CS) double network hydrogel matrix. The PVA-CS-Ag QDs, referred to as the PCA hydrogel coating exhibited excellent mechanical and physiochemical properties with controlled release of Ag QDs.

Fabrication of antibacterial polydopamine-carboxymethyl cellulose-Ag nanoparticle hydrogel coating for urinary catheters.

Urinary tract infections caused by catheter insertion are prevalent in hospital clinics, which can induce serious complications such as bacteriuria and sepsis, and even lead to patient death. The disposable catheters currently used in clinical practice suffer from poor biocompatibility and high infection rate. In this paper, we developed a polydopamine (PDA)-carboxymethylcellulose (CMC)-Ag nanoparticles (AgNPs) coating with both good antibacterial and anti-adhesion properties to bacteria on the surfaces of a disposable medical latex catheter by a simple dipping method.

Agar dilution method for detection of inducible clindamycin resistance in Staphylococcus spp.

We describe the development and validation of an agar dilution method for the detection of inducible clindamycin resistance by using 227 previously characterized erythromycin-resistant, clindamycin-susceptible Staphylococcus sp. isolates. Mueller-Hinton agar with defibrinated horse blood containing a range of erythromycin concentrations (1 to 8 mg/liter) combined with clindamycin at 0.

Comparison of single- and multilocus sequence typing and toxin gene profiling for characterization of methicillin-resistant Staphylococcus aureus.

We compared three novel methicillin-resistant Staphylococcus aureus (MRSA) genotyping methods with multilocus sequence typing (MLST) and spa typing to assess their utility for routine strain typing. The new methods were femA and nuc sequence typing and toxin gene profiling (TGP), using a multiplex-PCR-based reverse line blot assay to detect 13 pyrogenic superantigen and exfoliative toxin genes. Forty-two well-characterized MRSA strains, representing 15 MLSTs or 9 clonal clusters (CCs), were genotyped by all methods.

Influence of disk separation distance on accuracy of the disk approximation test for detection of inducible clindamycin resistance in Staphylococcus spp.

We undertook this study to assess the accuracy of the clindamycin-erythromycin disk approximation test (D-test) for detection of inducible clindamycin resistance in Staphylococcus spp. One hundred sixty-three Staphylococcus aureus and 68 coagulase-negative Staphylococcus (CoNS) spp. which were erythromycin nonsusceptible but clindamycin susceptible were tested using the D-test performed at both 15-mm and 22-mm disk separations and compared with genotyping as the "gold standard.