Clinical manifestations and outcomes of HSK following corneal transplantation.

Purpose: To investigate the clinical manifestations and outcomes of herpes simplex keratitis (HSK) infection following corneal transplantation.

Methods: This retrospective study analyzed medical records of patients who underwent corneal transplantation at the People's Hospital of Guangxi Zhuang Autonomous Region between January 2018 and March 2024, with a minimum follow-up period of 1 year. The study examined post-transplantation herpes simplex virus (HSV) infections, including the timing of HSV infection, HSK classification, clinical manifestations, and outcomes.

Evaporation-Driven Fabric for Synergistic Water-Electricity-Lithium Co-Production.

Water evaporation constitutes a ubiquitous physical phenomenon. This natural process enables efficient energy and resource harvesting through water interacting with materials with tailored structural, chemical, and thermal properties. Here, this work designs an evaporation-driven fabric (e-fabric) that enables the utilization of water-electricity-lithium from brine through three optimized functional layers.

A disproportionality analysis of adverse events caused by pexidartinib from the FDA adverse event reporting system.

Tenosynovial giant cell tumor (TGCT) is a rare neoplasm closely associated with dysregulation of the colony-stimulating factor 1(CSF1)/CSF1R signaling pathway, faces high recurrence rates despite surgical intervention, prompting exploration of CSF1R inhibitors like pexidartinib. This retrospective pharmacovigilance study analyzed pexidartinib-associated adverse events (AEs) from FDA Adverse Event Reporting System (FAERS) data (Q4 2019-Q3 2024), employing disproportionality analyses (ROR, PRR, BCPNN, EBGM) and sensitivity assessments to evaluate 844 reports. Hepatic events (46.

Fluorescent sensor for bisphenol S based on pH adjustment and polydopamine nanoparticles.

Initially, it was considered as a feasible solution to replace the harmful bisphenol A with structurally similar bisphenol S (BPS). However, with the deepening of research, BPS has also been pointed out to have similar endocrine-disrupting effects and physiological hazards to bisphenol A. Therefore, it is necessary to develop an efficient and convenient method for BPS detection.

The Impact of Animal Models and Strain Standardization on the Evaluation of Tuberculosis Vaccine Efficacy.

Tuberculosis (TB) remains one of the most significant challenges to global public health. Vaccine development is a critical strategy for the prevention and control of TB. However, evaluating the protective efficacy of TB vaccines faces numerous challenges, particularly in the selection of animal models and bacterial strains.

Research progress of dual-targeting CDKs regulators for cancer therapy.

Cyclin-dependent kinases (CDKs) are a class of enzymes that catalyze protein phosphorylation during cell cycle progression and transcriptional regulation. CDKs are involved in cell cycle regulation in combination with cyclins, and have become promising anticancer drug targets. In recent years, the research of CDK inhibitors has made great progress.

Detection of β-Hydroxybutyric Acid Based on a Fluorescent Probe of Lanthanide Complexes.

In this paper, a lanthanide complex-based fluorescent sensor Tb(4-MBA) was developed for the selective recognition of diabetic ketoacidosis (DKA) and the diabetes biomarker β-hydroxybutyric (β-Hb). β-Hb significantly enhanced the fluorescence emission of the Tb(4-MBA) complex at 539  nm. Based on the analysis of the surface electrostatic potential distribution and time-resolved spectra, we speculate that in the reaction system of β-Hb with Tb(4-MBA), β-Hb and Tb(4-MBA) may form a complex through hydrogen bonding interactions, which brings β-Hb closer to Tb and thus reduces the non-radiative energy loss of the solvent molecules to Tb and significantly enhances the Tb(4-MBA) fluorescence intensity.

A fluorescent probe based on the interaction of ofloxacin with gold nanoparticles for the sensitive detection of melamine.

Melamine (MEL) is frequently adulterated in dairy products to manipulate protein content test results due to its high nitrogen content. In this study, a fluorescent probe based on ofloxacin (OFL) and gold nanoparticles (AuNPs) was proposed for the specific and sensitive detection of MEL. In the pH range of 4.

Exploring the psychological landscape of thyroid nodules: resilience, anxiety, and ultrasound correlations.

Background: While thyroid nodules (TN) represent a prevalent clinical entity with ultrasound-guided management paradigms, the psychological sequelae of diagnostic imaging remain underexplored. This study investigates the complex interplay between ultrasound characteristics (C-TIRADS), psychological resilience, and anxiety manifestations in TN patients, addressing a critical gap in psychosomatic thyroidology.

Methods: In this prospective cross-sectional study, 303 consecutive TN patients (mean age 47.

Investigating the Citrus Aphid Species in Zhejiang, China: Morphometric Analysis and Genetic Distinctions.

Aphids (Hemiptera: Aphididae) are well-known agricultural pests, affecting global crop production both through direct feeding and as the vector of multiple plant viruses. The classification of citrus aphid species was outdated and limited within the Zhejiang Province, China. A comprehensive investigation was conducted to determine the aphid species associated with citrus cultivars from 2019 to 2024.

Mechanisms and Targeted Therapeutic Strategies in Sepsis-Induced Myocardial Dysfunction: The Role of NLRP3 Inflammasome-Mediated Inflammation.

Sepsis is a systemic inflammatory response syndrome triggered by infection, in which excessive immune responses can lead to multiple organ failure and shock. The heart, as one of the critical target organs in sepsis, is significantly impaired, which substantially increases the risk of mortality. Recent studies have increasingly highlighted the role of dysregulated inflammatory responses in the pathogenesis and progression of sepsis-induced myocardial dysfunction (SIMD).

The effects of childhood trauma and adult stress on obsessive-compulsive symptoms: the role of inflammation markers and thalamic functional connectivity.

Background: Emerging evidence suggests that childhood trauma and adult stress are significant contributors to the development of obsessive-compulsive disorder (OCD). However, the physiological mechanisms by which trauma and stress influence OCD remain unclear. The aim of this study was to investigate whether inflammation and thalamic functional connectivity mediate the relationship between trauma, stress, and the development of OCD.

Effects of Biological Characteristics and Environmental Factors on Swimming Performance of Endemic Fish in Southwest China.

Swimming is crucial to fish survival and reproduction, and is usually influenced by species, morphology, habitat environment and physiological condition. Understanding the changes in fish swimming ability and identifying the driving factors behind these changes is vital. In this study, seven endemic fish species from the Qingshui River, an important tributary of the upper Pearl River in Southwest China, were used to explore the effects of biological and environmental factors on fish swimming ability.

Integrative bioinformatics analysis of lipid metabolism-related genes and immune infiltration in endometriosis.

Endometriosis is referred to as a "benign cancer," severely impacting women's reproductive health. However, the pathogenesis of endometriosis remains unclear. This study aims to investigate the potential roles of lipid metabolism-related genes (LMRGs) and immune infiltration in the diagnosis and pathogenesis of endometriosis.

Iron oxide-supported InNiC intermetallic catalyst for the CO hydrogenation to methanol: Effect of pyrolyzed FeO support precursors.

Interest in renewable methanol produced from green hydrogen and CO has given particular momentum to the exploration of efficient catalysts. Although the newly developed InNiC/FeO catalyst, derived from the InO-NiO/α-FeO system, shows significant potential as a catalyst for the CO hydrogenation to methanol reaction, a comprehensive understanding of the chemical and structural origins that are inherently linked to catalyst synthesis is still insufficient. Herein, the study is focused on the effect of α-FeO precursors on catalyst performance of as-obtained InNiC/FeO.

Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024.

Objective: To understand the epidemiology and evolutionary characteristics of human adenovirus (HAdV) infecting children in Yancheng, China, during the winter of 2023-2024.

Methods: HAdV-positive throat swab samples were collected from pediatric patients in Yancheng. The Hexon, Penton base, and Fiber genes were amplified and sequenced for typing and phylogenetic analysis of HAdV.

Matrix completion-informed deep unfolded equilibrium models for self-supervised -space interpolation in MRI.

Background: Self-supervised methods for magnetic resonance imaging (MRI) reconstruction have garnered significant interest due to their ability to address the challenges of slow data acquisition and scarcity of fully sampled labels. Current regularization-based self-supervised techniques merge the theoretical foundations of regularization with the representational strengths of deep learning and enable effective reconstruction under higher acceleration rates, yet often fall short in interpretability, leaving their theoretical underpinnings lacking.

Purpose: In this paper, we introduce a novel self-supervised approach that provides stringent theoretical guarantees and interpretable networks while circumventing the need for fully sampled labels.

Mechanisms of Zanthoxyli Pericarpium-Zingiberis Rhizoma in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Validation.

Background: Malignant tumors, as a major challenge in global public health, have posed a significant threat to human life and health. Although traditional chemotherapy can inhibit tumor growth, it is often associated with serious adverse effects and tolerance. Against this background, Chinese medicine therapies have gradually gained wide recognition, and they play an important role in the treatment of gastric cancer (GC).

Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibit gastric cancer based on WGCNA and machine algorithms.

Objective: The aim of this study was to screen the biomarkers of ginger against gastric cancer (GC) by network pharmacology, WGCNA and machine algorithms. To find the upstream transcription factors and downstream signaling proteins constituting the signaling axis, so as to predict the possible mechanism of action of ginger against GC.

Methods: Ginger was screened for active ingredients and targets through public databases.

Nitrogen and sulfur co-doped carbon dots for the fluorescence detection of lactose in milk.

For lactose-intolerant patients, controlling lactose intake is crucial. To address this need, we developed carbon dot-based sensors for lactose detection in milk. Using citric acid and sulfamic acid as precursors, we synthesized nitrogen and sulfur co-doped carbon dots (N,S-CDs) via hydrothermal method.

A hybrid TCN-XGBoost model for agricultural product market price forecasting.

Price volatility in agricultural markets is influenced by seasonality, supply-demand fluctuations, policy changes, and climate. These factors significantly impact agricultural production and the broader macroeconomy. Traditional time series models, limited by linear assumptions, often fail to capture the nonlinear nature of price fluctuations.

Prevalence, Species Characterization, and Genetic Diversity of Infections in Rodents From Mudflat Wetlands Along the Eastern Coast of Jiangsu Province in China.

To investigate the infection status, species composition, and genetic diversity of in local rodent populations in coastal mudflat wetland habitats in eastern Jiangsu Province of China. From March to June 2023, rodents were captured in mudflat wetlands of Dongtai and Tinghu Counties, Eastern China. Rodent species were identified, and nucleic acids were extracted from liver and spleen tissues.

Armored polymer-fluid gels with integrated damping and impact protection across broad temperatures.

Unpreferable vibrations and impacts pose substantial risks to sensitive devices, structures, and the human body, demanding materials capable of providing both high energy dissipation and impact protection across a broad temperature range. Traditional damping materials often fail to meet these demands because of a trade-off between damping and mechanical strength. We introduce an innovative strategy to fabricate armored polymer-fluid gels (APFGs) that combine high damping and high modulus for effective damping and impact protection under extreme conditions.

Research advances in natural sesquiterpene lactones: overcoming cancer drug resistance through modulation of key signaling pathways.

Cancer remains a significant global health challenge, with current chemotherapeutic strategies frequently limited by the emergence of resistance. In this context, natural compounds with the potential to overcome resistance have garnered considerable attention. Among these, sesquiterpene lactones, primarily derived from plants in the Asteraceae family, stand out for their potential anticancer properties.

In vitro experiments and network pharmacology-based investigation of the molecular mechanism of neferine in the treatment of gastric cancer.

Background Gastric cancer is the world's leading tumor disease in terms of morbidity and mortality and is currently treated clinically with a comprehensive approach based on surgery. Studies have demonstrated the antitumor effects of neferine, but the anti-cancer mechanism for gastric cancer is not yet clear. Methods The Pubchem and Swiss TargetPrediction databases were searched to retrieve the targets of action of neferine.