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Article Abstract
A novel azaphilone dimer, humilone A (), along with its related monomer, humilone B (), was isolated from cultures of the marine-derived fungus sp. HK1-8 using a molecular networking-guided discovery approach. Further investigation of the molecular family of azaphilone dimers led to the putative identification of four analogues, humilones C-F (-), based on systematic analysis of their characteristic MS/MS fragmentation patterns. Detailed fragmentation studies of the dimers revealed that the predominant cleavage fragments originated from C-C bond scission at the dimeric methylene bridge. Compound displayed antifungal activity against .
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