Predicting Microsatellite Instability in Endometrial Cancer by Multimodal Magnetic Resonance Radiomics Combined with Clinical Factors.

Rationale And Objectives: To develop a nomogram integrating clinical and multimodal MRI features for non-invasive prediction of microsatellite instability (MSI) in endometrial cancer (EC), and to evaluate its diagnostic performance.

Materials And Methods: This retrospective multicenter study included 216 EC patients (mean age, 54.68 ± 8.

A multicenter retrospective study on anesthesia methods and their impact on neurocognitive outcomes and other complications in elderly patients undergoing hemiarthroplasty.

Objective: To evaluate the effects of various anesthesia techniques on perioperative neurocognitive disorders (PND) and other postoperative complications in elderly patients undergoing hemiarthroplasty for hip fractures.

Methods: This multicenter retrospective observational study analyzed 5,005 elderly patients (≥65 years) with hip fractures who underwent hemiarthroplasty and had complete perioperative clinical data. Patients were categorized into five anesthesia groups: a, Combined intravenous-inhalation anesthesia (IVA + IHA); b, IVA + IHA with peripheral nerve block (PNB); c, Intravenous anesthesia (IVA) with PNB; d, Spinal anesthesia (SA); e, SA with PNB.

Co-catalysis of modified metal-organic framework immobilized enzyme with nonionic surfactant for biodiesel preparation.

With the increasing demand for sustainable energy, enzyme-catalyzed biodiesel preparation has garnered significant interest owing to its green and efficient characteristics. However, conventional immobilized lipase (LIP) is susceptible to desorption and inactivation and fails to balance the catalytic efficiency and stability, limitations that seriously restrict the industrial application. To address this, we constructed a carrier through hydrophobically modifying University of Oslo-66-NH (UiO-66-NH), an amino-functionalized metal-organic framework (MOF), with octadecylphosphonic acid (OPA).

First Case of Nocardia seriolae Infection in China Cultured Channel Catfish (Ictalurus punctatus).

Nocardia seriolae is a causative agent for fish skin ulcers and sarcoidosis, resulting in significant losses in both brackish and freshwater fish farming industries. From October to November 2023, channel catfishes (Ictalurus punctatus) cultured in Xiaowan reservoir at Dali city, Yunnan province in China, showed gross pathological changes with skin ulcers, white nodules in the liver and heart, histopathological tests revealed the typical granulomas and chronic hepatitis changes in the liver, and the clumps of filamentous bacteria in the heart and spleen. A Gram-positive acid-fast bacterium (CCF_NS01) was isolated from viscera (liver, spleen and kidney); biochemical tests and 16sRNA-GyrB gene concatenated sequences analysis of this isolated microorganism identified it as N.

Engineering B cells to Express Fully Customizable Antibodies with Enhanced Fc Functions.

Genome editing within the constant region of the immunoglobulin Heavy chain locus () can reprogram B cells to express Heavy chain only antibodies (HCAbs) containing custom antigenrecognition domains. HCAb-engineered cells express both surface B cell receptor (BCR) and secreted antibody isoforms and respond to antigen. By selecting alternate editing sites within , we extended this approach to also allow customization of the constant (Fc) domain of the Heavy chain, producing HCAbs with enhanced effector functions or containing mutations to extend antibody half-life.

Impact of exercise on cardiovascular disease risk in overweight or obese children and adolescents: a systematic review and meta-analysis.

Background: The aim of this study was to systematically evaluate the effects of exercise on cardiovascular disease (CVD) risk factors in overweight and obese children and adolescents.

Methods: Two independent reviewers conducted a comprehensive search of databases, including PubMed, the Cochrane Library, Embase, Web of Science, CNKI, and Wan Fang, covering the period from January 1, 2008, to May 19, 2025. Eligible randomised controlled trials (RCTs) were included in the meta-analysis.

Targeting p-FGFR1 Enhances CD8+ T Cells Infiltration and Overcomes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma by Regulating the CXCL8-CXCR2 Axis.

Esophageal squamous cell carcinoma (ESCC) is a fatal malignant tumor. Several studies have demonstrated that immune checkpoint inhibitors can provide clinical benefits to patients with ESCC. However, the single-agent efficacy of these agents remains limited.

A rapid-release pure iodine coating on titanium implants to mitigate acute periprosthetic infections.

Background: Periprosthetic infections remain a significant challenge in orthopedic surgeries, primarily due to bacterial biofilm formation on implant surfaces. To address this issue, we developed a novel iodine-based coating on titanium implants designed to rapidly release iodine, thereby preventing acute infections. The efficacy and safety of this coating were assessed through both experiments and an rabbit model.

Development and validation of a visual prediction model for severe acute pancreatitis: a retrospective study.

Background: Acute pancreatitis (AP) is a common acute abdominal disease. The early identification of patients at risk of progression to severe AP (SAP) is crucial for developing effective therapeutic and nursing measures. Although many scoring systems exist for SAP risk assessment, none is widely accepted.

Cultural translation of the constipation assessment a study on the reliability and validity of the Chinese version of the constipation severity index.

Background: Assessing the severity of constipation in patients is important for tailoring treatment plans and monitoring outcomes. However, validated assessment tools for constipation severity are limited in China.

Objective: This study aimed to evaluate the psychometric properties of the Chinese version of the Constipation Severity Index (CSI).

Mogrosides Protect Against Diabetic Kidney Injury via Inhibiting Macrophage Activation in a Mouse Model.

Diabetic kidney injury is an almost unavoidable complication in diabetic patients. The activation of macrophages with high glucose in the patient's body is a key factor in triggering diabetic kidney disease (DKD). Mogrosides are commonly used sweeteners, but their effects on diabetic kidney injury are still unclear.

Coupling Effects of Environmental Factors on the Phytoplankton Community Structure in Ebinur Lake, a Saltwater Lake in China.

Studying the coupled effects of environmental factors on the structure of phytoplankton communities can deepen our understanding of the stability of aquatic ecosystems in extreme environments. This study examined the phytoplankton community structure and environmental factors of saline a lake during spring, summer, and autumn in 2019. A total of 95 phytoplankton species (belonging to 47 genera and 7 phyla) were identified in Ebinur Lake, reflecting a species richness lower than those of freshwater lakes while being greater than the levels observed in other saltwater lakes.

Myricetin, as a potential new antiviral agent against Rana grylio ranavirus (RGRV).

Ranaviruses are extremely lethal viruses that pose a significant threat to aquaculture. Therefore, developing therapeutic strategies is essential for controlling these viruses. Utilizing herbal bioactive ingredients for the prevention and management of aquatic diseases shows great promise.

Associations of the volume and proportion of vigorous-intensity physical activity with all-cause, cardiovascular, and cancer mortality: a systematic review and meta-analysis.

Objective: This study aims to systematically investigate the associations of varying volumes of vigorous-intensity physical activity (VPA) and its proportion to moderate-to-vigorous intensity physical activity (MVPA) with all-cause, cardiovascular disease (CVD), and cancer mortality.

Methods: The review was registered in the PROSPERO (CRD42024525067). Web of Science, Embase, and PubMed were searched from inception to March 22, 2024.

Exposure to the prenatal enriched environment alters maternal gut microbiota and promotes embryonic neurodevelopment via activating the AHR-Src pathway.

The signals from the maternal environment play pivotal roles in regulating fetal neurodevelopment. Postnatal enriched environment (EE) exposure promotes neurogenesis and neurodevelopment. However, the roles of prenatal EE on fetal neurodevelopment and the underlying mechanisms remain largely unknown.

Cold water swimming reshapes gut microbiome to improve high-fat diet-induced obesity.

Hypothermia and swimming have been shown to alleviate high-fat diet (HFD)-induced obesity, with effects linked to the gut microbiota (GM). However, whether the effects of cold water swimming (CWS) on GM can be effectively transferred through fecal microbiota transplantation (FMT) has not been investigated. This study established mice models of obesity, CWS and FMT to investigate the mechanism by which CWS reshapes GM to improve HFD-induced obesity.

ADP-heptose-LPS heptosyltransferase I (WaaC) as a key molecule maintains morphological structure and metabolic activity, simultaneously influences pathogenicity in Vibrio mimicus.

ADP-heptose-LPS heptosyltransferase I (encoded by waaC gene) is a crucial enzyme in the lipopolysaccharide (LPS) synthesis, maintaining the stability of LPS and cell walls in numerous Gram-negative bacteria. Vibrio mimicus is an epidemic pathogen that threatens aquatic animals and human health, resulting in high morbidity and mortality after infecting the fish. Currently, the role of waaC gene in V.

Risk factors associated with secondary displacement in fractures of the humeral greater tuberosity.

Background: The incidence of secondary displacement in fractures of the greater tuberosity of the humerus remains high, irrespective of whether conservative or surgical treatment is administered. However, the specific risk factors contributing to secondary displacement of the greater tuberosity of the humerus have not been previously reported. The primary objective of this study was to analyze the risk factors associated with secondary displacement of the greater tuberosity of the humerus and to summarize corresponding guidelines for clinical diagnosis and treatment.

Study on the correlation between Flavobacterium columnare infection and gill injury in Largemouth bass (Micropterus salmoides) and the protective effect of Enoxolone.

Columnaris disease, caused by Flavobacterium columnare, has a broad host range and can afflict multiple families and genera of freshwater fish. In addition, our prior research found that Enoxolone emerged as the most promising candidate with a low minimum inhibitory concentration and good cost-effectiveness. However, the therapeutic effect of Enoxolone on Micropterus salmoides infected with F.

Exploring the potential mechanisms of Jinglinzi powder in treating hepatocellular carcinoma based on LC-MS, network pharmacology, molecular docking, and experimental validation.

This study systematically predicts the active components, targets, and mechanisms of JLZP against HCC by integrating LC-MS, network pharmacology, and molecular docking, with experimental validation of its pro-pyroptotic effects. Through HERB and NPASS databases, 81 bioactive components of JLZP and 78 overlapping HCC-related targets were identified. Protein-protein interaction network and KEGG enrichment analyses revealed that JLZP likely induces cell death via cancer-related pathways.

Effects of protein supplementation on muscle mass, muscle strength, and physical performance in older adults with physical inactivity: a systematic review and meta-analysis.

Background: Maintaining skeletal muscle mass and function in older adults is of paramount importance for preserving both quality of life and overall health. Exercise is essential for muscle maintenance; however, for older individuals with comorbidities, engaging in physical exercise may pose challenges due to decreased endurance and the inability to reach optimal exercise intensities. Several studies have investigated the effects of protein supplementation on muscle mass, strength, and physical performance in older adults.

VCF2Dis: an ultra-fast and efficient tool to calculate pairwise genetic distance and construct population phylogeny from VCF files.

Background: Genetic distance metrics are crucial for understanding the evolutionary relationships and population structure of organisms. Progress in next-generation sequencing technology has given rise of genotyping data of thousands of individuals. The standard Variant Call Format (VCF) is widely used to store genomic variation information, but calculating genetic distance and constructing population phylogeny directly from large VCF files can be challenging.

Mettl3 regulates the pathogenesis of Alzheimer's disease via fine-tuning Lingo2.

Alzheimer's disease (AD) is the most common neurodegenerative disease, and diverse factors contribute to its pathogenesis. Previous studies have suggested the dysregulation of mA modification involves in AD, but the underlying mechanism and targets remain largely unknown. In the present study, we have shown that the levels of Mettl3 and mA modification are increased in specific brain regions of 5xFAD mice and post-mortem AD patients, respectively.

Genome-wide profiling and functional characterization of circular RNAs in neural development and injury: insights from a rat model research.

Circular RNAs (circRNAs) have re-emerged as promising gene regulators in various physiological and pathological conditions. However, the expression patterns of circRNAs in the developing spinal cord of mammals and the comprehensive distribution of circRNAs across different tissues remain poorly understood. In this study, rats were used as the model organism.

Synthesis and Superconductivity of Ternary A15-(Lu, Y)H at High Pressures.

Ternary hydrides, formed by introducing new elements into binary hydrides, are a crucial pathway for enhancing superconducting transition temperatures () or reducing the stable pressures. In this work, we have acquired the ternary hydride formed by Lu and Y atoms, inspired by the low stabilization pressure of the Lu-H system with its fully filled 4 electrons, as well as the higher of the Y-H system. By effectively controlling the high-pressure and high-temperature conditions, we have successfully synthesized -3 (Lu, Y)H (A15-type).