Factors Related to Long-Term Caregiving Burden Among Chimeric Antigen Receptor (CAR) T-Cell Recipients and Their Informal Caregivers.

Context: Caregivers are essential in the care of CAR T-cell patients, especially immediately before and after CAR T-cell therapy. However, the long-term CAR T-cell therapy caregiving implications are understudied.

Objectives: We aimed to characterize long-term caregiver health-related quality of life (HRQoL) and caregiving burden and understand the relationship between long-term caregiving burden and patient-reported HRQoL, cognitive function, and symptom burden.

Development and clinical implementation of an MRI-only planning workflow featuring deep learning-based synthetic CT for prostate cancer external beam radiotherapy.

Background: In external beam radiation therapy (EBRT) for prostate cancer, both MRI and CT are typically used-CT provides electron density for dose calculation and visualization of bony anatomy and fiducial markers, while MRI offers superior soft tissue contrast. With recent advances in deep learning, synthetic CT (sCT) images can now be generated from MRI, potentially eliminating the need for separate CT scans.

Purpose: To clinically implement an MRI-only planning (MROP) workflow for both X-ray and MRI-guided systems.

Transcriptional responses to oxygen gradients in cyanobacterial aggregates.

Cyanobacterial aggregates (CAs) are the main cause of harmful cyanobacterial blooms in freshwater lakes, posing serious risks to water quality and ecosystem health. The ecological success of CAs is closely linked to their abilities to adapt to fluctuating dissolved oxygen (DO) levels. In this study, we investigated the transcriptional responses of CA-associated microbial communities across a gradient of DO concentrations (0-6 mg/L) using incubation experiments combined with 16S rRNA transcript and metatranscriptomic sequencing.

Type I-F CRISPR-associated transposons contribute to genomic plasticity in and mediate efficient programmable DNA integration.

The genome plasticity of species and strains in the genus is closely associated with the diverse mobile genetic elements embedded in its genomes. One mobile element with potential for accurate and efficient DNA insertion in is the type I-F3 CRISPR-associated transposon (I-F3 CAST). However, relatively little is known about the distribution and ecological significance of I-F3 CASTs and whether they could be suitable as a tool for targeted genetic manipulation .

Identification of three novel GNAO1 variants in a Chinese cohort with GNAO1 encephalopathy: expanding the clinical and genetic spectrum.

Objective: To summarize the clinical characteristics of a cohort of nine Chinese children with GNAO1 encephalopathy and analyze their genotypes.

Methods: A retrospective study was conducted on nine children diagnosed with GNAO1 encephalopathy at the Neurology Department of two children's hospitals between January 2019 and December 2022. Their clinical manifestations, genetic test results, cranial imaging, electroencephalography and treatment were summarized.

Defective autophagy in vascular smooth muscle cells promote uremic accelerated atherosclerosis.

Individuals with chronic kidney disease (CKD) exhibit a significantly elevated risk of premature mortality, predominantly attributable to cardiovascular etiologies. Atherosclerosis is a multifactorial vascular pathology driven by dysregulated lipid metabolism. Notably, patients with CKD exhibit an accelerated progression of atherosclerosis, a condition referred to as uremia-accelerated atherosclerosis (UAAS).

Korean and Chinese citizens' pandemic fatigue and related factors amidst the prolonged COVID-19 pandemic: Implications for risk communication.

Pandemic fatigue has emerged as a significant public health challenge, particularly in countries that implemented prolonged COVID-19 public health and social measures (PHSM). Understanding the factors contributing to pandemic fatigue and its impact on adherence to health protective behaviors is essential for sustaining public engagement in long-term disease management. This study examines pandemic fatigue in China and South Korea, two countries that maintained prolonged COVID-19 public health and social measures, to identify key predictors and explore its relationship with health protective behaviors.

A dynamic reconstruction and motion estimation framework for cardiorespiratory motion-resolved real-time volumetric MR imaging (DREME-MR).

Based on a 3D pre-treatment magnetic resonance (MR) scan, we developed DREME-MR to jointly reconstruct the reference patient anatomy and solve a data-driven, patient-specific cardiorespiratory motion model. Via a motion encoder simultaneously learned during the reconstruction, DREME-MR further enables real-time volumetric MR imaging and cardiorespiratory motion tracking with minimal intra-treatment k-space data. Approach: DREME-MR integrates dynamic MRI reconstruction and real-time MR imaging into a unified, dual-task learning framework.

Feasibility and preliminary efficacy of a lymphedema and fibrosis self-management program for head and neck cancer survivors: a pilot randomized controlled trial.

Objectives: Survivors of head and neck cancer (HNC) are at high risk for developing lymphedema and fibrosis (LEF). Once diagnosed with LEF, survivors must engage in a lifelong program of self-care to minimize long-term adverse effects. However, evidence-based LEF self-management (SM) programs are lacking.

Integrating metabolic scaling and coexistence theories.

Metabolic scaling theory has been pivotal in formalizing the expected energy expenditures across populations as a function of body size. Coexistence theory has provided a mathematization of the environmental conditions compatible with multispecies coexistence. Yet, it has been challenging to explain how observed community-wide patterns, such as the inverse relationship between population abundance density and body size, can be unified under both theories.

SAM2-Aug: Prior knowledge-based Augmentation for Target Volume Auto-Segmentation in Adaptive Radiation Therapy Using Segment Anything Model 2.

Purpose: Accurate tumor segmentation is vital for adaptive radiation therapy (ART) but remains time-consuming and user-dependent. Segment Anything Model 2 (SAM2) shows promise for prompt-based segmentation but struggles with tumor accuracy. We propose prior knowledge-based augmentation strategies to enhance SAM2 for ART.

Coverage and Vaccine Hesitancy of Influenza Vaccination Among Reproductive-Age Women (18-49 Years Old) in China: A National Cross-Sectional Study.

: Influenza is a significant global respiratory infection, and vaccinating reproductive-age women, particularly in densely populated countries like China, cannot be overlooked. In this study, we aimed to determine influenza vaccination coverage, vaccine hesitancy, as well as associated factors among Chinese women aged 18-49 years old. : A cross-sectional survey among women aged 18-49 years was conducted in China from 15 to 30 March 2023.

Circular Polarimetric Imaging with a Metamaterial Integrated Long-Wavelength Infrared Focal Plane Array.

Long-wavelength infrared (LWIR) circular polarimetric imaging plays an important role in many areas. The immediacy of polarimetric imaging and the miniaturization of devices drive considerable efforts to division-of-focal-plane-array (DoFPA) circular polarimeters. However, the realization of such detectors is hampered by low polarization discrimination, reduced absorption in the detection material, and fabrication complexity.

Bovine serum albumin modified carbon dots and berberine composite promotes tumor mitochondrial dysfunction and apoptosis.

Precise delivery of antitumor drugs has become a research focus in cancer treatment. Herein, we developed a bovine serum albumin (BSA) modified carbon dots (CDs) and berberine (BBR) composite for improved intravenous BBR delivery. The surface-negatively charged CDs can associate with positively charged BBR through electrostatic interactions, resulting in CDs and BBR composite (BBR@CDs).

Dynamic Modulation of Multicellular Interactions via ATP-Dissipative DNA Assembly.

Living cells exhibit dynamic adaptability through ATP-fueled processes that are crucial for tissue development and immune responses. Conventional methods for controlling cell assembly lack the nonequilibrium, reversible behavior of natural systems. Here, we present an ATP-dissipative DNA assembly system that leverages DNA's programmability to enable adaptive, hierarchical structures with spatiotemporal control.

A Centimeter-Scale Quadruped Piezoelectric Robot with High Integration and Strong Robustness.

Centimeter-scale robots have unique advances such as small size, light weight, and flexible motions, which exhibit great application potential in many fields. Notably, high integration and robustness are 2 key factors determining the locomotion characteristics and practical applications. Here, we propose a novel centimeter-scale quadruped piezo robot.

Influence factors and improving strategies of perceived safety - an on-road study with L2 autonomous driving.

Perceived safety (PS) and trust are important factors that influence the adoption of autonomous driving. In order to study the factors influencing PS and the possibility of real-time monitoring, an on-road experiment with L2 autonomous driving with 30 participants was conducted. Participants experienced autonomous driving functions as co-drivers and rated PS through video replays.

Report on the quantitative intra-voxel incoherent motion diffusion MRI reconstruction grand challenge.

Purpose: The 2024 quantitative intra-voxel incoherent motion diffusion MRI (IVIM-dMRI) reconstruction grand challenge aimed to benchmark and advance reconstruction algorithms for extracting quantitative tissue parameters from diffusion MRI (dMRI) data. Focusing on the IVIM model, the challenge aimed to improve the accuracy and robustness of clinical parameter estimation, addressing key barriers to broader clinical adoption.

Methods: Participants were tasked with reconstructing fractional perfusion, pseudo-diffusion coefficient, and true diffusion coefficient from simulated -space data based on realistic digital VICTRE phantoms.

Implementation of a Program for Combined Intra-Gestational and Systemic Methotrexate Injection to Treat Non-Tubal Ectopic Pregnancy: A Report of Outcomes and Feasibility.

Non-tubal ectopic pregnancies (NTEP) are a rare and life-threatening subset of ectopic pregnancies, with their clinical management poorly defined. This study evaluated the effectiveness of combined methotrexate injection (intra-gestational/systemic) for NTEP in an outpatient setting. In this case series (January 2019-December 2023), our institution introduced a program to treat NTEP using ultrasound-guided transvaginal intra-gestational methotrexate injection (100 mg) and intramuscular methotrexate (25 mg) with fetal intracardiac potassium chloride, if cardiac activity present.

Canopy-Mediated Dynamics of Moss Communities in Primary Succession: Coupling of N-Fixation and Biomass Accumulation in Subalpine Forests Following Glacial Retreat.

Accelerated glacial retreat has exposed bare substrates in polar and alpine regions, creating opportunities for investigating primary vegetation succession. Mosses are pioneer species critical for soil development, nutrient cycling, and establishment of subsequent vegetation succession. However, the dynamics of moss communities during primary succession and their responses to canopy-mediated environmental changes are poorly known.

Bifidobacterium animalis subsp. Lactis BX-BC08 modulates gut microbiota and secretes alpha-Ketoglutaric acid to alleviate MC903-induced atopic dermatitis.

Objective: Bifidobacterium is known to be depleted in patients with atopic dermatitis (AD). This study aims to investigate the potential prophylactic effects of Bifidobacterium animalis subsp. lactis BX-BC08 (B.

Targeting tumor-associated macrophages in gastric cancer progression and therapy: insights from molecular mechanisms to therapeutic applications.

Gastric cancer (GC) is the fifth most common malignant tumor that imposes heavily public health burdens worldwide. Systemic therapies for gastric cancer (GC), such as chemotherapy, targeted therapy, and immunotherapy, have undergone significant advancements. Nevertheless, the extensive application of anti-cancer agents has resulted in an increasing array of challenges related to drug resistance, presenting a substantial barrier in GC treatment.

Mpox vaccination hesitancy and its associated factors among the general population in China: A national observational study.

Mpox, formerly known as monkeypox, has been spread to more than 100 countries until now. Vaccines are vital measures to protect against mpox infection. However, vaccine hesitancy remains a barrier to achieving widespread vaccination coverage.