Quercetin boosts gut microbiota-driven production of isovanillic acid to alleviate colitis via enhancing intestinal barrier function.

Ulcerative colitis (UC) is a severe inflammatory bowel disease marked by intestinal inflammation, compromised barrier function, and gut microbiota imbalance, with a restricted range of therapeutic options currently available. Quercetin, a flavonoid extracted from fruits and vegetables, have been shown significant anti-inflammatory and microbiota-modulating effects. However, the interactions between gut microbes and quercetin in colitis remain insufficiently elucidated.

Injectable biomimetic nano-hydrogel composite based on copper selenide nanoparticles and carboxymethyl chitosan for synergistic chemo-photothermal cancer therapy.

This study reports the synthesis and characterization of an injectable nano-hydrogel composite (m@NPs-HG) based on selenium nanoparticles (Se NPs) and carboxymethyl chitosan (CMCS) nanoparticles for enhanced cancer therapy. Selenium nanoparticles were stabilized using CMCS to form copper selenide nanoparticles (CSe NPs), while doxorubicin (DOX)-loaded CMCS nanoparticles (CD NPs) were encapsulated within cancer cell membranes to generate biomimetic nanoparticles (m@NPs). Subsequently, CSe NPs and m@NPs were integrated into a hydrogel via crosslinking with CuCl, resulting in the formation of m@NPs-HG.

Correlating Metal Spin Electron with CO Adsorption in Single-Atom Catalysts: A Theoretical Investigation.

Electron spin at metal sites plays a critical role in surface/interface reaction activity. Herein, a series of metal (Fe, Co, Ni, Pd, Pt, Cu, Ag, and Au) single-atom catalysts as activity center and CO as a probe molecule, to systematically investigate the role of spin electrons by calculations of structure stability, orbital energy level, and electron transfer. Fe and Pt single-atom structures are most stable in low-spin states, while others are stable in high-spin states.

Characterization of FLOWERING LOCUS T-related genes and their putative gene regulatory network in semi-winter Brassica napus cultivar Zhongshaung11.

In many species, FLOWERING LOCUS T (FT)-like genes promote the floral transition by integrating environmental signals, in particular photoperiod, and internal cues. Here we show that Brassica napus contains six FT-like genes and two pseudogenes belonging to three orthogroups. All B.

Inspiration of combined additive on the yield of humic and fulvic acids and the formation of functional groups to mitigate heavy metal bioremediation.

Current humic substances (HSs) production for bioremediation suffers from low yields and inconsistent functionality. The present work examined humic acid (HA) and fulvic acid (FA) extraction from compost treated with (1) molasses alone (CK), (2) Pseudomonas aeruginosa (T1), (3) Bacillus firmus (T2), and (4) a synergistic combination of molasses and both microbes (T3). The humic substances (HSs) were extracted using the standard alkaline extraction followed by the acid precipitation method.

Multifocal intraocular lenses improve near vision but increase optical aberrations in patients with non-proliferative diabetic retinopathy.

Objective: To evaluate the long-term effects of phacoemulsification with monofocal (SIOL) versus multifocal intraocular lens (MIOL) implantation on visual quality in patients with non-proliferative diabetic retinopathy (NPDR).

Methods: A retrospective analysis was performed on 138 NPDR patients who underwent cataract surgery at the First People's Hospital of Xianyang between August 2021 and August 2023. Patients were assigned to either the SIOL group (n=62) or the MIOL group (n=76).

Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions.

Bacterial cell wall peptidoglycan (PG) consists of alternating β-(1,4) linked N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG). The C-6 hydroxyl group of NAM is acetylated by transmembrane O-acetyltransferases post PG biosynthesis in many pathogenic bacteria. This modification is important for bacterial resistance to lysozyme.

The roles of loneliness and self-control in the association between social avoidance and nomophobia among college students.

Nomophobia has become an increasingly common mental health concern among college students. While prior research has examined various factors contributing to nomophobia, the relationships among social avoidance, loneliness, and self-control within the Chinese context remain underexplored. This study aims to investigate the impact of social avoidance on nomophobia, with a particular focus on the parallel mediating roles of loneliness and self-control.

Health Protective Behavior in Occupational Health Practice: A Concept Analysis.

Background And Aims: Health protective behavior (HPB) is critical in reducing occupational accidents and diseases, yet prior research lacks conceptual clarity. Existing definitions vary widely, ranging from compliance with medical advice to broader hazard avoidance, and fail to holistically address occupational contexts. These inconsistencies hinder the development of targeted interventions and standardized practices in workplace health protection.

Emotional attachment and resistance to change in the use of technology: A study among Chinese university music teachers.

While technology adoption has received widespread attention in teaching, little research has been conducted on the impact of emotional attachment and resistance to change on technology adoption by teachers, especially in the field of music. This study adopted an extended technology acceptance model to examine music teachers' technology adoption in the context of Chinese university teaching. These results suggest that music teachers in the Chinese universities have positive attitudes toward the use of technology in music education.

Comprehensive analysis of the physiological and molecular responses of phosphate-solubilizing bacterium DJB4-8 in promoting maize growth.

Phosphorus (P) is one of the essential macroelements for the growth of maize. The deficiency of P in maize will result in adverse effects, including chlorosis and reduced yield. The Hexi Corridor in China serves as the principal region for seed maize production, with chemical phosphate fertilizer remaining the predominant source of P delivery for local maize cultivation.

Cross-feeding and co-degradation within a bacterial consortium dominated by challenging-to-culture sp. HA-1 enhances sulfonamide degradation.

The use of sulfonamides (SAs) leads to residual environmental pollution. Bacteria play a crucial role in the degradation of SAs, and microbial consortium offers advantages over single bacterium. However, the complexity of the degradation processes and interaction mechanisms within such consortia remains a mystery.

Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis.

Background: Currently, there is a paucity of clinically effective medications for the treatment of diabetic cardiomyopathy (DCM), while the strategy of drug repurposing offers a promising avenue for advancing therapeutic development.

Methods: The investigation explored the ameliorative effects and uncovered underlying mechanisms of trapidil (TRA), a drug commonly employed in the management of coronary heart disease, on DCM by inhibiting myocardial pyroptosis. Type 1 DCM models were established utilizing C57BL/6 mice and primary neonatal mouse cardiomyocytes (NMCMs), which were subsequently treated with TRA.

Molecular Networking-Driven Discovery of Antifungal Azaphilone Dimers from the Marine-Derived Fungus sp. HK1-8.

A novel azaphilone dimer, humilone A (), along with its related monomer, humilone B (), was isolated from cultures of the marine-derived fungus sp. HK1-8 using a molecular networking-guided discovery approach. Further investigation of the molecular family of azaphilone dimers led to the putative identification of four analogues, humilones C-F (-), based on systematic analysis of their characteristic MS/MS fragmentation patterns.

Molecular Networking Reveals Indolo-Sesquiterpene Hybrids from the Marine-Derived Fungus N4-9.

Tandem mass spectrometry (MS/MS)-based molecular networking has emerged as a powerful tool for rapid dereplication of known compounds and discovery of novel structural analogues within the same metabolite class. In this study, the chemical diversity of indolo-sesquiterpene hybrids from the mangrove rhizosphere soil-derived fungus, N4-9, was investigated by using molecular networking strategies. The known indolo-sesquiterpene hybrid terreuside B () along with three new analogues, terreusides C-E (-), were targeted isolation from the fungal cultures.

Flexible phosphonium and sulfonate pair-to-pair self-assembled ionic organic single crystals for iodine capture.

In this work, four flexible chain phosphonium-based ionic organic single crystals (IOCs) are first facilely prepared by pair-to-pair ionic self-assembly of phosphonium salts and sulfonic acids (salts) under mild conditions. Their structures, morphology, stability, and surface areas are characterized in detail. Featuring a wealth of sulfonate and phenyl groups as powerful active sites for iodine adsorption, these materials exhibit considerable capture capacities.

Sanqi oral solution alleviates podocyte apoptosis in experimental membranous nephropathy by mediating EMT through the ERK/CK2-α/β-catenin pathway.

Introduction: Sanqi oral solution (SQ) is a Chinese medicine that has been used well to treat idiopathic membranous nephropathy (IMN). It has been demonstrated to mitigate IMN proteinuria by inhibiting podocyte apoptosis. however, the precise mechanism has not been fully elucidated.

Nervous system-gut microbiota-immune system axis: future directions for preventing tumor.

Tumor is one of the leading causes of death worldwide. The occurrence and development of tumors are related to multiple systems and factors such as the immune system, gut microbiota, and nervous system. The immune system plays a critical role in tumor development.

An excitation-wavelength-dependent organic photoluminescent molecule with high quantum yield integrating both ESIPT and PCET mechanisms.

Excitation wavelength-dependent (Ex-De) chromophores, which exhibit changes in spectral composition with varying excitation wavelengths, have garnered significant interest. However, the pursuit of novel photoluminescence (PL) mechanisms and high luminescence quantum yields is facing huge challenges. Here, we discover that the introduction of a spinacine moiety to 2-(2-hydroxy-5-methylphenyl)benzothiazole, a traditional excited-state intramolecular proton transfer (ESIPT) fluorophore, results in a novel Ex-De PL molecule.

Identification of orphan GPR25 as a receptor for the chemokine CXCL17.

C-X-C motif chemokine ligand 17 (CXCL17) is a small secretory protein primarily expressed in mucosal tissues, which likely functions as a chemoattractant; however, its receptor is controversial. Herein, we identified the rarely studied orphan G protein-coupled receptor 25 (GPR25) as a receptor of CXCL17 via prediction using the newly developed AlphaFold 3 algorithm and experimental validation. In the NanoLuc Binary Technology (NanoBiT)-based β-arrestin recruitment assay, recombinant human CXCL17 could activate human GPR25 in transfected human embryonic kidney (HEK) 293T cells with an EC value around 100 nm, but it had no activation effect on the other 17 tested G protein-coupled receptors.

Exploring the Biodiversity and Antibacterial Potential of the Culturable Soil Fungi in Nyingchi, Tibet.

The Qinghai-Tibet Plateau, known as "the third pole" of the Earth, boasts unique climatic conditions with abundant sunlight, low temperature, and significant annual temperature variations, nurturing a diverse array of soil microorganisms with rich metabolic products. In this study, 132 fungal isolates were isolated and identified from the soil samples collected in Nyingchi, Tibet, belonging to 32 genera and 59 species, while Ascomycota, Mucoromycota, and Basidiomycota accounted for 91.7%, 7.

Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35.

Background: Gut microbiota can significantly alter the risk or progression of cancer by maintaining gut immune system homeostasis. However, the exact mechanism by which the gut microbiota and its metabolites influence colorectal tumorigenesis is unclear.

Methods: The roles of tryptophan metabolite indole-3-acetic acid (IAA) in inflammation and tumor development were investigated in dextran sodium sulfate (DSS) and azoxymethane (AOM)-DSS mouse models with or without IAA supplementation and with or without -produced IAA.

Corrigendum: Comprehensive profiling reveals distinct microenvironment and metabolism characterization of lung adenocarcinoma.

[This corrects the article DOI: 10.3389/fgene.2021.

Time perspectives and precrastination: Understanding early task completion in a time-moving perspective.

This study examines the relationship between precrastination-a tendency to complete tasks early-and the time-moving perspective. Given the opposing nature of precrastination and procrastination, we hypothesize that precrastination correlates positively with a time-moving perspective, based on the finding that procrastination correlates with an ego-moving tendency. To test this, we conducted a survey with 366 participants (172 females aged 17 to 68), assessing their tendencies toward precrastination and their responses to the classic "ambiguous meeting question" (McGlone & Harding, 1998).

Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.

Xifeng Jiannao Pill (XFJNP), a traditional Chinese medicine formulation, has been shown to alleviate clinical symptoms in patients with Parkinson's disease (PD). However, the underlying mechanisms remain unclear. Therefore, this study employs network pharmacology and molecular biology to investigate the potential therapeutic mechanisms of XFJNP.