Malachite green in environmental samples: Updates on sources, fates, distribution and removal techniques.

Malachite green (MG) is a synthetic triphenylmethane dye originally employed as an industrial colorant in textile, paper, and leather industries. Its subsequent application in aquaculture was driven by its demonstrated antibacterial and antiparasitic properties. However, substantial evidence has revealed its high toxicity, including carcinogenic, teratogenic, and mutagenic effects, posing severe threats to both ecological systems and human health, leading to strict regulations or outright bans in numerous countries.

Cytological diagnosis of dysgerminoma associated with pregnancy via peritoneal effusion analysis: a case report.

Background: Dysgerminoma, a uncommon malignant neoplasm originating from primitive ovarian germ cells, is exceptionally rare during pregnancy. While several studies have documented dysgerminoma diagnosis via peritoneal effusion cytology, no cases identified during pregnancy have been reported to date. This study presents the first reported case of dysgerminoma diagnosed through peritoneal effusion cytology in a pregnant patient.

CompletionMamba: Taming State Space Model for Point Cloud Completion.

Point cloud completion aims to reconstruct complete 3D shapes from partial scans. The long-range dependencies between points and shape perception are crucial for this task. While Transformers are effective due to their global processing ability, the quadratic complexity of their attention mechanism makes them unsuitable for long sequences when computational resources are constrained.

Multiple-omics analysis of three novel haloalkaliphilic species of revealed that the phenolic acid-degrading abilities are ubiquitous in the genus.

Phenolic acids (PAs), which can exert toxic effects on seed germination and plant growth, are the most common allelopathic substances found in soils. To better understand the degradation fates of PAs in the rhizosphere of halophytes, five haloalkaliphilic PA-degrading bacteria, which were identified as three novel species of (namely, sp. nov.

Risk factors associated with renal injury in patients initially diagnosed with IgA vasculitis.

Objective: To explore the risk factors associated with renal injury in patients diagnosed with IgA vasculitis at initial presentation.

Methods: A retrospective analysis was conducted on the clinical data of 384 children who were newly diagnosed with Immunoglobulin A vasculitis (IgAV) and hospitalized between July 2020 and June 2023. The participants were categorized into two groups based on whether their 24-hour urinary protein levels exceeded 150 mg upon admission.

Immune microenvironment heterogeneity characterizes biologically distinct KRAS/SPOP and KRAS/PIK3CA mesonephric-like adenocarcinoma subtypes revealed by integrated whole-exome and transcriptomic profiling.

Objective: This study aims to uncover the molecular biology and immune microenvironment of gynecological mesonephric-like adenocarcinoma (MLA).

Methods: To determine the comprehensive characteristics of MLA, 17 patients with MLA were retrospectively enrolled in this study. Whole-exome sequencing and mRNA sequencing were performed to explore the molecular features.

Riboflavin metabolism involved into comparison of therapeutic action of wild-simulated and transplanted to treat chronic atrophic gastritis rats based on endogenous-xenobiotics metabolism.

Objective: (AR, Huangqi in Chinese) has been utilized generally as a bulk drug for the treatment of chronic atrophic gastritis (CAG) in China. The efficacy of wild-simulated AR (WAR) and transplanted AR (TAR) commercially available is unclear. This study aimed to further clarify the therapeutic action of WAR and TAR to treat CAG rats based on endogenous-xenobiotics metabolism.

CD8GZMKCD27CCR7 T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells.

Splenic sympathetic activity critically modulates peripheral immunity after ischemic stroke, thus intervention in spleen sympathetic activity represents a promising therapeutic strategy for stroke. However, the mechanisms underlying spleen-brain-immune axis communication remain poorly understood. Here, we utilized a surgical denervation protocol to perform splenic sympathetic denervation (SDN), which significantly attenuated brain injury following stroke.

Reduced water loss rather than increased photosynthesis controls CO-enhanced water-use efficiency.

Numerous leaf-level experiments suggest that plant intrinsic water-use efficiency (iWUE) increases under elevated CO because of reduced stomatal conductance and enhanced photosynthesis. However, it remains elusive whether this response can be extrapolated to the ecosystem scale, because confounding factors and compensating feedbacks are often involved in ecosystem iWUE variations. Here we develop a machine learning-based framework to disentangle the ecosystem-scale CO effects on iWUE and its two components, canopy conductance (Gc) and gross primary productivity (GPP), based on global networks of long-term eddy covariance observations.

When and where soil dryness matters to ecosystem photosynthesis.

Projected increases in the intensity and frequency of droughts in the twenty-first century are expected to cause a substantial negative impact on terrestrial gross primary productivity (GPP). Yet, the relative role of soil water supply (indicated by soil moisture) and atmospheric water demand (indicated by vapour pressure deficit, VPD) on GPP remains debated, primarily due to their strong covariations, the presence of confounding factors and unresolved causal relationships among the interconnected hydrometeorological drivers of GPP. Here using a causality-guided explainable artificial intelligence framework, we show that soil moisture is the dominant regulator of water stress, surpassing the role of VPD, when and where soil water supply limits ecosystem functions.

Enhanced Hydrogen Adsorption on InO(111) via Oxygen Vacancy Engineering.

The emergence of InO as an efficient catalyst for selective hydrogenation has attracted significant attention. However, the mechanism of hydrogen (H) dissociation on InO remains experimentally elusive. In this work, we show that the interaction of H with InO is strongly influenced by the presence of oxygen vacancies.

Expression and correlation of SOCS3 and Eotaxin mRNA and proteins levels in nasal mucosal tissue of allergic rhinitis patients.

Objective: This study aims to investigate the expression and interaction mechanisms of Suppressor of Cytokine Signaling 3 (SOCS3) and Eotaxin in the nasal mucosal tissues of patients with Allergic Rhinitis (AR).

Methods: In this retrospective study, we selected nasal mucosa tissues from 35 AR patients as the AR group, and nasal mucosa tissues from 22 patients with isolated nasal septum deviation as the control group. Utilizing reverse transcription polymerase chain reaction (RT-PCR) techniques, we measured the expression levels of SOCS3 mRNA and Eotaxin mRNA in both groups.

ROR1 expression in ovarian cancer patients and its association with chemotherapy response and prognosis.

Objective: To investigate the expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) in ovarian cancer tissues and its correlation with clinicopathologic features, chemotherapy sensitivity, and prognosis in patients with ovarian cancer.

Methods: Paraffin tissue blocks were collected from 227 ovarian cancer patients, and immunohistochemical (IHC) staining was performed to analyze the expression of ROR1. The associations between ROR1 expression and clinicopathologic features, treatment response, and prognosis were evaluated.

Identification of Pb-responsive GST transcripts in Salix integra and Pb tolerance of transgenic plants overexpressing SiGSTU55.

The escalating severity of soil Pb pollution has intensified the focus on phytoremediation technologies. The biomass advantages of woody plants offer broader prospects for their application in phytoremediation. Fast-growing woody plant Salix integra exhibit significant potential for remediating Pb pollution.

Research on the technology of unloading pressure and preventing punching in extra-thick coal seams.

This study addresses stress concentration in roadways and elastic energy accumulation in the cantilever beam of hard roofs within the goaf of extra-thick coal seams. Using the 61,607 working face of Longwanggou Mine as a case study, the key roof layer was identified through theoretical calculations, and hydraulic fracturing parameters were optimized via zoning and grading. Stress changes, displacement, and fracture distribution in the downtrack and retreat areas were analyzed using 3DEC software before and after fracturing.

Globally interconnected solar-wind system addresses future electricity demands.

Accelerating energy transition towards renewables is central to net-zero emissions. However, building a global power system dominated by solar and wind energy presents immense challenges. Here, we demonstrate the potential of a globally interconnected solar-wind system to meet future electricity demands.

Diminished biophysical cooling benefits of global forestation under rising atmospheric CO.

Forestation is a proposed solution for mitigating global warming through carbon sequestration. However, its biophysical effects through surface energy modulation, particularly under rising CO levels, is less understood. Here we investigate the biophysical effects of global potential forestation on near-surface air temperature (T) under increasing CO concentrations using a land-atmosphere coupled model with slab ocean module.

Feasibility and acceptability of human papillomavirus self-sampling compared with clinician sampling in urban areas of western China: a cross-sectional survey.

Introduction: Cervical cancer, driven by persistent high-risk human papillomavirus (hrHPV) infection, remains a global health challenge, especially in low- and middle-income areas such as western China. Despite the critical role of HPV testing in early detection, coverage in China remains low due to cultural, psychological, and other barriers. Self-collected urine and vaginal samples offer alternative methods for sample collection.

Dual-tracer PET in prostate synovial sarcoma: discordant FDG and PSMA uptake with metastatic patterns.

We present the case of primary prostatic synovial sarcoma exhibiting discordant tracer avidity on [F]-FDG PET/MRI and [F]-PSMA PET/CT-a metabolic divergence suggesting clonal evolution and potential eligibility for PSMA-targeted radioligand therapy to combat poor survival in this rare sarcoma subtype.

Immunotherapy in gestational trophoblastic neoplasia: advances and future directions.

Gestational trophoblastic neoplasia (GTN) is a rare but aggressive malignancy that follows normal or aberrant pregnancies. Until the advent of immunotherapy in 2017, surgery and chemotherapy were the standard treatment modalities, with chemotherapy remaining the cornerstone. However, chemoresistance and high-risk disease present significant challenges in managing GTN.

Distinct endometriosis involvement confers divergent oncologic outcomes in ovarian clear cell carcinoma.

Objective: To evaluate the clinicopathologic characteristics and survival outcomes of ovarian clear cell carcinoma (OCCC) patients with different endometriosis statuses.

Methods: This retrospective study included OCCC patients diagnosed between 2012 and 2021, classified into three groups based on the Sampson and Scott criteria: Without (no endometriosis), Arising (OCCC arising from endometriosis), and Coexisting (OCCC coexisting with endometriosis). Clinical and pathological characteristics were compared across groups, and survival outcomes were analyzed using Kaplan-Meier methods.

Development and characterization of the novel MYD88 mutated, 6q deleted BCWM.2 cell line for Waldenström macroglobulinaemia.

Cell lines have enabled a comprehensive understanding of disease biology and the advancement of new therapeutics in Waldenström macroglobulinaemia (WM). Herein, we report the development of BCWM.2, a novel WM cell line derived from an untreated symptomatic WM patient.

Deep learning enabled liquid-based cytology model for cervical precancer and cancer detection.

Deep learning (DL) enabled liquid-based cytology has potential for cervical cancer screening or triage. Here, we develop a DL model using whole cytology slides from 17,397 women and test it on 10,826 additional cases through a three-stage process. The DL model achieves robust performance across nine hospitals.

A CPApoptosis nano-actuator switches immune-off solid tumors to immune-on for fueling T-cell- based immunotherapy.

Most anticancer agents induce tumor apoptosis, but they often lack immunogenicity and display limited success when combined with mainstream immunotherapies, thus killing cancer cells through multiple cell death modalities as well as switching immune-off tumors to immune-on is a strategy with great promise. To this end, we developed a CPApoptosis (cuproptosis, pyroptosis, apoptosis) nano-actuator for immunologically cold solid tumors. In this study, elesclomol (ES), a mitochondrial targeting copper transporter, was encapsulated within bacterial outer membrane vesicles (OMVs).

VCF2Dis: an ultra-fast and efficient tool to calculate pairwise genetic distance and construct population phylogeny from VCF files.

Background: Genetic distance metrics are crucial for understanding the evolutionary relationships and population structure of organisms. Progress in next-generation sequencing technology has given rise of genotyping data of thousands of individuals. The standard Variant Call Format (VCF) is widely used to store genomic variation information, but calculating genetic distance and constructing population phylogeny directly from large VCF files can be challenging.