A thioether additive as an interfacial regulator for ultra-stable lithium-metal batteries.

Rapid inactive lithium accumulation and severe lithium dendrite growth critically limit the cycle life of metallic lithium anodes. Herein, cyclic thioether 1,3-dithiane is reported as a novel electrolyte additive for fabricating ultra-stable lithium-metal batteries. Through the preferential decomposition of 1,3-dithiane additive and PF anion ions, robust inorganic-rich electrode interphases could be generated at both the anode and the cathode, which is conducive to enhanced kinetics and structural stability of the electrode interface, endowing alleviated active lithium loss and dendrite-free lithium deposition.

A multicenter, real-world study analysis: pembrolizumab changes treatment strategy for the patient with recurrent/metastatic head and neck squamous cell carcinoma.

Anti-PD-1/PD-L1 has made breakthrough progress in the treatment of recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, the Asian population in KEYNOTE-048 only accounts for 13.2% of the total population, and there is a lack of data on the mainland Chinese population.

Characterization of private mutations in the spike protein of SARS-CoV-2 correlates with viral prevalence.

Background: SARS-CoV-2 has continued to spread globally since its outbreak. As the virus evolves, new variants affect the efficacy of current vaccines and treatments. Therefore, understanding and explaining the viral prevalence of SARS-CoV-2 is crucial for developing effective public health strategies.

Application of circulating tumor DNA liquid biopsy in nasopharyngeal carcinoma: A case report and review of literature.

Background: Circulating tumor DNA (ctDNA)-based liquid biopsy has been found to be effective for the detection of minimal residual disease and the evaluation of prognostic risk in various solid tumors, with good sensitivity and specificity for identifying patients at high risk of recurrence. However, use of its results as a biomarker for guiding the treatment and predicting the prognosis of nasopharyngeal carcinoma (NPC) has not been reported.

Case Summary: In this case study of a patient with stage IVb NPC, we utilized ctDNA as an independent biomarker to guide treatment.

Antiangiogenic Medications Impede the Oral Mucosal Microcirculation and Interfere with Oral Wound Healing: A Complication Deserving of Attention.

Long-term antiangiogenic therapy may be linked to medication-related osteonecrosis of the jaw (MRONJ), complicating surgical treatment due to impaired postoperative wound healing. However, the mechanisms underlying these healing difficulties remain unclear. This bidirectional cohort study explored the impact of antiangiogenic medications (AGM) in combination with antiresorptive medications (ARM) on oral mucosal microcirculation and its relationship with surgical outcomes in MRONJ patients.

Acidification of Polyphthalocyanine Boosts Solid-State Proton Battery Performance with High Specific Capacity and Robust Cycling Stability.

Solid-state proton batteries are regarded as one of the most promising energy storage technologies. However, the shortage of efficient protonic electrolytes significantly hinders their development. In this study, a simple, efficient, and scalable method for synthesizing metal-free polyphthalocyanine (HPPc) with high purity and crystallinity is presented, which is subsequently integrated with methanesulfonic acid (MeSA) to give a solid protonic electrolyte, MeSA@HPPc, demonstrating great potential for application in proton batteries.

A Single-Tube Two-Step MIRA-CRISPR/Cas12b Assay for the Rapid Detection of Mpox Virus.

Mpox is a zoonotic disease caused by the Mpox virus (MPXV). The rapid and accurate diagnosis of MPXV is essential for the timely and effective prevention, control, and treatment of the disease. In this study, we combined Multienzyme Isothermal Rapid Amplification (MIRA) (at 42 °C) and Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 12b(CRISPR/Cas12b) (at 60 °C) to develop a single-tube two-step assay for rapid MPXV detection, leveraging the distinct physical states of tricosane at these temperatures.

Camptothecin-loaded chondroitin sulfate-celecoxib reduction-sensitive micelles for enhanced colon cancer treatment.

Studies have shown that inflammation is closely linked to the cancer development, and the patients with inflammatory bowel disease (IBD) have a higher risk of colon cancer. Celecoxib (CXB) and camptothecin (CPT) showed potential treatment for IBD and colon cancers, respectively. However, their applications are limited by synchronous delivery, water insolubility, and off-target side effects.

Association of health literacy with illness perception of Chinese community patients with chronic disease.

Background: This study aimed to examine the association between health literacy and illness perception among Chinese patients with chronic disease in the community through a national cross-sectional study.

Methods: This cross-sectional study was conducted in China from June 20, 2022, to August 31, 2022, and used a multistage sampling approach to select patients with chronic diseases. The study included 5,525 participants from 15 provinces, drawn from the Psychology and Behavior Investigation of Chinese Residents in 2022.

Rapid visual detection of Monkeypox virus by one-step LAMP-CRISPR/Cas12b assay.

Background: Monkeypox virus (MPXV) infection has garnered significant global attention due to its rising incidence and substantial public health implications. A rapid, sensitive, and accurate diagnostic method is urgently required to enable early intervention and effective management of MPXV outbreaks.

Results: In this study, we developed a novel one-step assay that integrates loop-mediated isothermal amplification (LAMP) with CRISPR/Cas12b in one-pot for the detection of MPXV.

Quantitative and Aesthetic Analysis of Changes of the Distance Between the Eyebrows and the Eyes after "Width Reduced to Narrow" Double Eyelid Repair Surgery.

Background: Some patients will experience a change in the distance between the eyebrows and the eyes after "width reduced to narrow" double eyelid repair surgery. The objective of this study was to provide a quantitative analysis of the change in the distance between the eyebrows and the eyes of Asian women after "width reduced to narrow" double eyelid repair surgery.

Methods: Seventy-three patients who received "width reduced to narrow" double eyelid repair surgery from August 2021 to May 2024 were included for measurement and analysis of photographs taken preoperatively and postoperatively (more than 6 months after the surgical operation), and the perpendicular distance between the eyebrow down and the horizontal line of the pupil midpoint in the vertical line of the midpoint of the cornea (PTW) and margin reflex distance 1 (MRD1) were measured to analyze the change in the distance between the eyebrow and the eye before and after the surgery.

Amphiphilic Celecoxib-Polysaccharide Delivery System for Enhanced Colon-Targeted Colitis Therapy.

: Ulcerative colitis (UC), a subtype of chronic inflammatory bowel disease (IBD), is primarily treated with oral medications to reduce inflammation and alleviate symptoms. Celecoxib (CXB) is an attractive candidate for UC; however, its limited solubility and low bioavailability pose significant challenges to its clinical application. : We reported a novel chondroitin sulfate A-Celecoxib (CSA-CXB) polymeric nanoprodrug to address the limited solubility and low bioavailability of CXB.

Genetic characterization of coronaviruses causing common cold symptoms based on micro-targeted capture sequencing.

A novel micro-targeted capture sequencing method was developed for four coronaviruses that cause common cold symptoms, and its sensitivity and clinical performance were assessed using 14 pharyngeal swab samples. This technique achieved 100% genomic coverage for samples with a cycle threshold (Ct) value of 32 or lower. The genotypes of the clinical isolates were determined by phylogenetic analysis, and unique mutations were identified in the receptor-binding domain (RBD) of the spike protein.

Proline-based tripodal cages with guest-adaptive features for capturing hydrophilic and amphiphilic fluoride substances.

Proteins exhibit remarkable molecular recognition by dynamically adjusting their conformations to selectively interact with ligands at specialized binding sites. To bind hydrated ligands, proteins leverage amino acid residues with similar water affinities as the substrate, minimizing the energy required to strip water molecules from the hydrophilic substrates. In synthetic receptor design, replicating this sophisticated adaptability remains a challenge, as most artificial receptors are optimized to bind desolvated substances.

The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistance.

Mitochondria play a crucial role as organelles, managing several physiological processes such as redox balance, cell metabolism, and energy synthesis. Initially, the assumption was that mitochondria primarily resided in the host cells and could exclusively transmit from oocytes to offspring by a mechanism known as vertical inheritance of mitochondria. Recent scholarly works, however, suggest that certain cell types transmit their mitochondria to other developmental cell types via a mechanism referred to as intercellular or horizontal mitochondrial transfer.

Expansion counteraction effect assisted vanadate with rich oxygen vacancies as a high cycling stability cathode for aqueous zinc-ion batteries.

In this study, a novel tunnel structure vanadate NaVO (NaVO) cathode for aqueous zinc ion batteries (AZIBs) is facilely fabricated by thermal decomposition of polyoxovanadate containing NH ions. The NaVO cathode is characterized by abundant oxygen vacancies and nanometer dimensions. These attributes can offer extra reaction sites and suppress structural collapse during circulation.

Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis.

Abstract: Subacute thyroiditis (SAT) is an inflammatory thyroid disease characterized by neck pain, tenderness, general symptoms and thyroid dysfunction. Despite gaining new insights into the epidemiology, pathogenesis and treatment of SAT in recent years, the exact pathogenesis and determinants of its clinical progression remain unclear. Here, we profiled thyroid in situ protein alterations in fine-needle aspiration biopsy samples from SAT patients using proteomic analysis and uncovered 57 differentially abundant proteins.

Decomposition and comparative analysis of urban-rural differences in eHealth literacy among nursing students: A multisite cross-sectional study.

Background: Investigating the urban-rural differences in eHealth literacy among Chinese nursing students is imperative for enhancing healthcare education and practice. This study aimed to investigate the factors that contribute to urban-rural differences in eHealth literacy among Chinese nursing students and measure their respective contributions.

Design: A multisite cross-sectional study.

Confined Polyethylene Glycol Anchored in Kaolinite as High Ionic Conductivity Solid-State Electrolyte for Lithium Batteries.

Solid-state electrolytes (SSEs) have garnered significant attention as critical materials for enabling safer, energy-dense, and reversible electrochemical energy storage in batteries. Among the various types of solid electrolytes developed, composite polymer electrolytes (CPEs) have stood out as some of the most promising candidates due to their well-rounded performance. In this study, we choose polyethylene glycol (PEG) as the covalent grafting intercalant and lithium perchlorate as carrier source to prepare a fast lithium ion conductor, K-PEG-Li doped with clay-based active filler as a CPE.

Environmental DNA reveals the spatiotemporal distribution and migration characteristics of the Yangtze finless porpoise, the sole aquatic mammal in the Yangtze River.

The Yangtze Finless Porpoise (YFP) is one of the 13 global flagship species identified by the World Wildlife Fund and is classified as "Critically Endangered." It is also the only extant aquatic mammal in the Yangtze River. In this study, 44 sampling points were deployed across the middle and lower reaches of the Yangtze River, with vertical sampling sections established in four key areas.

Establishment and evaluation of MIRA-qPCR assay for the rapid and sensitively detection of .

(MP) is a common cause of respiratory infections, and its incidence has increased post-COVID-19 due to "immune debt." Real-time quantitative polymerase chain reaction (qPCR) is the standard for detecting MP, but it has a lengthy detection time. This study aimed to establish a highly sensitive rapid detection method for MP.

Acceptance level of advance care planning and its associated factors among the public: A nationwide survey.

Background: Advance care planning (ACP) can contribute to individuals making decisions about their healthcare preferences in advance of serious illness. Up to now, the acceptance level and associated factors of ACP among the public in China remain unclear. This study aims to investigate the acceptance level of ACP in China and identify factors associated with it based on the socioecological model.

Stromal cell-expressed malignant gene patterns contribute to the progression of squamous cell carcinomas across different sites.

Background: Squamous cell carcinomas (SCCs) across different anatomical locations possess common molecular features. Recent studies showed that stromal cells may contribute to tumor progression and metastasis of SCCs. Limited by current sequencing technology and analysis methods, it has been difficult to combine stroma expression profiles with a large number of clinical information.

Dehydroepiandrosterone attenuated the immune escape of oral squamous cell carcinoma through NF-κB p65/miR-15b-5p/B7-H4 axis.

Objectives: We aimed to explore the effects and mechanisms of action of dehydroepiandrosterone (DHEA) on immune evasion of oral squamous cell carcinoma (OSCC) to provide evidence for enhancing the effect of immunotherapy.

Materials And Methods: A xenograft mouse model and immunohistochemistry were used to reveal the patterns of tumor-infiltrating lymphocytes (TILs). The CAL27 and SCC VII cell lines were used for the in vitro study.