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Fluid flow in microporous and nanoporous media exhibits unique behaviors that deviate from classical continuum predictions due to dominant surface forces at small scales. Understanding these microscale flow mechanisms is critical for optimizing unconventional reservoir recovery and other energy applications. This review provides a comparative analysis of the existing literature, highlighting key advances in experimental techniques, theoretical models, and numerical simulations. We discuss how innovative micro/nanofluidic devices and high-resolution imaging methods now enable direct observation of confined flow phenomena, such as slip flow, phase transitions, and non-Darcy behavior. Recent theoretical models have clarified scale-dependent flow regimes by distinguishing microscale effects from macroscopic Darcy flow. Likewise, advanced numerical simulations-including molecular dynamics (MD), lattice Boltzmann methods (LBM), and hybrid multiscale frameworks-capture complex fluid-solid interactions and multiphase dynamics under realistic pressure and wettability conditions. Moreover, the integration of artificial intelligence (e.g., data-driven modeling and physics-informed neural networks) is accelerating data interpretation and multiscale modeling, offering improved predictive capabilities. Through this critical review, key phenomena, such as adsorption layers, fluid-solid interactions, and pore surface heterogeneity, are examined across studies, and persistent challenges are identified. Despite notable progress, challenges remain in replicating true reservoir conditions, bridging microscale and continuum models, and fully characterizing multiphase interface dynamics. By consolidating recent progress and perspectives, this review not only summarizes the state-of-the-art but underscores remaining knowledge gaps and future directions in micro/nanopore flow research.
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http://dx.doi.org/10.3390/molecules30081807 | DOI Listing |
BMC Health Serv Res
September 2025
Institute of General Practice, Rostock University Medical Center, Doberaner Str. 142, Rostock, 18057, Germany.
Background: Post-viral syndromes, including long- and post-COVID, often lead to persistent symptoms such as fatigue and dyspnoea, affecting patients' daily lives and ability to work. The COVI-Care M-V trial examines whether interprofessional, patient-centred teleconsultations, initiated by general practitioners in cooperation with specialists, can help reduce symptom burden and improve care for patients.
Methods: To evaluate the effectiveness of the intervention under routine care conditions, a cluster-randomised controlled trial is being conducted.
Ann Biomed Eng
September 2025
Department of Mechanical Engineering, Koc University, Rumeli Feneri Campus, Sarıyer, 34450, Istanbul, Turkey.
Purpose: The design and development of ventricular assist devices have heavily relied on computational tools, particularly computational fluid dynamics (CFD), since the early 2000s. However, traditional CFD-based optimization requires costly trial-and-error approaches involving multiple design cycles. This study aims to propose a more efficient VAD design and optimization framework that overcomes these limitations.
View Article and Find Full Text PDFAnaesthesiologie
September 2025
TUM School of Medicine and Health, Klinikum rechts der Isar, Department of Anesthesiology and Intensive Care, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Background: Medical societies around the world are exploring strategies to reduce their carbon footprint. In this context, organizational readiness can serve as an important facilitator for the success of change. In this study we assessed whether a series of educational interventions improved anesthesia departments' organizational readiness for climate change mitigation.
View Article and Find Full Text PDFOncogene
September 2025
Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.
Forkhead-box-protein P3 (FOXP3) is a key transcription factor in T regulatory cells (Tregs). However, its expression and significance in non-immune stromal cells in the tumor microenvironment remain unclear. Here, we demonstrated FOXP3 expression in stromal fibroblasts of mouse and human gastrointestinal tumors.
View Article and Find Full Text PDFEnviron Monit Assess
September 2025
School of Geological Survey, China University of Geosciences, Wuhan, 430074, China.
Cadmium (Cd) contamination in water poses a critical global challenge. A novel nanocomposite, montmorillonite (Mt)-supported nanoscale zero-valent iron (Mt-nZVI), synthesized by liquid phase reduction, offers a promising method for effectively removing Cd. The material underwent characterization through various techniques, including X-ray diffraction (XRD) and Scanning Electron Microscope(SEM).
View Article and Find Full Text PDF