Dynamic Restructuring of Stacking-Fault-Rich Copper Catalysts.

Copper (Cu) catalysts with abundant defects are pivotal for converting CO into valuable multi-carbon products. However, the practical application of Cu catalysts is challenged by the thermodynamic instability of the defects, often leading to surface reconstruction during catalytic processes. Here, it is found that particle size and COO-containing intermediates are key factors driving reconstruction, as the defect stability is size-dependent and can be amplified by leveraging the highly reactive intermediates as the initial reactant.

Making waves: Microbial-nitrate-zero valent iron/manganese synergy suppresses arsenic mobilization and greenhouse gas emissions in constructed wetlands.

Constructed wetlands (CWs) face dual challenges of arsenic contamination and greenhouse gas (GHG) emissions, particularly concerning the competing processes of As(III) immobilization and methane-dependent As(V) reduction (AOM-AsR). To address this dilemma, we developed a novel microbial-nitrate-zero valent iron/manganese synergy (MNZS) system that establishes dynamic redox gradients through Fe/Mn-mediated electron flux regulation. The MNZS mechanism leverages zero valent iron/manganese (ZVI/ZVM) oxidation to create oxygen-depleted microzones, generating bioavailable Fe(II)/Mn(II) species while initiating microbial nitrate-reducing-coupled Fe(II)/Mn(II) oxidation (NRFO/NRMO).

Fluid biomarkers in familial frontotemporal dementia: progress and prospects.

Familial frontotemporal dementia (FTD) is a genetically heterogeneous disease with various clinical manifestations, making it difficult to diagnose. There are three main gene mutations in familial FTD: repeat expansion in chromosome 9 open reading frame 72 (), microtubule-associated protein tau (), and progranulin (). These mutations can produce corresponding changes in fluid biomarkers years before symptoms appear.

Bio-Transport Regulation Inspired 5-Fluorouracil Keto to Enol Tautomerism Achieving High Proton Conductivity.

The strategic modulation of proton transport kinetics and precise control of migration energy barriers in metal-organic frameworks (MOFs) are essential for developing next-generation proton conductors. Inspired by biological proton channels, this study introduces a dynamic regulation strategy by keto-enol tautomerism to reconcile the intrinsic trade-off between low activation energy (E) and sustained proton mobility. We successfully construct a hierarchical proton conductive system (denoted as FU@MOF-808-SOH) by integrating 5-fluorouracil (5-FU) molecules into sulfonic-functionalized MOF-808 through a two-step post-synthetic modification.

Regioselective Multicomponent Sulfonylation/Cyclization of Unactivated Alkenes to Access Sulfonylated Six- and Seven-Membered Cyclic Enamines via SO Insertion.

Radical cascade cyclization of alkenes involving the insertion of sulfur dioxide has proven to be a promising tool to access sulfonylnated heterocycle compounds, whereas cyclization of unactivated alkenes has been much less explored. Here, we developed a three-component cascade of unactive alkenes with sulfur dioxide and aryldiazonium tetrafluoroborates to generate sulfonylated tetrahydropyridines and azepines via the cleavage of alkenyl C-H bonds. Moreover, this protocol exhibited excellent chemical and regioselectivity and compatibility with broad functional groups.

CCL2-Driven Inflammation Links Periodontitis to Anxiety.

Aim: This study investigates the association between periodontitis and anxiety, focusing on the role of the chemokine CCL2 in mediating this relationship.

Materials And Methods: This study comprises an analytical cross-sectional study and a preclinical in vivo study. In the analytical cross-sectional study, anxiety levels were assessed in individuals with periodontitis and healthy controls using the Hamilton Anxiety Rating Scale (HAMA).

Discovery of dimethyl quaternary ammonium salt based on harmane against MRSA infections by multi-target mechanism.

With rising antimicrobial resistance and continuous failure of conventional therapies, innovative drug development against methicillin-resistant Staphylococcus aureus (MRSA) is crucial for effective clinical treatment. Here, new dimethyl quaternary ammonium salt 5b derived from harmane were designed, exhibiting potent anti-MRSA activities including clinical strains (MIC = 0.25-0.

Light-driven lattice soft microrobot with multimodal locomotion.

Untethered microrobots hold significant promise in fields such as bionics, biomedicine, and micromechanics. However, replicating the diverse movements of natural microorganisms in artificial microrobots presents a considerable challenge. This paper introduces a laser-based approach that utilizes lattice metamaterials to enhance the deformability of hydrogel-based microrobots, resulting in untethered light-driven lattice soft microrobots (LSMR).

Diminished rest-activity rhythm is associated with postoperative complications and mortality: A prospective cohort study of UK Biobank participants.

Background: Circadian rhythm disruption, as a modifiable risk factor, has been increasingly recognised for its potential impact on adverse health outcomes, particularly in surgical populations where its implications warrant further investigation.

Objectives: To investigate associations between postoperative outcomes and preoperative rest-activity rhythm metrics from accelerometry.

Design: A cohort analysis of UK Biobank participants undergoing major surgery within 1 year of accelerometer monitoring.

The impact of nano-carbon suspension lymph node tracing on rectal cancer surgery post-neoadjuvant therapy.

Background: To explore the impact of using nano-carbon suspension for lymph node tracing on the number of detected lymph nodes and short-term clinical outcomes in patients undergoing laparoscopic radical resection for rectal cancer following neoadjuvant therapy.

Methods: This study retrospectively analyzed clinical data from 109 patients who underwent neoadjuvant therapy and laparoscopic radical resection for rectal cancer at Weifang People's Hospital from January 2020 to December 2022. Of these, 43 patients received an endoscopic submucosal injection of nano-carbon suspension (experimental group), with 22 patients receiving the injection before neoadjuvant therapy and 21 patients receiving it 24 h before surgery.

Activating Stable Multielectron Transfer via High-Frequency Na Jumping for a Sc-doped NaVMnSc(PO).

The NaVMn(PO) (NVMP) cathode is considered one of the most promising candidates for sodium-ion batteries (SIBs), but it suffers from a low capacity due to the limited kinetics of V/V and Mn/Mn in the electrochemical reaction. A higher capacity can be achieved by activating a redox pair with high valence states like V/V. However, activation of those redox pairs in conventional NVMP cathode requires a redox potential beyond 4.

Fluorescent sensor for bisphenol S based on pH adjustment and polydopamine nanoparticles.

Initially, it was considered as a feasible solution to replace the harmful bisphenol A with structurally similar bisphenol S (BPS). However, with the deepening of research, BPS has also been pointed out to have similar endocrine-disrupting effects and physiological hazards to bisphenol A. Therefore, it is necessary to develop an efficient and convenient method for BPS detection.

From fish to fiber: 3D-nanoprinted optical neuromast for multi-integrated underwater detection.

Fish possess high sensitivity to acoustic, vibrational, and hydrodynamic stimuli through unique sensing cells, providing unparalleled paradigms for developing underwater detection methods. However, artificial perception devices face challenges in replicating comparable sensitivity and multi-dimensional integration of fish in function and scale. Here, we propose a biomimetic optical fiber neuromast (BOFN) by leveraging synergistic optical-mechanical interactions for multifunctional underwater detection and communication.

Molecular characteristics and antimicrobial susceptibility of carbapenem-resistant in a multicenter study in Ningbo, China.

Objective: To analyze the molecular epidemiology and antimicrobial resistance profiles of carbapenem-resistant (CR-KP) isolates in Ningbo, with the aim of providing a theoretical basis for hospital infection control strategies and the implementation of precise clinical diagnosis and treatment protocols.

Methods: During the period from April 30, 2023 to June 30, 2024, clinical isolates of were collected from multiple centers in Ningbo, including The Affiliated Li Huili Hospital (Yinzhou District, Ningbo), Xiangshan Red Cross Taiwan Compatriot Hospital Medical and Health Group (Xiangshan, Ningbo), and the Second Hospital of Ninghai County (Ninghai, Ningbo). A total of 81 CR-KP strains were identified using the broth dilution method for carbapenem resistance screening.

Identification of the T-box transcription factor t-bet in chickens and its role in immune response.

T-bet (T-box transcription factor TBX21), encoded by the Tbx21 gene, is a key regulator of T helper 1 (Th1) cell differentiation and cellular immunity. However, the role of T-bet in avian species remains elusive. To investigate the role of T-bet in avian immune response, we cloned chicken T-bet (chT-bet) from a White Leghorn chicken spleen-derived cDNA library.

Features and Prognosis of Patients With Retroperitoneal Fibrosis Developing Fibrosing Mediastinitis: Case-Control Study and Systematic Review.

Objective: Retroperitoneal fibrosis (RPF) complicated by mediastinal fibrosis (MF) is rare but fatal. We aimed to explore the features and indicators of poor prognosis for the population of those affected.

Methods: Patients with idiopathic RPF were recruited in Peking University International Hospital.

Targeting p-FGFR1 Enhances CD8+ T Cells Infiltration and Overcomes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma by Regulating the CXCL8-CXCR2 Axis.

Esophageal squamous cell carcinoma (ESCC) is a fatal malignant tumor. Several studies have demonstrated that immune checkpoint inhibitors can provide clinical benefits to patients with ESCC. However, the single-agent efficacy of these agents remains limited.

Study on the mechanism of Yihuang powder ethanol extract on spleen deficiency diarrhea in young rats based on intestinal flora and metabonomics.

Infantile spleen deficiency diarrhea (SDD) impacts children's health. Yihuang Powder (YHP) is a traditional prescription for treating it, and the ethanol extract of YHP (EYHP) has been optimized by the research group, yet its differences from the traditional water extract of YHP (WYHP) remain unclear. This study aimed to clarify the variances in chemical composition and pharmacological effects between EYHP and WYHP, and reveal EYHP's mechanism in treating SDD via intestinal flora and fecal metabolomics.

Risk of Neurodevelopmental Disorders in Preschool Children Associated with the Longitudinal Trajectory of Phthalates during Pregnancy: Potential Mechanisms Based on Metabonomics of Cord Blood.

Phthalate exposure during pregnancy may result in neurotoxicity to offspring, but no studies have investigated the effects of longitudinal phthalate trajectories during pregnancy on children. Therefore, exposure trajectories were constructed by using urine concentrations of phthalates at different times. Similarly, 3220 children were screened for symptoms of autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and emotional and behavioral problems (EBPs) via multiple measures between the ages of 1.

Research on the Energy Transfer Law of Polymer Gel Profile Control Flooding in Low-Permeability Oil Reservoirs.

To investigate the energy conduction behavior of polymer gel profile control and flooding in low-permeability reservoirs, a parallel dual-tube displacement experiment was conducted to simulate reservoirs with different permeability ratios. Injection schemes included constant rates from 0.40 to 1.

Wearable Biosensing of Caffeine via Microfluidic-Integrated Agarose Hydrogels for Personalized Metabolic Monitoring.

Wearable sweat sensors have gained tremendous attention on account of performing noninvasive and real-time monitoring of sweat analytes, providing a view of the human physiological state at the molecular level. Caffeine is a methylxanthine alkaloid, and its levels in the human body are directly related to health. Developing a wearable device for dynamically assessing caffeine levels in sweat could facilitate real-time personalized health monitoring.

Accelerometer-measured circadian alignment predicts all-cause and cardiovascular mortality in middle-aged and older adults.

Aims: Circadian alignment plays a key role in cardiometabolic regulation. We examined whether accelerometer-derived alignment metrics independently predict all-cause and cardiovascular mortality in middle-aged and older adults.

Methods: We included 4,814 U.

Immunomodulatory effects of ulinastatin combined with continuous blood purification in sepsis: a systematic review and meta-analysis.

Background: Sepsis involves a dysregulated immune response to infection, causing inflammation and organ dysfunction. This systematic review and meta-analysis evaluated the immunomodulatory effects of ulinastatin combined with continuous blood purification (CBP) in sepsis.

Methods: This study involved a literature search, data extraction, quality assessment, and meta-analysis to evaluate the effects of ulinastatin combined with CBP.

Impairing antioxidant protection by diminishing hyaluronic acid using nanoliposomes for tumor therapy.

HO plays a significant role in tumor development. However, tumor cells possess certain protective mechanisms that reduce the cytotoxic effects of HO. Researchers have observed a notable increase in the expression of hyaluronic acid (HA), which possesses antioxidant properties, within the tumor microenvironment.

A fluorescent probe based on the interaction of ofloxacin with gold nanoparticles for the sensitive detection of melamine.

Melamine (MEL) is frequently adulterated in dairy products to manipulate protein content test results due to its high nitrogen content. In this study, a fluorescent probe based on ofloxacin (OFL) and gold nanoparticles (AuNPs) was proposed for the specific and sensitive detection of MEL. In the pH range of 4.