The interaction between blood lipids and ASCVD increases the risk of DKD: a nonlinear relationship transforms into a linear relationship, a cross-sectional study.

Background: Atherosclerotic cardiovascular disease (ASCVD) and diabetic kidney disease (DKD) are interconnected vascular complications in diabetes, with dyslipidemia playing a key role. The modifying effect of ASCVD on the lipid-DKD relationship in diabetic patients without lipid-lowering treatment remains unclear.

Methods: This retrospective study included 26,476 type 2 diabetic patients without lipid-lowering therapy.

Causal Link of Seven Trace Elements and Eight Nutrients With Meningioma: A Bidirectional Two-Sample Mendelian Randomization Analysis.

Background: Meningiomas, the second most common intracranial tumors, account for over one-third of primary central nervous system tumors. Recent studies suggest a link between trace elements, nutrients, and tumor development. This study used Mendelian randomization (MR) to investigate causal links between trace elements, nutrients, and meningioma.

Charge transfer engineering of carbon-coated porous ZnO to enhance oxygen reduction for high-efficiency piezocatalytic HO production.

Piezocatalysis holds remarkable potential for enabling eco-friendly and sustainable HO production. In this study, a porous nanosheet-structured ZnO was synthesized morphological engineering, demonstrating an enhanced surface area and superior stress responsiveness. Furthermore, a carbon layer derived from sodium lignosulfonate was introduced to construct a series of porous C/ZnO composites.

Efficacy and safety of cAMP-biased GLP-1 receptor agonist ecnoglutide versus dulaglutide in patients with type 2 diabetes and elevated glucose concentrations on metformin monotherapy (EECOH-2): a 52-week, multicentre, open-label, non-inferiority, randomised, phase 3 trial.

Background: Ecnoglutide is a novel biased GLP-1 receptor agonist that preferentially activates the cAMP pathway over β-arrestin recruitment. We aimed to assess both non-inferiority and superiority of ecnoglutide versus dulaglutide, also a GLP-1 receptor agonist, in patients with type 2 diabetes.

Methods: We conducted a 52-week, open-label, active-controlled, phase 3 trial at 52 hospitals in China.

Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition.

Defense-associated reverse transcriptase (DRT) systems are implicated in prokaryotic resistance to viral infections, yet the molecular mechanisms underlying their functionality remain largely unknown. Here, we characterize a two-component DRT9 system, composed of a reverse transcriptase (RT) and a non-coding RNA (ncRNA), which exhibits a protein-primed DNA synthesis activity upon phage infection. We also determine its cryo-electron microscopy (cryo-EM) structures in different functional states.

Physiological changes and gene expression in the mixotrophic haptophyte, Prymnesium parvum, respond to mixed nitrogen sources.

Prymnesium parvum is a toxin-producing haptophyte that adapts to various conditions in aquaculture wastewater, using strategies like allelopathy, toxicity, and predation to survive. However, knowledge about physiological and genetic responses of P. parvum to mixed nitrogen sources in aquaculture wastewater is still limited.

A versatile apparatus for cold ion-molecule reaction dynamics: Integration of laser-cooled ions with velocity- and quantum-state- controlled molecular beams under ultra-high vacuum.

We describe a versatile experimental apparatus designed for investigating ion-molecule reaction dynamics at low temperatures under ultra-high vacuum conditions (<8 × 10-11 Torr). The system integrates laser-cooled atomic ions confined in a linear Paul trap with a pulsed molecular beam featuring simultaneous quantum-state and velocity selection. Reaction products are identified using fluorescence imaging and a time-of-flight mass spectrometer.

Exploitation and Comprehensive Performance Evaluation of Long-Afterglow Luminescent Road Marking Coatings Based on Combined Weighting-VIKOR Method.

Long-afterglow luminescent coatings, as photoluminescent materials, can effectively enhance road visibility at night, thereby ensuring traffic safety. Therefore, developing long-afterglow luminescent coatings with excellent afterglow performance and pavement properties is crucial. In this study, the combination weighting-VIKOR method was applied to evaluate seven indicators: luminescent brightness, luminous flux, abrasion resistance, skid resistance, adhesion, stain resistance, and ultraviolet aging resistance, to determine the optimal coating ratio.

[Application value of pediatric sepsis-induced coagulopathy score and mean platelet volume/platelet count ratio in children with sepsis].

Objective: To investigate the application value of pediatric sepsis-induced coagulation (pSIC) score and mean platelet volume/platelet count (MPV/PLT) ratio in the diagnosis of pediatric sepsis and the determination of critical pediatric sepsis.

Methods: A retrospective cohort study was conducted, selecting 112 children with sepsis (sepsis group) admitted to pediatric intensive care unit (PICU) of Liaocheng Second People's Hospital from January 2020 to December 2023 as the study objects, and 50 children without sepsis admitted to the pediatric surgery department of our hospital during the same period for elective surgery due to inguinal hernia as the control (control group). The children with sepsis were divided into two groups according to the pediatric critical case score (PCIS).

Valorization of blueberry pomace and red mud to zero valent iron biochar for antibiotic degradation with diminishment of toxic reagents.

Application of zero valent iron biochar (ZVI-BC) activated persulfate (PS) oxidation in various antibiotics treatments has been universally confirmed. Full utilization of biomass waste characteristics to reduce usage of toxic reagents in the preparation of ZVI-BC is an environmental optimization strategy. Herein, tetracycline (TC) degradation based on PS-oxidation activated by a novel ZVI-BC (ZVI-FeO-BC) was assessed, in which blueberry pomace extraction substitutes part of sodium borohydride and red mud substitutes iron salt.

Predictors and Prognosis of Mild Regurgitation After Rheumatic Mitral Valve Repair: A Dual-Center Cohort Analysis Based on Cardiac Computer Tomography.

Objectives: Rheumatic mitral disease (RMD) remains a significant health issue, especially in developing regions. Although mitral valve (MV) repair improves outcomes, residual mild mitral regurgitation (MR) is common. This study aims to identify clinical and anatomical factors associated with residual mild MR after MV repair and to assess its impact on MR progression and survival.

Protective effect of high-density lipoprotein in infective endocarditis patients after valve surgery.

Introduction: Lipoproteins and insulin resistance are associated with the prognosis of cardiovascular disease, with strong evidence supporting a causal relationship for some; however, whether lipoproteins and insulin resistance have prognostic value in patients with infective endocarditis after valve surgery remains unclear.

Methods: We included 278 consecutive patients with a definite diagnosis of IE who underwent valve surgery from January 2010 to December 2022. Mortality was analyzed in relation to lipid profile and insulin resistance.

Unveiling the Correlation between the Alkyl Chain Length of Amphiphiles in Chiral Supramolecular Nanocatalysts and Enantioselectivity.

The correlation between the molecular structure of chiral amphiphiles and the enantioselectivity exhibited by their corresponding chiral supramolecular assemblies is a critical factor in enabling asymmetric catalysis. Herein, the self-assembly of l/d-phenylglycine-based amphiphiles (l/d-PhgC, = 8, 12, 15, 16, 17, 18, and 20) with varying alkyl chain lengths into chiral supramolecular catalysts via Cu(II) coordination is reported, and their enantioselectivity in catalyzing the asymmetric Diels-Alder reaction is systematically investigated. Among the series, the l-PhgC-based supramolecular catalyst achieves exceptional enantioselectivity (96% ), whereas analogs with shorter ( < 16) or longer ( > 18) alkyl chains display diminished selectivity or even racemic outcomes.

The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency.

The STING pathway is increasingly recognized as a key regulator of neuroinflammation in neurodegenerative disease, but its role in noninflammatory conditions remains unclear. We generated a postnatal inducible whole-body Ngly1 knockout mouse (iNgly1-/-) to model NGLY1 deficiency, an early-onset neurodegenerative disorder. iNgly1-/- mice exhibit progressive motor deficits, Purkinje cell loss, and shortened lifespan without evidence of gliosis or immune activation.

Multifunctional Bioactive Cu-Sm-Based Nanozyme Systems for Psoriasis Therapy.

As a persistent inflammatory dermatological disorder, psoriasis impacts a global population of millions, with existing therapies frequently limited by side effects, high toxicity, and low effectiveness. Herein, we present the design and synthesis of a copper-samarium (Cu-Sm)-based bimetallic nanozyme (CS NPs) with strong antioxidant and anti-inflammatory characteristics for psoriasis therapy. CS NPs imitate natural antioxidant enzymes and efficiently neutralize HO, OH, and O.

Phosphodiesterase 2A as a Therapeutic Target for Relieving Mechanical Allodynia and Modulating Microglial Polarization in Neuropathic Pain Models Following Spinal Cord Injury.

Spinal cord injury (SCI) is a severe clinical condition often accompanied by multiple complications, with neuropathic pain (NP) being one of the most persistent and difficult conditions to treat. The underlying mechanisms of NP remain unclear, and effective clinical treatments are lacking. Some studies suggest that phosphodiesterase 2A (PDE2A) may contribute to the development of NP.

Glutathione-based supramolecular chiral nanozyme for colorimetric enantioselective sensing of 3,4-dihydroxyphenylalanine.

The determination of the absolute configuration and enantiomeric composition of chiral species is of great significance. Nevertheless, the accurate quantification through output signals related to the identity of chiral analytes has been rarely reported in this regard. In this study, through the self-assembly of glutathione (GSH) and Cu, supramolecular chiral nanoparticles (GSH-Cu) were constructed for the enantioselective sensing of chiral 3,4-dihydroxyphenylalanine (DOPA).

Efficacy and safety of a biased GLP-1 receptor agonist ecnoglutide in adults with overweight or obesity: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

Background: Ecnoglutide is a novel cyclic adenosine monophosphate (cAMP)-biased GLP-1 receptor agonist currently in development for weight management. We aimed to assess the efficacy and safety of once weekly ecnoglutide versus placebo for the treatment of overweight or obesity in Chinese adults.

Methods: This randomised, double-blind, placebo-controlled, phase 3 trial was done at 36 medical centres across China.

Potential of Urinary Mutation and Methylation Biomarkers in Selecting Candidates for Repeat Transurethral Resection of Bladder Tumor in Non-muscle-invasive Bladder Cancer: A Prospective Multicenter Study.

Background And Objective: The necessity of repeat transurethral resection of bladder tumor (re-TURBT) in patients with non-muscle-invasive bladder cancer (NMIBC) remains a matter of debate. The role of liquid biopsy in predicting residual tumor status and selecting patients who can be spared re-TURBT is still undefined. The aim of our study was to assess the efficacy of the urinary OncoUrine assay for mutation and methylation markers in determining the necessity for re-TURBT in NMIBC.

Porphyrin-based supramolecular chiral assembly for enantioselective interaction and augmented photodynamic therapy.

Supramolecular chiral assemblies are mostly studied as drug carriers because of their enantioselective interaction with biological systems. However, this approach may compromise chirality-dependent therapeutic efficacy and potentially underestimate the significance of chirality in nanomedicine. Herein, supramolecular chiral nanoparticles, D/L-arginine (Arg)-meso-tetra(4-carboxyphenyl) porphine (TCPP), were constructed through the self-assembly of D/L-Arg and TCPP.

Overexpression of TaPIP1A enhances drought and salt stress tolerance in Arabidopsis: cross-species conservation and molecular dynamics.

Understanding the mechanisms underlying plant responses to abiotic stress is crucial for improving crop resilience. This study characterizes the role of , a member of the plasma membrane intrinsic proteins (PIPs) in wheat, highlighting its critical function in mediating stress responses. We demonstrate that enhances tolerance to salt and drought stress through specific protein-protein interactions and transcriptional regulation.

Whole-lesion-aware network based on freehand ultrasound video for breast cancer assessment: a prospective multicenter study.

Background: The clinical application of artificial intelligence (AI) models based on breast ultrasound static images has been hindered in real-world workflows due to operator-dependence of standardized image acquisition and incomplete view of breast lesions on static images. To better exploit the real-time advantages of ultrasound and more conducive to clinical application, we proposed a whole-lesion-aware network based on freehand ultrasound video (WAUVE) scanning in an arbitrary direction for predicting overall breast cancer risk score.

Methods: The WAUVE was developed using 2912 videos (2912 lesions) of 2771 patients retrospectively collected from May 2020 to August 2022 in two hospitals.

Knowledge, Attitudes, and Practices Toward Unexplained Recurrent Pregnancy Loss Among Afflicted Women.

Background: To explore the knowledge, attitudes, and practices (KAP) regarding recurrent pregnancy loss (RPL) of women with unexplained RPL.

Methods: This cross-sectional study enrolled women with unexplained RPL in the Reproductive Medicine Centre of Shanxi Maternal and Child Health Hospital between August 28 and September 28, 2024. Data were collected through a self-designed questionnaire encompassing sociodemographic characteristics and three dimensions of KAP.

miR-1236-3p targets Toll-like receptor 4 to suppress the anti- activity of macrophage.

() modulates host innate immunity via Toll-like receptor 4 (TLR4), associated with the susceptibility to . Bioinformatics predicted miR-1236-3p could be a potential target for the 3'-UTR of the gene. However, the clinical significance and underlying mechanisms remain unclear.