Specific genomic alterations and aggressive clinical features of sporadic thyroid carcinomas in children and adolescents: findings from an in-house cohort study.

Introduction: Papillary thyroid carcinoma is the most common pathological subtype of thyroid cancer in both children/adolescents (TCCA) and adults (TCA). TCCA manifests more aggressive and invasive behaviors than TCA, which may be attributed to specific genomic alterations.

Methods: To better understand the specific molecular, pathological and clinical manifestations of TCCA, we retrospectively analyzed a cohort of 60 patients with sporadic papillary thyroid carcinoma, including 20 TCCAs and 40 TCAs.

Improvements in depression symptomatology in a sample of undergraduate students: a pre-post Balint group intervention study.

Background/objective: Previous studies have explored the effects of Balint group interventions on reducing depressive symptoms among medical workers; however, its effects on other populations have not been analyzed. This study addressed this gap by investigating whether this intervention can reduce depressive tendencies in college students and its potential mechanism.

Methods: The effects of the 6-week Balint group intervention were assessed using an experimental/control group and pre-/post-test design.

How parental mediation affects adolescents' problematic smartphone use: the chain mediating role of basic psychological needs and positive outcome expectations.

Purpose: Problematic smartphone use can significantly jeopardize adolescents' academic development as well as their physical and mental health. Although previous studies have explored the role of parental mediation strategies in adolescents' problematic smartphone use, the underlying mechanisms remain unclear. This study aims to investigate the relationship between parental mediation and adolescents' problematic smartphone use, with a specific focus on the chain mediation effects of basic psychological needs and positive outcome expectations.

Effect of Remimazolam versus Propofol on Hemodynamics in Elderly Hypertensive Patients Undergoing Gastroenteroscopy: A Multicenter, Randomized Controlled Clinical Trial.

Purpose: This study aimed to compare the effects of remimazolam and propofol on hemodynamics in elderly hypertensive patients undergoing gastroenteroscopy.

Methods: In this multicenter, single-blind, randomized clinical trial, 220 hypertensive patients (65-75 years) scheduled for gastroenteroscopy were randomly assigned to receive either remimazolam (group R, n=110; 0.3 mg/kg induction followed by 0.

Do College Freshmen Who Engage More in Online Social Comparison Tend to Be More Confused About Themselves? The Roles of Rumination and Self-Compassion.

Online social comparisons play a vital role in adolescents and young adults' self-development. This study extended research on the influence of online social comparisons on self-concept clarity among college freshmen. This study investigated the mediating role of rumination in the relationship between online social comparisons and self-concept clarity among college freshmen and further examined the moderating effect of self-compassion on this mediational pathway.

The mediating role of psychological inflexibility in the association between physical activity and depressive symptoms among college students.

Background: Depressive symptoms are prevalent mental health issues among college students. Physical activity has been recognized as a potential protective factor. However, the mechanisms through which physical activity alleviates depressive symptoms remain unclear.

Mechanisms of Zanthoxyli Pericarpium-Zingiberis Rhizoma in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Validation.

Background: Malignant tumors, as a major challenge in global public health, have posed a significant threat to human life and health. Although traditional chemotherapy can inhibit tumor growth, it is often associated with serious adverse effects and tolerance. Against this background, Chinese medicine therapies have gradually gained wide recognition, and they play an important role in the treatment of gastric cancer (GC).

Evaluating rural sports tourism competitiveness: A framework applied to Shandong province.

Rural sports tourism performs a crucial role in developing the rural sports industry and promoting rural revitalization. We investigate the competitiveness of rural sports tourism in Shandong Province through niche theory, developing a five-tier index system in the context of resource base, industrial development, location conditions, fundamental guarantees, and construction management. A least squares optimization model is used to identify both subjective and objective weights for the indicators.

Violent or competitive? Unpacking adolescent cyber-aggressive behavior in text, video, and game context.

Introduction: Cyber-aggressive behavior in adolescents is significantly influenced by violence and competition, yet their distinct roles and interactions with contextual and personality factors remain underexplored. This study investigates how violent versus competitive triggers, contextual mediums (text, video, game), and social comparison tendencies shape cyber-aggression.

Methods: Two experimental studies were conducted.

A chain mediation model reveals the association between parental mediation and smartphone addiction of Chinese adolescents.

The family plays an immensely crucial role in the development of adolescents, significantly influencing their behavioral patterns. To explore the impact mechanism of the parental mediation (active mediation, restrictive mediation, and parental monitoring) on adolescents' smartphone addiction, and analyze the chain-mediating role of basic psychological needs and fear of missing out (FoMO). Parental Mediation Scale, Smartphone Addiction Scale, Basic Psychological Needs Scale and Fear of Missing Out Scale were administered to 5,841 adolescents.

Association between multiple metals mixture and diabetic retinopathy in older adults with diabetes mellitus: a cross-sectional study in China.

Previous studies have linked single metal with diabetic retinopathy (DR), but information about the combined effects of multiple metals mixture was scarce. Thus, we performed this cross-sectional study to investigate the single and joint associations between multiple metals mixture and DR risk among elderly diabetic population in China. A total of 1127 elderly adults (aged ≥ 60) with diabetes mellitus from a large-scale DR screening program in southern China included.

Role of Glucose Metabolism in the Effects of Serum Metals on Telomere Length: Findings in Chinese Diabetic Population.

The effects of metal exposure on telomere length have attracted considerable attention, but definitive evidence is still lacking in the diabetic population. Thus, this study was conducted to explore the associations of metal mixture with telomere length and the mediated effects of glucose metabolism among the Chinese diabetic population. Eleven metals in serum and relative telomere length of leucocyte were quantified among 1516 diabetic population based on a large-scale diabetic retinopathy screening program in southern China.

OLFML3 Promotes IRG1 Mitochondrial Localization and Modulates Mitochondrial Function in Macrophages.

Olfactomedin-like protein 3 (OLFML3), belonging to olfactomedin (OLF) protein family, has poorly defined functions. Recent studies have reported the functions of OLFML3 in anti-viral immunity and tumorigenesis. In this study, we investigated the roles of OLFML3 in macrophages.

A comparison of the acute effects of high intensity interval training and moderate intensity continuous training on working memory and emotional state in adolescent women with subthreshold depression.

Objective: Various guidelines emphasize the cognitive and emotional benefits of physical activity. However, it is not yet clear what kind of exercise intensity is suitable for individuals with subthreshold depression. Therefore, this study aims to examine the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on the working memory and emotional state.

Review: performance of jujube and its extracts in cancer: therapeutic, toxicity-reducing and potentiating effects.

Cancer is one of the most serious public health challenges in the world. The number of new and fatal patients with cancer continues to increase every year, which poses a serious threat to human health. Although there are effective treatments such as radiotherapy and chemotherapy for cancers, they are often accompanied by serious side effects.

Contrasting drought sensitivity of Eurasian and North American grasslands.

Extreme droughts generally decrease productivity in grassland ecosystems with negative consequences for nature's contribution to people. The extent to which this negative effect varies among grassland types and over time in response to multi-year extreme drought remains unclear. Here, using a coordinated distributed experiment that simulated four years of growing-season drought (around 66% rainfall reduction), we compared drought sensitivity within and among six representative grasslands spanning broad precipitation gradients in each of Eurasia and North America-two of the Northern Hemisphere's largest grass-dominated regions.

Sedentary behaviors negatively related to depressive symptoms in college students: The roles of type and duration of sedentary behaviors.

Objective: This study aimed to examine the associations of different types and duration with sedentary behaviors and depressive symptoms among college students.

Methods: A cross-sectional study was conducted at a university in Shanghai, China, utilizing convenience sampling to recruit 3,190 participants (mean age 20.06 ± 1.

Transgenerational Plasticity Enhances the Tolerance of Duckweed () to Stress from Exudates of .

Transgenerational plasticity (TGP) refers to the influence of ancestral environmental signals on offspring's traits across generations. While evidence of TGP in plants is growing, its role in plant adaptation over successive generations remains unclear, particularly in floating plants facing fluctuating environments. Duckweed (), a common ecological remediation material, often coexists with the harmful bloom-forming cyanobacterium , which releases a highly toxic exudate mixture (MaE) during its growth.

Effects of open-skill and closed-skill exercise on subthreshold depression in female adolescents: A randomized controlled trial.

Background: Subthreshold depression (SD) affects a significant proportion of adolescent females, posing a risk of major depression in later life. This study examines the effects of open-skill exercise (OSE) and closed-skill exercise (CSE) on SD, executive function (EF), and emotional states in female adolescents.

Methods: A double-blind randomized controlled trial involved 95 female adolescents (mean age = 16.

eEF2K as an important kinase associated with cancer survival and prognosis.

Eukaryotic Elongation Factor 2 Kinase (eEF2K), a member of the α-kinase family, services as a crucial negative regulator of protein synthesis, particularly under conditions of cellular stress. A pan-cancer analysis of eEF2K expression, genetic variants, and clinical relevance across multiple tumor types was performed using data from the Cancer Genome Atlas (TCGA) and GEO. Our findings suggest that eEF2K has dual roles in cancer progression, with its expression correlating with patient prognosis.

Exercise intensity of virtual reality exergaming modulates the responses to executive function and affective response in sedentary young adults: A randomized, controlled crossover feasibility study.

Virtual reality (VR) exergaming is a novel strategy to encourage physical activity and boost emotional well-being. However, its effects on executive function (EF) are not fully understood. This study assessed the immediate and retention effects of immersive VR exergaming, at varying exercise intensities, on EF and affect among sedentary college students.

Network pharmacology study and experimental validation of Xiaojianzhong decoction against gastric cancer.

Background: Cancer is one of the most serious threats to human health worldwide. Conventional treatments such as surgery and chemotherapy are associated with some drawbacks. In recent years, traditional Chinese medicine treatment has been increasingly advocated by patients and attracted attention from clinicians, and has become an indispensable part of the comprehensive treatment for gastric cancer.