Cardiac Dual-Targeting Nanocatalysts for Heart Failure Therapy by Breaking the ROS-Inflammation Positive Feedback.

Heart failure (HF) is a global public health challenge closely associated with oxidative stress and immune dysregulation. However, current therapeutic strategies for HF generally lack specific targeting to cardiac tissue, and the high perfusion rate of the heart further exacerbates insufficient drug accumulation at lesion sites, thus compromising therapeutic efficacy. Inspired by the barb-hook of Xanthium strumarium, FeO@UiO-66 is functionalized with tannic acid (TA) to obtain a dual-target nanocatalyst, termed FUTA.

Developing a Pressure Injury Predictive Indicator System for Data Mining in Health Care Information Systems: A Sequential Mixed-Methods Study.

Objective: Prevalence of hospital-acquired pressure injury (PI), as a critical measurement of medical care quality, has shown an upward trend. The aim of this study was to determine the predictive indicators of potential PIs and ensure that the predictive indicators can automatically be mined from electronic medical record systems.

Methods: The methods include 2 parts.

Correction to: A 3D Braincase of the Early Jawed Vertebrate from Australia.

[This corrects the article DOI: 10.1093/nsr/nwae444.].

Enhancing Neural Representations of Motor Imagery through Action-Specific Brain Connectivity Patterns.

Motor imagery (MI) is a cognitive process that allows individuals to mentally simulate movements without physical execution. However, the exploration of functional connectivity (FC) and lateralization mechanisms under different MI actions remains insufficiently understood. In this work, the common orthogonal basis extraction (COBE) algorithm was employed to isolate action-specific components by removing shared background components from the raw FC of the MI process.

[Post-aging comparative study of snowplow and conventional techniques for the resin restoration of defective primary teeth].

Objectives: This study aims to evaluate the differences in shear bond strength, marginal adaptation, and nano-microleakage after aging among snowplow, layered filling, and lining techniques applied to the resin-bonded restoration of defective primary teeth.

Methods: In this study, 51 freshly extracted, crown-intact primary anterior teeth and 30 primary molars were collected. The experimental groups were as follows: layered filling group, lining group, and snowplow group.

Movable Oil Saturation Quantitation Evaluation in Shale Oil: Novel Insights from Distribution.

The quantification of movable shale oil is crucial for the effective exploration and development of shale oil resources. Nuclear magnetic resonance (NMR), a nondestructive and noninvasive technique, has become an indispensable tool for evaluating movable oil saturation. However, the small core sizes, high-frequency instrumentation, costly measurements, and significant losses of light hydrocarbons pose substantial challenges in accurately assessing movable oil.

Effects of weekly unilateral application of 1% atropine on reducing anisometropia in Chinese children with low myopia.

Purpose: To evaluate the efficacy of weekly unilateral application of 1 % atropine on reducing anisometropia in Chinese children with low myopia.

Methods: In this retrospective cohort study, anisometropic children aged 6-12 years receiving atropine in the more myopic eye for at least 3 months were included in atropine group (n = 150), and baseline matched counterparts without atropine use were included in control group (n = 50). Changes in spherical equivalent refraction (SER), axial length (AL) and other biometric parameters between each visits were analyzed.

Early-life gut microbiome maturity regulates blood-brain barrier and cognitive development.

The gut microbiome is an emerging factor in the neurobiology of disease. Blood-brain barrier (BBB) integrity is essential for proper brain function. However, the role the initial microbiome plays in BBB and brain development is unclear.

Multifunctional Responsive Gas-Releasing Metal Organic Framework Nanoplatform for Tumor Therapy Application.

Gas therapy (GT), which regulates the tumor microenvironment by releasing therapeutic gas molecules (e.g., O, NO), has taken an innovative direction in tumor therapy.

Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial.

Commercial autologous anti-CD19 chimeric antigen receptor-T cell therapies are effective in B cell malignancies and autoimmune diseases but are limited by personalized manufacturing, high costs and the risk from random chimeric antigen receptor insertion into the genome. To overcome these challenges, we developed YTS109, a hypoimmune allogeneic T cell product engineered using CRISPR-Cas9 to knock out TRAC, PD1, HLA-A, HLA-B and CIITA, with a CD19-targeting synthetic TCR and antigen receptor (STAR) precisely integrated into the TRAC locus to enable physiological, TCR-like signaling. As part of a multi-disease cohort trial, this article includes all enrolled five patients with severe, refractory systemic lupus erythematosus (SLE) complicated by lupus nephritis, who received lymphodepletion followed by YTS109 at 3 × 10 STAR⁺ T cells per kg body weight.

Isolation and Purification of Novel Antioxidant Peptides from Mussel () Prepared by Marine Z-1 Protease.

Mussels are nutrient-rich but perishable, resulting in substantial resource loss. A protease-producing strain ( Z-1, ) isolated from marine sludge was used to hydrolyze mussels, producing Y-1, a hydrolysate with antioxidant activity. In this study, ultrafiltration, gel chromatography, and LC-MS/MS were employed to isolate and identify bioactive peptides from the hydrolysate.

The relationship between the expression of serum PTEN and TLR4 and the severity and prognosis of neonatal sepsis.

Background: To investigate the relationship between the expression of serum PTEN and TLR4 and the severity and prognosis of neonatal septicemia and the guiding significance of management strategy.

Methods: 116 newborns with sepsis admitted to the neonatal department of our hospital from March 2021 to June 2023 were recruited as research subjects. According to the Sequential Organ Failure Assessment (SOFA) scoring system, newborns with scores of 1 to 18 were set into the mild sepsis group (n = 64), newborns with scores from 19 to 24 were set into the severe sepsis group (n = 52), and 8 patients died in the severe sepsis group (death group), 44 cases survived (survival group).

The effects of dance intervention on clinical symptoms and cognitive deficits in hospitalized patients with chronic schizophrenia: a randomized controlled trial.

Background: Schizophrenia is a severe mental disorder that imposes significant social burdens. Traditional treatmens, however, have limited effectiveness in addressing negative symptoms and cognitive deficits. Recent studies have indicated interventions promoting sensorimotor integration may offer potential benefits for schizophrenia treatment.

Serum sortilin as a potential diagnostic and therapeutic target for cardiovascular calcification in uremic patients: A single-center prospective and observational study.

Background: Cardiovascular disease (CVD) is the principal cause of mortality in chronic kidney disease (CKD) patients. Vascular calcification (VC) and cardiac valve calcification (CVC) significantly contribute to the increased CVD incidence in uremic patients. This study sought to determine the relationship between serum sortilin protein and both VC and CVC in uremic patients.

Proteomics on choroidal neovascularization based on itraq and the protective effect of TAB1 in CNV.

Choroidal neovascularization (CNV) is a severe pathological outcome of age-related macular degeneration (AMD) which could lead to blindness. The present study was aimed at exploring the mechanisms of CNV, hoping to provide new clues in finding the treatment target of CNV. ITRAQ approach was applied to analyze the proteins in choroidal neovascularization of CNV and normal rats.

Prediction of Tl(I) adsorption onto metal oxides and identification of critical factors using a machine learning-based model.

Thallium is a highly toxic element, which is widely found all over the world. Adsorption is one of the most common techniques for thallium removal. Traditional adsorption studies face several limitations, such as a limited ability to predict adsorption results, inability to concurrently deal with the effects of multiple factors on adsorption outcomes, and fail to quantify the importance of these factors.

The mRNA vaccine encoding Gc protein confers complete protection against severe fever with thrombocytopaenia syndrome virus.

Severe fever with thrombocytopaenia syndrome virus (SFTSV), an emerging tick-borne pathogen, causes haemorrhagic fever in infected patients and is associated with a high mortality rate in humans. The imperative need for vaccines against this lethal virus is underscored by a lack of effective preventive measures. The results of this study yield notable advancements: the successful development of an SFTSV mRNA vaccine encoding the glycoprotein C (Gc) gene, achieving N-linked glycosylation in the expressed protein.

Poplar Sex-Determining Gene Directly Affects Tree Growth Through Regulating Cytokinin Signalling Pathway.

Sex separation in dioecious plants is triggered by the sex-determining gene, which primarily drives sexual dimorphism in reproductive organs. However, whether the plant sex-determining gene directly affects plant growth remains controversial. Here, we investigate the effect of the FERR gene, the sex-determining gene in Populus deltoides, on tree growth.

Correlation and Influencing Factor Analysis Between Gal-3 and Recurrent Patients With Nonvalvular Atrial Fibrillation After Radiofrequency Ablation.

This prospective cohort study was aimed at evaluating the association of galectin-3 (Gal-3) and other prognostic factors with atrial fibrillation (AF) recurrence in patients with nonvalvular AF undergoing radiofrequency catheter ablation (RFCA). Overall, 92 patients were included, with the AF group comprising 70 patients and the control group comprising 20 (supraventricular tachycardic) patients. Preablation parameters were recorded, including baseline Gal-3 levels.

A coherence-based robust frequency-dependent variable step size method for active road noise control.

Active road noise control (ARNC) is an effective method for mitigating low-frequency noise in vehicle cabins. Previous work introduced a decoupling-whitening frequency domain filtered-error least mean square (DWFDFeLMS) algorithm, which exhibits rapid convergence characteristics for steady-state environments. However, uncorrelated disturbances significantly impact the convergence performance and stability of adaptive algorithms in practical applications.

Genome-wide Genetic Mutations Accumulated in Pigs Genome-edited for Xenotransplantation and Their Filial Generation.

Although xenotransplantation has been revolutionized by the development of genome-edited pigs, it is still unknown whether these pigs and their offspring remain genomically stable. Here, we show that GGTA1-knockout (GTKO) pigs accumulated an average of 1205 genome-wide genetic mutations, and their filial 1 (F1) offspring contained an average of 18 de novo mutations compared with wild-type controls and their parents. The majority of mutations were in regions annotated as intergenic regions, without altering protein functions, and were not located at predicted off-target mutation sites.

The power of storytelling: Empowering new parents to overcome fear of childbirth - A randomised controlled trial.

Background: Fear of childbirth (FoC) impacts many first-time mothers. The "Stories-Empowered Education for New Parents" (SEEN) programme, a community-based intervention grounded in story and narrative transportation theories, offers a promising approach to address FoC.

Methods: This randomised controlled trial assessed SEEN's efficacy in first-time mothers.

A nomogram for predicting malnutrition risk in patients with chronic heart failure and correlation study between GHRL, MSTN, CRP, Hs-CRP.

Objective: This study aimed to construct a nomogram to identify risk factors for malnutrition in patients with chronic heart failure (CHF) and to explore the correlation between Ghrelin (GHRL), Myostatin (MSTN), C-reactive protein (CRP) and High-sensitivity C-reactive protein (Hs-CRP) to further elucidate the potential pathophysiological mechanisms linking malnutrition/sarcopenia and inflammation.

Methods: A total of 128 patients with congestive heart failure (CHF) admitted to the Cardiology Department of Guang'anmen Hospital, China Academy of Chinese Medical Sciences, between February 2022 and February 2023, were included in the study. Based on their MNA-SF scale scores, the patients were classified into two groups: the malnutrition group (107 patients) and the non-malnutrition group (21 patients).

Nonclinical absorption, distribution, metabolism, excretion and biomarkers properties of a modified N-acetylgalactosamine-conjugated small-interfering RNA for hypercholesteremia.

DTX-007 is a double-stranded small-interfering RNA that decreases the expression of the proprotein convertase subtilisin/kexin type 9 protein through downregulation of its mRNA by conjugating with 3 N-acetylgalactosamine moieties to improve its hepatic distribution when administered via subcutaneous injection for the treatment of hypercholesterolemia. The nonclinical pharmacokinetics and the absorption, distribution, metabolism, and excretion characteristics of DTX-007 were evaluated in both in vivo and in vitro systems. Plasma protein binding exhibited concentration dependence across all examined species, approximating 99% at clinically relevant concentrations in humans.

Genetic diversity analysis of IVM resistant Haemonchus contortus in sheep in inner Mongolia of China.

Haemonchus contortus is widely distributed in the world, which is seriously harmful to small ruminants and has serious resistance to common anthelmintics. Over time, the prevalence and intensity of host infection with this parasite have gradually increased, so it is necessary to study the phylogenetic and genetic changes of single anthelmintic resistant strains. This study is the first to analyze the genetic diversity and population structure about IVM-resistant H.