Thinned and Welded Silver Nanowires for Intelligent Pressure and Humidity Sensing Enabled by Machine Learning.

The rapid development of flexible and wearable technologies urgently requires high-performance and compatible flexible electrodes. Silver nanowires (AgNWs) are considered a promising conductive material, but their inherent structural drawbacks significantly hinder their widespread application. Here, an innovative and facile strategy is employed to simultaneously enhance the electrical and optical properties of AgNWs by precisely tuning their microstructure.

The n-γ discrimination method for over-range waveforms in digitizer.

This paper aims to address the issue of neutron-gamma discrimination in over-range waveforms by proposing an innovative method based on Pulse Shape Discrimination (PSD) technology. Utilizing a DT5751 digitizer and an EJ-301 detector, signal waveforms from aCf neutron source were acquired and analyzed. The study delves into the specific impact of the over-range waveforms on the PSD spectrum and the resulting n-γ discrimination challenges.

Updated insights on memory disorder associated risk of medication: A real-world pharmacovigilance analysis.

Objective: This study aims to use the Food and Drug Administration Adverse Event Reporting System (FAERS) to identify medications linked to memory disorders and to offer updated insights into medication-induced memory disorders.

Methods: We analyzed adverse event (AE) reports related to memory disorders in the FAERS database from 2004 to 2023 and compiled a list of potential medications along with their associated AEs. The disproportionality analysis was employed to assess the potential associations between medications and memory disorder events.

The Module WmABF1-1-WmMYB111 Manipulates the Leaf Senescence of Welwitschia by Integrative Regulation of Abscisic Acid Biosynthesis, Chlorophyll Degradation and Nitrogen Transportation.

Welwitschia mirabilis has been well noted for its two continuously grown leaves which could survive for thousands of years in the desert. Compared to great efforts on elucidation of Welwitschia's leaf adaptivity to external stresses, the regulatory mechanism of its internal leaf aging was largely unknown. Here, we revealed the module WmABF1-1-WmMYB111 has manipulated the proactive leaf senescence of Welwitschia by integrative regulation of abscisic acid (ABA) biosynthesis, chlorophyll degradation and nitrogen (N) transportation.

Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most prevalent primary malignant tumor, with sorafenib as the main treatment for advanced cases. However, the development of resistance to sorafenib, often driven by cancer stemness, significantly limits its therapeutic efficacy. Minichromosome maintenance complex component 10 (MCM10), a critical regulator of DNA replication and tumor progression, has been implicated in cancer stemness and therapeutic resistance.

Conversion therapy followed by surgery and adjuvant therapy improves survival in Barcelona C stage hepatocellular carcinoma - A propensity score-matched analysis.

Conversion therapy with a combination of tyrosine kinase inhibitor and anti-programmed death-1 antibody sequential surgery and postoperative adjuvant therapy has shown improved survival benefits in patients with Barcelona C stage (BCLC-C) hepatocellular carcinoma (HCC). We aimed to compare the survival benefits in a retrospective cohort of patients with BCLC-C HCC who underwent surgery after conversion therapy with adjuvant therapy and surgery alone. The conversion therapy group was derived from a prospective clinical study, and from January 2015 to September 2023, we selected patients diagnosed with BCLC-C HCC who underwent liver resection at Chinese PLA General Hospital as the surgical group.

Comparative Effectiveness and Safety of Molecular Targeted Therapy Plus PD-(L)1 with or without TACE in Unresectable Hepatocellular Carcinoma: A Retrospective Study.

Objective: This study aims to compare the effectiveness and safety of TACE combined with molecular targeted therapy (MTT) plus Programmed death-ligand 1 (PD-(L)1) antibodies versus MTT plus PD-(L)1 antibodies for HCC patients.

Methods: Data from HCC patients who received either MTT plus PD-(L)1 (systemic therapy group) or TACE combined with MTT plus PD-(L)1 (combination therapy group) were retrospectively analyzed. The primary outcome was the objective reaction rate (ORR) at the initial assessment post-treatment initiation.

The origin, evolution, and diversification of MADS-box transcription factors in green plants.

MADS-box genes are among the most important regulatory elements in eukaryotes and have undergone substantial diversification during the evolution of green plants (Viridiplantae). Although the evolution and function of MADS-box genes have been studied extensively, our understanding of their origin and diversification in Viridiplantae remains incomplete. Here, we performed systematic analyses of genomic data from 551 representative eukaryotes, focusing on both sequences and protein structures, to clarify the evolutionary history of MADS-box genes across green-plant lineages.

Maize ZmEREB130 transcription factor negatively regulates growth and seed size.

The APETALA2/Ethylene Response Element Binding Protein (AP2/EREBP) is a kind of plant-specific transcription factor and plays a pivotal role in governing plant growth, ontogenesis, and stress acclimation processes. However, the AP2 members modulating plant height and seed morphogenesis remain largely unelucidated. In the present study, the maize ZmEREB130 gene was cloned and functionally validated in modulating growth and seed size development.

Aromatic Patch in WhiB-Like Transcription Factors Facilitates Primary Sigma Factor Interaction in .

Unlabelled: WhiB-like (Wbl) family proteins are a group of small iron-sulfur ([4Fe-4S]) cluster-containing transcription factors and are uniquely found in Actinobacteria and actinobacteriophages. They play pivotal roles in diverse biological processes, including cell development, redox stress response and antibiotic resistance. However, the lack of a canonical DNA binding motif in most Wbl proteins has long obscured the mechanistic understanding of how Wbl family proteins regulate gene expression.

Atmospheric Water Sorption-Desorption as a Pathway for Green Energy Generation.

Beyond the indispensable resource for living creatures, water has recently been explored as an eco-friendly source of energy, known as the hydrovoltaic technology. Of significant interest, the cyclic sorption/desorption of water molecules physically and chemically induces the gaseous/liquid-solid interactions with the substances, demonstrating potential for harnessing electricity. Existing efforts have focused on materials engineering and structural design of the energy generators, enhancing the generated electricity for real-life applications.

Constructing Water-Retaining/Ion-Regulating Bi-Layers for Highly Durable, All-Climate, Efficient Moisture Electric Generators.

Moisture electric generators (MEGs), which can directly convert chemical energy in moisture into electricity have demonstrated great potential for powering wearable electronics and IoT devices. However, state-of-the-art MEGs suffer from transient power output and rely on high relative humidity (RH) as well as mild temperature, hampering their practical applications. Herein, a novel high-performance MEG is reported by designing ionic hydrogel and graphene oxide dual-layered devices, where the water-enriched hydrogel enables continuous power outputs under various conditions while the inherent layering nanochannels effectively regulate ion diffusion for stable and efficient performance improvement.

The value of targeted next-generation sequencing in the diagnosis and differential diagnosis of paucibacillary pulmonary tuberculosis.

Background: The diagnostic utility of broad-spectrum pathogen-specific targeted next-generation sequencing (tNGS) for paucibacillary pulmonary tuberculosis (PTB) in general hospital settings remains insufficiently characterized compared to validated Mycobacterium-specific tNGS.

Objective: To investigate the clinical value of broad-spectrum pathogen-specific tNGS in diagnosing and differentially diagnosing paucibacillary PTB in real-world clinical practice.

Methods: This retrospective study analyzed data from 423 patients admitted to the First Affiliated Hospital of Chongqing Medical University from January 1, 2024, to October 31, 2024.

Ion-Electron Interactions in 2D Nanomaterials-Based Artificial Synapses for Neuromorphic Applications.

With the increasing limitations of conventional computing techniques, particularly the von Neumann bottleneck, the brain's seamless integration of memory and processing through synapses offers a valuable model for technological innovation. Inspired by biological synapse facilitating adaptive, low-power computation by modulating signal transmission via ionic conduction, iontronic synaptic devices have emerged as one of the most promising candidates for neuromorphic computing. Meanwhile, the atomic-scale thickness and tunable electronic properties of van der Waals two-dimensional (2D) materials enable the possibility of designing highly integrated, energy-efficient devices that closely replicate synaptic plasticity.

Deciphering the operation efficiency and fermentation model in mixed microbial cultures system for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis.

The polyhydroxyalkanoates (PHAs) synthesis craft by using diversified organic acids from anaerobic fermentation was restricted due to the poor compatibility and uncertain biopolymer types. Odd-chain VFAs favor the accumulation of co-polyesters. In this study, propionic and valeric acids were utilized as substrates for mixed microbial cultures (MMC) acclimation, in the expectation of synthesizing poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with exceptional properties.

Topology optimization of random memristors for input-aware dynamic SNN.

Machine learning has advanced unprecedentedly, exemplified by GPT-4 and SORA. However, they cannot parallel human brains in efficiency and adaptability due to differences in signal representation, optimization, runtime reconfigurability, and hardware architecture. To address these challenges, we introduce pruning optimization for input-aware dynamic memristive spiking neural network (PRIME).

Maize ZmBES1/BZR1-4 recruits ZmTLP5 to regulate drought tolerance and seed development by regulating ZmPum6 and ZmMBP1.

BES1/BZR1, a kind of plant-specific transcription factor (TF), has been reported to regulate growth, development, and stress response. However, the maize BES1/BZR1 members are still largely unknown. In this study, we investigated the function and regulatory mechanism of maize ZmBES1/BZR1-4 in regulating drought response and seed development.

Ploidy status analysis in small cell lung cancer cells and its use in cytopathological diagnosis.

Objective: To explore the characteristics of the ploidy status of Small Cell Lung Cancer (SCLC) cells and assesses its efficacy in cytopathological diagnosis of SCLC.

Methods: A retrospective analysis was performed on patients who agreed to DNA image cytometry (DNA ICM) and serum tumor biomarker testing. Samples for ploidy assessment, all from bronchial procedures, were analyzed using DNA ICM.

DNA methylation dynamics in gymnosperm duplicate genes: implications for genome evolution and stress adaptation.

Duplicate genes are pivotal in driving evolutionary innovation, often exhibiting expression divergence that offers a system to investigate the role of DNA methylation in transcriptional regulation. However, previous studies have predominantly focused on angiosperms, leaving the methylation patterns in major lineages of land plants still unclear. This study explores DNA methylation evolution in duplicate genes across representative gymnosperm species with large genomes, spanning over 300 million years, using genomic, transcriptomic, and high-depth DNA methylomic data.

Integrative phylogenetic analysis of the genus Episoriculus (Mammalia: Eulipotyphla: Soricidae).

Shrews in the genus Episoriculus are among the least-known mammals in China, where representatives occur mainly in the Himalayan and Hengduan mountains. We sequence one mitochondrial and three nuclear genes from 77 individuals referable to this genus, collect morphometric data for five shape and 11 skull measurements from 56 specimens, and use museum collections and GenBank sequences to analyze phylogenetic relationships between this and related genera in an integrated molecular and morphometric approach. Whereas historically anywhere from two to eight species have been recognized in this genus, we conclude that six (Episoriculus baileyi, E.

Boron controls apical dominance in Pea (Pisum sativum) via promoting polar auxin transport.

Plant architecture and subsequent productivity are determined by the shoot apical dominance, which is disturbed by the deficiency of boron, one of the essential trace elements for plant growth and reproduction. However, the mechanism by which B controls shoot apical dominance or axillary bud outgrows under B deficiency is still unclear. This work aimed to investigate the mechanistic basis of this process, with focus on the interaction between B and polar auxin transport.

Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition).

Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious in treating advanced HCC, significantly extending patients' survival and providing a potential for sequential curative surgery. After sequential curative hepatectomy or liver transplantation following conversion therapy, patients can receive long-term survival benefits.

Genomic, transcriptomic, and metabolomic analyses reveal convergent evolution of oxime biosynthesis in Darwin's orchid.

Angraecum sesquipedale, also known as Darwin's orchid, possesses an exceptionally long nectar spur. Charles Darwin predicted the orchid to be pollinated by a hawkmoth with a correspondingly long proboscis, later identified as Xanthopan praedicta. In this plant-pollinator interaction, the A.

Space-Confinement and in Situ Reduction of Pt with 1T-MoS for Exceptional Hydrogen Evolution Reaction in Simulated Seawater.

Efficient catalysts for hydrogen generation from seawater are essential for advancing clean energy technologies. In this study, we present a straightforward method for producing Pt nanoparticles enclosed within metallic 1T-phase MoS nanosheets on graphite paper as a promising catalyst for the hydrogen evolution reaction (HER). The resulting 14.

Synergetic Phase Modulation and N-Doping of MoS for Highly Sensitive Flexible NO Sensors.

Molybdenum disulfide (MoS) is a promising electronic material owing to its excellent electrochemical features, high carrier mobility at room temperature, and widely tunable electronic properties. Here, through precursor engineering and post-treatments to tailor their phase and doping, electronic characteristics of MoS are significantly modified. It is found that 2H semiconductor phase with nitrogen doping (N-doping) in flexible gas sensors constructed with Ag electrodes exhibits the highest sensitivity of ≈2500% toward 10 ppm of NO.