Heparin-loaded silk fibroin microparticles/bacterial nanocellulose (Hep@SFMPs/BNC) conduits for application as small-caliber artificial blood vessels.

Small-caliber artificial blood vessels are highly demanded and face challenges, including thrombosis and intimal hyperplasia. The excellent properties of bacterial nanocellulose (BNC) make it an excellent material for preparing artificial blood vessels. Heparin (Hep)-loaded silk fibroin microparticles (SFMPs) were synthesized in situ within the conduit wall via liquid pressure injection and phase separation, aiming to improve BNC's anticoagulant properties.

Ethanol-mediated freeze-drying enables robust bacterial cellulose aerogels for enhanced drug loading and hemostasis dressing.

This work reports an ethanol-mediated freeze-drying (EMFD) strategy that enables the scalable production of high-performance bacterial cellulose aerogels (BCAs), effectively addressing key limitations of conventional methods such as supercritical drying and standard freeze-drying, including fragility, low mechanical strength, and high cost. Specifically, by replacing water in bacterial cellulose hydrogels (BCHs) with ethanol-water solution (EWs) prior to freeze-drying, the process limits ice crystal formation and reduces capillary forces and adhesion, thereby preserving structural integrity and enhancing mechanical properties. The effects of EWs concentration on BCA morphology, volume shrinkage, mechanical strength, and pore structure were systematically investigated.

[Human epidermal growth factor gel for pin tract infection following halo-pelvic ring traction procedure in patients with severe spinal deformity].

Objective: To explore the efficacy and safety of human epidermal growth factor gel in the treatment of pin tract infections after surgery in patients with severe spinal deformity.

Methods: A retrospective case-control study was conducted to analyze the clinical data of 26 patients with pin tract infections after skull-pelvic ring traction for severe spinal deformity admitted from February 2019 to May 2022. Among them, 11 were male and 15 were female;the age ranged from 18 to 31 years, with an average of (24.

Avian Influenza Surveillance Among Migratory Birds, Poultry, and Humans Around Nansi Lake, China, 2021-2024.

Avian influenza A viruses (AIVs) pose a significant pandemic threat due to their cross-species transmission potential. However, AIV surveillance at the critical "migratory birds-poultry-exposed population" interface remains limited. Between 2021 and 2024, we implemented a prospective One Health surveillance program around Nansi Lake, monitoring AIVs in migratory birds, poultry, and environmental samples, as well as serological investigations against representative AIVs among migratory birds or poultry-exposed subjects.

Amino Nests Boost Pd/SiO Single-Atom Catalysts for Efficient Selective Semi-Hydrogenation of Acetylene.

The selective hydrogenation of acetylene to ethylene is a critical industrial process for purifying ethylene feedstocks. Palladium single-atom catalysts (Pd SACs) exhibit exceptional ethylene selectivity in this hydrogenation reaction. However, their isolated active sites show limited ability to capture and adsorb trace acetylene molecules from ethylene-rich streams, resulting in relatively low hydrogenation activity.

A multicenter, real-world study analysis: pembrolizumab changes treatment strategy for the patient with recurrent/metastatic head and neck squamous cell carcinoma.

Anti-PD-1/PD-L1 has made breakthrough progress in the treatment of recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, the Asian population in KEYNOTE-048 only accounts for 13.2% of the total population, and there is a lack of data on the mainland Chinese population.

A microporous hemostatic and antibacterial multifunctional composite foam wound dressing derived from oxidized bacterial cellulose.

Pure bacterial cellulose dressings exhibit limited therapeutic outcomes in skin wound management due to inadequate fluid absorption capacity, poor antimicrobial efficacy, and lack of bioactive components. To address these challenges, this study developed an innovative microporous multifunctional composite foam dressing (pOBC/CP/HA) via a novel in situ gas formation strategy applied to oxidized bacterial cellulose (OBC). This methodology generated microporous OBC (pOBC) by inducing bubble formation through a chemical reaction.

Exploring the Impact of Urinary Metal Exposure on Blood Lipid Profiles in Chinese Adults: Mediating Roles of Health-Related Indicators.

Background: The relationship between urinary metal exposure and lipid profiles remains unclear, particularly regarding potential mediators. This study aimed to investigate associations between urinary metals and lipid levels and to explore mediating health indicators.

Methods: We included 14 817 participants in the CMEC (Chinese Multi-Ethnic Cohort) study baseline data.

Development of SNP panel for genetic diversity assessment, fingerprinting identification and backcross breeding in .

Unlabelled: Broccoli ( L. var. ) is a globally important vegetable due to its rich nutrients as well as its anti-cancer effect.

Sparse point annotations for remote sensing image segmentation.

In the realm of deep learning, fine-grained semantic segmentation of Remote Sensing Images (RSIs) requires densely annotated pixel samples. However, acquiring such precise labels for training often incurs substantial financial and human costs. While point annotations are easier to acquire than pixel-wise annotations, they lack detailed contour information and spatial coverage.

Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.

The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major metabolism-related peripheral organs or immune system dysfunction. Multi-organ metabolomic profiling and network analysis of aged mice (24 months old) identified nicotine-responsive pathways related to glycolipid metabolism and energy homeostasis.

Mutagenesis of Highland barley (Hordeum vulgare L. Var. nudum) using nitrogen ion beam implantation: screening of phenotypic Var.ations and comparative transcriptome analysis.

Background: Highland barley (Hordeum vulgare L. var. nudum) is a key crop of the Qinghai-Tibet Plateau, renowned for its nutritional value and exceptional adaptability to high-altitude environments.

Achieving "True" Selective Hydrogenation by CO Treatment of the Pt/TiO Catalyst.

Selective hydrogenation represents a fundamental chemical transformation in industrial catalysis, yet achieving high selectivity remains a formidable challenge, particularly toward the conversion of less reactive functional groups over more reactive ones. Current approaches often rely on a preferential manner, requiring precise reaction control to prevent complete substrate conversion, which limits the operational flexibility and complicates product separation. Here, we demonstrate that a Pt/TiO catalyst, when subjected to a simple CO gas thermal treatment, can enable the true selective hydrogenation of the thermally less reactive -NO group while preserving the more reactive -C═C bond.

The Association of Urinary Zinc with Metabolic Syndrome and the Mediating Role of Liver Enzymes in the Bouyei Ethnic Group in China.

Metabolic Syndrome (MetS) is a major public health problem that has imposed enormous socio-economic burdens in most countries and regions. This study aims to investigate the association of urinary Zinc (Zn) with the risk of MetS and its components among the Bouyei ethnic group, and the role of liver enzymes as mediators in this relationship. Zn concentrations in the urine of 5033 participants were measured by inductively coupled plasma mass spectrometry.

[Single-position O-arm X-ray navigation assisted oblique lateral interbody fusion combined with minimally invasive percutaneous pedicle nail internal fixation for lumbar spondylolisthesis].

Objective: To investigate the early clinical efficacy of single-position O-arm navigation-assisted oblique lateral interbody fusion(OLIF) combined with minimally invasive percutaneous pedicle screw fixation(PPS) in the treatment of lumbar spondylolisthesis.

Methods: A retrospective analysis was conducted on 22 patients with lumbar spondylolisthesis who underwent OLIF-PPS surgery including 11 males and 11 females with a mean age of (64.6±1.

New Litchidiols and Their Derivatives of Oxidation and Polymerization contribute to the Occurrence of Dark Pericarp Disease in Litchi.

Litchi dark pericarp disease (DPD) is a physiological disorder caused by manganese (Mn) stress and characterized by dark brown spots on the pericarp. The unknown pigments in the dark spots have hindered the progress in understanding its underlying mechanisms. In this study, we successfully isolated and identified four highly abundant and browning-prone light-colored litchidiols, six litchidiones (the oxides of litchidiols) and five dark dimers of litchidiols.

Spicy food consumption and biological aging across multiple organ systems: a longitudinal analysis from the China Multi-Ethnic cohort.

Background: Biological aging is a common starting point for many chronic diseases and multimorbidity. Spicy food consumption is showing a growing trend worldwide. However, the association of spicy food consumption with the comprehensive biological age (BA) and organ-specific BAs remains unclear.

Evolution and classification of Ser/Thr phosphatase PP2C family in bacteria: Sequence conservation, structures, domain distribution.

Serine/threonine kinases (STKs) and serine/threonine phosphatases (STPs) are widely present across various organisms and play crucial roles in regulating cellular processes such as growth, proliferation, signal transduction, and other physiological functions. Recent research has increasingly focused on the regulation of STKs and STPs in bacteria. STKs have been well studied, identified and characterized in a variety of bacterial species.

Nap duration and its association with hypertension-diabetes comorbidity in minority populations: evidence from the CMEC study.

Objective: Limited information is available on the effect of nap duration and hypertension-diabetes comorbidity (HDC) in minority people. We aimed to explore the relationship between nap duration and HDC for the co-management of hypertension and diabetes mellitus in the minority.

Methods: A total of 16,911 participants from the China Multi-Ethnic Cohort (CMEC) were enrolled in this cross-sectional study.

Fabrication of sustainable, antibacterial, and water-stable paper-based materials from kapok fiber, carboxymethyl cellulose and cationic starch for disposable hygiene products.

Natural paper-based materials are desirable candidate materials for disposable hygiene products due to their environmental sustainability, cost-effectiveness, and biodegradability. However, their practical application is often hindered by poor water stability and limited functional properties. In this study, we developed a wet-laid web formation and hot-pressing technique to produce porous, layered paper-based materials with high porosity, flexibility, water stability, and antibacterial properties.

CNPY2 drives DSS-induced colitis via the macrophage-ROS axis.

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, driven by genetic, environmental, and immune system factors. However, its exact mechanisms remain unclear. Here, we demonstrate that CNPY2 plays a critical role in colitis by modulating macrophage activity.

Analysis of the association between mixed exposure to multiple metals and comorbidity of hypertension and abnormal bone mass: Baseline data from the Chinese multi-ethnic cohort study (CMEC).

Comorbidity represents an increasingly significant public health challenge. While numerous studies have confirmed the association between metals and both hypertension and osteopenia, the relationship between the multi-faceted effects of mixed metal exposure and the comorbidity of hypertension with abnormal bone mass, as well as age-specific associations, remains unclear. This study utilized baseline data from the China Multi-Ethnic Cohort Study, investigating 9870 Chinese ethnic minorities (Dong and Miao) aged 30-79 years.

Investigation on the thermal activation of peroxydisulfate by using the hydrodynamic cavitation: A case study on tetracycline degradation.

The synergetic technology of hydrodynamic cavitation (HC) and peroxydisulfate (PDS) has been adopted for the treatment of organic pollutants, while the rationale behind the thermal-activation of PDS in this process remains lacking. This paper presented investigation on the degradation of tetracycline under two types of operating conditions, including "internal reaction conditions" (pH value and TC/PDS molar ratio) and "external physical conditions" (hole shape, solution temperature and inlet pressure). Special emphasis was paid on the analysis of thermal effects through a robust modeling approach.

Rutin ameliorates stress-induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin-5 axis.

Background: Emerging evidence suggests that chronic stress compromises blood‒brain barrier (BBB) integrity by disrupting brain microvascular endothelial cells (BMECs), contributing to the development of cognitive impairments. Thus, targeting the BBB is expected to be a promising treatment strategy. The biological function of rutin has been investigated in neurological disorders; however, its regulatory role in stress-induced BBB damage and cognitive decline and the underlying mechanisms remain elusive.

Thermostability Improvement of the Chitinase from for Efficient Chitin Oligosaccharide Production via Computational Design.

The chitinase A1 from WL-12 (BcChiA1) exhibits promising potential for producing chitin oligosaccharides (CHOs), while its application is limited by its poor thermal stability. In this study, a set of thermostable variants were obtained by modifying BcChiA1 using a comprehensive strategy based on a computer-aided design. A combination of five beneficial single-point mutations (S67G/K177R/A220V/N257Y/N271E) to BcChiA1 generated a markedly improved variant, Mu5.