Binocular visual performance and optical quality of trifocal intraocular lens in Chinese patients with high myopic cataract.

Purpose: To evaluate the visual performance and optical quality of a trifocal intraocular lens (IOL) in patients with high myopic cataracts.

Methods: This is a prospective, multicenter, non-randomized cohort study. Patients scheduled for cataract surgery with binocular AcrySof IQ® PanOptix® TFNT00 IOL implantation were enrolled.

Evidence summary of meaning in life intervention for cancer patients.

Objective: To evaluate and summarize evidence on intervention of the meaning of life of cancer patients, and provide evidence-based basis for clinical practice.

Methods: According to the "6S" evidence model, The literature related to the life meaning intervention in cancer patients were systematically searched in domestic and foreign evidence-based resource databases,comprehensive databases and professional society websites from the inception of database to Oct 2023. Two researchers evaluated the quality of the literature, extracted and integrated evidence.

Predicting survival of persons with newly-diagnosed multiple myeloma.

Background: Predicting survival in newly diagnosed multiple myeloma (NDMM) patients accurately remains challenging. Although mSMART3.0 is widely used it has not been rigorously tested for prediction accuracy.

Free prostate-specific antigen, total prostate-specific antigen, and their ratio associated with diabetic kidney disease: new evidence from male patients with diabetes in the United States.

Objectives: To examine the associations between prostate-specific antigen (PSA)-related biomarkers and diabetic kidney disease (DKD) in male patients with diabetes.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2010, including 1,681 male diabetic patients (409 of whom had DKD). Multivariable logistic regression models adjusted for age, race, body mass index (BMI), hypertension, and cardiovascular disease were employed to evaluate the relationships between total PSA (TPSA), free PSA (FPSA), and the FPSA/TPSA ratio with DKD.

AD16 Modulates Microglial Activation and Polarization to Mitigate Neuroinflammation in Ischemic Stroke Models Through α7nAChR-ERK-STAT3 Signaling.

Background: Neuroinflammation constitutes a critical pathological event subsequent to ischemic stroke. AD16, a novel anti-neuroinflammatory compound, has demonstrated efficacy in alleviating neuroinflammation in neonatal rats induced by ischemia-hypoxia. This study aims to elucidate the therapeutic utility and underlying mechanisms of AD16 in an adult ischemic stroke rat model.

Topping influences crop photosynthesis and alters the absorption and redistribution of nutrients: a case study of tobacco.

Topping eliminates apical dominance in tobacco, enhancing the quality of the upper leaves. However, the mechanisms by which topping influences photosynthesis and the leaf structure, and regulation of chemical composition remain unclear. This study investigated the regulatory mechanisms of different topping periods (buttoning, budding, first flower, and full flower topping and without topping) on photosynthesis, the leaf structure, and the chemical composition in tobacco by integrating photosynthetic physiology, anatomical, and chemical composition analyses.

A multi-omic analysis to investigate the causal associations between circulating proteins and risk of spontaneous abortion and their potential implications.

Objective: Spontaneous abortion is a complex disorder with a significant genetic component. Identifying genetic variants influencing spontaneous abortion risk could unveil biological pathways and potential therapeutic targets.

Methods: We performed Mendelian randomization using cis- and trans-protein quantitative trait loci (pQTLs) as instrumental variables to assess causal effects of circulating proteins on spontaneous abortion.

Inhibition of aflatoxin B1-induced murine hepatocyte pyroptosis by Bacillus amyloliquefaciens by activation of the Nrf2/HO-1 pathway.

Human and animals are continuously exposed to variable levels of mycotoxin that occur naturally in the diet. Aflatoxin B1 (AFB1) is the most toxic and carcinogenic aflatoxin. Probiotics have a vital role in mycotoxin detoxification.

A comprehensive review of ethnopharmacology, phytochemistry, pharmacological effects, and quality control of Bletilla striata.

Ethnopharmacological Relevance: Bletilla striata (Thunb.) Rchb.F.

Engineered PW-polyoxometalate docked Fe sites on CoFe hydroxide anode for durable seawater electrolysis.

Seawater electrolysis driven by offshore renewable energy is a promising avenue for large-scale hydrogen production but faces challenges in designing robust anodes that suppress surface chlorine reactions and corrosion at high current densities. Here we report a strategy by selectively docking PW-polyoxometalate (PW-POM) onto Fe sites of CoFe hydroxide anode to modulate the electronic structure of adjacent Co active centers and regulate Cl⁻/OH⁻ adsorption for efficient alkaline seawater oxidation. Our CoFe-based anode achieves low overpotentials, high catalytic selectivity, and notable durability, with continuous operation at 1 A cm⁻² for over 1300 hours and at 2 A cm⁻² more than 600 hours.

Synthesis and anticancer activity of Pt(iv) prodrugs containing 3-bromopyruvic acid as an axial ligand.

A Pt(iv) prodrug of oxaliplatin incorporating the glycolysis inhibitor 3-bromopyruvic acid, BrPt3, was designed and investigated. The prodrug is reduced in the presence of ascorbic acid, releasing its active Pt(ii) species and axial ligand. In cytotoxicity studies, BrPt3 exhibited stronger anticancer activity than oxaliplatin against all tested cancer cell lines, particularly in oxaliplatin-resistant A549/OXP cells.

Oxidative Stress Score as a Simplified Surrogate for Prognostic Stratification and Therapeutic Decision-Making in Multiple Myeloma.

Oxidative stress contributes to the initiation and progression of multiple myeloma and can be reflected by various biochemical indicators. However, whether systemic oxidative stress level can serve as a simple and effective alternative for prognostic risk stratification in newly diagnosed multiple myeloma (NDMM) patients remains to be explored and validated in large clinical cohorts. A retrospective analysis was conducted on 1107 NDMM patients, 774 patients were randomly assigned to the training cohort and 333 to the validation cohort.

Aromatic Patch in WhiB-Like Transcription Factors Facilitates Primary Sigma Factor Interaction in .

Unlabelled: WhiB-like (Wbl) family proteins are a group of small iron-sulfur ([4Fe-4S]) cluster-containing transcription factors and are uniquely found in Actinobacteria and actinobacteriophages. They play pivotal roles in diverse biological processes, including cell development, redox stress response and antibiotic resistance. However, the lack of a canonical DNA binding motif in most Wbl proteins has long obscured the mechanistic understanding of how Wbl family proteins regulate gene expression.

Plaque disclosing agent as a plaque control guide for oral hygiene in chronic periodontitis based on guided biofilm therapy: A retrospective cohort study.

We assessed the effectiveness of plaque disclosing agents as a visual aid for biofilm removal during professional oral hygiene instruction. A total of 220 patients with chronic periodontitis were enrolled in the study and divided into a control group (CG; traditional interventions) and an observation group (OG; guided biofilm therapy concepts applied). Plaque index (PI), bleeding on probing (BOP), and pocket depth (PD) were compared between the 2 groups.

Hexafluorophosphate additive enables durable seawater oxidation at ampere-level current density.

Direct seawater electrolysis at ampere-level current densities, powered by coastal/offshore renewables, is an attractive avenue for sustainable hydrogen production but is undermined by chloride-induced anode degradation. Here we demonstrate the use of hexafluorophosphate (PF₆⁻) as an electrolyte additive to overcome this limitation, achieving prolonged operation for over 5,000 hours at 1 A cm and 2300 hours at 2 A cm using NiFe layered double hydroxide (LDH) as anode. Together with the experimental findings, PF₆⁻ can intercalate into LDH interlayers and adsorb onto the electrode surface under an applied electric field, blocking Cl⁻ and stabilizing Fe to prevent segregation.

The Relationship Between Palliative Care Needs and Spiritual Well-being of Maintenance Hemodialysis Individuals in China: A Cross-Sectional Study.

This study investigated the current status of palliative care needs among maintenance hemodialysis individuals and their correlation with spiritual well-being. In this cross-sectional study, 363 maintenance hemodialysis individuals at five hospital hemodialysis centers in Chengdu, Sichuan Province, China, were surveyed using the General Information Questionnaire, the Disease-Related Information Questionnaire, the Palliative Care Outcome Scale (POS), and the Assessment of Chronic Disease Therapeutic Function-Mental Health Scale (FACIT-Sp-12). While the FACIT-Sp-12 scale has certain limitations-particularly that its "peace" and "meaning" subscales predominantly reflect mental health rather than spiritual well-being, with only the "faith" subscale truly measuring spiritual well-being (thus requiring cautious interpretation)-it has demonstrated satisfactory reliability and validity in Chinese patients undergoing maintenance hemodialysis.

Soil Fungal Diversity, Community Structure, and Network Stability in the Southwestern Tibetan Plateau.

Despite substantial research on how environmental factors affect fungal diversity, the mechanisms shaping regional-scale diversity patterns remain poorly understood. This study employed ITS high-throughput sequencing to evaluate soil fungal diversity, community composition, and co-occurrence networks across alpine meadows, desert steppes, and alpine shrublands in the southwestern Tibetan Plateau. We found significantly higher fungal α-diversity in alpine meadows and desert steppes than in alpine shrublands.

Highly Stretchable, Low Hysteresis, and Transparent Ionogels as Conductors for Dielectric Elastomer Actuators.

As conductive materials, ionogels have attracted significant attention for their potential applications in flexible wearable electronics. However, preparing an ionogel with mechanical properties akin to human skin while also achieving transparency, adhesion, and low hysteresis through simple processes remains challenging. Here, we introduce a multifunctional ionogel synthesized via a one-step photopolymerization method.

Decoding the role of intratumoral microbiota in gastric cancer.

Intratumoral microbiota are increasingly recognized for their impact on gastric cancer, with growing evidence highlighting their complexity and significance. This review synthesizes current knowledge on the origins, heterogeneity, detection, and mechanistic roles of intratumoral microbiota in gastric carcinogenesis. In gastric cancer, intratumoral microbiota can originate from mucosal disruption and may migrate from normal adjacent tissues or be influenced by the TME.

PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models.

Poisoning caused by the mushroom toxin α-amanitin accounts for ∼90 % of food poisoning deaths resulting from mushrooms in China. However, Drosophila melanogaster uses PP2A to mitigate effects of α-amanitin. Our objectives were to test the hypothesis that modulation of PP2A protects mammals against deleterious effects of α-amanitin.

Quantifying regional transport contributions to PM-bound trace elements in a southeast coastal island of China: Insights from a machine learning approach.

Identifying and quantifying pollution sources and their associated health risks are essential for formulating effective pollution control policies. This study analyzed PM-bound trace elements based on one year of sampling data collected from a low-PM island in southeastern coastal China. A de-weathered model based on the eXtreme Gradient Boosting (XGBoost) algorithm was applied to remove meteorological influences and estimate local baseline pollutant concentrations.

Deep Learning-Assisted 3D Pressure Sensors for Control of Unmanned Aerial Vehicles.

Accurately and reliably detecting and recognizing human body movements in real time, relaying appropriate commands to the machine, have substantial implications for virtual reality, remote control, and robotics applications. Nonetheless, most contemporary wearable analysis and control systems attain action recognition by setting sensor thresholds. In routine usage, the stringent trigger conditions facilitate inadvertent contact, resulting in a poorer user experience.

Evaluating the Output Performance of the Semiconductor Bridge Through Principal Component Analysis.

The complex burst characteristic parameters of SCB were subjected to dimensionality reduction using principal component analysis (PCA), enabling accurate evaluation of the output performance of SCB. The accuracy and reliability of the PCA method were also validated. A 100 μF tantalum capacitor was utilized to excite the SCB, while a digital oscilloscope recorded the characteristic parameters of the SCB explosion.