A computational investigation on the total cavopulmonary connection circulation assisted by an axial flow pump.

Objective: Fontan surgery constructs Total Cavo-Pulmonary Connection Circulation (TCPC), but lacks power. Cavopulmonary circulation assist devices (CPAD) has been proposed to support the Fontan circulation. The virtual implantation of blood pumps into the real TCPC structure to analyze the output characteristics of blood pump and flow pattern can better guide design of the pump and the formulation of powered Fontan surgical protocols.

Selective Catalytic Depolymerization of Lignin to Targeted Phenolic Monomers Using Noble Metals Supported on MgAlO without External Hydrogen.

Reductive catalytic depolymerization of lignin to obtain value-added phenolic monomers has great potential. However, achieving the efficient depolymerization of lignin under hydrogen-free conditions while selectively obtaining specific monomers remains a significant challenge. In this study, MgAlO-based catalysts with well-developed pore structures and abundant oxygen vacancies were fabricated, exhibiting excellent catalytic performance in the depolymerization of various kinds of biomass.

Codon Usage Pattern of Papillomavirus E6, E7, and L1 Genes Across Hosts.

This study investigates the codon usage preferences of papillomaviruses across different hosts and examines the evolutionary relationships of key genes (L1, E6, and E7). Complete genome sequences of 86 papillomavirus strains were retrieved from the PaVE database. Phylogenetic trees were constructed using MAFFT and ITOL, and codon usage indices, including RSCU, ENC, CAI, and GC3, were calculated using CodonW.

Atomical-Rippled-Nanodomains Stabilized Large Polarization in BiSmCoO Double-Perovskite Films.

Double-perovskite ferroelectrics have attracted increasing attention due to their highly tunable structures, multifunctional coupling effects, and potential applications in next-generation nonvolatile ferroelectric semiconductor devices. Here, an atomical-rippled-nanodomains (ARNs) are introduced to BiCoO and SmCoO solid solution double-perovskite film due to its ferroelectric single-domain coupling. By engineering triaxial tensile strain, the ferroelectric ARNs are robustly formed in BiSmCoO double-perovskite films, leading to a large ferroelectric polarization (≈23.

Reversing the Reaction Order Between FA and Rb Enhances the Photovoltaic Performance of Blade-Coated Perovskite Solar Cells.

Manipulating the kinetics of the reaction between A-site cations and Pb-I frameworks holds paramount importance for achieving high-quality, phase-homogeneous FA-dominant perovskites. It has been observed that when rubidium (Rb) serves as an A-site cation dopant, it tends to accumulate in the bulk region of the perovskite structure due to its pronounced affinity for Pb-I frameworks compared to FA. Consequently, Rb ions struggle to alleviate the exaggerated tensile strain induced by the bulky FA cations on the perovskite surface.

 sp. nov., a new species of the genus (Chrysophyceae).

The genus , belonging to the family Dinobryaceae, has been documented to have only sporadic occurrences in freshwater habitats. However, the species diversity of this genus remains largely unexplored due to the scarcity of available molecular sequences. This limitation has significantly hindered a comprehensive understanding of both the species diversity and evolutionary relationships of the genus .

A Unified Peptide Generative Framework via a Weakly Order-Dependent Autoregressive Language Model and Lifelong Learning.

Bioactive peptides have become strong candidates for a variety of clinical therapies due to their diverse advantages, which promote the development of deep generative models for peptide generation. Considering that existing methods cannot effectively deal with the conformational flexibility of peptides and find it difficult to capture accurate residue-to-residue interaction dependencies, we propose a unified peptide generative framework, PepGenWL, via a weakly order-dependent autoregressive language model and lifelong learning. PepGenWL introduces tolerance for out-of-order input as an inductive bias into the autoregressive language model, coupled with Mixture-of-Experts-style plugins to maintain the optimal trade-off between memory stability and learning plasticity across multiple rounds of fine-tuning.

Enhance Thermostability of β-Cyclodextrin Glycosyltransferase by Hydrophobic Interactions in the β-Sheet Structure.

β-Cyclodextrin (β-CD) is an attractive material with broad market potential across various industries. β-CD is produced from starch by β-cyclodextrin glycosyltransferase (β-CGTase), while the thermal stability of β-CGTase is one of the critical limitations in industrial β-CD production. Enhancing the thermal stability of β-CGTase is essential for increasing the β-CD yield and reducing production costs.

Microalgal proteins for a circular bioeconomy: Nutritional, material, and chemical valorization.

Microalgae have attracted increasing attention as a renewable biomass source due to their rapid growth, high protein content, and potential for carbon capture and wastewater treatment. However, current research and industrial utilization primarily focus on lipids and carbohydrates for biofuel and bioproduct generation, while protein-rich residues are often discarded as waste. The valorization of microalgal proteins remains in its infancy, with limited studies addressing their full potential.

Development of a prediction model for ambient dose equivalent rate distribution based on ecological half-life profiles using LASSO regression and KURAMA data.

The two-component model, comprising a fast-decay and a slow-decay component, has been widely used to approximate the decreasing trends of air dose rates in contaminated areas surrounding major nuclear accident sites. However, its adequacy is yet to be thoroughly validated. This study analyzed extensive car-borne survey data collected from 2011 to 2016 after the Fukushima Daiichi Nuclear Power Plant accident using the least absolute shrinkage and selection operator regression with a high-degree-of-freedom model.

Advances in immunotherapy and targeted therapy for advanced clear-cell renal cell carcinoma: current strategies and future directions.

Renal cell carcinoma (RCC), particularly the clear-cell subtype (ccRCC), accounts for 75-85% of kidney cancers and exhibits distinct genetic and biological heterogeneity. While surgical resection remains the mainstay of treatment for localized ccRCC, the persistence of recurrence rates underscores the significant unmet need for effective adjuvant therapies. Recent advancements in immunotherapy and targeted therapies have revolutionized the management of RCC.

A moderated mediation model of avoidance attachment and depression among Chinese online daters: A social enhancement perspective.

Psychologically vulnerable groups, such as those with avoidance attachment, are at a heightened risk for well-being issues, including depression. In the realm of online dating, these individuals frequently encounter ghosting and romantic disillusionment, yet the mechanisms linking these experiences to depression remain unclear. Grounded in the social enhancement hypothesis, this study proposes a moderated mediation model to explore how avoidance attachment contributes to depression among Chinese online daters.

Prognostic and clinicopathological value of fibrinogen-to-albumin ratio in colorectal cancer: a meta-analysis.

Background: The fibrinogen-to-albumin ratio (FAR) has been extensively studied for its potential to predict the prognosis of patients with colorectal cancer (CRC). However, findings have been inconsistent. Therefore, this meta-analysis aims to examine the prognostic value of FAR in CRC.

Causal relationship between gut microbiota and viral infectious disease: A 2-sample Mendelian randomization study.

The interaction of the dysbiosis of the gut microbiota (GM) with viral infectious disease (VID) has drawn our attention, and a better understanding of the effects of GM on VID might provide potential therapeutic approaches. However, the causal effects between GM and different types of VID remain unclear. We aimed to reveal the causal relationships between GM and VID, including adenovirus, cytomegalovirus, Epstein-Barr virus (EBV), influenza virus subtype H1N1 (H1N1) and herpes simplex virus 1 (HSV-1) infection.

Optimizing piezoelectric actuator placement for enhanced vibration control using genetic algorithms.

Active vibration control in flexible structures remains a critical challenge in engineering applications. This study proposes an optimization framework for piezoelectric sensor and actuator configurations in cantilever beams using a genetic algorithm. An objective function based on controllability and observability criteria was formulated, integrating modal strain and natural frequency analyses.

Deciphering the anti-senescent effects of Clioquinol: Lifespan prolongation, metabolic homeostasis, and phenotypic rehabilitation in Drosophila melanogaster.

Clioquinol (CQ), a halogenated 8-hydroxyquinoline, was once an oral antiparasitic for intestinal amoebiasis in the 1950s-1970s but was withdrawn due to neurotoxicity. Lately, it shows activities beyond antimicrobials, like in osteoarthritis and neurodegenerative diseases, yet its anti-aging effects are unclear. This study used Drosophila melanogaster to test CQ's effects on healthy aging and age-related diseases.

Nitrogen metabolism functional shifts of indigenous bacteria and effect on nitrogen removal in microalgae-based municipal wastewater treatment system across aeration modes.

Although the effect of aeration intensity on the performance of microalgae-based wastewater treatment systems has been widely studied, the impact of aeration mode has received less attention. This study explored how different aeration modes influence nitrogen metabolism in microalgae-based wastewater systems using metagenomic analysis. Both continuous aeration (CA) and intermittent aeration (IA) supported rapid bacterial growth and effective pollutant removal.

New records of the colonial chrysophyte (Chrysophyceae, Ochromonadales) in China.

Background: The genus was established in 2019. Its morphological characteristics are similar to and , but it differs from both. This genus connects individual cells into communities through a dichotomous branching structure, which distinguishes it from and .

Nanomaterials Mediated Enhancement of CAR-T for HCC: Revolutionizing Immunotherapy Strategies.

Hepatocellular carcinoma (HCC) presents significant challenges due to its aggressive nature and resistance to conventional treatments. While CAR-T therapy has shown promise in hematologic cancers, its application in HCC is limited by the tumor microenvironment (TME), insufficient T-cell infiltration, and antigenic heterogeneity. Nanomaterials offer a promising solution by enhancing CAR-T cell delivery, activation, persistence, and overcoming the immunosuppressive TME.

Generative prediction of real-world prevalent SARS-CoV-2 mutation with in silico virus evolution.

Predicting the mutation prevalence trends of emerging viruses in the real world is an efficient means to update vaccines or drugs in advance. It is crucial to develop a computational method for the prediction of real-world prevalent SARS-CoV-2 mutations considering the impact of multiple selective pressures within and between hosts. Here, a deep-learning generative framework for real-world prevalent SARS-CoV-2 mutation prediction, named ViralForesight, is developed on top of protein language models and in silico virus evolution.

The Relationship between Renal Interstitial Vasculopathy and Clinical and Prognosis of Patients with Lupus Nephritis.

Introduction: Renal vascular lesions (RVLs) are a common histopathological feature in lupus nephritis (LN). Despite their frequent occurrence, the clinical significance and prognostic impact of RVLs remain poorly understood. The main objectives of our study were to investigate the clinicopathological characteristics associated with RVLs in LN and to assess their prognostic implications in patients with LN.

Validation of Targeted Relationships of Novel circRNA803/lncRNA MSTRG.19726-oar-let-7a-CPEB1 ceRNA Networks, Key to Follicle Development in Single-Litter and Multi-Litter Sheep Based on Whole-Transcriptome Sequencing.

The objective of this study is to investigate the molecular regulatory mechanisms of non-coding RNA (ncRNA) during the developmental process of multi-litter sheep ovaries and identify key regulatory genes that enhance the reproductive capacity of sheep. This study selected Small-Tail Han sheep (multi-litter sheep) and Ujumuqin sheep (single-litter sheep) as comparative models, constructed the expression profiles of ncRNAs and mRNAs in ovarian tissues, identified differentially expressed (DE) lncRNAs, circRNAs, miRNAs, and mRNAs, and performed target gene prediction along with functional and signaling pathway enrichment analyses. Reproduction-related pathways were further screened to construct competing endogenous RNA (ceRNA) regulatory networks (lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA).

Multiple influences on cyanobacterial abundance and diversity in the Beijing-Tianjin-Hebei Economic Circle and nearby areas of China.

In recent years, there has been a marked increase in the frequency and duration of cyanobacterial blooms, which has attracted widespread attention from all sectors of society. However, the processes and pathways leading to the formation of cyanobacterial blooms are largely stochastic, and a targeted quantitative model incorporating multiple drivers is required. A series of fieldwork and analytical procedures were conducted on 11 lakes in Beijing-Tianjin-Hebei and neighboring regions.