The relationship between the expression of serum PTEN and TLR4 and the severity and prognosis of neonatal sepsis.

Background: To investigate the relationship between the expression of serum PTEN and TLR4 and the severity and prognosis of neonatal septicemia and the guiding significance of management strategy.

Methods: 116 newborns with sepsis admitted to the neonatal department of our hospital from March 2021 to June 2023 were recruited as research subjects. According to the Sequential Organ Failure Assessment (SOFA) scoring system, newborns with scores of 1 to 18 were set into the mild sepsis group (n = 64), newborns with scores from 19 to 24 were set into the severe sepsis group (n = 52), and 8 patients died in the severe sepsis group (death group), 44 cases survived (survival group).

Long noncoding RNA Nron and its functional motif modulate macrophage-mediated inflammatory response.

Introduction: Non-resolving macrophage-mediated inflammation is closely linked to the pathogenesis of systemic inflammatory response syndrome. Despite years of clinical trials attempting to mitigate the harmful effects of excessive inflammation, these efforts have largely been unsuccessful. Therefore, it is essential to develop novel therapeutic strategies.

WATER NEWS: a field approach for sustainable detection of pathogens in wastewater.

Wastewater surveillance is a critical tool in responding to the COVID-19 pandemic, yet traditional centralized methods are unsustainable due to their high costs and complex implementation requirements. Here, we introduce Wastewater Analysis and Tracking for Epidemiological Recognition: Necessary Early Warning System (WATER NEWS)-a field clustered regularly interspaced short palindromic repeats-diagnostic approach designed for robust and cost-effective pathogen detection in wastewater treatment plants (WWTPs). WATER NEWS combined a one-pot assay, an optimized reporter probe, on-site nucleic acid extraction, an improved freeze-drying process and a user-friendly, low-cost, battery-operated device, thereby overcoming the limitations of field-deployable wastewater surveillance.

The role of one's own social network position in learning new networks: Brokerage is associated with better network learning.

Navigating our complex social lives requires understanding where others sit in our social networks. Some individuals may be more attuned to the structure of their social world, and thus, better able to learn new social networks due to having accumulated accurate priors about social network structure in their own lives. Correspondingly, such individuals may acquire more advantageous positions in their own social networks.

The clinical value of serum sST2 and cfDNA in guiding evidence-based nursing care for children with severe pneumonia complicated by myocardial damage.

Background: To investigate how serum sST2 and cfDNA can be used to inform evidence-based nursing practices for children with severe pneumonia and myocardial damage.

Methods: 100 children with severe pneumonia complicated with myocardial damage were recruited as research subjects. After assessing serum sST2 and cfDNA concentrations, the individuals were categorised into a control cohort (receiving standard treatment, n=50) and an experimental cohort (receiving evidence-based treatment guided by serum sST2 and cfDNA markers, n=50).

High Performance Aluminum Ion Batteries Enabled by the Coordination Between Vanadium-Based PBAs Cathode and Aqueous Eutectic Electrolyte.

The practical application of aqueous aluminumion batteries (AAlBs) faced with critical challenges, such as low rate performance and poor cycling stability due to the absence of ideal cathode materials. To address the bottlenecks of low electrochemical activity, structural instability, and narrow voltage window in Prussian blue analogues (PBAs) for AAIBs, this study develops a universal synthesis strategy integrating acid-assisted method with ligand modulation to prepare high-performance vanadium-based PBAs (V-PBAs) cathodes. Through precise coordination environment control, V and Fe/Co/Ni synergistically enhance multi-electron redox activity.

Triple Redox-Enabled High-Entropy Metal-Organic Coordination Driving High-Performance Aqueous Zinc-Ion Batteries.

High entropy (HE) nanomaterials offer a promising strategy for advancing aqueous zinc-ion batteries (AZIBs). In this study, 1,4-dihydroxyanthraquinone (1,4-DHAQ) is employed as an organic ligand to coordinate with multiple metal ions, forming a series of binary to quinary high-entropy (HE) nanomaterials. All synthesized materials exhibit a layered flower cluster structure.

Endometrial diseases: a summary of small experimental animal model†.

Endometrium plays a crucial role in embryonic growth and development. Endometrial-related diseases, such as endometritis, endometriosis, endometrial cancer, and intrauterine adhesions, hurt fertility and women's health. At present, these diseases often lack effective or permanent treatments, necessitating the construction of analogous animal models for research and solution development.

Manganese-Based Metal-Organic Coordination for Aqueous Zinc-Ion Batteries With Varying Mechanical Adaptability and Machine Learning-Assisted Performance Decoding.

Aqueous zinc-ion batteries (AZIBs) have garnered significant attention owing to their high safety and low cost; however, their development is hindered by the poor cycling stability and low capacity of traditional inorganic cathode materials. This study innovatively utilizes dihydroxy/diamino anthraquinone (DHAQ/DAAQ) ligands featuring π-conjugated systems and quinone-based redox activity. By precisely regulating the substitution sites (1,2-/1,4-/1,5-) and coordinating them with Mn, layered flower-cluster Manganese-based metal-organic coordination is successfully constructed.

3D‑3D registration of labial anterior dentition: A potential method for personal identification in living individuals.

Recent advancements in 3D video surveillance and dental reconstruction enable pre-acquisition of 3D labial anterior dentition models, offering forensic odontologists critical data for identification when facial obstructions impede traditional methods. However, no prior studies have validated the reliability of 3D-3D registration for exclusive use of labial anterior dentition features in dental identification. This study proposes a protocol for 3D-3D registration of labial dentition and systematically evaluates its forensic efficacy across two precision scenarios: high- (intraoral scans) and low-precision (3D facial scans).

[Study on the gene expression and regulation mechanisms of fibroblasts in acute inflammatory response].

Objective To investigate the gene expression and regulatory mechanisms of mouse embryonic fibroblasts (MEFs) under inflammatory conditions, aiming to elucidate the role of MEFs in inflammatory responses and provide a foundation for discovering anti-inflammatory drugs that act by modulating MEF function. Methods MEFs cultured in vitro were divided into the following groups: lipopolysaccharides (LPS)-treated group, inflammatory conditioned medium (CM)-treated group, and control group, which were treated with LPS, CM, and equal volume solvent, respectively. Transcriptome sequencing was used to analyze the effects of two stimuli on gene expression profile of MEFs.

Promoting reaction kinetics in lithium-sulfur batteries: A study of bifunctional UIO-66-NH-HSO@rGO for Li transport and polysulfide adsorption.

Lithium-sulfur batteries (LSBs) are recognized for their high energy density; however, challenges such as the lithium polysulfide (LiPS) shuttle effect and sluggish reaction kinetics remain unresolved. To mitigate these issues, a dual-functional metal-organic framework material integrated with graphene (UIO-66-NH-HSO@rGO) has been developed, with its Li transport and LiPS anchoring capabilities systematically investigated. Through density functional theory (DFT) calculations, it was demonstrated that the -HSO group in UIO-66-NH-HSO facilitates LiPS adsorption via strong electrostatic interactions while repelling polysulfide anions, whereas the -NH group chemically anchors these anions, thereby enhancing Li transport and LiPS trapping.

Tspan9 Exacerbates Cardiac Hypertrophy by Impairing Cardiac Autophagy.

Pathological cardiac hypertrophy leads to heart failure. In this study, we aimed to explore the role of transmembrane protein Tspan9 in the development of cardiac hypertrophy and failure. We found that Tspan9 was upregulated in the hearts of patients with hypertrophic cardiomyopathy (HCM), in the hearts of mice subjected to transverse aortic constriction (TAC), as well as in phenylephrine-induced hypertrophic neonatal rat cardiomyocytes (NRCMs).

Microfluidic-engineering Prussian blue hydrogel microspheres for enhanced osteoarthritis antioxidant therapy.

Osteoarthritis (OA), a degenerative joint disorder and leading cause of global disabilty, imposes substantial societal and familial burdens. Current antioxidant therapies for OA are hindered by poor targeting and transient efficacy, failing to address the excessive reactive oxygen species (ROS)-driven pathogenesis. Herein, we innovatively integrate Prussian blue (PB) nanozymes with alginate-hyaluronic acid (HA) hydrogel microspheres through microfluidic engineering, creating the injectable AlgHA@PB platform that synergizes dual therapeutic mechanisms: ROS scavenging and oxygen generation via PB nanozymes, and sustained intra-articular retention and mechanical compatibility enabled by the hydrogel microsphere architecture.

The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage.

Background: The paper aimed to explore the significance of serum soluble ST2 (sST2) and circulating cell-free DNA (cfDNA) in predicting cardiac functions in children with severe pneumonia complicated by myocardial damage.

Methods: This case series study evaluated the serum sST2 and cfDNA levels of 60 children with severe pneumonia complicated by myocardial damage, assessing clinical data, biomarker levels, and cardiac function.

Results: We analyzed data from a cohort of 60 patients with a mean age of 4.

Two-phase flow pattern transition behaviors on experimental established ordinal pattern networks.

Identifying the flow pattern transition dynamics is a fundamental challenge in modeling a two-phase flow system. In this paper, we investigate the gas-liquid two-phase flow pattern transition behaviors with analyzing the topology structures of the experimental established gas-liquid two-phase flow complex networks. First, we carry out a series of gas-liquid two-phase flow experiments in a vertical 50 mm inner diameter pipe.

Synergy of dissolving microneedles and ultrasound to enhance transdermal delivery for rheumatoid arthritis.

Dissolving microneedles (DMNs) are an emerging transdermal drug delivery system that has gained increasing attention as an alternative to traditional oral and injectable methods for treating rheumatoid arthritis (RA). However, these DMNs encounter challenges related to insufficient drug diffusion through passive mechanisms. To address this issue, we developed biocompatible DMNs fabricated from hyaluronic acid (HA) loaded with ultrasound-responsive nanoparticles, aiming at enhancing drug permeation and diffusion through ultrasound (US) assistance.

Quantifying assembly processes of dissolved organic matter pools in eutrophication using high-resolution mass spectrometry and ecological models.

Dissolved organic matter (DOM) represents a large, dynamic pool of carbon, playing a crucial role in eutrophic aquatic ecosystems through its continuous transport and transformation. However, the assembly mechanisms of DOM under different eutrophic conditions remain elusive, hindering the understanding of carbon dynamics and the prediction of carbon fate. Here we collected 72 lake water samples during two sampling events in Chaohu Lake, the fifth largest freshwater lake in China, and performed high-resolution mass spectrometry (HRMS) and ecological null modeling to quantify the assembly processes of DOM in eutrophication.

Development and Validation of an Interpretable Machine Learning Model for Prediction of the Risk of Clinically Ineffective Reperfusion in Patients Following Thrombectomy for Ischemic Stroke.

Background: Despite successful recanalization after thrombectomy in patients with acute ischemic stroke, poor prognosis often persists. This study aimed to investigate the factors contributing to clinically ineffective reperfusion (CIR), develop and validate a machine-learning model to predict CIR, and provide guidance for future clinical treatments.

Methods: We collected data from patients undergoing thrombectomy at Shanghai Fourth People's Hospital between December 2021 and June 2024.

Research Progress on Micro/Nanopore Flow Behavior.

Fluid flow in microporous and nanoporous media exhibits unique behaviors that deviate from classical continuum predictions due to dominant surface forces at small scales. Understanding these microscale flow mechanisms is critical for optimizing unconventional reservoir recovery and other energy applications. This review provides a comparative analysis of the existing literature, highlighting key advances in experimental techniques, theoretical models, and numerical simulations.

Application of bacteria-mediated gene therapy in tumor treatment.

Introduction: Gene therapy refers to the use of vectors to introduce target genes into target cells to exert a therapeutic effect on tumors. As a new type of tumor therapy, gene therapy has the advantage of precision and specificity. Excellent delivery vehicles have a major impact on the efficiency, precision and safety of gene therapy.

Ultrasound Molecular Imaging With VEGFR2-Targeted Microbubbles to Evaluate Intrauterine Adhesion After Endometrial Injury and Monitor the Therapeutic Effects.

Objectives: To assess the severity of intrauterine adhesion (IUA) after endometrial injury via ultrasound molecular imaging (USMI) of vascular endothelial growth factor receptor 2 (VEGFR2) expression on the uterine endothelium.

Methods: MB was constructed via "biotin-avidin-biotin" bridging technology. A rat IUA animal model was constructed via chemical injury.

Exploring the potential of green-synthesized hydroxyapatite for cadmium remediation in paddy soils.

The Cadmium contamination in paddy soils significantly threatens soil health and food safety. This study addresses the urgent need for cost-effective and sustainable remediation methods by evaluating the efficacy of green-synthesized hydroxyapatite (GHAP) in immobilizing Cd in paddy soils. The investigation focused on the effects of applying GHAP, commercial hydroxyapatite (CHAP), and pure hydroxyapatite (CK) on soil physicochemical properties, as well as Cd mobility and transfer within the soil-rice system.

Rice bran peptides with α-glucosidase inhibition activity delay the in vitro starch digestion of different rice foods.

Rice bran peptides (RBPs) with α-glucosidase inhibition activity have shown great efficacy in reducing postprandial blood glucose levels. This study investigated the inhibitory mechanism of RBPs on amyloglucosidase (AMG) and their potential for modulating starch digestion in rice-based foods. The results demonstrated that RBPs significantly reduced the digestibility and estimated glycemic index (eGI) values of all rice foods in a dose-dependent manner.

Research progress on ultrasound in bacteria-mediated tumor treatment.

Bacteria-mediated tumor treatment (BMTT) has recently garnered significant attention as a promising avenue in tumor treatment. Despite the application of various strains in animal models and clinical trials, the effectiveness of BMTT has been hindered by its toxicity and inefficiency. In recent years, it has been explored that applying the biological effects of ultrasound could further improve the precision and effectiveness of BMTT.