Multi-tracer PET and MR imaging visualize distinct metabolic and inflammatory profiles in the white matter of NMOSD and MOGAD.

This study investigates distinct neuroinflammatory patterns in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using multi-tracer PET and MR imaging. Eight NMOSD (5F/3M; median age 36.5) and six MOGAD patients (2F/4M; median age 34.

DTI-ALPS index-assessed glymphatic dysfunction mediates Alzheimer's cognitive decline via amyloid-β-dependent pathways: multimodal PET/MRI study.

Purpose: The role of glymphatic dysfunction in Alzheimer's disease (AD), as measured by diffusion tensor imaging along perivascular spaces (DTI-ALPS) indexing of perivascular function, its progression, and its interaction with amyloid-β (Aβ) and tau proteins, remains controversial. To investigate whether the DTI-ALPS index mediates AD-related cognitive decline through Aβ/tau-dependent pathways using tri-tracer PET/MRI.

Methods: This retrospective study (2021-2024) analyzed 140 participants (median age 69.

Dual-tracer PET in prostate synovial sarcoma: discordant FDG and PSMA uptake with metastatic patterns.

We present the case of primary prostatic synovial sarcoma exhibiting discordant tracer avidity on [F]-FDG PET/MRI and [F]-PSMA PET/CT-a metabolic divergence suggesting clonal evolution and potential eligibility for PSMA-targeted radioligand therapy to combat poor survival in this rare sarcoma subtype.

Exploring the nigrostriatal and digestive interplays in Parkinson's disease using dynamic total-body [C]CFT PET/CT.

Purpose: Dynamic total-body imaging enables new perspectives to investigate the potential relationship between the central and peripheral regions. Employing uEXPLORER dynamic [C]CFT PET/CT imaging with voxel-wise simplified reference tissue model (SRTM) kinetic modeling and semi-quantitative measures, we explored how the correlation pattern between nigrostriatal and digestive regions differed between the healthy participants as controls (HC) and patients with Parkinson's disease (PD).

Methods: Eleven participants (six HCs and five PDs) underwent 75-min dynamic [C]CFT scans on a total-body PET/CT scanner (uEXPLORER, United Imaging Healthcare) were retrospectively enrolled.

Circ_0020014 mediates CTSB expression and participates in IL-1β-prompted chondrocyte injury via interacting with miR-24-3p.

Background: Recent studies have shown that circRNAs are involved in the pathogenesis of osteoarthritis (OA) by affecting various fundamental cellular characteristics of chondrocytes. The purpose of this paper is to investigate the role and regulatory mechanism of hsa_circ_0020014 (circ_0020014) in chondrocytes of OA.

Methods: The inflammatory cytokine interleukin 1 beta (IL-1β) was used to stimulate human chondrocytes.

Amphiphysin-IgG autoimmune sciatic neuropathy and facial neuropathy related to primary central nervous system lymphoma: A case report.

We reported a 61-year-old man presented with 10-month progressing left sciatic neuropathy and 10-day right facial neuropathy. Serum amphiphysin-IgG was positive. F-FDG PET/CT of the whole body showed no signs of malignancy.

Feasibility of acquisitions using total-body PET/CT with a half-dose [Ga]Ga-FAPI-04 activity in oncology patients.

Background: [Ga]Ga-FAPI-04 (gallium-68-labeled fibroblast activation protein inhibitor-04) PET/CT has been widely used in diagnosing malignant tumors. Total-body PET/CT has a long axial field of view and provides higher sensitivity compared to traditional PET/CT. However, whether the reduced injected dose of [Ga]Ga-FAPI-04 could obtain qualified imaging has not been evaluated.

Pilot study on C-CFT dynamic imaging using total-body PET/CT: biodistribution and radiation dosimetry in Parkinson's disease.

Objective: Total-body PET/CT equipment, uEXPLORER, is a newly developed imaging technology with a superior resolution, high sensitivity, and high signal-to-noise ratio, providing unique application advantages in the pharmacokinetic evaluation of positron tracers. While C-CFT PET/CT has been widely utilized in the early diagnosis of Parkinson's disease (PD), it is limited by the short half-life of the radionuclide and an incomplete understanding of its biological distribution in humans. This study aimed to use a total-body PET/CT dynamic scan with C-CFT imaging to describe the real-time internal biodistribution in PD patients and to obtain accurate radiation dosimetry.

A novel classification model based on cerebral 18F-FDG uptake pattern facilitates the diagnosis of acute/subacute seropositive autoimmune encephalitis.

Purpose: To explore the intrinsic alteration of cerebral 18F-FDG metabolism in acute/subacute seropositive autoimmune encephalitis (AE) and to propose a universal classification model based on 18F-FDG metabolic patterns to predict AE.

Methods: Cerebral 18F-FDG PET images of 42 acute/subacute seropositive AE patients and 45 healthy controls (HCs) were compared using voxelwise and region of interest (ROI)-based schemes. The mean standardized uptake value ratios (SUVRs) of 59 subregions according to a modified Automated Anatomical Labeling (AAL) atlas were compared using a t-test.

Hypometabolism of the left middle/medial frontal lobe on FDG-PET in anti-NMDA receptor encephalitis: Comparison with MRI and EEG findings.

Objectives: To investigate changes in brain-glucose metabolism in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, and compare results with MRI and electroencephalography (EEG) findings at different disease stages.

Methods: The clinical data of 18 patients (median age, 35 years; 11 men) were retrospectively collected. Patients were divided into groups based on the time of symptom onset to examination, (≤1 month, >1 but ≤3 months, >3 months).

First Total-Body Kinetic Modeling and Parametric Imaging of Dynamic Ga-FAPI-04 PET in Pancreatic and Gastric Cancer.

Fibroblast activation protein inhibitor (FAPI) is an ideal diagnostic and therapeutic target in malignant tumors. However, the knowledge of kinetic modeling and parametric imaging of Ga-FAPI is limited. The purpose of this study was to explore the pharmacokinetics of Ga-FAPI-04 PET/CT in pancreatic cancer and gastric cancer and to conduct parametric imaging of dynamic total-body data compared with SUV imaging.

Research on melanoma image segmentation by incorporating medical prior knowledge.

Background: Melanoma image segmentation has important clinical value in the diagnosis and treatment of skin diseases. However, due to the difficulty of obtaining data sets, and the sample imbalance, the quality of melanoma image data sets is low, which reduces the accuracy and the effectiveness of computer aided diagnosis of melanoma image.

Objective: In this work, a method of melanoma image segmentation by incorporating medical prior knowledge is proposed to improve the fidelity of melanoma image segmentation.

CT enterography for evaluation of disease activity in patients with ileocolonic Crohn's disease.

Background: CT enterography (CTE) is used routinely for assessment of activity and severity in Crohn's disease (CD), but there are few CTE scoring systems. The aim of this study was to develop a quantitative CTE scoring system for ileocolonic Crohn's disease activity.

Methods: Forty-nine CD patients with ileocolonic involvement were retrospectively included between March 2015 and May 2018.

Cerebral Metabolic Network in Patients With Anti--Methyl-D-Aspartate Receptor Encephalitis on 18F-FDG PET Imaging.

Background: Anti--methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis (AE), and the prognosis may significantly be improved if identified earlier and immune-related treated more effectively. This study evaluated the brain metabolic network using fluorodeoxyglucose positron emission tomography (FDG PET).

Material And Methods: FDG PET imaging of patients with NMDAR encephalitis was used to investigate the metabolic connectivity network, which was analyzed using the graph theory.

Plant growth-promoting abilities and community structure of culturable endophytic bacteria from the fruit of an invasive plant .

Diversity of endophytic bacterial communities of capsular fruit, upper and lower seeds of an invasive plant growing in Xinjiang, China, was investigated. All isolates from the seed capsules, the upper seeds, and the lower seeds were identified by 16S rRNA gene sequencing, and sequences were compared to bacterial databases to define operational taxonomic units (OTUs). Finally, we obtained 316 endophytic isolates corresponding to 58 OTUs based on 16S rRNA gene sequences.

Allelopathic, Phytotoxic, and Insecticidal Effects of Serg. Essential Oil and Its Major Constituents.

The chemical profile of essential oil (EO) and its allelopathic, phytotoxic, and insecticidal activity was evaluated. Carvacrol, p-cymene, and γ-terpinene were detected as the major components of the EO, representing 85.9% of the total oil.

Chemical Composition and Phytotoxic Activity of Seriphidium terrae-albae (Krasch.) Poljakov (Compositae) Essential Oil.

To evaluate the potential value of Seriphidium terrae-albae (Krasch.) Poljakov essential oil as bioherbicide, its chemical composition as well as phytotoxic activity was investigated. Seventeen compounds were identified via GC/MS, representing 98.

miR-27a induced by colon cancer cells in HLECs promotes lymphangiogenesis by targeting SMAD4.

Aim: Metastasis of tumor cells occurs through lymphatic vessels, blood vessels and transcoelomic spreading. Growing evidence from in vivo and in vitro studies has indicated that tumor lymphangiogenesis facilitates metastasis. However, the regulation of lymphangiogenesis in colon cancer remains unclear.