The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.

Ferroptosis is a novel type of programmed cell death caused by iron-dependent lipid peroxidation. Targeted induction of ferroptosis holds great promise for cancer treatment. SNHG, a newly recognized lncRNA family, has been reported to implicate in the proliferation, invasion, migration or drug resistance of cancer cells.

Longitudinal changes in estimated glomerular filtration rates in chronic hepatitis B patients treated with Tenofovir Alafenamide Entecavir.

Background: For individuals with chronic hepatitis B (CHB) at higher risk of nephrotoxicity, entecavir (ETV) and tenofovir alafenamide (TAF) are recommended antiviral options. This study aimed to investigate kidney safety among treatment-naïve individuals with CHB receiving TAF versus ETV.

Method: Treatment-naïve individuals with CHB receiving either TAF or ETV from July 2019 to December 2020 were included.

Crossing nerve transfer restores limb movement by reorganizing the cortico-rubro-spinal pathway in peripheral nerve injury.

Peripheral nerves connect the central nervous system to the limbs. Crossing nerve transfer (CNT) promotes motor recovery after unilateral brain injury by inducing functional reorganization in central neural circuits. However, how specific circuits reorganize following peripheral nerve injury (PNI) under intact central pathways remains unclear.

General Synthesis of 2D Mesoporous Multimetal Spinel Supracrystals for High-Efficiency Electrochemical Applications.

Two-dimensional (2D) mesoporous metal oxide crystals that integrate atomic-level single crystallinity with ordered mesoporosity represent a promising but rarely realized class of materials, particularly in multicomponent systems. Here, we report a universal strategy for synthesizing freestanding 2D mesoporous spinel supracrystals with tunable compositions, spanning from unary to multinary spinel oxide systems. This approach decouples crystalline framework formation from mesopore generation, combining emulsion-mediated, on-surface crystallization of 2D nanocrystal superlattices with thermally-induced collective nanocrystal reorientation and facet-selective epitaxial fusion.

Ecological functions coupled with plasmid and phage-mediated dissemination drive the global prevalence of high-risk antimicrobial resistance genes in influent.

Antibiotic resistance genes (ARGs) in wastewater treatment plant (WWTP) influent pose potential global risk to public health. However, the spatiotemporal distribution of global influent ARGs, the highly prevalent core ARGs components, and their transmission mechanisms remain unclear. The resistance risk ranking integrating abundance, mobility, and pathogenicity in actual influent samples is still undefined.

Metabolic Reprogramming-Related Genes in Lung Adenocarcinoma: Identification and Prognostic Model Construction.

Background: Lung adenocarcinoma (LUAD), the predominant histological subtype of lung cancer, persists in presenting a dismally low 5-year overall survival (OS) rate, notwithstanding advancements in treatment modalities. There exists a pressing necessity for the identification of innovative biomarkers that can enhance prognostic assessments and facilitate individualized therapeutic strategies. The objective of this investigation was to clarify the involvement of genes associated with metabolic reprogramming in the progression of LUAD and to evaluate their viability as prognostic indicators.

Characterization of key spike RBD residues influencing SARS-CoV-2 variant adaptation to avian ACE2.

Introduction: The beta-coronavirus SARS-CoV-2 has been revealed to infect mammals and other species, which potentially promotes the virus adaptation to broader species and the emergence of new variants. The host range of different SARS-CoV-2 variants are mainly determined by the affinity of the receptor-binding domain (RBD) of the spike protein to the host receptor angiotensin-converting enzyme 2 (ACE2). Thus, this study aims to elucidate the detailed mechanisms of such dynamic adaptation of indicated SARS-CoV-2 variants.

Assessing barriers and facilitators of attitudes toward seasonal influenza vaccination among pregnant women using the Health Belief Model.

Pregnant women are at elevated risk of severe influenza-related complications and maternal influenza vaccination protects mothers and infants. Nevertheless, the global maternal influenza vaccination rates remain critically low. This cross-sectional survey, conducted in Shanghai during 2023-2024, applied the Health Belief Model (HBM) to evaluate the attitudes and determinants of seasonal influenza vaccination among 3219 pregnant women.

Association of triglyceride-glucose-related indices with all-cause and cause-specific mortality in individuals with prediabetesss.

Background: The triglyceride-glucose (TyG) index has been linked to the occurrence of prediabetes, but there is limited evidence regarding its association with mortality in individuals with prediabetes. Thus, this study aimed to explore the association between TyG-related indices and all-cause and cause-specific mortality in individuals with prediabetes.

Method: Based on NHANES data from 1999 to 2018, the TyG index, TyG-waist circumference (TyG-WC), and TyG-waist-to-height ratio (TyG-WHtR) were calculated.

The immunomodulatory role of tumor-initiating cells in digestive system tumors: from mechanisms to therapy.

Targeting tumor-initiating cells (TICs) in digestive system tumors is a feasible strategy to boost the effectiveness of cancer immunotherapy. Because of their stem cell-like properties, TICs can cause tumor heterogeneity, recurrence, and resistance to conventional medicines, which can seriously impair treatment outcomes. This review discusses the unique features of TICs inside various digestive system tumors, such as colorectal, pancreatic, liver, and gastric cancers.

Systematic Characterization of Optical Aberrations Reveals Cryo-FLM Localization Fidelity.

Cryo-correlative light and electron microscopy (cryo-CLEM) facilitates imaging and structural analysis by combining the molecular specificity of fluorescence microscopy with the ultrastructural resolution of cryo-electron microscopy. By further combining single molecule localization with cryo-CLEM, molecular positions of individual emitters can be revealed in the context of the electron density map of a cell, providing unique insights to profound questions in cell biology and virology. However, cryogenic fluorescence light microscopy (cryo-FLM) suffers from severe and spatially heterogeneous optical aberrations that distort the point spread function, limiting the accuracy of molecular localizations as well as downstream cryo-transmission electron microscopy workflows.

Immunogenicity and safety study of 23-valent pneumococcal polysaccharide vaccine revaccination among elderly individuals aged 60-70 years in Shanghai, China.

Background: To understand the immunogenicity and safety of the 23-valent pneumococcal polysaccharide vaccine in elderly individuals aged 60-70 years in Shanghai after revaccination.

Methods: A total of 330 elderly people aged 60-70 years were recruited to study the immunogenicity and safety of PPSV23 revaccination. The group with a history of PPSV23 vaccination and an interval of 5 years or more was selected as the revaccination group (n=220), and the group without any pneumococcal vaccine was selected as the first vaccination group (n=110).

Proteomic Tracking Extracellular Vesicle RNA Interactors in Recipient Immune Cells through Orthogonal Labelings.

RNA cargos in extracellular vesicles (EVs) mediate intercellular communication by engaging RNA-binding proteins (RBPs) in recipient cells. Here, we introduce extracellular RNA interactome capture through orthogonal labelings (ERICOL), a targeted cross-linking and quantitative chemical proteomic strategy based on metabolic labeling of RNAs and stable isotope labeling of proteins for systematic profiling of EV RBPs in recipient cells. Time-resolved analysis of tumor-derived EVs in Jurkat T cells revealed dynamic patterns of EV RNA uptake and RBP engagement.

Preparation and properties of sulfomethylated lignin-based highly flexible polyurethane foam.

Polyurethane (PU) can be synthesized by replacing petrochemical polyols partially with lignin, thus improving the environmental benefit and the comprehensive performance of the foam. Herein, sulfomethylated Kraft lignin (SKL) is obtained by sulfonation of Kraft lignin (KL), and then it is used as filler to synthesize the sulfomethylated lignin-based flexible polyurethane foam (SLFPUF). The effects of SKL with different sulfonations on SLFPUF are explored.

Interleukin-33 promotes dopaminergic neuron survival and inhibits glial activation in Parkinson's disease models.

Interleukin-33 (IL33) plays a critical role in modulating immune and inflammatory responses across various diseases, yet its influence on Parkinson's disease (PD) remains elusive. In this study, we provide substantial evidence that global depletion of Il33 exacerbates PD pathology and motor deficits in vivo. Moreover, Il33 deficiency diminishes the communication between astrocytes and microglia, leading to a more profound injury to primary neurons in vitro.

Development of TPP-HK conjugates as membrane-targeting antibacterial agents against methicillin-resistant Staphylococcus aureus.

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) greatly threatens human health. Here, a series of TPP-HK conjugates with potent bacterial cytoplasmic membrane-targeting capabilities were developed to combat the escalating threat of MRSA infections. Among them, TH16 showed excellent antibacterial activity and low frequency resistance.

Age-related inflammatory biomarkers in early-onset osteoporosis in females with Gaucher disease.

Unlabelled: Gaucher disease (GD), the most common lysosomal disorder, is caused by a deficiency of the enzyme glucocerebrosidase (GCase). Accumulation of the substrate, glycosylceramide (Gb-1), and its lysosomal derivative, glucosylsphingosine, Lyso-Gb1, are associated with immune-mediated inflammation. Patients with GD experience progressive bone disease, including early-onset osteoporosis (OSR).

Altered salivary profiles in adolescents with dental caries and central obesity: a cross-sectional study.

Objectives: To explore the associations among salivary profiles, dental caries, and central obesity in adolescents.

Methods: This cross-sectional study involved 184 adolescents aged 12-15 years. Anthropometric measurements and dental examinations were conducted.

Sympathetic neurosignaling in head and neck squamous cell carcinoma: bridging tumor biology, pain, and therapeutic innovation.

The sympathetic nervous system (SNS), as an important component of the peripheral nervous system, has emerged as a crucial regulator of solid tumors, from carcinogenesis to progression, metastasis, and pain. This review brings together emerging evidence that SNS signaling is involved in head and neck squamous cell carcinoma (HNSCC) progression, metastasis, and cancer-associated pain. Possible cellular and molecular mechanisms regarding the involvement are also discussed.

Distinct Abiotic and Biotic Vanadate Reduction by Pyrite: Mineralogical, Electrochemical, and Isotopic Insights.

Vanadate [V(V)] reduction, a key process of vanadium(V) cycling and detoxification, is of geochemical interest and environmental importance, which can be driven by reducing minerals solely or by mediated by microorganisms. However, the discrepancies between abiotic and biotic processes remain poorly understood. This study demonstrated that widespread pyrite (FeS) could reduce V(V) both directly and through microbial mediation by (), with distinct outcomes.

The relationship between abdominal fat and sleep quality after combined exercise in patients with type 2 diabetes mellitus.

Background: Exercise holds promise as a non-pharmacological intervention for improving sleep quality. Therefore, this study investigated the potential relationship between abdominal fat and sleep quality after combined exercise in patients with T2DM (Type 2 diabetes mellitus).

Material And Methods: A total of 100 adults with T2DM (52 women, 48 men), aged 55-75years, were enrolled in the study who were sufficiently active and physically fit were recruited and were randomized equally into four groups: a control group, an AEX group (aerobic exercise), a REX group (resistance exercise) and a COMB group (combination exercise).

Simultaneous particle tracking, phase retrieval and point spread function reconstruction.

3D tracking and localization of particles, typically fluorescently labeled biomolecules, provides a direct means of monitoring cellular transport and communication. However, sample-induced wavefront distortions of emitted fluorescent light as it passes through the sample and onto the detector often yield point spread function (PSF) aberrations, presenting an important challenge to 3D particle tracking using pre-calibrated PSFs. PSF calibration is typically performed outside cellular samples, ignoring sample-induced aberrations, which can result in localization errors on the order of tens to hundreds of nanometers, ultimately compromising sub-diffraction limited tracking.