Clinical application of radiofrequency technology in the treatment of facial skin wrinkles and laxity.

Background: Aging is an inevitable aspect of human life, characterized by the gradual decline in the function of individual cells and structural components, including bones, muscles, and ligaments.

Aim: To evaluate the clinical effects of radiofrequency technology in treating facial skin wrinkles and laxity.

Methods: This study included 60 female patients, aged 36-58 years (mean age 47.

Radiotherapy versus no radiotherapy for rectal neuroendocrine carcinoma patients treated with surgery and chemotherapy: a population-based cohort study.

Background: Chemotherapy is regularly recommended for surgically rectal neuroendocrine carcinoma (NEC) patients. However, the additional benefit of perioperative radiotherapy for these patients is unclear to date. This study aims to evaluate the outcome of radiotherapy in rectal NECs who treated with surgery and chemotherapy.

Analysis of three cases of disseminated BCG infection in infants after BCG vaccination in Beijing, China.

We report and analyze three cases of disseminated BCG infection in infants after BCG vaccination that occurred between 2022 and 2024 in Chaoyang District, Beijing, which were the only three monitored during the clinical application we conducted. All the patients had primary immunodeficiency disease (PID). Two cases had defects in the JAK3 and TNFRSF13B genes; one case had multiple gene defects in CR2, IFNAR2, TLR2, and exon 13 of DOCK11.

A national, multicenter, retrospective study of human immunodeficiency virus infection-associated lymphoma in China.

Since the widespread use of combination antiretroviral therapy, the incidence of opportunistic infections has decreased in HIV infection populations. However, HIV-associated lymphoma become the most common causes of cancer death. Little is known about the epidemiology, survival and treatment of HIV-associated lymphoma patients in China as these are less common than HIV-negative lymphoma.

Efficacy and safety of Kunxinning granules in patients with menopausal syndrome: a multicenter, randomized, double-blinded, and placebo-controlled trial.

Background: Menopausal syndrome is a general term for a series of physical and psychological symptoms that women experience during menopause and perimenopause, which can lead to the occurrence of a variety of diseases. Many ingredients in Kunxinning granules have been used clinically to treat menopausal syndrome. However, evidence for its effectiveness is lacking.

Understanding barriers to breast screening: an online survey of non-attenders as part of a service evaluation in the breast screening programme in England.

Background: Early detection of breast cancer through organised mammography screening of asymptomatic individuals reduces breast cancer mortality. Breast screening is offered every three years to women aged 50 to 71 years in England. However, over a third of eligible women did not attend in 2022-2023.

Diffuse Large B-Cell Lymphoma with Cardiac Metastasis: A Case Report.

BACKGROUND Diffuse large B-cell lymphoma (DLBCL) is an aggressive tumor derived from mature B cells and is the most common type of non-Hodgkin's lymphoma (NHL). Cardiac invasion is rare and heart rupture or cardiac arrest can cause increased risk. Patients with DLBCL progress rapidly and are prone to recurrence, although its 5-year survival rate is high.

Structure, sensing and control of pneumatic upper limb rehabilitation system: Review and prospect.

With the development of society, the service level of rehabilitation institutions needs to be improved. Pneumatic drive technology has attracted widespread attention due to its high safety and easy control. As a new type of driving element, pneumatic artificial muscle has important advantages in the field of assisted rehabilitation robots due to its light weight, large output force ratio, strong flexibility, low cost and easy maintenance.

Overexpression of GPX4 in diabetic rat kidney alleviates renal injury induced by ferroptosis.

Ferroptosis-mediated injury in diabetic kidney (DKD) is receiving increasing attention. Glutathione Peroxidase 4 (GPX4) has long been considered a key protein to prevent ferroptosis, but its exact role in the progression of DKD, where this protein down-regulated, remains unclear. Thus, to clarify GPX4 in DKD progression, we have used adeno-associated viruses (AAVs) to overexpress it in kidneys of DKD rats.

Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment.

Radiation-induced liver disease (RILD) severely impairs the outcome of patients receiving irradiation (IR); however, its underlying mechanism remains unknown. GSDMD drives the progression of pyroptosis, and can be induced by IR in the gut and bone marrow, but its role in RILD remains unknown. Here we show that GSDMD is significantly upregulated and positively correlated with RILD severity in a mouse model.

Polyene Cyclization/Mannich Cascade for Streamlined Construction of the A/E/F Tricyclic System of Diterpenoid Alkaloids.

The A/E/F tricyclic system characteristic of C-, C-, and denudatine-type C-diterpenoid alkaloids was constructed via a strategically designed polyene cyclization/Mannich cascade. The configurational inversion of the phenyl group at C7 successfully proceeded through a radical cascade process involving sequential 1,5-HAT and intermolecular HAT, ultimately establishing the desired tricyclic system with an β-oriented phenyl group.

IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis.

This study reveals the core mechanism by which insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) drives tumor progression and radiotherapy resistance in gastric cancer (GC) through mA-dependent regulation of hypoxia-inducible factor 1α (HIF1α). Clinical analyses show that IGF2BP2 is significantly overexpressed in gastric cancer tissues, and its expression level is closely associated with tumor size and poor patient prognosis. Functional studies demonstrate that elevated expression of IGF2BP2 accelerates the transition of gastric cancer cells from the G1 phase to the G2/M phase of the cell cycle and markedly enhances cell proliferation and migration through anti-apoptotic effects.

Migrasomes: key players in immune regulation and promising medical applications.

Migrasomes are newly discovered extracellular organelles released by migrating cells, such as immune cells, tumor cells, and other special functional cells like podocytes and embryonic cells. They contain a diverse array of constituents, including proteins, lipids, and RNA which can be released to the designated location to activate surrounding cells, thereby facilitating intercellular communication and signal transduction. Since then, our understanding of the mechanism and function of the migrasomes has expanded exponentially, with recent evidence indicating they are involved in various physiological and pathological processes, particularly in immune regulation.

Inhibition of PDK modulates radiotherapy resistance in gastric cancer.

To explore the effect of sodium dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, on the progression of gastric cancer and resistance to radiotherapy, we analyzed histopathological microarrays from 60 gastric cancer and paracancerous tissues to determine PDK expression and its prognostic significance. 5-Ethynyl-2'-deoxyuridine (EdU) incorporation assay and Transwell migration assay were used to investigate the effects of PDK inhibition on gastric cancer cell proliferation and migration. Flow cytometry revealed that PDK inhibition promoted apoptosis and induced G1 phase cell cycle arrest.

Exploring the mechanisms of Chaige Kangyi Recipe in treating recurrent pregnancy loss with insulin resistance.

Chinese herbal medicine effectively treats recurrent pregnancy loss, though its mechanism is unclear. This study used RStudio 4.3.

Comprehensive analysis of prognosis and tumor immune microenvironment of cuproptosis-related gene CDKN2A in lung adenocarcinoma.

Background: Recent research has increasingly highlighted the significance of various forms of cell death in contributing to tumor heterogeneity and modulating anti-tumor immunity. However, the potential implications of cuproptosis-related genes (CRGs) in lung adenocarcinoma (LUAD) remains poorly explored.

Methods: We conducted a comprehensive analysis of the expression profiles of 19 CRGs in LUAD based on The Cancer Genome Atlas (TCGA).

Genetic characterization of four bacteriophages of Salmonella enterica derived from different geographic regions in China via genomic comparison.

Based on the AT content > GC content in four Salmonella enterica lytic bacteriophage genomes, information entropy analysis revealed that overall nucleotide usage bias is shaped in the gene population. This genetic feature directly contributes to synonymous codons tending toward the A/T end rather than the C/G end. Furthermore, the interplay between the nucleotide composition constraint from the bacteriophage itself and the natural selection caused by outside environments forces our bacteriophages into similar evolutionary trends in terms of overall codon usage patterns.

Ultrasensitive Electrochemical Screening of Circulating Tumor Cells Over Single-Atom Nanozyme Integrated 3D Nanoarray.

Late-stage diagnosis is a major contributor to cancer mortality and thus leads to increased fatality, making early detection crucial for improving survival rates. Circulating tumor cells (CTC), detectable before primary tumors become clinically apparent, have emerged as vital biomarkers for the early identification of aggressive cancers. Here, develop a single-atom nanozyme integrated nanoarray as a 3D nano-biointerface for ultrasensitive electrochemical screening of CTCs from hepatocellular carcinoma.

Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-induced lung injury.

Infection with Influenza A virus (IAV) induces severe inflammatory responses and lung injury, contributing significantly to mortality and morbidity rates. Alterations in the microbial composition of the lungs and intestinal tract resulting from infection could influence disease progression and treatment outcomes. Xiyanping (XYP) injection has demonstrated efficacy in clinical treatment across various viral infections.

Analysis of a case of pilomatricoma in an adolescent after receiving recombinant hepatitis B vaccine (CHO cell) in Beijing of China.

We report and analyze a case of pilomatricoma in an adolescent after receiving recombinant hepatitis B vaccine (CHO cell) in Chaoyang District of Beijing and to evaluate the causality between the disease and vaccination. Based on the professional branch of this case, we organized a seminar and we invited specialists in vaccinology, epidemiology, dermatology, infectiology, and immunology to participate in the conference. Specialists evaluated the relevance and causality between the vaccination and disease.

Proteomic and spectral analysis reveals the role of extracellular polymeric substances in mercury biosorption by activated sludge under high-altitude conditions.

In high-altitude regions, elevated mercury (Hg) levels in wastewater treatment plants (WWTPs) influent raise concerns about treatment efficiency and environmental impact. This study investigated the Hg biosorption capacity of activated sludge under high-altitude conditions, focusing on the binding mechanisms between EPS and Hg, and variations in EPS secretion. Low pressure, oxygen, and temperature at high altitudes increase EPS secretion, enhancing Hg biosorption.

Optimal frailty assessment tool for elderly patients with heart failure based on outcome prediction: protocol for a multicentre prospective cohort study.

Introduction: Frailty significantly influences the prognosis of elderly patients diagnosed with heart failure. The assessment of frailty is a critical initial step in the management of these patients, as a systematic and precise evaluation facilitates the identification of individuals at high risk. This identification enables timely and targeted interventions, which can subsequently reduce the likelihood of adverse cardiovascular events and improve the quality of life for elderly patients with heart failure.

Modulation bandwidth analysis of GaN-based micro-LED deduced by an equivalent circuit model.

We establish an equivalent circuit model of the GaN-based micro-LED system incorporating the parasitic parameters of the printed circuit board and bonding wires. Our deep analysis reveals that the parameters of intrinsic micro-LED significantly impact the modulation bandwidth of micro-LED. As the resistance and capacitance of micro-LED increases, the bandwidth of micro-LED decreases sharply.

Integrin β6/Annexin A2 axis triggers autophagy to orchestrate hepatocellular carcinoma radioresistance.

Radiotherapy (RT) is one of the main therapies for hepatocellular carcinoma (HCC), but its effectiveness has been constrained due to the resistance effect of radiation. Thus, the factors involved in radioresistance are evaluated and the underlying molecular mechanisms are also done. In this present study, we identified Integrin β6 (ITGB6) as a potential radioresistant gene through an integrative analysis of transcriptomic profiles, proteome datasets and survival using HCC cases treated with IR.