Study on toughening polylactic acid/poly(butylene adipate-co-terephthalate) with a curing network based on dynamically crosslinked epoxidized soybean oil.

A dynamically crosslinked network VEC (vulcanized ESO and CA) was synthesized in situ via zinc acetate-catalyzed epoxy ring-opening between epoxidized soybean oil (ESO) and anhydrous citric acid (CA), then incorporated into polylactic acid (PLA)/polybutylene adipate terephthalate (PBAT) blends to enhance interfacial compatibility. The dynamic ester-exchange network acted as an intermediate phase, improving the integration of the flexible PBAT phase within the rigid PLA matrix. VEC content critically influenced mechanical properties, with in-situ crosslinking during dynamic vulcanization enhancing chain interactions and blend homogeneity.

Intelligent bacterial platform induces programmed death-ligand 1 lysosomal degradation to enhance antitumor immunity.

Engineered bacteria have emerged as a promising therapeutic strategy for tumor therapy by exploiting the unique features of the tumor microenvironment (TME). In this study, we developed a low-endotoxin Escherichia coli expression system to produce a fusion protein comprising the CXCL12 with the nanobody KN035 Hypoxia and immunosuppression drive the selective colonization of engineered bacteria in tumor tissues, minimizing host toxicity. Unlike conventional PD-L1 antibodies that merely block immune checkpoints, our CXCL12-KN035 fusion protein simultaneously targets the CXCR7 receptor and PD-L1 on tumor cells, inducing receptor internalization and subsequent lysosomal degradation of PD-L1.

Differential expression of extracellular vesicle microRNA and granulosa cell mRNA in polycystic ovary syndrome with insulin resistance.

Research Question: How does the microRNA (miRNA)-mRNA regulatory network in polycystic ovary syndrome (PCOS) with insulin resistance (PCOS-IR) manifest, based on miRNA sequencing of follicular fluid-derived extracellular vesicles and mRNA sequencing of granulosa cells from clinical patients?

Design: Follicular fluid and granulosa cells were collected from patients with PCOS-IR and PCOS and healthy controls. Differentially expressed miRNA (DEmiR) and differentially expressed mRNA (DEmRNA) among the three groups were identified and analysed using high-throughput sequencing. DEmiR expression was validated by quantitative real-time (qRT)-PCR.

Adaptive Feature- and Scale-Based Object Tracking with Correlation Filters for Resource-Constrained End Devices in the IoT.

Sixth-generation (6G) wireless technology has facilitated the rapid development of the Internet of Things (IoT), enabling various end devices to be deployed in applications such as wireless multimedia sensor networks. However, most end devices encounter difficulties when dealing a large amount of IoT video data due to their lack of computational resources for visual object tracking. Discriminative correlation filter (DCF)-based tracking approaches possess favorable properties for resource-constrained end devices, such as low computational costs and robustness to motion blur and illumination variations.

Isolation and Purification of Novel Antioxidant Peptides from Mussel () Prepared by Marine Z-1 Protease.

Mussels are nutrient-rich but perishable, resulting in substantial resource loss. A protease-producing strain ( Z-1, ) isolated from marine sludge was used to hydrolyze mussels, producing Y-1, a hydrolysate with antioxidant activity. In this study, ultrafiltration, gel chromatography, and LC-MS/MS were employed to isolate and identify bioactive peptides from the hydrolysate.

Sex-specific networks of depressive symptoms and cognitive deficits in major depressive disorder: A network analysis approach.

Background: Major depressive disorder (MDD) represents a prevalent mental health condition characterized by profound cognitive and emotional disturbances. Emerging evidence suggests sex differences in how these symptoms interact with cognitive deficits, yet the mechanisms remain unclear. Traditional methods have limitations in capturing these complex interactions.

National trends in depressive symptoms, antidepressant use, and mental health consultations among US adults, 2005-2020.

Objectives: Depression significantly contributes to the global disease burden. This study aims to monitor national trends in depressive symptoms, antidepressant use and mental health consultations among American adults and identify key subgroups that require attention.

Study Design: Serial cross-sectional analysis.

Bidirectional Multiscale Efficient Dilated Convolutional Recurrent Neural Network Improved by Swarm Intelligence Optimization.

In recent years, bidirectional convolutional recurrent neural networks (RNNs) have made significant breakthroughs in addressing a wide range of challenging problems related to time series and prediction applications. However, the performance of the models is highly dependent on the hyperparameters chosen. Hence, we propose an automatic method for hyperparameter optimization and apply a bidirectional convolutional RNN based on the improved swarm intelligence optimization (sparrow search) to solve regression prediction problems.

Molybdenum Boride MBene with an Ultraclean Surface for Stable and Portable Detection of Environment Toxins.

The inherently poor chemical stability and sensitivity of two-dimensional MXene materials pose significant challenges for their application in non-noble metal surface enhanced Raman scattering (SERS) under harsh conditions. Herein, a novel unfunctionalized MoB MBene with an ultraclean surface is reported as a stable, ultrasensitive SERS substrate for portable detection of environment toxins. The MoB MBene enables the detection of R6G down to 10 M with an SPF of 4.

Aging-associated mechanisms of atrial fibrillation progression and their therapeutic potential.

Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart contribute to an increased AF susceptibility. This work critically reviews the key molecular mechanisms that may underpin the complex association between aging and AF.

Monolithic X-ray achromat.

X-ray imaging techniques employing diffractive and refractive lenses face the challenge of chromatic aberration if X-ray beams with a broad photon energy range are used. Recent advances combining a compound refractive lens and a Fresnel zone plate have enabled the development of achromatic lenses for X-rays, which exhibit a constant focal length over a wider range of photon energies. However, in this first demonstration, the potential of the achromatic X-ray lens was limited by the challenging task of aligning the two individual separate components.

Comparative analysis of overlap and π-shaped esophagojejunostomy in totally laparoscopic total gastrectomy with propensity score matching.

This study aims to compare the short-term therapeutic effects, surgical efficacy, and safety of esophagojejunostomy using the overlap and π-shaped methods in totally laparoscopic total gastrectomy (TLTG). A retrospective analysis was performed on 304 patients who underwent TLTG with either the overlap or π-shaped anastomosis from January 2019 to October 2023. Propensity score matching (PSM) was applied to adjust for potential confounders.

Distortion Evolution of Two-Dimensional Molecular Crystals for Branched Optical Waveguides.

Two-dimensional (2D) molecular crystals with irregular morphologies are promising candidates for constructing multifunctional optoelectronics. However, the impact of crystal distortion on morphological irregularities has been largely overlooked, despite its potential for engineering crystal structures with superior functionalities. Here, we report a competitive facet-selective growth strategy for synthesizing 2D molecular crystals with irregular morphologies, ranging from rhombus sheets to distorted compass shapes.

Design and validation of a prism-based single-camera system for multi-viewpoint stereoscopic imaging.

Stereoscopic imaging from multiple viewpoints offers critical advantages in machine vision and related applications, yet traditional multi-camera setups require complex synchronization mechanisms. This study introduces a prism-based single-camera stereoscopic imaging system featuring a bonded multi-sub-eye structure of prisms and plano-convex lenses. The prisms deflect light paths, while the plano-convex lenses ensure approximate parallel beam output, enabling the formation of stereo images in four distinct regions on a single image sensor.

Influence of computed tomography-based pelvimetric parameters and surgical approaches on surgical difficulty in mid‑low rectal cancer.

Introduction: Despite a lack of a well-defined concept of 'pelvic difficulties', pelvimetric parameters significantly influence surgical difficulty and outcomes in mid-low rectal cancer (MLRC).

Aim: The objective of this study was to explore the influence of pelvimetric parameters and surgical approaches on the difficulty of surgical procedures in MLRC.

Materials And Methods: A retrospective analysis was performed at the Northern Jiangsu People's Hospital, including patients with a diagnosis of MLRC who underwent total mesorectal excision between January 2016 and June 2023.

Screening Cholesterol-Lowering through Experiments, Whole Genomics Analysis, and Approaches: From the Perspective of Bile Salt Hydrolase and Cholesterol.

Hypercholesterolemia is a cardiovascular condition resulting from elevated cholesterol levels. This study screened seven strains with efficient cholesterol (CHOL)-lowering abilities and investigated the mechanisms of CHOL degradation. HPLC analysis indicated that D5205 had high bile salt hydrolase (BSH) activity with a bile salt metabolism rate of 31.

Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics.

Aim: Huachansu injection (HCSI) shows effective medicinal functions against osteosarcoma. This study aimed to reveal the underlying mechanisms of HCSI against osteosarcoma by integrating metabolomics, network pharmacology and bioinformatics.

Methods: Metabolomics was used to identify different metabolites and pathways.

1-Month Versus 12-Month Dual Antiplatelet Therapy for Patients with Chronic Total Occlusion After Successful Percutaneous Coronary Intervention.

Purpose: Compared with long-term dual antiplatelet therapy (DAPT, aspirin with clopidogrel or ticagrelor), short-term DAPT followed by single antiplatelet therapy (SAPT, clopidogrel or ticagrelor) has demonstrated superiority in reducing bleeding risk while maintaining non-inferior in cardiovascular benefits in coronary heart disease (CHD) after successful percutaneous coronary intervention (PCI). However, no prospective study has explored the benefits of this short-term regimen on patients with chronic total occlusion (CTO) undergoing PCI.

Methods: Consecutive patients who underwent successful elective CTO-PCI were prospectively enrolled from April 2019 to May 2021.

BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma.

Long-term survival of glioblastoma multiforme (GBM) remains challenging, spurring the development of novel therapies such as oncolytic virus therapy. While oncolytic virus shows promise in clinical trials, many patients do not respond to this therapy. Here, we perform a CRISPR screening and identify the non-canonical BRG1/BRM-associated factor (ncBAF) complex as a pivotal tumor-intrinsic factor for oncolytic virotherapy resistance.

Investigation and analysis of mental health status of the older adult in western rural areas.

Background: The mental health of the older adult in western rural areas is an area of growing concern. Mental health, as defined by the World Health Organization, encompasses emotional, psychological, and social well-being, affecting how individuals think, feel, and act. In this study, we operationalize mental health through four validated dimensions: depression (emotional well-being), anxiety (psychological stability), loneliness (social connectedness), and life satisfaction (overall subjective well-being), which together provide a comprehensive assessment of mental health status.

High fidelity influence analysis of material and structure on sealing characteristics of aviation pipeline fittings based on multi-scale model.

As an important component connecting and sealing the high-pressure fluid in the hydraulic pipeline, the reliability and stability of the aviation pipeline fittings are critical. The purpose of this paper is to better understand and analyze the multiple parameters influence on sealing characteristics of aviation pipeline fittings. This article significantly improves the accuracy of sealing contact state analysis based on multi-scale models.

AI-Driven Comprehensive SERS-LFIA System: Improving Virus Automated Diagnostics Through SERS Image Recognition and Deep Learning.

Highly infectious and pathogenic viruses seriously threaten global public health, underscoring the need for rapid and accurate diagnostic methods to effectively manage and control outbreaks. In this study, we developed a comprehensive Surface-Enhanced Raman Scattering-Lateral Flow Immunoassay (SERS-LFIA) detection system that integrates SERS scanning imaging with artificial intelligence (AI)-based result discrimination. This system was based on an ultra-sensitive SERS-LFIA strip with SiO-Au NSs as the immunoprobe (with a theoretical limit of detection (LOD) of 1.