Effects of Liver Enzyme Levels During Pregnancy on Birth Weight.

Objectives: To investigate the association between maternal liver enzyme concentrations during pregnancy and the risk of abnormal birth weight.

Methods: This is a prospective birth cohort study querying the pregnant women from Fujian Maternal and Child Health Hospital, affiliated with Fujian Medical University, China. Liver enzyme levels, including gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were measured in the first and third trimesters, and changes in liver enzyme levels were calculated based on these measurements.

Impact of bed morphology on microplastic transport at a confluence between a channel and a pipeline.

Urban drainage systems are crucial pathways for the transport of terrestrial microplastics (MPs) to urban rivers. This study investigates the impact of the bed morphology on the transport of MPs at a laboratory-scale 90° confluence between an open channel and a pipeline. A series of flume experiments were conducted to identify the bed morphology and MPs distribution downstream the confluence junction for different confluence discharge ratios (Q/Q) and pipe heights (h).

Citric Acid and Polyethylene glycol Modified Na-Cyclodextrin MOFs for Efficient Antibiotic Removal and In-Depth Investigation of Adsorption Mechanisms.

Antibiotics in wastewater have a significant threat to human health and ecosystems. Metal-organic frameworks (MOFs) are among the most promising adsorbents for removing antibiotics from wastewater. In the present study, an environmentally friendly sodium-based cyclodextrin metal organic framework (CD-MOF) was synthesized and further modified with citric acid (CA) and polyethylene glycol (PEG) to enhance its water stability and adsorption capacity.

Galvanic-Cell-Based Self-Powered Bioelectronic Devices.

Bioelectronic devices hold significant promise for advancing biomedical technologies, addressing critical healthcare challenges, and improving the quality of human life. Conventional bioelectronic devices are typically powered by external, bulky batteries connected by extended electrical wires, which limit the compactness and miniaturization of bioelectronics, restrict patient mobility, and increase the risk of complications such as infections and device-related failures. This perspective discusses the emerging concept of galvanic-cell-based self-powered bioelectronic devices, in which galvanic electrodes serve directly as the tissue-contacting interfaces.

Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis.

Introduction: Neuroprotective agents for acute ischemic stroke often fall short in efficacy due to the blood-brain barrier challenges, lack of target specificity, and limited effectiveness. Recently, plant-derived extracellular vesicle-like particles (EVLP) have shown promise in their multifaceted functions.

Objectives: The neuroprotective advantages that EVLP produced from Houttuynia cordata Thunb against cerebral ischemia/reperfusion injury are investigated.

Associations between season of conception and maternal and perinatal health: a prospective birth cohort study.

Background: Global maternal health progress stagnated during the Sustainable Development Goal era, while the impact of meteorological conditions on maternal-infant outcomes remains contentious. We aimed to investigate the relationship between the season of conception and adverse perinatal outcomes.

Methods: We conducted a prospective cohort study, collecting basic demographic characteristics of pregnant women and estimating the season of conception based on the date of the last menstrual period.

Lateral approach for total knee arthroplasty in patients with valgus deformity: A step-by-step surgical technique.

Background: The lateral approach in total knee arthroplasty (TKA) is indicated primarily for patients with valgus knee deformity, as it allows direct access to the lateral anatomy and systematic correction of associated pathologies.

Surgical Technique: This technique involves strategic lateral soft tissue releases, which improve exposure to the posterolateral corner, enhance tibial rotation, and support patellar alignment without compromising medial vascularity or requiring a tibial tubercle osteotomy for joint exposure. Critical steps in the lateral TKA approach include maintaining a capsular-synovial overlap and preserving the Hoffa fat pad for optimal joint closure, releasing the lateral soft-tissue structures, and using a contralateral tibial cutting guide for enhanced access and protection of the patellar tendon.

Occurrence, maternal transfer, and risk implications of parabens in humpback dolphins from the South China Sea.

Parabens (PBs), extensively used as preservatives in food, cosmetics, and pharmaceuticals, are increasingly detected across diverse environmental matrices. Nevertheless, their presence and potential impacts on marine apex predators remain poorly understood. Here, hepatic tissues from 87 Indo-Pacific humpback dolphins collected from the northern South China Sea (NSCS) during 2004-2021 were analyzed for four PBs and five paraben metabolites (m-PBs) to investigate their bioaccumulation characters and potential health risks.

First trimester metabolic syndrome insulin resistance index and offspring congenital heart disease risk: The mediating role of gestational diabetes mellitus.

Background: The purpose of this research was to investigate the association between the first trimester metabolic score for insulin resistance (METS-IR) index and offspring congenital heart disease (CHD), and to pay special attention to the mediating role of gestational diabetes mellitus (GDM).

Methods: A total of 21,401 women without pre-existing diabetes were enrolled in a prospective birth cohort study conducted in China. The participants were categorized into four groups based on their METS-IR index scores.

Phenotypic Identification and Fine-Mapping of the Rice Narrow-Leaf Mutant .

Leaf morphology significantly impacts rice ( L.) plant architecture and yield. Here, we identified and characterized a novel narrow-leaf mutant, , derived from indica rice cultivar 'Huazhan' using EMS mutagenesis.

Machine learning identifies PYGM as a macrophage polarization-linked metabolic biomarker in rectal cancer prognosis.

Background: Macrophage polarization plays a pivotal role in shaping the tumor microenvironment and influencing rectal cancer progression. However, the metabolic and prognostic regulators governing this process remain largely undefined.

Methods: We constructed a macrophage polarization gene signature (MPGS) by integrating weighted gene co-expression network analysis (WGCNA) with multiple machine learning algorithms across two independent cohorts: 363 rectal cancer samples from GSE87211 and 177 samples from The Cancer Genome Atlas (TCGA).

Triple-Shell Hollow FeS/MoS Heterostructure Anodes: Synergistic Effects of Built-In Electric Field on Ultra-Stable Sodium Storage.

Metal sulfides are intensively pursed as promising anode materials for sodium-ion batteries (SIBs) owing to their high theoretical capacities, abundant and inexpensive raw materials, however, challenges remain in designing their structures, particularly due to the slow Na⁺ storage kinetics in individual sulfide, and unshaped and inefficient heterostructure persists the issue of low intrinsic ion conductivity. Herein, hollow triple-shell FeS/MoS@NC structure by integrating molecular and microstructural engineering is constructed. The intimate connection between FeS and MoS in FeS/MoS@NC arises from the simultaneous sulfidation of Fe(MoO).

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle.

The heart adapts to cardiac demand via chemical modifications of contractile myofilament proteins. Many of these modifications, such as phosphorylation, occur in proteins' intrinsically disordered regions (IDRs). These IDRs, though challenging to study, are recognized as dynamic, tunable regulators of protein function.

A multicenter, real-world study analysis: pembrolizumab changes treatment strategy for the patient with recurrent/metastatic head and neck squamous cell carcinoma.

Anti-PD-1/PD-L1 has made breakthrough progress in the treatment of recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, the Asian population in KEYNOTE-048 only accounts for 13.2% of the total population, and there is a lack of data on the mainland Chinese population.

SGLT2 Inhibitors and Improved Survival in Patients with Diabetes and Acute Myocardial Infarction: Evidence from an Electronic Health Record-Based Cohort Study.

Background: Emerging evidence suggests that sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce cardiovascular events in patients with diabetes mellitus (DM) after acute myocardial infarction (AMI), but evidence in Asian populations remains limited.

Objective: We assessed the impact of SGLT2 inhibitors on in-hospital, 30-day, and 30-day to 1-year mortality in a Northern Chinese real-world cohort.

Methods: An electronic health record-based cohort was constructed from the Tianjin Health and Medical Data Platform from January 2013 to December 2022.

Effect of time-weighted average 25(OH)D on the occurrence of major adverse kidney events in IgA nephropathy-from a 10-year population-based cohort study.

Background: Vitamin D (VD) deficiency has been found to be common and associated with a higher risk of adverse outcomes in chronic kidney disease (CKD), according to certain studies. However, whether it is associated with the progression of IgA nephropathy (IgAN) and the efficacy of supplementation remains a topic of debate.

Methods: A total of 866 patients with IgAN were included.

Direct Growth and Integration of Silicon Nanowire Transistors on Polymer Substrates.

The direct low-temperature synthesis of crystalline silicon nanowires (c-SiNWs) on flexible polymer substrates remains a critical yet unrealized milestone for scalable flexible thin-film transistors (TFTs), hindered by the interfacial mechanical mismatch between rigid silicon and deformable polymers and the ultralow thermal budgets imposed by the flexible substrates. Though nanoscale SiNW channels can be patterned/grown and transferred onto polymer substrates, high-precision postgrowth transferring and alignment of these tiny SiNW channels remain technically difficult or too cost-intensive for the implementation of large-area electronics. Here, we demonstrate a direct growth of orderly c-SiNW channels upon a flexible polyimide (PI) film for the first time, through an in-plane solid-liquid-solid (IPSLS) mechanism at 200 °C, achieving uniform diameters of 44 ± 5 nm.

[Research progress on the potential mechanisms and effects of the cholinergic anti-inflammatory pathway in sepsis].

Sepsis is a common clinical syndrome in intensive care unit (ICU) with high morbidity and high mortality, making it a global health issue. The estimated global incidence of sepsis is 437/100 000, with an in-hospital mortality of 17%, which is higher in developing countries and underdeveloped regions. Despite some progress in sepsis treatment in recent years, the complexity of its pathophysiology limits therapeutic effectiveness.

[Spatio-temporal Changes and Driving Factors of Carbon Storage in the Middle Reaches of the Yellow River Based on PLUS-InVEST-GeoDetector Model].

Studying the temporal and spatial variation characteristics and driving factors of carbon reserves in the middle reaches of the Yellow River is crucial for achieving sustainable development and regional ecological conservation against the backdrop of the "double carbon" plan. Based on the five-year interval, the land use data of the middle reaches of the Yellow River from 2000 to 2020 were selected, and the spatio-temporal evolution characteristics of carbon reserves were estimated and analyzed by coupling with the PLUS-InVEST-GeoDetector model, and the driving factors affecting the spatio-temporal differentiation of carbon reserves were discussed. Finally, the carbon reserves of the middle reaches of the Yellow River in 2030 were predicted under four developmental scenarios： natural development, ecological protection, economic development, and cultivated land protection.

Grand canonical Monte Carlo simulation on the metal-doped zeolite for enhancing separation of organic sulfur.

Content: In this study, the effects of metal doping (Al, Cu, Fe) on the performance of MFI for adsorption and removal of organic sulfur (carbonyl sulfide (COS), methyl sulfide (CHSH), carbon disulfide (CS), and ethyl mercaptan (CHSH)) were systematically investigated. The mechanisms of metal doping on the adsorption sites and the competing adsorption behaviors were revealed. Under the independent adsorption conditions, Al doping resulted in an enhancement in the adsorption of COS and CS.

Successful treatment of a scalp arteriovenous malformation with ulcerative hemorrhage and localized alopecia.

Background: Scalp arteriovenous malformation (AVM) and its clinical course associated with ulcerative hemorrhage and local alopecia are rarely reported.

Case Report: An 18-year-old male presented to a vascular anomalies center with scalp AVM and ulcerative hemorrhages over a 6-month period due to post-excision recurrence, initially associated with thinning hair and scalp erythema around the AVM lesion. After meticulous debridement, the patient was immediately given an ethanol embolization.

Molecular Windows into the Brain: Advances in BBB-Penetrable NIR Fluorescent Imaging Probes.

The blood-brain barrier (BBB) is a highly selective permeability barrier that restricts the delivery of diagnostic and therapeutic agents to the brain. Recent advances in near-infrared (NIR) fluorescent probes capable of crossing the BBB have enabled noninvasive in vivo imaging and diagnosis of brain disorders, including depression, epilepsy, stroke, glioma, Alzheimer's disease (AD), and Parkinson's disease (PD). This review highlights the latest developments in the design of BBB-penetrable NIR probes for imaging these neurological conditions.

Phase-shifting profilometry resistant to varying ambient light.

Conventional phase-shifting methods rely on the assumption of constant ambient light (AL), which is often violated in practical applications. To address this issue, what we believe to be a novel phase-shifting method resisting varying AL is proposed. The core idea is to cancel out the time-varying fringe background while preserving the sinusoidal component in the captured fringe images.

Observations and potential source regions of HFC-152a in southeastern China.

Under the global HFCs reduction framework of the Kigali Amendment (KA) to the Montreal Protocol (MP), although HFC-152a is widely used as an ozone-friendly alternative in fields such as refrigeration and foam blowing agents, its production volume has gradually increased in recent years, prompting regulatory attention. In this study, we conducted a continuous daily in-situ observation of HFC-152a at a remote site in southeastern China from May 2023 to May 2024. HFC-152a exhibits seasonal variations in mixing ratios and enhancements, with summer values being lower than in other seasons.