Comparison of Short- and Long-Term Cardiovascular Disease Risk Assessment Tools in US Young Adults.

Background: In 2023, the American Heart Association published the Predicting Risk of Cardiovascular Disease Events (PREVENT) equations for estimating atherosclerotic cardiovascular disease (ASCVD) risk in adults aged 30 to 79 years. We compared PREVENT's performance with existing US guideline recommended models-Pooled Cohort Equations for 10-year ASCVD risk and FHS (Framingham Heart Study) equations for 30-year ASCVD risk-among young adults.

Methods: We analyzed adults aged 20 to 39 years without baseline ASCVD from 2 sources: (1) pooled data from 2 large epidemiologic cohorts (CARDIA [Coronary Artery Risk Development in Young Adults] and FHS, n=7763), and (2) electronic health records from Kaiser Permanente Southern California (n=266 378).

The Regulatory Mechanism of MicroRNA-144-3p on Damage to Endometrial Epithelial Cells Exposed to Copper Ions In Vitro.

Objective: To investigate the differential expression of microRNA-144-3p in endometrial cells exposed to copper ions in vitro. The specific mechanism by which microRNA-144-3p is involved in Cu-induced damage to the human endometrial epithelial cells (HEECs) was explored.

Methods: HEECs were cultured in copper-containing culture medium to simulate changes in the endometrium after copper intrauterine device (Cu-IUD) implantation.

Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.

Autologous nerve transplantation is currently recognized as the gold standard for treating severe peripheral nerve injuries in clinical practice. However, challenges such as a limited supply of donors, complications in the donor area, and the formation of neuromas necessitate the optimization of existing transplantation strategies. Additionally, the development of new and promising repair methods is a critical issue in the field of peripheral nerve research.

Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock.

Background/objectives: Burns can cause severe physiological disturbances. Oral rehydration therapy (ORT) is an alternative to intravenous fluids. However, the World Health Organization-recommended oral rehydration solution (WHO-ORS) lacks specific components to address the critical physiological changes in patients with burns.

The association between soy consumption and metabolic syndrome in Chinese adults: a cross-sectional study.

Background: Evidence on the association between soy consumption and metabolic syndrome (MetS) remains limited and inconclusive. This study aimed to investigate the relationship between soy intake and the prevalence of MetS and its components in a Chinese population.

Methods: A cross-sectional analysis was conducted among 5,107 adults residing in Suzhou Industrial Park, Suzhou, China.

The peach NAC transcription factor SMB-LIKE1 (PpeSML1) integrates hormonal signaling to trigger senescence and chlorophyll degradation during fruit abortion.

Fruit abortion represents a significant challenge in horticulture, leading to reduced yields and compromised fruit quality. This study explored the mechanisms underlying fruit abortion in peach, with a particular focus on the role of the NAC transcription factor (TF) SMB-LIKE1 (PpeSML1). RNA-Seq analysis and functional assays revealed that PpeSML1 promotes senescence and inhibits growth by activating pathways related to chlorophyll degradation and stress responses.

"Dual-Key"-Controlled Activatable Semiconducting Polymer Nanoprobe for Highly Precision Phototheranostics Under NIR-II Light Excitation.

The development of activatable optical probes has proved to be a promising approach to improve the accuracy of phototheranostics. However, most such probes are usually responsive to single pathological factor and visible-near-infrared-I light upon activation, which restricts the theranostic specificity and tissue penetration depth, respectively. Herein, we develop a nitric oxide (NO) and acidity dual-stimuli responsive semiconducting polymer nanoprobe for activatable near-infrared-II (NIR-II) photoacoustic imaging (PAI) and photothermal therapy (PTT).

Enhancing Fucoxanthin Pickering Emulsion Stability and Encapsulation with Seaweed Cellulose Nanofibrils Using High-Pressure Homogenization.

Poor solubility and bioavailability have limited the application of fucoxanthin in drug and functional food processing. In order to encapsulate fucoxanthin in delivery systems, in this study, cellulose was isolated from industrial brown algae residues and high-pressure homogenized into cellulose nanofibrils (CNFs). Then, fucoxanthin was encapsulated into the Pickering emulsion stabilized by the CNFs.

DFCNet: Dual-Stage Frequency-Domain Calibration Network for Low-Light Image Enhancement.

Imaging technologies are widely used in surveillance, medical diagnostics, and other critical applications. However, under low-light conditions, captured images often suffer from insufficient brightness, blurred details, and excessive noise, degrading quality and hindering downstream tasks. Conventional low-light image enhancement (LLIE) methods not only require annotated data but also often involve heavy models with high computational costs, making them unsuitable for real-time processing.

A sustainable fertilization strategy to boost maize yield and photosynthetic resilience in saline soils.

Introduction: Soil salinization is a major constraint to crop production in arid and semi-arid regions. Combined application of organic and inorganic nitrogen (OIN) has been recognized as an effective strategy to improve productivity in saline soils. However, mechanisms underlying yield improvement related to photosynthesis and antioxidant responses remain unclear.

A real-world study on the expression and clinical application of IMP3 immunohistochemistry in bone tumors.

Previous studies have confirmed that insulin-like growth factor 2 mRNA-binding protein 3 (IMP3) is widely expressed in various malignant tumors. However, no systematic study has assessed the expression of IMP3 in bone tumors. We immunohistochemically examined 1381 bone tumor specimens for IMP3 expression, analyzed its differential expression among various types of bone tumors, and evaluated its potential application in surgical pathology.

Core-Shell Catalysts with Superhydrophobicity for Enhanced Oxygen Reduction Kinetics in Zinc-Air Batteries.

Zinc-air batteries (ZABs) operating in gas-solid-liquid three-phase systems suffer from sluggish reaction kinetics and low power output, which severely hinder their commercialization. To address these challenges, an integrated strategy is proposed combining core-shell heterophase catalytic species with superhydrophobic properties. The H─CoFe─CNT catalyst, featuring carbon nanotube-grown hollow cubic carbon cages, incorporates metal carbide@metal core-shell heterophase catalytic species and exhibits superhydrophobicity.

Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.

In Diffuse Large B-cell Lymphoma (DLBCL), elevated anti-apoptotic BCL2-family proteins (e.g., MCL1, BCL2, BCLXL) and NF-κB subunits (RelA, RelB, cRel) confer poor prognosis.

Bioinspired pullulan-tannic acid hydrogels with high toughness, stretchability, adhesion and self-healing properties.

Inspired by the high-density hydrogen bonds in spider silk and the mussel adhesive mechanism, pullulan-tannic acid (TA) hydrogels with high stretchability, toughness, adhesiveness, and rapid self-healing capabilities were successfully fabricated via a hydrogen-bond-driven co-assembly strategy combined with controlled evaporation. Infrared spectroscopy confirmed the presence of hydrogen bonds between pullulan and TA, while scanning electron microscopy revealed the porous network structure of the hydrogels. The tensile strength (TS), Young's modulus (YM), and toughness values of PulTA5 hydrogels were 0.

Organic cation transporter 1 and cytochrome P450s play crucial roles in coptisine- and worenine-induced hepatotoxicity.

Coptisine and worenine, isoquinoline alkaloids prevalent in traditional herbal medicines from Papaveraceae (eg, Corydalis Rhizoma) and Ranunculaceae (eg, Coptidis Rhizoma), exhibit significant pharmacologic effects, including cardioprotective and anticancer properties. However, little information is available concerning coptisine- or worenine-induced toxicity, particularly hepatotoxicity, and the underlying mechanisms. Coptisine and worenine contain methylenedioxyphenyl groups, which may be metabolized by cytochrome P450s (P450s) to form reactive metabolites and subsequently induce toxicity.

Uniaxial Mechanical Behavior and Constitutive Modeling of Early-Age Steel Fiber-Reinforced Concrete Under Variable-Temperature Curing Conditions.

In high geothermal tunnels (>28 °C), curing temperature critically affects early-age concrete mechanics and durability. Uniaxial compression tests under six curing conditions, combined with CT scanning and machine learning-based crack analysis, were used to evaluate the impacts of curing age, temperature, and fiber content. The test results indicate that concrete exhibits optimal development of mechanical properties under ambient temperature conditions.

Chidamide and anlotinib synergistically inhibit high grade B-cell lymphomas via PI3K/AKT signaling pathway.

High-grade B-cell lymphoma with concurrent MYC and BCL2/BCL6 rearrangements (HGBL-DHL) is a challenging disease resistant to front-line immunochemotherapies, which urgently requires novel therapeutic approaches. Herein, combination of chidamide and anlotinib demonstrated potential synergistic anti-lymphoma effects against HGBL-DHL. The cooperative effect of cell proliferation inhibition, apoptosis induction, and cell cycle arrest were demonstrated in cell lines through Cell Counting Kit-8, Annexin V/PI staining, and PI staining respectively.

Investigation of NbO/SiO short-wave pass filters for beam-splitting application in a PV/CSP solar hybrid system.

Multilayer thin-film filters for beam-splitting applications were designed, fabricated, and characterized. Optimized 13- and 35-layer / filters on K9 substrates achieved wideband transmission in the range of [580-1100 nm]. Optical and structural characterizations were performed using spectrometry, atomic force microscopy (AFM), and X-ray diffraction (XRD).

Chikungunya's global rebound and Asia's growing vulnerability: Implications for integrated vector control and pandemic preparedness.

Chikungunya fever is a mosquito-borne disease caused by an RNA virus of the Alphavirus genus and is characterized by fever and severe joint pain. The disease is primarily transmitted by Aedes aegypti and Ae. albopictus mosquitoes.

A national, multicenter, retrospective study of human immunodeficiency virus infection-associated lymphoma in China.

Since the widespread use of combination antiretroviral therapy, the incidence of opportunistic infections has decreased in HIV infection populations. However, HIV-associated lymphoma become the most common causes of cancer death. Little is known about the epidemiology, survival and treatment of HIV-associated lymphoma patients in China as these are less common than HIV-negative lymphoma.

Loop Site Mutation-Enhanced Sensing Performance of G-Triplex Probe: Preliminary Exploration on Its Stability and "Structure-Efficiency" Relationship.

G-triplex is a unique topological structure formed by G-rich nucleic acid sequences with three G-tracts. It can bind to small ligands and function as a label-free sensing probe. However, the number of discovered G-triplex/small ligands with stable structures and excellent performance is still limited, requiring deeper insight on their "structure-efficiency" relationships.

Zearalenone at environmental levels promoted ER- positive breast cancer cell lines through the hedgehog pathway.

Zearalenone (ZEA) has been recognized as a common exogenous nonsteroidal estrogen in environments which possessed a disruptive effect on organisms. Exposure to exogenous estrogen has been revealed to affect breast cancer development. However, whether ZEA exerts estrogenic effects to influence and cause breast cancer is poorly documented.

Critical dimensions in strengthening education and instructor training using fuzzy based decision algorithm and CRITIC WASPAS method.

Quality education and instructor training are foundational to the development of any society, as they directly influence the effectiveness of learning and the overall performance of educational systems. Decision-making is crucial in enhancing quality education and instructor training by ensuring teaching policies. This article modifies some robust mathematical methodologies of the fuzzy framework and decision-making techniques to aggregate an authentic ranking of preferences.