Dietary DL-methionine supplementation improves growth performance of Linwu ducks by regulating redox state and intestinal mucosal morphology.

This study was designed to investigate the effects of dietary supplementation with different levels of DL-methionine (DL-Met) on growth performance, intestinal mucosal morphology and antioxidant capacity of Linwu ducks. The experiment was conducted to classify 330 healthy 49 days of age female Linwu ducks into 5 treatment groups with 6 replicates per treatment and fed diets with DL-Met levels of 2.5 g/kg, 3.

Altered salivary profiles in adolescents with dental caries and central obesity: a cross-sectional study.

Objectives: To explore the associations among salivary profiles, dental caries, and central obesity in adolescents.

Methods: This cross-sectional study involved 184 adolescents aged 12-15 years. Anthropometric measurements and dental examinations were conducted.

Development of Cysteic Acid-Modified FAP Radioligands for Enhanced Renal Clearance: From Preclinical Optimization to First-in-Human Study.

Fibroblast activation protein (FAP)-targeting radioligands hold promise for cancer theranostics. Cyclic peptide-based DOTA-FAP-2286 radioligands have demonstrated high kidney uptake and retention, raising concerns regarding potential nephrotoxicity. Hence, we aimed to design three cysteic acid-modified FAP-targeting cyclic peptide ligands (DOTA-C1/C2/C3-FAP-2286) for reducing renal retention and optimizing pharmacokinetic properties.

Continuous renal replacement therapy in extremely low birth weight infants: a series of 5 cases.

Background: Continuous renal replacement therapy (CRRT) plays a pivotal role in delivering renal support to critical patients with acute kidney injury (AKI). However, administering CRRT to extremely low birth weight (ELBW) infants, defined as those with a birth weight under 1000 g, presents distinct challenges. We summarized our experiences of the ELBW infants who were treated with CRRT at a tertiary medical center in China, and evaluated its feasibility and safety in this group of patients.

Antimicrobial Peptide P-113-DPS Suppresses the Cariogenic Virulence of .

Dental caries is a widespread and contagious chronic infectious condition. As the principal cariogenic bacterium involved in dental caries, () possesses cariogenicity-related properties, including acidogenicity, aciduricity, and exopolysaccharide (EPS) synthesis. Our previously designed peptide, P-113-DPS, has demonstrated antibacterial effects on ; however, its detailed impact on its cariogenic virulence factors remains unclear.

Potentiating the Learning Outcomes in Paediatric Dentistry via Clinical Vicarious Learning Dialogue Videos: A Mixed Study.

Introduction: Vicarious learning has demonstrated potential in dental education, particularly in enhancing cognitive engagement, analytical thinking, and self-efficacies among students. This study examined the impact of implementing a series of vicarious learning dialogue videos (VLDVs) to improve the critical thinking, operative skills, and confidence of newly engaged dental undergraduate students in paediatric dentistry.

Materials And Methods: VLDVs were accessible to students through the university learning platform for self-directed access in a paediatric dentistry clinical course.

Filming evolution dynamics of Hg nanodroplets mediated at solid-gas and solid-liquid interfaces by in-situ TEM.

Nanodroplets at multiphase interfaces are ubiquitous in nature with implications ranging from fundamental interfacial science to industrial applications including catalytic, environmental, biological and medical processes. Direct observation of full dynamic evolutions of liquid metal nanodroplets at nanoscale multiphase interfaces offers indispensable insights, however, remains challenging and unclear. Here, we fabricate gas and liquid cells containing HgS nanocrystals through electrospinning and achieve the statistical investigations of full picture of Hg nanodroplets evolving at solid-gas and solid-liquid interfaces by in-situ transmission electron microscopy.

Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis.

This study aims to explore the potential correlation between circulating inflammatory proteins and carcinoid syndrome (CS). Using summary data from genome-wide association studies (GWAS), we conducted a Mendelian randomization (MR) analysis with two samples, treating 91 circulating inflammatory proteins as exposure factors and CS as the outcome. Based on genetic loci closely associated with circulating inflammatory proteins selected as instrumental variables, we primarily employed the inverse-variance weighted (IVW) method for analysis, combined with the weighted median method (WM), simple median method (SM), weighted mode estimation (WME), and MR-Egger regression for comprehensive analysis.

Multiomics analysis demonstrated a strong correlation between lipid-mediated chronic kidney disease and stroke: Potential benefits of affected patient cohorts.

Objective: Patients with chronic kidney disease (CKD) exhibit a disproportionately elevated risk of stroke, frequently compounded by renal impairment. Therapeutic strategies for stroke based on Traditional Chinese Medicine's 'kidney-brain axis' theory demonstrate clinical efficacy, indicating that there may be a potential association between chronic kidney disease and stroke, which needs further exploration and verification.

Methods: In this study, databases such as GEO, NHANES, and GWAS were used to collect data related to CKD and stroke.

Visualizing In Situ Nucleation and Growth Dynamics of CdSe-Based Heterostructures Regulated by the Water/Oil-Phase Microenvironment.

Wet-chemical reactions, covering almost all solution-based synthesis in either the oil-phase or water-phase microenvironment, lead to the as-formed products with distinct morphologies, structures, and functionalities. However, crystal nucleation and growth dynamics under those microenvironments for the same material system have not been clarified. Using in situ transmission electron microscopy on the classical II-VI CdSe-based heterostructures with atomic scale resolution, notably, we revealed the formation of Au on the CdSe surface in the oil phase while the AuSe product was nucleated in the water phase.

Machine Learning for Chromatin Regulators in Coronary Artery Disease Diagnosis.

Objective: This study aims to investigate the mechanisms underlying the role of chromatin regulator-related genes (CRRGs) in coronary artery disease (CAD) and develop a diagnostic model for CAD.

Methods: We downloaded CAD datasets from the GEO database and utilized R software for machine learning, modeling, and classification of CAD based on CRRGs.

Results: The random forest model was found to be the best approach, identifying USP44, MOCS1, SSRP1, ZNF516, and SCML1 as the top contributing genes for CAD diagnosis and prevention.

The effect of baseline versus early glucocorticoid use on immune checkpoint inhibitor efficacy in patients with advanced NSCLC.

Purpose: This study aims to investigate the specific effects of glucocorticoids (GC) on the efficacy of immune checkpoint inhibitors (ICIs), and whether this effect is influenced by the timing and dosage of GC administration. Changes in the neutrophil percentage and the helper/suppressor T lymphocyte ratio [NEUT %/(CD4+/CD8+)] during GC administration were monitored.

Methods: The clinical results of 130 patients with advanced non-small cell lung cancer (NSCLC) treated with ICIs were analyzed and compared with those of patients who did not use GC.

Study on Highly Sensitive Capacitive Pressure Sensor Based on Silk Fibroin-Lignin Nanoparticles Hydrogel.

Silk fibroin (SF) hydrogel has been proven to have excellent applications in the field of pressure sensors, but its sensing performance still needs improvement. A flexible hydrogel prepared from natural macromolecular materials was developed, and lignin nanoparticles (LNPs) were introduced during the preparation of the SF hydrogel. When LNPs account for 3% of SF, the sensing unit of the SF-LNPs hydrogel exhibits high stress sensitivity (1.

Fast and Smart State Characterization of Large-Format Lithium-Ion Batteries via Phased-Array Ultrasonic Sensing Technology.

Lithium-ion batteries (LIBs) are widely used in electric vehicles and energy storage systems, making accurate state transition monitoring a key research topic. This paper presents a characterization method for large-format LIBs based on phased-array ultrasonic technology (PAUT). A finite element model of a large-format aluminum shell lithium-ion battery is developed on the basis of ultrasonic wave propagation in multilayer porous media.

Alterations in salivary profile in individuals with dental caries and/or obesity: A systematic review and meta-analysis.

Objectives: To investigate current evidence on the association of salivary profile with dental caries and obesity.

Data/sources: A comprehensive search was conducted on PubMed, Web of Science, Embase, ProQuest Medical Database, ProQuest Sci-Tech Premium, and Cochrane Library up to June 2024. Observational studies comparing salivary profiles in individuals with dental caries and/or obesity were included.

Alleviating Effect of Lipid Phytochemicals in Seed Oil ( L.) on Oxidative Stress Injury Induced by HO in HepG2 Cells via Keap1/Nrf2/ARE Signaling Pathway.

α-tocopherol (α-T), β-sitosterol (β-S), canolol (CA), and sinapic acid (SA) are the four main endogenous lipid phytochemicals (LP) found in L. seed oil, which possess the bioactivity to prevent the risk of several chronic diseases via antioxidant-associated mechanisms. Discovering the enhancer effects or synergies between LP is valuable for resisting oxidative stress and improving health benefits.

[F]AlF-CBP imaging of type I collagen for non-invasive monitoring of pulmonary fibrosis in preclinical models.

Purpose: Pulmonary fibrosis is an irreversible scar-forming condition for which there is a lack of non-invasive and specific methods for monitoring its progression and therapy efficacy. However, the disease is known to be accompanied by collagen accumulation. Here, we developed a novel positron emission tomography (PET) probe targeting type I collagen to evaluate its utility for the non-invasive assessment of pulmonary fibrosis.

Association between biological ageing and periodontitis: Evidence from a cross-sectional survey and multi-omics Mendelian randomization analysis.

Aim: To investigate the relationship and potential causality between biological ageing and periodontitis.

Materials And Methods: We obtained the National Health and Nutrition Examination Survey (NHANES) and genome-wide association study (GWAS) summary statistics as well as single-cell sequencing data. Multivariate regression analysis based on cross-sectional data, Mendelian randomization (MR) and multi-omics integration analysis were employed to explore the causal association and potential molecular mechanisms between biological ageing and periodontitis.

Cerebral [F]AIF-FAPI-42-Based PET Imaging of Fibroblast Activation Protein for Non-invasive Quantification of Fibrosis After Ischemic Stroke.

The development of fibrosis after injury to the brain or spinal cord limits the regeneration of the central nervous system in adult mammals. However, the extent of fibrosis in the injured brain has not been systematically investigated in mammals in vivo. This study aimed to assess whether [F]AlF-FAPI-42-based cerebral positron emission tomography (PET) can be utilized to assess the extent of fibrosis in ischemic regions of the brain in vivo.