Pathway analysis of nursing interns' professional benefit perception and influencing factors: a cross-sectional study.

Aim: This study aims to examine the current professional benefit perception among nursing interns and explore their interactions with perspective taking, compassion satisfaction, and secondary traumatic stress.

Background: The professional benefit perception is a crucial determinant in the career decisions of nursing interns. Understanding the pathways through which various factors influence this perception can inform the development of targeted intervention strategies.

Effects and moderator of high-intensity interval training and moderate-intensity continuous training among children and adolescents with overweight or obese: a systematic review and meta-analysis.

Objectives: This meta-analysis aimed to synthesize current evidence and address inconsistencies in the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on children and adolescents with overweight or obesity. We sought to: (1) assess the effects of HIIT and MICT non-exercise controls; (2) compare HIIT and MICT directly; and (3) identify potential moderators through subgroup analyses.

Methods: Systematic searches were conducted in PubMed, Web of Science, China National Knowledge Infrastructure, and CSTJ.

Effect of Remimazolam versus Propofol on Hemodynamics in Elderly Hypertensive Patients Undergoing Gastroenteroscopy: A Multicenter, Randomized Controlled Clinical Trial.

Purpose: This study aimed to compare the effects of remimazolam and propofol on hemodynamics in elderly hypertensive patients undergoing gastroenteroscopy.

Methods: In this multicenter, single-blind, randomized clinical trial, 220 hypertensive patients (65-75 years) scheduled for gastroenteroscopy were randomly assigned to receive either remimazolam (group R, n=110; 0.3 mg/kg induction followed by 0.

Advancements in understanding tumor-resident bacteria and their application in cancer therapy.

Recent advances in next-generation sequencing and bioinformatics have driven growing interest in the distinct roles of intratumoral microbiota, particularly intracellular bacteria, during tumor evolution. These bacteria increase the likelihood of metastasis, play important roles in cancer progression, and impact therapy efficiency. The present review explores the sources, mechanisms of invasion into cancer cells, and potential survival strategies of intracellular bacteria in neoplasms, highlighting their critical role in cancer development.

Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.

Objective: Magnesium (Mg) deficiency may accelerate neurodegenerative disease progression, but current cognitive impairment biomarkers have significant limitations. This study aimed to investigate the association between Mg depletion score (MDS) and cognitive impairment.

Design: This study is a cross-sectional analysis using data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) to examine the relationship between MDS and cognitive performance.

Advances in metabolomics of biomarkers for ischemic stroke: From bench to clinic.

Ischemic stroke, a neurological impairment caused by cerebral vascular occlusion, accounts for 87% of the cases of stroke. Recent studies have shown that changes in the abundance of metabolites can directly reveal the cellular phenotypes and identify the clinical implications of stroke diagnosis and therapy. However, systematic research to clarify the relationship between biomarkers and the mechanisms of ischemic stroke remains limited.

Metagenomics reveals unique gut mycobiome biomarkers in major depressive disorder - a non-invasive method.

Background: An increasing amount of evidence suggests a potential link between alterations in the intestinal microbiota and the onset of various psychiatric disorders, including depression. Nevertheless, the precise nature of the link between depression and the intestinal microbiota remains largely unknown. A significant proportion of previous research has concentrated on the study of gut bacterial communities, with relatively little attention paid to the link between gut mycobiome and depression.

Beyond lipid management: Clofibrate's anti-neuroinflammation role via NF-κB inhibition in ischemic stroke.

Ischemic stroke(IS) is the second leading cause of mortality and disability worldwide and neuroimmunity plays an important role in its occurrence and development. The pathogenesis of IS is associated with various metabolic disorders. Yet reports on the amelioration of neuroinflammation by modulating metabolic disorders in clinical practice are scarce.

Metabolic Regulation as a Potential Therapeutic Approach for Alzheimer's Disease.

Lecanemab, a therapeutic antibody designed to target amyloid-beta (Aβ) clearance, has recently been approved by the FDA and introduced in multiple countries, representing a significant milestone in advancing Alzheimer's disease (AD) treatment. However, its limited clinical efficacy underscores the need for further investigation of disease pathogenesis. Emerging evidence suggests that glucose and lipid metabolism dysfunction plays a critical role in AD, with metabolic changes emerging as one of the most significantly altered pathways in the early stage of pathology.

Chinese Expert Consensus on Integrated Chinese and Western Medicine for the Treatment of Tic Disorders.

Objective: Tic disorders are neurodevelopmental conditions that manifest in childhood or adolescence and can significantly impact the quality of life of affected children and their families to varying degrees. Integrated traditional Chinese and Western medicine treatment strategies have demonstrated more pronounced efficacy and better safety profiles. However, there is currently no standardized clinical expert consensus on this approach.

Income-related benefit mobility before and after Urban and Rural Resident Basic Medical Insurance integration: a longitudinal analysis of China.

Background: To improve equity in medical insurance benefits, the Chinese government integrated the New Rural Cooperative Medical Scheme for rural residents and the Urban Resident Basic Medical Insurance for nonworking urban residents into a unified Urban and Rural Resident Basic Medical Insurance system (URRBMI). This study aims to assess income-related mobility in medical insurance benefits before and after the integration of the two schemes, and to explore its contribution to improving medical insurance equity.

Methods: The panel data were obtained from the 2011 and 2018 China Health and Retirement Longitudinal Study, with 9,662 participants.

An Analog Sensor Signal Processing Method Susceptible to Anthropogenic Noise Based on Improved Adaptive Singular Spectrum Analysis.

Sensor measurements are often affected by complex ambient noise and complicating signal processing tasks. The singular spectrum decomposition (SSA) algorithm, while widely used, faces challenges such as the difficulty of determining the number of decomposition layers, requiring iterative adjustments that reduce precision and increase processing time. This paper proposes an improved adaptive singular spectrum analysis (ASSA) algorithm that integrates a deep residual network (Res-Net) for automatic recognition.

Utilizing metagenomic profiling and machine learning model to identify bacterial biomarkers for major depressive disorder.

Background: Major depressive disorder (MDD) is highly heterogeneous, which provides a significant challenge in the management of this disorder. However, the pathogenesis of major depressive disorder is not fully understood. Studies have shown that depression is highly correlated with gut flora.

A μGal MOEMS gravimeter designed with free-form anti-springs.

Gravimeter measures gravitational acceleration, which is valuable for geophysical applications such as hazard forecasting and prospecting. Gravimeters have historically been large and expensive instruments. Micro-Electro-Mechanical-System gravimeters feature small size and low cost through scaling and integration, which may allow large-scale deployment.

Relationship between chromatin configuration and maturation ability of rat oocytes in vitro and in vivo.

Purpose: Embryo engineering requires a large number of oocytes, which undergo in vitro maturation (IVM). Understanding how to select the best quality oocytes is key to improving IVM efficiency. Oocytes have different germinal vesicle (GV) chromatin configurations, which may explain the heterogeneity in oocyte quality during IVM.

A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway.

Ethnopharmacological Relevance: Ganoderma lucidum (Curtis) P. Karst (G. lucidum) is a traditional Chinese medicinal fungus, used to exert a beneficial effect on central nervous system, such as Parkinson's disease (PD).

Measurement of inherent optical properties of water based on multiple scattering profiles using underwater off-axis single-photon lidar.

Accurately measuring inherent optical properties (IOPs) in water is fundamental for characterizing light transmission in aquatic environments and advancing our understanding of biogeochemical processes. Lidar, with its capability for continuous day-and-night observations and strong water penetration, holds great potential for detecting optical parameters in water. However, ocean lidar faces challenges in addressing ill-posed equations and mitigating the effects of multiple scattering when detecting IOPs.

Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.

Ganoderma lucidum is a traditional Chinese medicine used to treat Alzheimer's disease (AD), whose main active ingredient is polysaccharides. A heteropolysaccharide named GLPZ-1 was isolated from Ganoderma lucidum. GLPZ-1 (6.

Single-Molecule Observation of Competitive Protein-Protein Interactions Utilizing a Nanopore.

Two or more protein ligands may compete against each other to interact transiently with a protein receptor. While this is a ubiquitous phenomenon in cell signaling, existing technologies cannot identify its kinetic complexity because specific subpopulations of binding events of different ligands are hidden in the averaging process in an ensemble. In addition, the limited time resolution of prevailing methods makes detecting and discriminating binding events among diverse interacting partners challenging.

Anaerobic co-biodegradation of polyhydroxyalkanoate and swine manure for volatile fatty acid production: The impact of C/N ratios and microbial dynamics.

Polyhydroxyalkanoate (PHA) is the important biodegradable plastic, however, biodegradation of PHA waste in anaerobic environments emits more CH, a potent greenhouse gas. Bioconversion of PHA waste to useful byproducts - volatile fatty acids (VFAs) is a practical method to upcycle carbon from PHA. In this study, PHA waste was anaerobically co-digested with swine manure (SM) (the typical high nitrogen waste) at different C/N ratios.

Precursor engineering towards orange- and red-emissive carbon dots for LEDs with tunable emission colors.

Carbon dots (CDs) have attracted significant research interest due to their great potential in optoelectronic applications. Although various CDs have been synthesized the "bottom-up" pathway, few studies have focused on understanding the origins of the structural and optical diversities of CDs. In this study, two benzenoid acids with a slight structural variation (, 9-oxo-9-fluorene-2,7-dicarboxylic acid (FR) and 4,4'-biphenyl dicarboxylic acid (BP)) are employed as precursors, yielding orange- and red-emissive CDs with quantum yields of 43.

Lactylation and Ischemic Stroke: Research Progress and Potential Relationship.

Ischemic stroke is caused by interrupted cerebral blood flow and is a leading cause of mortality and disability worldwide. Significant advancements have been achieved in comprehending the pathophysiology of stroke and the fundamental mechanisms responsible for ischemic damage. Lactylation, as a newly discovered post-translational modification, has been reported to participate in several physiological and pathological processes.

Exploring the regional cooling efficiency of urban residential vegetation using scenario simulation.

The study of the cooling efficiency of vegetation in urban residential areas at a micro-scale is important for improving the thermal environment of those areas. The quantitative analysis of the effect of the layout of different building patterns on the cooling efficiency of green space is particularly crucial. This study takes a typical residential area with a row-column arrangement in Jiangning District, Nanjing City, Jiangsu Province, China, as the research object.