Quercetin boosts gut microbiota-driven production of isovanillic acid to alleviate colitis via enhancing intestinal barrier function.

Ulcerative colitis (UC) is a severe inflammatory bowel disease marked by intestinal inflammation, compromised barrier function, and gut microbiota imbalance, with a restricted range of therapeutic options currently available. Quercetin, a flavonoid extracted from fruits and vegetables, have been shown significant anti-inflammatory and microbiota-modulating effects. However, the interactions between gut microbes and quercetin in colitis remain insufficiently elucidated.

In Situ Exfoliation of Covalent Metal-Organic Frameworks for Enhancing Photocatalytic Hydrogen Peroxide Production.

Two-dimensional nanosheets exhibit largely enhanced photocatalytic activities for hydrogen peroxide (HO) production. Conventionally, the nanosheets are fabricated through ex situ approaches (i.e.

Serum trimethylamine N-oxide and long-term mortality risk in rural Northern China: A family-based cohort study.

The current study aims to assess associations between trimethylamine N-oxide (TMAO) levels and mortality, and to investigate modification effects of genetics. A total of 500 participants from a family-based cohort study were enrolled from 2005 to 2017 and followed up until 2020 in Fangshan District, Beijing, China. Serum TMAO levels were measured using the enzyme-linked immunosorbent assay (ELISA) kit.

The circRNA-mediated ceRNA molecular regulatory network in fatigue-type type 2 diabete.

Fatigue is a common but poorly understood issue in type 2 diabetes (T2DM) that affects quality of life. Although ceRNA networks regulate disease progression, their role in T2DM-related fatigue (F-T2DM) is unclear. This study developed a circRNA-mediated ceRNA network to uncover the molecular interactions causing fatigue in F-T2DM.

Smart textile interfaces based on protein structure-reconstructed bovine serum albumin hydrogel fibers for disability support.

Human-machine interaction (HMI) textile interfaces with safe ingredients for intelligent wearable sensing systems are critical in the era of information and the metaverse. To address the dual limitations of traditional synthetic polymer hydrogels (poor biocompatibility) and pure protein-based materials (limited mechanical performance), this study has redesigned the protein structure for a bovine serum albumin (BSA)-based composite hydrogel fibers system. By leveraging the synergistic interplay of dynamic ionic crosslinking and covalent crosslinking, the hydrogel system achieves enhancements in both mechanical strength and processability.

Deficiency of Kif15 impairing synaptic development leads to mood disorder in mice.

The harmony of neuronal excitation and inhibition is essential for precise neuronal circuitry in the developmental brain, and thus affects the human emotion. Abnormalities of synaptic morphology directly affect neuronal function and contribute to a variety of psychiatric disorders. Previous studies have shown that Kif15 (Kinesin-12), a microtubule-associated motor protein, affects neurite growth, navigation, and branching during neuronal development, revealing the potential of Kif15 to influence neuronal dendritic morphology.

Impact of comprehensive tobacco control policies on stroke and acute myocardial infarction among patients with hypertension and type 2 diabetes in Beijing, China: An interrupted time-series analysis.

Background And Aims: Tobacco control policies enhance cardiovascular health at the population level, but their effects on high-risk individuals, such as those with type 2 diabetes mellitus (T2DM) or hypertension, remain unclear. This study evaluated the association between a tobacco control policy and hospital admissions for stroke and acute myocardial infarction (AMI) in hypertensive and T2DM individuals.

Design: Interrupted time series study.

Machine learning-enhanced digital microscopy for personalized assessment of red blood cell storage lesions.

Background And Objectives: This study aims to develop a novel platform combining machine learning and microscope images for personalized assessment of red blood cell (RBC) storage lesions. RBCs undergo storage lesions, which adversely affect transfusion outcomes. Currently, there is no individualized assessment method for RBC aging applicable in clinical practice.

Intraventricular metastasis with malignant progression of an intraspinal solitary fibrous tumor: a case report and review of the literature.

Background: Solitary fibrous tumors are rare central nervous system neoplasms with high rates of local recurrence and distant metastasis. To date, no instances of metastatic dissemination from the spine to the ventricle with malignant progression have been documented.

Case Presentation: A 32-year-old male patient of Chinese ethnicity was diagnosed with a grade 2 intraspinal solitary fibrous tumor, demonstrating metastatic spread to the trigone region of the lateral ventricle.

Modeling post-gastrula development via bidirectional pluripotent stem cells.

The absence of stem cells capable of efficiently generating both trophoblast and epiblast lineages has hindered precise recapitulation of embryonic development. Through high-content chemical screening, we established an (AS and LY) AL medium to generate mouse bidirectional pluripotent stem cells (BPSCs) characterized by concurrent expression of OCT4 and CDX2. Mouse BPSCs demonstrated highly plastic differentiation into trophoblast, epiblast and primitive endoderm (PrE) lineages in vitro within 48 h without exogenous inducing factors and efficiently contributed to embryonic and extraembryonic tissues in vivo.

Physiological Level of Eosinophils Is Essential for the Regeneration and Homeostasis of Murine Hematopoietic Stem Cells.

Background: Eosinophils play a crucial role in host defense and immunity, yet their regulatory functions within the hematopoietic homeostasis remain poorly understood. Our prior investigations revealed that pathologically elevated eosinophil levels in asthma not only disrupt bone marrow hematopoietic stem cell (HSC) quiescence but also establish a self-reinforcing cycle of eosinophil lineage commitment. Here, we further investigate the critical role of physiologically steady-state levels of eosinophils in maintaining HSC functions.

Chinese expert consensus on the combined use of antiviral drugs for novel coronavirus infection.

The persistent mutation of the novel coronavirus (SARS-CoV-2) not only remains a threat to human health but also continues to challenge existing antiviral therapeutic strategies. In current clinical practice, the resistance of novel coronavirus to antivirals, the rebound of viral load after treatment with drugs such as nirmatrelvir/ritonavir (NTV/r), and the urgent need for rapid clearance of the virus in the management of critically and emergently ill patients suggest that the existing single-drug regimens may have limitations and that the intensity of suppression may be insufficient in some cases. In clinical practice, we have observed that a combination of antivirals with different mechanisms of action can result in better efficacy and not significantly increase adverse drug reactions (ADRs).

Urinary 3-methylhistidine as a potential biomarker for sepsis-associated acute kidney injury: multidimensional metabolomics analysis in mice and human.

Background: Sepsis-associated acute kidney injury (SA-AKI) is strongly associated with increased mortality in critical patients. The early detection of SA-AKI is crucial for clinical intervention. This study aims to integrate multiple metabolomics data related to SA-AKI to identify and validate novel metabolic markers.

Effectiveness and satisfaction of fully self-service fundus disease screening among middle-aged individuals: a cross-sectional study.

Purpose: To investigate the imaging quality, efficiency and satisfaction of fully self-service fundus photography compared with traditional fundus photography performed by experienced operators among middle-aged individuals.

Methods: Participants aged 45-64 in the community of Shanghai were included, and eye disease screenings were carried out after obtaining informed consent. All participants had no cataracts or other conditions that could potentially compromise the quality of fundus imaging.

Effect of long-acting injectable antipsychotics on treatment adherence and healthcare utilization in Chinese patients with schizophrenia: a mirror-image study.

Background: Long-acting injectable (LAI) antipsychotics can improve treatment adherence in patients with schizophrenia. Despite their benefits, LAIs are underused in China compared to other countries. Little real-world evidence describes the impact of switching from oral to LAI antipsychotics on adherence and healthcare utilization in clinical practice in China, which could help address this gap.

Erratum: Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect .

[This corrects the article DOI: 10.7150/thno.53121.

Graphene-Inspired Mono-Elemental 2D Materials: Synthesis, Properties, and Potential Applications of Xenes.

Xenes, a class of mono-elemental two-dimensional (2D) materials, have emerged as promising candidate materials for next-generation electronic and energy devices due to their unique structural and electronic properties. This review first systematically categorizes the eighteen experimentally realized Xenes into Group III-VI and other group categories, summarizing their synthesis routes, ranging from top-down exfoliation to bottom-up methods. Based on density functional theory (DFT), this paper focuses on theoretical predictions of stable phases and substrate interactions, which guide experimental preparation.

METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells.

Unlabelled: METTL3 and METTL14, key components of the m6A methyltransferase complex, have been extensively studied in the context of various cancers. However, their roles in regulating alternative splicing in pancreatic cancer remain largely unexplored. In this study, we analyzed high-throughput RNA-seq data (GSE146806), alongside CLIP-seq datasets (GSE132306 and SRP163326), to investigate the molecular mechanisms underlying METTL3_14-mediated regulation.

Respiratory pathogens in infants and young children with acute respiratory illness: a prospective cohort study, China, 2023-2024.

Background: Infants are vulnerable to acute respiratory infections (ARIs), which result in pediatric morbidity and even fatalities. A surge of ARIs among infants and young children was reported in China in 2023, garnering global attention. We aimed to investigate the frequency and types of respiratory pathogens associated with the risk of acute respiratory illnesses in infants and young children during this period.

Overcoming feature scarcity in complex system prediction: An alternative delay embedding.

Predicting the future dynamics of complex systems remains challenging in scientific research. Traditional methods generally approach this issue by approximating the correlations between predictors (features) and target variables, often employing predictors from a pool of target-related variables (system components). However, these approaches are inherently constrained when reliable target-related features are scarce.

Experimental study of the rotation characteristics of magnetically driven vacuum-arc cathode spots.

Achieving uniform, stable, and reliable erosion of electrode materials is crucial for enhancing the performance and lifespan of vacuum-arc devices. This study investigates the rotation and erosion characteristics of cathode spots on Cu and Ti cathodes with various applied magnetic fields. The results indicate that with the discharge current changes, cathode spots evolve from a single spot to multiple spots and then back to a single spot.

Dietary Supplementation with Probiotics Alleviates Intestinal Injury in LPS-Challenged Piglets.

This study aimed to assess whether dietary supplementation with probiotics could alleviate intestinal injury in lipopolysaccharide (LPS)-challenged piglets. Healthy weaned piglets were randomly allocated to four individual groups ( = 6): (1) a control group; (2) an LPS group; (3) an LPS + group; and (4) an LPS + group. The control and LPS groups received a basal diet, while the probiotic groups were provided with the same basal diet supplemented with 6 × 10 cfu/g of () or a combination of () and () at a dosage of 3 × 10 cfu/g, respectively.

Experimental Study on the Pore Structure Evolution of Sandstone Under Brine Erosion.

The mechanical properties of sandstone, a common building material, are influenced by a variety of factors. In the coastal areas of China, groundwater has gradually become salinized into brine, which inevitably alters the original microstructure of rocks and affects the stability of underground structures. To clarify the evolution of the rock microstructure under brine erosion, this study used NMR technology to investigate the pore evolution characteristics of red sandstone under brine erosion.